Full Text Journal Articles by
Author Eric Hendrickson

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Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.

Ryan M Baxley, Wendy Leung, Megan M Schmit, Jacob Peter Matson, Lulu Yin, Marissa K Oram, Liangjun Wang, John Taylor, Jack Hedberg, Colette B Rogers, Adam J Harvey, Debashree Basu, Jenny C Taylor, Alistair T Pagnamenta, Helene Dreau, Jude Craft, Elizabeth Ormondroyd, Hugh Watkins, Eric A Hendrickson, Emily M Mace, Jordan S Orange, Hideki Aihara, Grant S Stewart, Edward Blair, Jeanette Gowen Cook, Anja-Katrin Bielinsky,

Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients with distinctive, but overlapping, clinical phenotypes: natural killer (NK) cell deficiency (NKD) and restrictive cardiomyopathy (RCM) with hypoplasia of the spleen and thymus. To understand the mechanism of MCM10-associated disease, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1626]

Cited: 0 times

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Split Staphylococcus aureus prime editor for AAV delivery

Eric Aird, Alina Zdechlik, Brian Ruis, Colette Rogers, Andrew Lemmex, Andrew Nelson, Eric Hendrickson, Daniel Schmidt, Wendy Gordon,

Prime editing brings immense promise to correct a large number of human pathogenic mutations and enact diverse edit types without introducing widespread undesired editing events. Delivery of prime editors in vivo would enable such edits to be introduced in a clinical setting. The coding sequence for prime editor, however, is ... Read more >>

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Five-year trends in maternal cardiac arrest in Maryland: 2013-2017.

Allison Lankford, Jonathan Chow, Eric Hendrickson, Myung Sun Jung, Bhavani Kodali, Andrew Malinow, Katherine Goetzinger, Michael Mazzeffi,

<h4>Background</h4>The United States (US) maternal mortality rate (MMR) continues to increase. Until recently, the MMR in Maryland (MD) was consistently higher than the national average. Maternal cardiac arrest (MCA) is a rare condition, but can lead to devastating consequences. The incidence of MCA in the US is approximately 6-8 per ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-4]

Cited: 0 times

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Telomere replication-When the going gets tough.

Susanna Stroik, Eric A Hendrickson,

Telomeres consist of repetitive tracts of DNA that shield a chromosome's contents from erosion and replicative attrition. However, telomeres are also late-replicating regions of the genome in which a myriad of replicative obstructions reside. The obstacles contained within telomeres, as well as their genomic location, drive replicative stalling and subsequent ... Read more >>

DNA Repair (Amst) (DNA repair)
[2020, 94:102875]

Cited: 2 times

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EXO1 resection at G-quadruplex structures facilitates resolution and replication.

Susanna Stroik, Kevin Kurtz, Kevin Lin, Sergey Karachenets, Chad L Myers, Anja-Katrin Bielinsky, Eric A Hendrickson,

G-quadruplexes represent unique roadblocks to DNA replication, which tends to stall at these secondary structures. Although G-quadruplexes can be found throughout the genome, telomeres, due to their G-richness, are particularly predisposed to forming these structures and thus represent difficult-to-replicate regions. Here, we demonstrate that exonuclease 1 (EXO1) plays a key ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2020, 48(9):4960-4975]

Cited: 7 times

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Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery.

Maya Raghunandan, Jung Eun Yeo, Ryan Walter, Kai Saito, Adam J Harvey, Stacie Ittershagen, Eun-A Lee, Jihyeon Yang, Maureen E Hoatlin, Anja K Bielinsky, Eric A Hendrickson, Orlando Schärer, Alexandra Sobeck,

Fanconi anemia (FA) is a chromosome instability syndrome characterized by increased cancer predisposition. Specifically, the FA pathway functions to protect genome stability during DNA replication. The central FA pathway protein, FANCD2, locates to stalled replication forks and recruits homologous recombination (HR) factors such as CtBP interacting protein (CtIP) to promote ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2020, 29(7):1083-1095]

Cited: 4 times

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RAD52: Viral Friend or Foe?

Eric A Hendrickson,

Mammalian Radiation Sensitive 52 (RAD52) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

Cited: 4 times

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Telomere fusions and translocations: a bridge too far?

Susanna Stroik, Eric A Hendrickson,

Telomere fusions inevitably arise as a cell's last-ditch effort to protect exposed chromosomal ends when telomeres are lost due to aging-associated erosion, breakage, failed replication, or a plethora of other cellular mistakes. Fusion of an exposed chromosomal end to another telomere presumably presents a superficially attractive option to the cell ... Read more >>

Curr Opin Genet Dev (Current opinion in genetics & development)
[2020, 60:85-91]

Cited: 2 times

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Bi-allelic MCM10 mutations cause telomere shortening with immune dysfunction and cardiomyopathy

Ryan Baxley, Wendy Leung, Megan Schmit, Jacob Peter Matson, Marissa Oram, Liangjun Wang, John Taylor, Lulu Yin, Jack Hedberg, Colette Rogers, Adam Harvey, Debashree Basu, Jenny Taylor, Alistair Pagnamenta, Helene Dreau, Jude Craft, Elizabeth Ormondroyd, Hugh Watkins, Eric Hendrickson, Emily Mace, Jordan Orange, Hideki Aihara, Grant Stewart, Edward Blair, Jeanette Gowen Cook, Anja-Katrin Bielinsky,

<h4>ABSTRACT</h4> Minichromosome maintenance protein 10 (Mcm10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 mutations in patients with distinctive but overlapping clinical phenotypes – natural killer (NK) cell deficiency (NKD) and restrictive cardiomyopathy (RCM) with hypoplasia of the spleen and thymus. To understand the mechanism of ... Read more >>

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Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination.

Brian Ruis, Amy Molan, Taylor Takasugi, Eric A Hendrickson,

The repair of DNA double-stranded breaks (DSBs) is an essential function performed by the Classical Non-Homologous End-Joining (C-NHEJ) pathway in higher eukaryotes. C-NHEJ, in fact, does double duty as it is also required for the repair of the intermediates formed during lymphoid B- and T-cell recombination. Consequently, the failure to ... Read more >>

DNA Repair (Amst) (DNA repair)
[2020, 85:102738]

Cited: 2 times

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CtIP is essential for telomere replication.

Susanna Stroik, Kevin Kurtz, Eric A Hendrickson,

The maintenance of telomere length is critical to longevity and survival. Specifically, the failure to properly replicate, resect, and/or form appropriate telomeric structures drives telomere shortening and, in turn, genomic instability. The endonuclease CtIP is a DNA repair protein that is well-known to promote genome stability through the resection of ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2019, 47(17):8927-8940]

Cited: 4 times

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Both the classical and alternative non-homologous end joining pathways contribute to the fusion of drastically shortened telomeres induced by TRF2 overexpression.

Bernadette Nera, Hui-Shun Huang, Eric A Hendrickson, Lifeng Xu,

The double-stranded telomeric binding protein TRF2 is expressed in many human cancers at elevated levels. Moreover, experimental overexpression of TRF2 in human cells causes replication stalling in telomeric tracts, which leads to drastic telomere shortening and fusion of deprotected chromosome ends. To understand which end joining pathway is involved in ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2019, 18(8):880-888]

Cited: 1 time

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Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin.

Kez Cleal, Rhiannon E Jones, Julia W Grimstead, Eric A Hendrickson, Duncan M Baird,

Telomere erosion, dysfunction, and fusion can lead to a state of cellular crisis characterized by large-scale genome instability. We investigated the impact of a telomere-driven crisis on the structural integrity of the genome by undertaking whole-genome sequence analyses of clonal populations of cells that had escaped crisis. Quantification of large-scale ... Read more >>

Genome Res (Genome research)
[2019, 29(5):737-749]

Cited: 12 times

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Conversion Tract Analysis of Homology-Directed Genome Editing Using Oligonucleotide Donors.

Yinan Kan, Eric A Hendrickson,

Homology-directed genome editing is the intentional alteration of an endogenous genetic locus using information from an exogenous homology donor. A conversion tract is defined as the amount of genetic information that is converted from the homology donor to a given strand of the targeted chromosomal locus. Because of this, conversion ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2019, 1999:131-144]

Cited: 0 times

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PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation.

Greg Ngo, Sam Hyatt, Julia Grimstead, Rhiannon Jones, Eric Hendrickson, Chris Pepper, Duncan Baird,

Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage cancers, often show signs of a telomere crisis, suggesting that escape from telomere ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(101):37549-37563]

Cited: 3 times

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PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ.

Adam Harvey, Nicholas Mielke, Julia W Grimstead, Rhiannon E Jones, Thanh Nguyen, Matthew Mueller, Duncan M Baird, Eric A Hendrickson,

Poly-ADP ribose polymerase 1 (<i>PARP1</i>) is clinically important because of its synthetic lethality with breast cancer allele 1 and 2 mutations, which are causative for inherited breast and ovarian cancers. Biochemically, PARP1 is a single-stranded DNA break repair protein that is needed for preserving genomic integrity. In addition, PARP1 has ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(78):34821-34837]

Cited: 6 times

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TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining.

Ajinkya S Kawale, Konstantin Akopiants, Kristoffer Valerie, Brian Ruis, Eric A Hendrickson, Shar-Yin N Huang, Yves Pommier, Lawrence F Povirk,

The Artemis nuclease and tyrosyl-DNA phosphodiesterase (TDP1) are each capable of resolving protruding 3'-phosphoglycolate (PG) termini of DNA double-strand breaks (DSBs). Consequently, both a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3'-PG-terminated DSBs. Unexpectedly, however, a knockdown or ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2018, 46(17):8926-8939]

Cited: 5 times

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CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.

Peili Gu, Shuting Jia, Taylor Takasugi, Eric Smith, Jayakrishnan Nandakumar, Eric Hendrickson, Sandy Chang,

Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC1, a component of the CST (CTC1, STN1, and TEN1) complex important for telomere length maintenance. The molecular basis of how CP mutations impact upon telomere length remains unclear. The CP CTC1<sup>L1142H</sup> mutation has been previously shown ... Read more >>

Aging Cell (Aging cell)
[2018, 17(4):e12783]

Cited: 13 times

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Telomeres and Chromosomal Translocations : There's a Ligase at the End of the Translocation.

Duncan M Baird, Eric A Hendrickson,

Chromosomal translocations are now well understood to not only constitute signature molecular markers for certain human cancers but often also to be causative in the genesis of that tumor. Despite the obvious importance of such events, the molecular mechanism of chromosomal translocations in human cells remains poorly understood. Part of ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2018, 1044:89-112]

Cited: 3 times

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FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.

Elizabeth L Thompson, Jung E Yeo, Eun-A Lee, Yinan Kan, Maya Raghunandan, Constanze Wiek, Helmut Hanenberg, Orlando D Schärer, Eric A Hendrickson, Alexandra Sobeck,

Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin, the FA core complex monoubiquitinates and recruits the central FANCI and FANCD2 proteins that subsequently ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2017, 45(20):11837-11857]

Cited: 17 times

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Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.

Yinan Kan, Nizar N Batada, Eric A Hendrickson,

Homology-directed repair (HDR) maintains genomic integrity by eliminating lesions such as DNA double-strand breaks (DSBs), interstrand crosslinks (ICLs) and stalled replication forks and thus a deficiency in HDR is associated with genomic instability and cancer predisposition. The mechanism of HDR is best understood and most rigorously characterized in yeast. The ... Read more >>

DNA Repair (Amst) (DNA repair)
[2017, 55:64-75]

Cited: 12 times

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Mechanisms of precise genome editing using oligonucleotide donors.

Yinan Kan, Brian Ruis, Taylor Takasugi, Eric A Hendrickson,

The use of programmable meganucleases is transforming genome editing and functional genomics. CRISPR/Cas9 was developed such that targeted genomic lesions could be introduced in vivo with unprecedented ease. In the presence of homology donors, these lesions facilitate high-efficiency precise genome editing (PGE) via homology-directed repair (HDR) pathways. However, the identity ... Read more >>

Genome Res (Genome research)
[2017, 27(7):1099-1111]

Cited: 31 times

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Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.

Kate Liddiard, Brian Ruis, Taylor Takasugi, Adam Harvey, Kevin E Ashelford, Eric A Hendrickson, Duncan M Baird,

Telomeres shorten with each cell division and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale genomic rearrangements of the kind frequently observed in human cancers. We have characterized more than 1400 telomere fusion events at the single-molecule level, using a combination of high-throughput sequence analysis together with ... Read more >>

Genome Res (Genome research)
[2016, 26(5):588-600]

Cited: 18 times

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Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.

Jessica A Neal, Yao Xu, Masumi Abe, Eric Hendrickson, Katheryn Meek,

Unlike most DNA-dependent protein kinase, catalytic subunit (DNA-PKcs)-deficient mouse cell strains, we show in the present study that targeted deletion of DNA-PKcs in two different human cell lines abrogates VDJ signal end joining in episomal assays. Although the mechanism is not well defined, DNA-PKcs deficiency results in spontaneous reduction of ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2016, 196(7):3032-3042]

Cited: 13 times

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FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.

Maria Castella, Celine Jacquemont, Elizabeth L Thompson, Jung Eun Yeo, Ronald S Cheung, Jen-Wei Huang, Alexandra Sobeck, Eric A Hendrickson, Toshiyasu Taniguchi,

The Fanconi anemia (FA)-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex). However, the regulation of the FA core complex itself is poorly ... Read more >>

PLoS Genet (PLoS genetics)
[2015, 11(10):e1005563]

Cited: 40 times

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