Full Text Journal Articles by
Author Eric A Moulton

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In Memoriam Joel D. Greenspan 1952-2021.

Timothy J Meeker, Raimi L Quiton, Eric A Moulton,

Pain (Pain)
[2021, :]

Cited: 0 times

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A lateralized model of the pain-depression dyad.

Anne Margarette S Maallo, Eric A Moulton, Christine B Sieberg, Donald B Giddon, David Borsook, Scott A Holmes,

Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, we review the association of pain with depression, especially when symptoms are lateralized on either ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 127:876-883]

Cited: 0 times

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Atypical spatiotemporal activation of cerebellar lobules during emotional face processing in adolescents with autism.

Charis Styliadis, Rachel Leung, Selin Özcan, Eric A Moulton, Elizabeth Pang, Margot J Taylor, Christos Papadelis,

Autism spectrum disorder (ASD) is characterized by social deficits and atypical facial processing of emotional expressions. The underlying neuropathology of these abnormalities is still unclear. Recent studies implicate cerebellum in emotional processing; other studies show cerebellar abnormalities in ASD. Here, we elucidate the spatiotemporal activation of cerebellar lobules in ASD ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2021, 42(7):2099-2114]

Cited: 1 time

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Blue light activates pulvinar nuclei in longstanding idiopathic photophobia: A case report.

Athanasios Panorgias, Danielle Lee, Katie E Silva, David Borsook, Eric A Moulton,

Numerous pathologies can contribute to photophobia. When considering light transduction alone, photophobia may be triggered through melanopsin pathways (non-image forming), rod and cone pathways (image-forming), or some combination of the two. We evaluated a 39 year old female patient with longstanding idiopathic photophobia that was exacerbated by blue light, and ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:102096]

Cited: 1 time

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C-Fiber Assays in the Cornea vs. Skin.

Eric A Moulton, David Borsook,

C-fibers are unmyelinated nerve fibers that transmit high threshold mechanical, thermal, and chemical signals that are associated with pain sensations. This review examines current literature on measuring altered peripheral nerve morphology and discusses the most relevant aspects of corneal microscopy, especially whether corneal imaging presents significant method advantages over skin ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(11):]

Cited: 1 time

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Pain affect disrupted in children with posterior cerebellar tumor resection.

Katie E Silva, Julie Rosner, Nicole J Ullrich, Christine Chordas, Peter E Manley, Eric A Moulton,

<h4>Objectives</h4>Damage to the posterior cerebellum can cause affective deficits in patients. In adults, cerebellar infarcts result in thermal hyperalgesia and affect descending modulation of pain. This study evaluated the effect of resection of low-grade cerebellar tumors on pain processing in human children.<h4>Methods</h4>Twelve pediatric patients treated with surgery only for low-grade ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(2):344-354]

Cited: 3 times

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Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye.

Perry Rosenthal, David Borsook, Eric A Moulton,

The cornea is supplied principally by the ophthalmic branch of the trigeminal nerve and is the most densely innervated organ in the human body. Under normal conditions, the corneal nerve terminals incorporate sensors that monitor the thickness and integrity of the tear film, which are essential for meaningful vision. A ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2016, 57(13):5285-5287]

Cited: 14 times

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Female migraineurs show lack of insular thinning with age.

Nasim Maleki, Gabi Barmettler, Eric A Moulton, Steven Scrivani, Rosanna Veggeberg, Egilius L H Spierings, Rami Burstein, Lino Becerra, David Borsook,

Gray matter loss in cortical regions is a normal ageing process for the healthy brain. There have been few studies on the process of ageing of the brain in chronic neurological disorders. In this study, we evaluated changes in the cortical thickness by age in 92 female subjects (46 patients ... Read more >>

Pain (Pain)
[2015, 156(7):1232-1239]

Cited: 22 times

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The cerebellum and addiction: insights gained from neuroimaging research.

Eric A Moulton, Igor Elman, Lino R Becerra, Rita Z Goldstein, David Borsook,

Although cerebellar alterations have been consistently noted in the addiction literature, the pathophysiology of this link remains unclear. The cerebellum is commonly classified as a motor structure, but human functional neuroimaging along with clinical observations in cerebellar stroke patients and anatomical tract tracing in non-human primates suggests its involvement in ... Read more >>

Addict Biol (Addiction biology)
[2014, 19(3):317-331]

Cited: 56 times

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Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine.

Eric A Moulton, Lino Becerra, Adriana Johnson, Rami Burstein, David Borsook,

The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine functional connectivity (FC) changes between the hypothalamus and the rest of the brain in migraine patients vs. control ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e95508]

Cited: 48 times

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The human amygdala and pain: evidence from neuroimaging.

Laura E Simons, Eric A Moulton, Clas Linnman, Elizabeth Carpino, Lino Becerra, David Borsook,

The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala is well suited to play a ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2014, 35(2):527-538]

Cited: 82 times

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An approach to localizing corneal pain representation in human primary somatosensory cortex.

Eric A Moulton, Lino Becerra, Perry Rosenthal, David Borsook,

The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation of the cornea to painful stimuli in human primary somatosensory cortex using functional magnetic resonance imaging (fMRI). In ... Read more >>

PLoS One (PloS one)
[2012, 7(9):e44643]

Cited: 16 times

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BOLD responses in somatosensory cortices better reflect heat sensation than pain.

Eric A Moulton, Gautam Pendse, Lino R Becerra, David Borsook,

The discovery of cortical networks that participate in pain processing has led to the common generalization that blood oxygen level-dependent (BOLD) responses in these areas indicate the processing of pain. Physical stimuli have fundamental properties that elicit sensations distinguishable from pain, such as heat. We hypothesized that pain intensity coding ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2012, 32(17):6024-6031]

Cited: 48 times

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Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images.

Eric A Moulton, Igor Elman, Gautam Pendse, Jeremy Schmahmann, Lino Becerra, David Borsook,

The cerebellum is reliably activated during both acute and chronic pain conditions, but it is unclear whether the response to aversive painful stimuli can be generalized to other aversive stimuli. We hypothesized that cerebellar activation during pain reflects higher-level encoding of aversive stimuli. We used functional magnetic resonance imaging (fMRI) ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2011, 31(10):3795-3804]

Cited: 100 times

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Neuroimaging of the periaqueductal gray: state of the field.

Clas Linnman, Eric A Moulton, Gabi Barmettler, Lino Becerra, David Borsook,

This review and meta-analysis aims at summarizing and integrating the human neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original manuscripts on human neuroimaging of the PAG were identified. A narrative review and meta-analysis using activation likelihood estimates is included. Behaviors covered include pain and pain modulation, anxiety, bladder ... Read more >>

Neuroimage (NeuroImage)
[2012, 60(1):505-522]

Cited: 167 times

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The cerebellum and pain: passive integrator or active participator?

Eric A Moulton, Jeremy D Schmahmann, Lino Becerra, David Borsook,

The cerebellum is classically considered to be a brain region involved in motor processing, but it has also been implicated in non-motor, and even cognitive, functions. Though previous research suggests that the cerebellum responds to noxious stimuli, its specific role during pain is unclear. Pain is a multidimensional experience that ... Read more >>

Brain Res Rev (Brain research reviews)
[2010, 65(1):14-27]

Cited: 136 times

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A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study.

Steven Scrivani, Diana Wallin, Eric A Moulton, Sadie Cole, Ajay D Wasan, Larry Lockerman, Zahid Bajwa, Jaymin Upadhyay, Lino Becerra, David Borsook,

Using functional magnetic resonance imaging (fMRI) methods, we evaluated the effects of lamotrigine vs placebo in a double-blind 1:1 randomized trial. Six patients with neuropathic pain were recruited for the study. All subjects had baseline pain >4/10 on a visual analog scale (VAS) and allodynia to brush as inclusion criteria ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2010, 11(6):920-941]

Cited: 11 times

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Interictal dysfunction of a brainstem descending modulatory center in migraine patients.

Eric A Moulton, Rami Burstein, Shannon Tully, Richard Hargreaves, Lino Becerra, David Borsook,

<h4>Background</h4>The brainstem contains descending circuitry that can modulate nociceptive processing (neural signals associated with pain) in the dorsal horn of the spinal cord and the medullary dorsal horn. In migraineurs, abnormal brainstem function during attacks suggest that dysfunction of descending modulation may facilitate migraine attacks, either by reducing descending inhibition ... Read more >>

PLoS One (PloS one)
[2008, 3(11):e3799]

Cited: 123 times

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Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex.

Eric A Moulton, Gautam Pendse, Susie Morris, Matthew Aiello-Lammens, Lino Becerra, David Borsook,

Though somatotypic representation within the face in human primary somatosensory cortex (S1) to innocuous stimuli is controversial; previous work suggests that painful heat is represented based on an "onion-skin" or segmental pattern on the face. The aim of this study was to determine if face somatotopy for brush stimuli in ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2009, 30(3):757-765]

Cited: 25 times

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Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux).

David Borsook, Eric A Moulton, Gautam Pendse, Susie Morris, Sadie H Cole, Matthew Aiello-Lammens, Steven Scrivani, Lino R Becerra,

A 53-year old woman with tic doloureaux, affecting her right maxillary division of the trigeminal nerve (V2), could elicit shooting pains by slightly tapping her teeth when off medication. The pains, which she normally rated as > 6/10 on a visual analog scale (VAS), were electric shock-like in nature. She ... Read more >>

Mol Pain (Molecular pain)
[2007, 3:34]

Cited: 17 times

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Neuroimaging revolutionizes therapeutic approaches to chronic pain.

David Borsook, Eric A Moulton, Karl F Schmidt, Lino R Becerra,

An understanding of how the brain changes in chronic pain or responds to pharmacological or other therapeutic interventions has been significantly changed as a result of developments in neuroimaging of the CNS. These developments have occurred in 3 domains : (1) Anatomical Imaging which has demonstrated changes in brain volume ... Read more >>

Mol Pain (Molecular pain)
[2007, 3:25]

Cited: 40 times

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Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study.

Eric A Moulton, Gautam Pendse, Susie Morris, Andrew Strassman, Matthew Aiello-Lammens, Lino Becerra, David Borsook,

The aim of this study was to differentiate the processing of nociceptive information, matched for pain intensity, from capsaicin-induced hyperalgesic vs. control skin at multiple levels in the trigeminal nociceptive pathway. Using an event-related fMRI approach, 12 male subjects underwent three functional scans beginning 1 h after topical application of ... Read more >>

Neuroimage (NeuroImage)
[2007, 35(4):1586-1600]

Cited: 34 times

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Sex differences in the cerebral BOLD signal response to painful heat stimuli.

Eric A Moulton, Michael L Keaser, Rao P Gullapalli, Ranjan Maitra, Joel D Greenspan,

There are limited data addressing the question of sex differences in pain-related cerebral processing. This study examined whether pain-related blood oxygenation level-dependent (BOLD) signal change measured with functional magnetic resonance imaging (fMRI) demonstrated sex differences, under conditions of equivalent pain perception. Twenty-eight healthy volunteers (17 women, 11 men) were subject ... Read more >>

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2006, 291(2):R257-67]

Cited: 30 times

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