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Impact of the Revised European Tobacco Product Directive on the Quality of E-cigarette Refill Liquids in Belgium.

Sophia Barhdadi, Goedele Moens, Michael Canfyn, Celine Vanhee, Bart Desmedt, Patricia Courselle, Vera Rogiers, Tamara Vanhaecke, Eric Deconinck,

<h4>Introduction</h4>Since its introduction, the e-cigarette has become a commonly used consumer product. In this study, we investigate whether regulatory changes had an impact on the quality of refill liquids (e-liquids) available on the Belgian market through analysis of their chemical composition. Hence, the nicotine concentration accuracy was investigated in samples ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2021, 23(1):227-234]

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Corrigendum to: Impact of the Revised European Tobacco Product Directive on the Quality of E-cigarette Refill Liquids in Belgium.

Sophia Barhdadi, Goedele Moens, Michael Canfyn, Celine Vanhee, Bart Desmedt, Patricia Courselle, Vera Rogiers, Tamara Vanhaecke, Eric Deconinck,

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2021, 23(1):235]

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Optimizing selection of double cord blood units for transplantation of adult patients with malignant diseases.

Giancarlo Fatobene, Fernanda Volt, Frederico Moreira, Lívia Mariano, Patrice Chevallier, Sabine Furst, Hélène Labussière-Wallet, Régis Peffault de la Tour, Eric Deconinck, Thomas Cluzeau, Nigel Russell, Dimitrios Karakasis, Edouard Forcade, Annalisa Ruggeri, Eliane Gluckman, Vanderson Rocha,

Double-unit unrelated cord blood transplantation (DUCBT) is an option in patients for whom a single unit is not sufficient to provide an adequate number of cells. As current guidelines on UCB unit selection are mainly based on single-unit UCB data, we performed a retrospective analysis of 1375 adult recipients of ... Read more >>

Blood Adv (Blood advances)
[2020, 4(24):6327-6335]

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Scoring system for clinically significant CMV infection in seropositive recipients following allogenic hematopoietic cell transplant: an SFGM-TC study.

David Beauvais, Elodie Drumez, Didier Blaise, Régis Peffault de Latour, Edouard Forcade, Patrice Ceballos, Anne Uyttebroeck, Hélène Labussière, Stéphanie Nguyen, Jean-Henri Bourhis, Patrice Chevallier, Anne Thiebaut, Xavier Poiré, Sébastien Maury, Eric Deconinck, Thomas Cluzeau, Eolia Brissot, Anne Huynh, Marie-Thérèse Rubio, Alain Duhamel, Ibrahim Yakoub-Agha,

In order to identify cytomegalovirus (CMV)-seropositive patients who are at risk of developing CMV infection following first allogeneic hematopoietic cell transplantation (allo-HCT), we built up a scoring system based on patient/donor characteristics and transplantation modalities. To this end, 3690 consecutive patients were chronologically divided into a derivation cohort (2010-2012, n = 2180) ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics.

Xavier Roussel, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Walid Warda, Mathieu Neto da Rocha, Rim Trad, Eric Deconinck, Marina Deschamps, Christophe Ferrand,

Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations. Insight into Leukemia stem cells (LSCs) and assessment of cell surface markers have enabled characterization of LSCs from hematopoietic stem and progenitor ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:599933]

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Identification of flavouring substances of genotoxic concern present in e-cigarette refills.

Sophia Barhdadi, Birgit Mertens, Melissa Van Bossuyt, Jolien Van De Maele, Roel Anthonissen, Michael Canfyn, Patricia Courselle, Vera Rogiers, Eric Deconinck, Tamara Vanhaecke,

E-cigarettes have become very popular, a trend that has been stimulated by the wide variety of available e-liquid flavours. Considering the large number of e-liquid flavours (>7000), there is an urgent need to establish a screening strategy to prioritize the flavouring substances of highest concern for human health. In the ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2021, 147:111864]

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An infrared spectroscopic approach to characterise white powders, easily applicable in the context of drug checking, drug prevention and on-site analysis.

Eric Deconinck, Camille Aït-Kaci, Andries Raes, Michaël Canfyn, Jean-Luc Bothy, Céline Duchateau, Corenthin Mees, Kris De Braekeleer, Lies Gremaux, Peter Blanckaert,

More and more events, such as the summer music festivals, are considering the possibilities for implementing on-site testing of psychoactive drugs in the context of prevention and harm reduction. Although the on-site identification is already implemented by plenty of drug checking services, the required rapid quantitative dosing of the composition ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, :]

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Comparison of mycophenolate mofetil and calcineurin inhibitor versus calcineurin inhibitor-based graft-versus-host-disease prophylaxis for matched unrelated donor transplant in acute myeloid leukemia. A study from the ALWP of the EBMT.

Annalisa Paviglianiti, Myriam Labopin, Didier Blaise, Gerard Socié, Claude Eric Bulabois, Bruno Lioure, Patrice Ceballos, Igor Wolfgang Blau, Gaelle Guillerm, Johan Maertens, Patrice Chevallier, Anne Huynh, Pascal Turlure, Eric Deconinck, Edouard Forcade, Arnon Nagler, Mohamad Mohty,

The association of Cyclosporine A (CsA) and mycophenolate mofetil (MMF) has increased in the setting of reduced intensity conditioning (RIC). Nevertheless, the use of CsA or CsA+MMF has not been reported in a large and uniform cohort. We analyzed 497 patients with acute myeloid leukemia in complete remission (CR) who ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Grade 2 acute GVHD is a factor of good prognosis in patients receiving peripheral blood stem cells haplo-transplant with post-transplant cyclophosphamide.

Patrice Chevallier, Ana Berceanu, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Berthe-Marie Imbert, Etienne Daguindau, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Benoît Tessoulin, Sophie Vantyghem, Yohan Desbrosses, Céline Bressollette, Alix Duquesne, Marion Eveillard, Yannick Le Bris, Anne Dormoy, Caroline Malugani, Eric Deconinck, Philippe Moreau, Steven Le Gouill, Marie C Béné, Thierry Guillaume,

<h4>Background</h4>The impact of acute graft versus host disease (GVHD) on survivals for patients receiving a haploidentical allogeneic stem-cell transplant (Allo-SCT) with peripheral blood stem-cells (PBSC) complemented by post-transplant cyclophosphamide (PTCY) is ill-known.<h4>Material and methods</h4>This retrospective study included 131 patients who received a PBSC haplograft in order to precise the impact ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2020, :1-9]

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Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape.

Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi,

Neoplasms involving plasmacytoid Dendritic Cells (pDCs) include Blastic pDC Neoplasms (BPDCN) and other pDC proliferations, where pDCs are associated with myeloid malignancies: most frequently Chronic MyeloMonocytic Leukemia (CMML) but also Acute Myeloid Leukemia (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of pDCs in pDC-AML, ... Read more >>

Haematologica (Haematologica)
[2020, Online ahead of print:]

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Tandem autologous-reduced intensity allogeneic stem cell transplantation in high-risk relapsed Hodgkin lymphoma: a retrospective study of the Lymphoma Working Party-EBMT.

Leyre Bento, Ariane Boumendil, Hervé Finel, Irma Khvedelidze, Didier Blaise, Nathalie Fegueux, Luca Castagna, Edouard Forcade, Patrice Chevallier, Nicola Mordini, Pauline Brice, Eric Deconinck, Martin Gramatzki, Paolo Corradini, Mathilde Hunault, Maurizio Musso, Anna Tsoulkani, Dolores Caballero, Sandro Nati, Silvia Montoto, Anna Sureda, ,

Autologous hematopoietic stem cell transplantation (ASCT) is curative for a proportion of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL). However, there is a small group of patients with high-risk of relapse after ASCT that might benefit from other approaches. We conducted a retrospective analysis on 126 patients treated with tandem ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party.

Johannes Schetelig, Patrice Chevallier, Michel van Gelder, Jennifer Hoek, Olivier Hermine, Ronjon Chakraverty, Paul Browne, Noel Milpied, Michele Malagola, Gerard Socié, Julio Delgado, Eric Deconinck, Ghandi Damaj, Sebastian Maury, Dietrich Beelen, Stéphanie Nguyen Quoc, Paneesha Shankara, Arne Brecht, Jiri Mayer, Mathilde Hunault-Berger, Jörg Bittenbring, Catherine Thieblemont, Stéphane Lepretre, Henning Baldauf, Liesbeth C de Wreede, Olivier Tournilhac, Ibrahim Yakoub-Agha, Nicolaus Kröger, Peter Dreger,

No studies have been reported so far on bridging treatment with idelalisib for patients with chronic lymphocytic leukemia (CLL) prior to allogeneic hematopoietic cell transplantation (alloHCT). To study potential carry-over effects of idelalisib and to assess the impact of pathway-inhibitor (PI) failure we performed a retrospective EBMT registry-based study. Patients ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia.

Rémi Letestu, Abdelmalek Dahmani, Marouane Boubaya, Lucile Baseggio, Lydia Campos, Bernard Chatelain, Agathe Debliquis, Bernard Drénou, Marie-Christine Jacob, Eric Legac, Magali Le Garff-Tavernier, Anne-Catherine Lhoumeau, Claire Quiney, Nelly Robillard, Michel Ticchioni, Carmen Aanei, Sandrine Katsahian, Roselyne Delepine, Sandrine Vaudaux, Valérie Rouillé, Marie-Christine Béné, Caroline Dartigeas, Eric Van Den Neste, Stéphane Leprêtre, Pierre Feugier, Guillaume Cartron, Véronique Leblond, Vincent Lévy, Florence Cymbalista, ,

Measurable residual disease (MRD) status is widely adopted in clinical trials in patients with chronic lymphocytic leukemia (CLL). Findings from FILO group trials (CLL2007FMP, CLL2007SA, CLL2010FMP) enabled investigation of the prognostic value of high-sensitivity (0.7 × 10<sup>-5</sup>) MRD assessment using flow cytometry, in blood (N = 401) and bone marrow (N = 339), after fludarabine, cyclophosphamide, ... Read more >>

Leukemia (Leukemia)
[2020, :]

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Total body irradiation + fludarabine compared to busulfan + fludarabine as "reduced-toxicity conditioning" for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by the Acute Leukemia Working Party of the EBMT.

Sebastian Giebel, Myriam Labopin, Malgorzata Sobczyk-Kruszelnicka, Matthias Stelljes, Jenny L Byrne, Nathalie Fegueux, Dietrich W Beelen, Montserrat Rovira, Alexandros Spyridonidis, Didier Blaise, Martin Bornhäuser, Ihsan Karadogan, Bipin N Savani, Arnon Nagler, Mohamad Mohty, ,

The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two "reduced-toxicity" regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2020, :]

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Structural study of L-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy.

Xiaolong Xu, Magdalena Woźniczka, Kristof Van Hecke, Dieter Buyst, Dimitrije Mara, Chris Vervaet, Karen Herman, Evelien Wynendaele, Eric Deconinck, Bart De Spiegeleer,

L-ascorbic acid 2-phosphate magnesium (APMg) salt is a vitamin C derivative frequently used as a raw material in cell and tissue therapy. APMg is not only used as a replacement of the unstable ascorbate, but also shows additional cell-biological functionalities. However, its unknown structural characteristics hamper the mechanistic elucidation of ... Read more >>

J Biol Inorg Chem (Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry)
[2020, 25(6):875-885]

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Pyogenic Granuloma During Ibrutinib Therapy for B-Cell Neoplasia.

Xavier Roussel, Romain Charollais, Eric Deconinck, Etienne Daguindau, Annie Brion,

JCO Oncol Pract (JCO oncology practice)
[2020, 16(12):834-836]

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Platelet transfusions in haematologic malignancies in the last six months of life.

Julie Moracchini, Audrey Seigeot, Fanny Angelot-Delettre, Angélique Vienot, Régis Aubry, Étienne Daguindau, Eric Deconinck, Sandra Frache, Pierre Tiberghien,

BACKGROUND AND OBJECTIVES:Practices in end-of-life platelet transfusions in haematologic malignancies are variable. Our aim was to describe the platelet transfusion burden and parameters linked to this indication in such a setting and thereby contribute to defining optimal practices. MATERIALS AND METHODS:From July 2015 to December 2016, all consecutive deceased adult ... Read more >>

Vox Sang (Vox sanguinis)
[2020, :]

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Awareness of users and motivational factors for using new psychoactive substances in Belgium.

Sarah Simonis, Michaël Canfyn, Anton Van Dijck, Tina Van Havere, Eric Deconinck, Peter Blanckaert, Lies Gremeaux,

<h4>Background</h4>Few data on motivations for using new psychoactive substances (NPS) are available. However, the cost, the legal status, and their accessibility through channels like internet contributed to the popularity of NPS. The objective of this article are first to gain a deeper understanding of the culture surrounding NPS in Belgium ... Read more >>

Harm Reduct J (Harm reduction journal)
[2020, 17(1):52]

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Impact of detectable measurable residual disease on umbilical cord blood transplantation.

Frédéric Baron, Myriam Labopin, Annalisa Ruggeri, Jorge Sierra, Stephen Robinson, Hélène Labussière-Wallet, Michael Potter, Josep-Maria Ribera, Eric Deconinck, Alessandro Rambaldi, Pierre-Simon Rohrlich, Thierry de Revel, Eliane Gluckman, Arnon Nagler, Mohamad Mohty,

The impact of measurable residual disease (MRD) on cord blood transplantation (CBT) outcomes has remained debated. To address this issue, we assessed the impact of measurable MRD at CBT on outcomes in large cohort of patients with acute leukemia. Inclusion criteria included adult patients with acute myeloid (AML) or acute ... Read more >>

Am J Hematol (American journal of hematology)
[2020, 95(9):1057-1065]

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Antiplatelet Antibodies Do Not Predict the Response to Intravenous Immunoglobulins during Immune Thrombocytopenia.

Thomas Rogier, Maxime Samson, Guillaume Mourey, Nicolas Falvo, Nadine Magy-Bertrand, Sethi Ouandji, Jean-Baptiste Picque, Hélène Greigert, Christelle Mausservey, Arthur Imbach, Thibault Ghesquière, Laurent Voillat, Denis Caillot, Eric Deconinck, Bernard Bonnotte, Sylvain Audia,

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to autoantibodies targeting platelet glycoproteins (GP). The mechanism of platelet destruction could differ depending on the specificity of antiplatelet antibodies: anti-GPIIb/IIIa antibodies lead to phagocytosis by splenic macrophages, in a Fcγ receptor (FcγR)-dependent manner while anti-GPIb/IX antibodies induce platelet desialylation leading ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(6):]

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Cytogenetic risk score maintains its prognostic significance in AML patients with detectable measurable residual disease undergoing transplantation in remission: On behalf of the acute leukemia working party of the European society for blood and marrow transplantation.

Arnon Nagler, Myriam Labopin, Jonathan Canaani, Riitta Niittyvuopio, Gerard Socié, Nicolaus Kröger, Maija Itäla-Remes, Ibrahim Yakoub-Agha, Hélène Labussière-Wallet, Maria P Gallego-Hernanz, Eric Deconinck, Patrice Chevallier, Jürgen Finke, Jordi Esteve, Mohamad Mohty,

While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prognostic cytogenetic model (Canaani et al. ... Read more >>

Am J Hematol (American journal of hematology)
[2020, :]

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Discrimination of legal and illegal Cannabis spp. according to European legislation using near infrared spectroscopy and chemometrics.

Céline Duchateau, Jean-Michel Kauffmann, Michaël Canfyn, Caroline Stévigny, Kris De Braekeleer, Eric Deconinck,

Aerial parts containing cannabidiol can be purchased in a legal way but cannabis used as recreational drug is illegal in most European countries. Δ9-tetrahydrocannabinol is one of the main cannabinoids responsible for the psychotropic effect. European Union countries and Switzerland authorize a concentration of THC of 0.2 % and 1.0 ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(9):1309-1319]

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Post-transplant cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia in first complete remission undergoing allogeneic stem cell transplantation from 10/10 HLA-matched unrelated donors.

Eolia Brissot, Myriam Labopin, Ian Moiseev, J J Cornelissen, Ellen Meijer, Gwendolyn Van Gorkom, Montserrat Rovira, Fabio Ciceri, Laimonas Griskevicius, Didier Blaise, Edouard Forcade, Martin Mistrik, Stephan Mielke, Claude Eric Bulabois, Riitta Niittyvuopio, Eric Deconinck, Annalisa Ruggeri, Jaime Sanz, Alexandros Spyridonidis, Bipin Savani, Sebastian Giebel, Arnon Nagler, Mohamad Mohty,

BACKGROUND:Graft-versus-host disease (GVHD) remains a major contributor to mortality and morbidity after allogeneic stem-cell transplantation (allo-HSCT). The updated recommendations suggest that rabbit antithymocyte globulin or anti-T-lymphocyte globulin (ATG) should be used for GVHD prophylaxis in patients undergoing matched-unrelated donor (MUD) allo-HSCT. More recently, using post-transplant cyclophosphamide (PTCY) in the haploidentical ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2020, 13(1):87]

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Report on a new opioid NPS: chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol.

Annelies Cannaert, Fabian Hulpia, Martijn Risseeuw, Katleen Van Uytfanghe, Eric Deconinck, Serge Van Calenbergh, Peter Blanckaert, Christophe Stove,

In this paper, the identification and full characterization of a novel non-fentanyl opioid sourced online, which is a member of the 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives related to MT-45, is reported. The sample was sold under the name 'diphenpipenol', (3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethyl]phenol), although extensive NMR analysis showed that the product obtained was actually a diphenpipenol ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2020, :]

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CD34+ cell dose effects on clinical outcomes after T-cell replete haploidentical allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia using peripheral blood stem cells. A study from the acute leukemia working Party of the European Society for blood and marrow transplantation (EBMT).

Enrico Maffini, Myriam Labopin, Didier Blaise, Fabio Ciceri, Zafer Gülbas, Eric Deconinck, Veronique Leblond, Patrick Chevallier, Gerard Sociè, Mercedes C Araujo, Yener Koc, Bipin N Savani, Norbert C Gorin, Francesco Lanza, Arnon Nagler, Mohamad Mohty,

Previous observations have reported controversial conclusions regarding cell dose and survival endpoints after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a retrospective analysis on 414 adult patients (median age 54 years, range, 18-74 years) with acute myeloid leukemia (AML) in first and second complete remission. They received a T-cell replete allogeneic ... Read more >>

Am J Hematol (American journal of hematology)
[2020, 95(8):892-899]

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