Full Text Journal Articles by
Author Eric A Woodcock

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Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.

Eric A Woodcock, Ansel T Hillmer, Christine M Sandiego, Paul Maruff, Richard E Carson, Kelly P Cosgrove, Robert H Pietrzak,

Psychiatric and neurologic disorders are often characterized by both neuroinflammation and cognitive dysfunction. To date, however, the relationship between neuroinflammation and cognitive dysfunction remains understudied in humans. Preclinical research indicates that experimental induction of neuroinflammation reliably impairs memory processes. In this paradigm development study, we translated those robust preclinical findings ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2020, :]

Cited: 0 times

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N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.

Eric A Woodcock, Leslie H Lundahl, Dalal Khatib, Jeffrey A Stanley, Mark K Greenwald,

N-acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine- and cue-primed reinstatement of cocaine-seeking behavior in preclinical studies. In this inpatient study, the effects of NAC maintenance versus placebo on cocaine-seeking behavior were examined during cocaine-primed and unprimed self-administration sessions among non-treatment-seeking, cocaine-dependent individuals. Twelve participants completed this double-blind, ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12900]

Cited: 0 times

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Quantification of [11C]PBR28 data after systemic lipopolysaccharide challenge.

Eric A Woodcock, Martin Schain, Kelly P Cosgrove, Ansel T Hillmer,

BACKGROUND:Lipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study neuroimmune signaling. To evaluate optimal analysis of these data, this work compared the sensitivity of six quantification approaches. METHODS:[11C]PBR28 data from healthy ... Read more >>

EJNMMI Res (EJNMMI research)
[2020, 10(1):19]

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Sex and the dopaminergic system: Insights from addiction studies.

Eric A Woodcock, Yasmin Zakiniaeiz, Evan D Morris, Kelly P Cosgrove,

Sex differences are present in psychiatric disorders associated with disrupted dopamine function, and thus, sex differences in dopamine neurobiology may underlie these clinical disparities. In this chapter, we review sex differences in the dopaminergic system with a focus on substance use disorders, especially tobacco smoking, as our exemplar disorder. This ... Read more >>

Handb Clin Neurol (Handbook of clinical neurology)
[2020, 175:141-165]

Cited: 0 times

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A neurobiological correlate of stress-induced nicotine-seeking behavior among cigarette smokers.

Eric A Woodcock, Jeffrey A Stanley, Vaibhav A Diwadkar, Dalal Khatib, Mark K Greenwald,

Stress is known to influence smoking relapse. Experimental studies indicate that acute stress increases nicotine-seeking behavior, yet neurobiological mechanisms remain poorly understood. Herein, we investigated disrupted excitatory neural activity in the dorsolateral prefrontal cortex (dlPFC) as a mechanism of stress-induced nicotine-seeking behavior. Non-treatment-seeking cigarette smokers were screened for psychiatric, medical, ... Read more >>

Addict Biol (Addiction biology)
[2020, 25(4):e12819]

Cited: 0 times

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Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

Eric A Woodcock, Ansel T Hillmer, Graeme F Mason, Kelly P Cosgrove,

There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune ... Read more >>

Mol Neuropsychiatry (Molecular neuropsychiatry)
[2019, 5(3):125-146]

Cited: 2 times

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Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation.

Eric A Woodcock, Mark K Greenwald, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanley,

Working memory processes are associated with the dorsolateral prefrontal cortex (dlPFC). Prior research using proton functional magnetic resonance spectroscopy (1H fMRS) observed significant dlPFC glutamate modulation during letter 2-back performance, indicative of working memory-driven increase in excitatory neural activity. Acute stress has been shown to impair working memory performance. Herein, ... Read more >>

Neuroimage (NeuroImage)
[2019, 186:437-445]

Cited: 1 time

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Working Memory Modulates Glutamate Levels in the Dorsolateral Prefrontal Cortex during 1H fMRS.

Eric A Woodcock, Chaitali Anand, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanley,

Glutamate is involved in excitatory neurotransmission and metabolic processes related to brain function. Previous studies using proton functional magnetic resonance spectroscopy (1H fMRS) have demonstrated elevated cortical glutamate levels by 2-4% during visual and motor stimulation, relative to periods of no stimulation. Here, we extended this approach to working memory ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2018, 9:66]

Cited: 2 times

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Mediational Pathways Among Trait Impulsivity, Heroin-use Consequences, and Current Mood State.

Holly H Reid, Leslie H Lundahl, Jamey J Lister, Eric A Woodcock, Mark K Greenwald,

Background:This study examined whether lifetime heroin-use consequences mediate the relationship between trait impulsivity and three current mood outcomes: depression symptoms, stress levels, and perception of life events. Method:Regular heroin users (N = 163) were assessed using the Barratt Impulsiveness Scale (BIS-11) to measure trait impulsivity; a standardized Drug History and ... Read more >>

Addict Res Theory (Addiction research & theory)
[2018, 26(5):421-429]

Cited: 0 times

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Automated Voxel Placement: A Linux-based Suite of Tools for Accurate and Reliable Single Voxel Coregistration.

Eric A Woodcock, Muzamil Arshad, Dalal Khatib, Jeffrey A Stanley,

Background:Single-voxel proton magnetic resonance spectroscopy (1H MRS) is a powerful technique for studying in vivo neurochemistry, but has an often-overlooked source of error variance: inconsistent voxel placement between scans. We developed and evaluated an Automated Voxel Placement (AVP) procedure for accurate and reliable 1H MRS voxel prescription. AVP is a ... Read more >>

J Neuroimaging Psychiatry Neurol (Journal of neuroimaging in psychiatry & neurology)
[2018, 3(1):1-8]

Cited: 1 time

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Differences in steady-state glutamate levels and variability between 'non-task-active' conditions: Evidence from 1H fMRS of the prefrontal cortex.

Jonathan Lynn, Eric A Woodcock, Chaitali Anand, Dalal Khatib, Jeffrey A Stanley,

Proton functional magnetic resonance spectroscopy (1H fMRS) is a noninvasive neuroimaging technique capable of detecting dynamic changes in glutamate related to task-related demands at a temporal resolution under 1 min. Several recent 1H fMRS studies demonstrated elevated steady-state levels of glutamate of 2% or greater during different 'task-active' conditions, relative to ... Read more >>

Neuroimage (NeuroImage)
[2018, 172:554-561]

Cited: 2 times

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Developing a scale of domains of negative consequences of chronic heroin use.

Tabitha E H Moses, Eric A Woodcock, Jamey J Lister, Leslie H Lundahl, Mark K Greenwald,

BACKGROUND:Chronic use of heroin typically leads to numerous negative life consequences and serious clinical impairment. Increased negative consequences can result in poor treatment outcomes as well as adverse health effects and impaired social functioning. Certain risk factors, including early substance use initiation, concurrent use of other illicit substances, and injection ... Read more >>

Addict Behav (Addictive behaviors)
[2018, 77:260-266]

Cited: 3 times

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Network Profiles of the Dorsal Anterior Cingulate and Dorsal Prefrontal Cortex in Schizophrenia During Hippocampal-Based Associative Memory.

Eric A Woodcock, Sunali Wadehra, Vaibhav A Diwadkar,

Schizophrenia is a disorder characterized by brain network dysfunction, particularly during behavioral tasks that depend on frontal and hippocampal mechanisms. Here, we investigated network profiles of the regions of the frontal cortex during memory encoding and retrieval, phases of processing essential to associative memory. Schizophrenia patients (n = 12) and ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2016, 10:32]

Cited: 8 times

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Investigating bang for your training buck: a randomized controlled trial comparing three methods of training clinicians in two core strategies of dialectical behavior therapy.

Linda A Dimeff, Melanie S Harned, Eric A Woodcock, Julie M Skutch, Kelly Koerner, Marsha M Linehan,

The present study examined the efficacy of online training (OLT), instructor-led training (ILT), and a treatment manual (TM) in training mental health clinicians in two core strategies of Dialectical Behavior Therapy (DBT): chain analysis and validation. A randomized controlled trial compared OLT, ILT, and TM among clinicians naïve to DBT ... Read more >>

Behav Ther (Behavior therapy)
[2015, 46(3):283-295]

Cited: 10 times

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Heroin delay discounting: Modulation by pharmacological state, drug-use impulsivity, and intelligence.

Jonathan J K Stoltman, Eric A Woodcock, Jamey J Lister, Leslie H Lundahl, Mark K Greenwald,

Delay discounting (DD) refers to how rapidly an individual devalues goods based on delays to receipt. DD usually is considered a trait variable but can be state dependent, yet few studies have assessed commodity valuation at short, naturalistically relevant time intervals that might enable state-dependent analysis. This study aimed to ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2015, 23(6):455-463]

Cited: 2 times

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Methadone maintenance dose modulates anterior cingulate glutamate levels in heroin-dependent individuals: A preliminary in vivo (1)H MRS study.

Mark K Greenwald, Eric A Woodcock, Dalal Khatib, Jeffrey A Stanley,

Mu-opioid receptor agonists alter brain glutamate (GLU) levels in laboratory animals. This clinical study used proton magnetic resonance spectroscopy ((1)H MRS) to examine regional brain GLU levels during experimental manipulation of methadone (MTD) maintenance dose under double-blind, within-subject conditions in seven heroin-dependent volunteers. Subjects were scanned first at a high ... Read more >>

Psychiatry Res (Psychiatry research)
[2015, 233(2):218-224]

Cited: 6 times

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The dorsal prefrontal and dorsal anterior cingulate cortices exert complementary network signatures during encoding and retrieval in associative memory.

Eric A Woodcock, Richard White, Vaibhav A Diwadkar,

Cognitive control includes processes that facilitate execution of effortful cognitive tasks, including associative memory. Regions implicated in cognitive control during associative memory include the dorsal prefrontal (dPFC) and dorsal anterior cingulate cortex (dACC). Here we investigated the relative degrees of network-related interactions originating in the dPFC and dACC during oscillating ... Read more >>

Behav. Brain Res. (Behavioural brain research)
[2015, 290:152-160]

Cited: 7 times

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Functional mu opioid receptor polymorphism (OPRM1 A(118) G) associated with heroin use outcomes in Caucasian males: A pilot study.

Eric A Woodcock, Leslie H Lundahl, Margit Burmeister, Mark K Greenwald,

Heroin's analgesic, euphoric and dependence-producing effects are primarily mediated by the mu opioid receptor (MOR). A single gene, OPRM1, encodes the MOR. The functional polymorphism A(118)G, located in exon 1 of the OPRM1 gene, results in anatomically-specific reductions in MOR expression, which may alter an individual's response to heroin. In ... Read more >>

Am J Addict (The American journal on addictions)
[2015, 24(4):329-335]

Cited: 12 times

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Progression to regular heroin use: examination of patterns, predictors, and consequences.

Eric A Woodcock, Leslie H Lundahl, Jonathan J K Stoltman, Mark K Greenwald,

The present study retrospectively evaluated the chronology and predictors of substance use progression in current heroin-using individuals.Out-of-treatment heroin users (urinalysis-verified; N=562) were screened for laboratory-based research studies using questionnaires and urinalysis. Comprehensive substance use histories were collected. Between- and within-substance use progression was analyzed using stepwise linear regression models.The strongest ... Read more >>

Addict Behav (Addictive behaviors)
[2015, 45:287-293]

Cited: 13 times

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Exploration of the telescoping effect among not-in-treatment, intensive heroin-using research volunteers.

Jonathan J K Stoltman, Eric A Woodcock, Jamey J Lister, Mark K Greenwald, Leslie H Lundahl,

Addiction research literature suggests some demographic groups exhibit a later age of substance use initiation, more rapid escalation to dependence, and worse substance use-related outcomes. This 'telescoping' effect has been observed more often in females but has not yet been examined in not-in-treatment heroin users or racial subgroups.Not-in-treatment, intensive heroin-using ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2015, 148:217-220]

Cited: 7 times

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Predictors of buprenorphine initial outpatient maintenance and dose taper response among non-treatment-seeking heroin dependent volunteers.

Eric A Woodcock, Leslie H Lundahl, Mark K Greenwald,

Buprenorphine (BUP) is effective for treating opioid use disorder. Individuals' heroin-use characteristics may predict their responses to BUP, which could differ during maintenance and dose-taper phases. If so, treatment providers could use pre-treatment characteristics to personalize level of individual care and possibly improve treatment outcomes.Non-treatment-seeking heroin-dependent volunteers (N=34) initiated outpatient ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2015, 146:89-96]

Cited: 4 times

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Exposing clinicians to exposure: a randomized controlled dissemination trial of exposure therapy for anxiety disorders.

Melanie S Harned, Linda A Dimeff, Eric A Woodcock, Tim Kelly, Jake Zavertnik, Ignacio Contreras, Sankirtana M Danner,

The present study evaluated three technology-based methods of training mental health providers in exposure therapy (ET) for anxiety disorders. Training methods were designed to address common barriers to the dissemination of ET, including limited access to training, negative clinician attitudes toward ET, and lack of support during and following training.Clinicians ... Read more >>

Behav Ther (Behavior therapy)
[2014, 45(6):731-744]

Cited: 16 times

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Disseminating behavioural activation for depression via online training: preliminary steps.

Sam Hubley, Eric A Woodcock, Linda A Dimeff, Sona Dimidjian,

Despite the availability of evidence-based treatments for depression, large gaps exist between empirical research and clinical practice.To make preliminary steps toward the dissemination of Behavioural Activation (BA) via online training by examining clinicians' interest in learning BA via online training and the effects of a preliminary version of BA online ... Read more >>

Behav Cogn Psychother (Behavioural and cognitive psychotherapy)
[2015, 43(2):224-238]

Cited: 6 times

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Predicting adoption of exposure therapy in a randomized controlled dissemination trial.

Melanie S Harned, Linda A Dimeff, Eric A Woodcock, Ignacio Contreras,

The present study examined organizational, client, and therapist characteristics as predictors of use of and proficiency in exposure therapy (ET) after training. Therapists naïve to ET (N=181) were randomized to: (1) online training (OLT), (2) OLT plus motivational enhancement (ME), or (3) OLT+ME plus a learning community. Twelve weeks after ... Read more >>

J Anxiety Disord (Journal of anxiety disorders)
[2013, 27(8):754-762]

Cited: 24 times

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Overcoming barriers to disseminating exposure therapies for anxiety disorders: a pilot randomized controlled trial of training methods.

Melanie S Harned, Linda A Dimeff, Eric A Woodcock, Julie M Skutch,

The present study evaluated methods for training mental health providers (N=46) in exposure therapies (ETs) for anxiety disorders. A pilot randomized controlled trial compared: (1) an interactive, multimedia online training (ET OLT), (2) the ET OLT plus a brief Motivational Interviewing-based intervention (ET OLT+MI), and (3) a placebo control OLT. ... Read more >>

J Anxiety Disord (Journal of anxiety disorders)
[2011, 25(2):155-163]

Cited: 17 times

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