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Report on a new opioid NPS: chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol.

Annelies Cannaert, Fabian Hulpia, Martijn Risseeuw, Katleen Van Uytfanghe, Eric Deconinck, Serge Van Calenbergh, Peter Blanckaert, Christophe Stove,

In this paper, the identification and full characterization of a novel non-fentanyl opioid sourced online, which is a member of the 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives related to MT-45, is reported. The sample was sold under the name 'diphenpipenol', (3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethyl]phenol), although extensive NMR analysis showed that the product obtained was actually a diphenpipenol ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2020, :]

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Cytogenetic risk score maintains its prognostic significance in AML patients with detectable measurable residual disease undergoing transplantation in remission: on behalf of the ALWP/EBMT.

Arnon Nagler, Myriam Labopin, Jonathan Canaani, Riitta Niittyvuopio, Gerard Socié, Nicolaus Kröger, Maija Itäla-Remes, Ibrahim Yakoub-Agha, Hélène Labussière-Wallet, Maria Pilar Gallego-Hernanz, Eric Deconinck, Patrice Chevallier, Jürgen Finke, Jordi Esteve, Mohamad Mohty,

While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prognostic cytogenetic model (Leukemia 2019) we ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2020, :]

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Impact of detectable measurable residual disease on umbilical cord blood transplantation.

Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Jorge Sierra, Stephen Robinson, Hélène Labussière-Wallet, Michael Potter, Josep-Maria Ribera, Eric Deconinck, Alessandro Rambaldi, Pierre-Simon Rohrlich, Thierry de Revel, Eliane Gluckman, Arnon Nagler, Mohamad Mohty,

The impact of measurable residual disease (MRD) on cord blood transplantation (CBT) outcomes has remained debated. To address this issue, we assessed the impact of measurable MRD at CBT on outcomes in large cohort of patients with acute leukemia. Inclusion criteria included adult patients with acute myeloid (AML) or acute ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2020, :]

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Discrimination of legal and illegal Cannabis spp. according to European legislation using near infrared spectroscopy and chemometrics.

Céline Duchateau, Jean-Michel Kauffmann, Michaël Canfyn, Caroline Stévigny, Kris De Braekeleer, Eric Deconinck,

Aerial parts containing cannabidiol can be purchased in a legal way but cannabis used as recreational drug is illegal in most European countries. Δ9-tetrahydrocannabinol is one of the main cannabinoids responsible for the psychotropic effect. European Union countries and Switzerland authorize a concentration of THC of 0.2% and 1.0% w/w, ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, :]

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CD34+ cell dose effects on clinical outcomes after T-cell replete haploidentical allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia using peripheral blood stem cells. A study from the acute leukemia working Party of the European Society for blood and marrow transplantation (EBMT).

Enrico Maffini, Myriam Labopin, Didier Blaise, Fabio Ciceri, Zafer Gülbas, Eric Deconinck, Veronique Leblond, Patrick Chevallier, Gerard Sociè, Mercedes C Araujo, Yener Koc, Bipin N Savani, Norbert C Gorin, Francesco Lanza, Arnon Nagler, Mohamad Mohty,

Previous observations have reported controversial conclusions regarding cell dose and survival endpoints after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a retrospective analysis on 414 adult patients (median age 54 years, range, 18-74 years) with acute myeloid leukemia (AML) in first and second complete remission. They received a T-cell replete allogeneic ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2020, :]

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Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials.

Yaxin Tie, Céline Duchateau, Shana Van de Steene, Corenthin Mees, Kris De Braekeleer, Thomas De Beer, Erwin Adams, Eric Deconinck,

The threats of substandard and falsified (SF) antimicrobials, posed to public health, include serious adverse drug effects, treatment failures and even development of antimicrobial resistance. Next to these issues, it has no doubt that efficient methods for on-site screening are required to avoid that SF antimicrobials reach the patient or ... Read more >>

Talanta (Talanta)
[2020, 217:121026]

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Blastic Plasmacytoid Dendritic Cell Neoplasm: The European Perspective.

Eric Deconinck,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) has to be considered an orphan tumoral disease. BPDCN is a good model concerning the structuring and the organization of a concerted medical program on a nation-based, transnational, or international level. In 2019 in France the diagnosis process for BPDCN was clearly established. Two ... Read more >>

Hematol. Oncol. Clin. North Am. (Hematology/oncology clinics of North America)
[2020, 34(3):613-620]

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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman.

Claire Cochet, Marion Simonet, Julie Cattin, Jean-Patrick Metz, Ana Berceanu, Eric Deconinck, Etienne Daguindau, Françoise Schillinger, Pierre Fenaux, Nicolas Mottet, Yohan Desbrosses,

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3686584]

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Blastic Plasmacytoid Dendritic Cell Neoplasm: Clinical Presentation and Diagnosis.

Eric Deconinck, Tony Petrella, Francine Garnache Ottou,

Clinical and biological presentation of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) is depicted to highlight criteria that might alert physicians. Diagnosis of BPDCN is still challenging and requires (1) immunophenotyping of blood or bone marrow aspiration using several markers (CD4, CD56, HLA-DR, myeloid and lymphoid lineage markers) and ... Read more >>

Hematol. Oncol. Clin. North Am. (Hematology/oncology clinics of North America)
[2020, 34(3):491-500]

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CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm.

Elodie Bôle-Richard, Maxime Fredon, Sabeha Biichlé, François Anna, Jean-Marie Certoux, Florian Renosi, Frédéric Tsé, Chloé Molimard, Séverine Valmary-Degano, Alizée Jenvrin, Walid Warda, Jean-René Pallandre, Francis Bonnefoy, Margaux Poussard, Marina Deschamps, Tony Petrella, Christophe Roumier, Elizabeth Macintyre, Frédéric Féger, Eolia Brissot, Mohamad Mohty, Kiave-Yune HoWangYin, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin, Yann Godet, Delphine Binda, Maïder Pagadoy, Eric Deconinck, Etienne Daguindau, Philippe Saas, Christophe Ferrand, Fanny Angelot-Delettre, Olivier Adotévi, Francine Garnache-Ottou,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is associated with a remarkably poor prognosis and with no treatment consensus. The identification of relevant therapeutic targets is challenging. Here, we investigated the immune functions, antileukemia efficacy and safety of CD28/4-1BB CAR T cells targeting CD123 the interleukin (IL)-3 receptor alpha chain which ... Read more >>

Leukemia (Leukemia)
[2020, :]

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The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.

Celine Vanhee, Antoine Francotte, Steven Janvier, Eric Deconinck,

At the end of 2017 and 2018 two different unknown suspicious preparations were encountered and were subjected to a plethora of different analyses in order to identify, if present, any bioactive compound. It turned out that these samples contained the assumedly cognitive enhancing research peptides Selank and Semax, which, to ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(3):371-381]

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Substandard and falsified antimicrobials: A potential biohazard in disguise?

Yaxin Tie, Erwin Adams, Eric Deconinck, Celine Vanhee,

Drug Test Anal (Drug testing and analysis)
[2020, 12(2):285-291]

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Impact of the revised European Tobacco Product Directive on the quality of e-cigarette refill liquids in Belgium.

Sophia Barhdadi, Goedele Moens, Michael Canfyn, Celine Vanhee, Bart Desmedt, Patricia Courselle, Vera Rogiers, Tamara Vanhaecke, Eric Deconinck,

INTRODUCTION:Since its introduction, the e-cigarette has become a commonly used consumer product. In this study, we investigate whether regulatory changes had an impact on the quality of refill liquids (e-liquids) available on the Belgian market through analysis of their chemical composition. Hence, the nicotine concentration accuracy was investigated in samples ... Read more >>

Nicotine Tob. Res. (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, :]

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Sensitizing fragrances in absorbent hygiene products.

Bart Desmedt, Quinten Marcelis, Dea Zhilivoda, Eric Deconinck,

BACKGROUND:Allergenic fragrances are present in a wide range of products but they are not regulated in all industries to the same extent. In Europe, absorbent hygiene products (AHPs) are only covered by the general product safety directive and therefore fragrances can be used freely, whereas in cosmetics and toys the ... Read more >>

Contact Derm. (Contact dermatitis)
[2020, 82(5):279-282]

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Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene.

Peter Blanckaert, Annelies Cannaert, Katleen Van Uytfanghe, Fabian Hulpia, Eric Deconinck, Serge Van Calenbergh, Christophe Stove,

This paper reports on the identification and full chemical characterization of isotonitazene (N,N-diethyl-2-[5-nitro-2-({4-[(propan-2-yl)oxy]phenyl}methyl)-1H-benzimidazol-1-yl]ethan-1-amine), a potent NPS opioid and the first member of the benzimidazole class of compounds to be available on online markets. Interestingly, this compound was sold under the name etonitazene, a structural analog. Identification of isotonitazene was performed ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(4):422-430]

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Donor selection for a second allogeneic stem cell transplantation in AML patients relapsing after a first transplant: a study of the Acute Leukemia Working Party of EBMT.

Avichai Shimoni, Myriam Labopin, Jürgen Finke, Fabio Ciceri, Eric Deconinck, Nicolaus Kröger, Martin Gramatzki, Matthias Stelljes, Didier Blaise, Friedrich Stoelzel, Patrice Chevallier, Ernst Holler, Nathalie Fegueux, Mohamad Mohty, Arnon Nagler,

Second allogeneic stem-cell transplantation (SCT2) is a therapeutic option for patients with AML relapsing after a first transplant. Prior studies have shown similar results after SCT2 from the same or different donor; however, there are limited data on second non-T-depleted haplo-identical transplant in this setting. We retrospectively analyzed SCT2 outcomes ... Read more >>

Blood Cancer J (Blood cancer journal)
[2019, 9(12):88]

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How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

Francine Garnache-Ottou, Chrystelle Vidal, Sabeha Biichlé, Florian Renosi, Eve Poret, Maïder Pagadoy, Maxime Desmarets, Anne Roggy, Estelle Seilles, Lou Soret, Françoise Schillinger, Sandrine Puyraimond, Tony Petrella, Claude Preudhomme, Christophe Roumier, Elisabeth A MacIntyre, Véronique Harrivel, Yohan Desbrosses, Bérengère Gruson, Franck Geneviève, Sylvain Thepot, Yuriy Drebit, Thibaut Leguay, François-Xavier Gros, Nicolas Lechevalier, Pascale Saussoy, Véronique Salaun, Edouard Cornet, Zehaira Benseddik, Richard Veyrat-Masson, Orianne Wagner-Ballon, Célia Salanoubat, Marc Maynadié, Julien Guy, Denis Caillot, Marie-Christine Jacob, Jean-Yves Cahn, Rémy Gressin, Johann Rose, Bruno Quesnel, Estelle Guerin, Franck Trimoreau, Jean Feuillard, Marie-Pierre Gourin, Adriana Plesa, Lucile Baseggio, Isabelle Arnoux, Norbert Vey, Didier Blaise, Romaric Lacroix, Christine Arnoulet, Blandine Benet, Véronique Dorvaux, Caroline Bret, Bernard Drenou, Agathe Debliquis, Véronique Latger-Cannard, Caroline Bonmati, Marie-Christine Bene, Pierre Peterlin, Michel Ticchioni, Pierre-Simon Rohrlich, Anne Arnaud, Stefan Wickenhauser, Valérie Bardet, Sabine Brechignac, Benjamin Papoular, Victoria Raggueneau, Jacques Vargaftig, Rémi Letestu, Daniel Lusina, Thorsten Braun, Vincent Foissaud, Jérôme Tamburini, Hind Bennani, Nicolas Freynet, Catherine Cordonnier, Magali Le Garff-Tavernier, Nathalie Jacques, Karim Maloum, Damien Roos-Weil, Didier Bouscary, Vahid Asnafi, Ludovic Lhermitte, Felipe Suarez, Etienne Lengline, Frédéric Féger, Giorgia Battipaglia, Mohamad Mohty, Sabrina Bouyer, Ouda Ghoual, Elodie Dindinaud, Caroline Basle, Mathieu Puyade, Carinne Lafon, Thierry Fest, Mikael Roussel, Xavier Cahu, Elsa Bera, Sylvie Daliphard, Fabrice Jardin, Lydia Campos, Françoise Solly, Denis Guyotat, Anne-Cécile Galoisy, Alice Eischen, Caroline Mayeur-Rousse, Blandine Guffroy, Christian Recher, Marie Loosveld, Alice Garnier, Vincent Barlogis, Maria Alessandra Rosenthal, Sophie Brun, Nathalie Contentin, Sébastien Maury, Mary Callanan, Christine Lefebvre, Natacha Maillard, Patricia Okamba, Christophe Ferrand, Olivier Adotevi, Philippe Saas, Fanny Angelot-Delettre, Delphine Binda, Eric Deconinck,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (2000-2013), we described clinical and biological data focusing on morphologies and immunophenotype. We found ... Read more >>

Blood Adv (Blood advances)
[2019, 3(24):4238-4251]

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The impact of anti-thymocyte globulin on the outcomes of Patients with AML with or without measurable residual disease at the time of allogeneic hematopoietic cell transplantation.

Arnon Nagler, Bhagirathbhai Dholaria, Myriam Labopin, Gerard Socie, Anne Huynh, Maija Itälä-Remes, Eric Deconinck, Ibrahim Yakoub-Agha, Jean-Yves Cahn, Jean-Henri Bourhis, Hélène Labussière-Wallet, Sylvain Chantepie, Jordi Esteve, Bipin Savani, Mohamad Mohty,

Measurable residual disease (MRD) status pre-allogeneic hematopoietic cell transplantation (allo-HCT) has been shown to predict transplant outcomes. We investigated the effect of Anti-Thymocyte Globulin (ATG) on acute myelogenous leukemia (AML) relapse by pretransplant MRD status. AML patients undergoing allo-HCT in first complete remission from either a matched sibling or unrelated ... Read more >>

Leukemia (Leukemia)
[2020, 34(4):1144-1153]

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Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study.

Effie W Petersdorf, Mary Carrington, Colm O'hUigin, Mats Bengtsson, Dianne De Santis, Valerie Dubois, Ted Gooley, Mary Horowitz, Katharine Hsu, J Alejandro Madrigal, Martin J Maiers, Mari Malkki, Caroline McKallor, Yasuo Morishima, Machteld Oudshoorn, Stephen R Spellman, Jean Villard, Phil Stevenson, ,

BACKGROUND:The success of unrelated haemopoietic cell transplantation (HCT) is limited by graft-versus-host disease (GVHD), which is the main post-transplantation challenge when HLA-matched donors are unavailable. A sequence dimorphism in exon 1 of HLA-B gives rise to leader peptides containing methionine (Met; M) or threonine (Thr; T), which differentially influence natural ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2020, 7(1):e50-e60]

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Correction of Severe Myelofibrosis, Impaired Platelet Functions and Abnormalities in a Patient with Gray Platelet Syndrome Successfully Treated by Stem Cell Transplantation.

Rémi Favier, Xavier Roussel, Sylvain Audia, Jean Claude Bordet, Emmanuel De Maistre, Pierre Hirsch, Anne Neuhart, Isabelle Bedgedjian, Vasiliki Gkalea, Marie Favier, Etienne Daguindau, Paquita Nurden, Eric Deconinck,

Gray platelet syndrome (GPS) is an inherited disorder. Patients harboring GPS have thrombocytopenia with large platelets lacking α-granules. A long-term complication is myelofibrosis with pancytopenia. Hematopoietic stem cell transplant (HSCT) could be a curative treatment. We report a male GPS patient with severe pancytopenia, splenomegaly and a secondary myelofibrosis needing ... Read more >>

Platelets (Platelets)
[2020, 31(4):536-540]

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Evaluation of impurities and dissolution profiles of illegal antimicrobial drugs encountered in Belgium.

Yaxin Tie, Kevin van Loock, Eric Deconinck, Erwin Adams,

Substandard and falsified (SF) antimicrobials are gaining popularity in both developing and developed countries, posing a growing threat to public health. In general, the evaluation of SF antimicrobial drugs mainly focuses on the identification and quantification of the pharmaceutical active ingredients, ignoring other parameters of drug quality control. This study ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(1):53-66]

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Prognostic impact of EBV serostatus in patients with lymphomas or chronic malignancies undergoing allogeneic HCT.

Jan Styczynski, Gloria Tridello, Lidia Gil, Per Ljungman, Malgorzata Mikulska, Katherine N Ward, Catherine Cordonnier, Rafael de la Camara, Diana Averbuch, Nina Knelange, Gerard Socié, Patrice Chevallier, Didier Blaise, Ibrahim Yakoub-Agha, Edouard Forcade, Jan Cornelissen, Johan Maertens, Eefke Petersen, Stéphanie Nguyen-Quoc, Hendrik Veelken, Nicolaas Schaap, Jakob Passweg, Mauricette Michallet, Nathalie Fegueux, Eric Deconinck, Nigel Russell, Grzegorz Basak, Peter Bader, Silvia Montoto, Nicolaus Kröger, Simone Cesaro, ,

The influence of the donor (D) and recipient (R) pre-transplant Epstein-Barr Virus (EBV) serostatus on transplant outcomes (overall survival, relapse-free survival, relapse incidence, non-relapse mortality, acute and chronic GVHD) in 12,931 patients with lymphomas or chronic malignancies undergoing allogeneic hematopoietic cell transplant (allo-HCT) between 1997-2016 was analyzed. In multivariate analysis, ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2019, 54(12):2060-2071]

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Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Xavier Roussel, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Philippe Saas, Christophe Ferrand, Estelle Seilles, Fabienne Pouthier, Eric Deconinck, Fabrice Larosa,

PURPOSE OF THE STUDY:Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4+ T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated ... Read more >>

Curr Res Transl Med (Current research in translational medicine)
[2019, 67(4):135-143]

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Trends in the analysis of falsified and illegal medicines.

Eric Deconinck,

Talanta (Talanta)
[2019, 203:328-329]

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Lessons to be learned from toxicological analyses in intoxicated patients and seized materials at an electronic music dance festival.

Paul Calle, Kristof Maudens, Sabine Lemoyne, Simon Geerts, Diederik Van Sassenbroeck, Peter Jensen, Jorne Van Overloop, Eric Deconinck, Peter Blanckaert,

Medical problems related to illicit drug use are frequently encountered at electronic dance music (EDM) events. In this prospective study, the medical problems and toxicological analyses on intoxicated persons and seized materials are described jointly. The aim of this study is to find out to what extent these efforts may ... Read more >>

Forensic Sci. Int. (Forensic science international)
[2019, 299:174-179]

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