Full Text Journal Articles by
Author Ergin Kilic

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Additive Value of Transrectal Systematic Ventral Biopsies in Combination with Magnet Resonance Imaging/Ultrasound Fusion-Guided Biopsy in Patients with 3 or More Negative Prostate Biopsies.

Andreas Maxeiner, Alexander M Nest, Carsten Stephan, Hannes Cash, Alexander D J Baur, Thomas Fischer, Ergin Kilic, Sophie K Piper, Claus-P Nowak, Jonas Busch, Kurt Miller, Josef Mang,

INTRODUCTION:Patients with consistent suspicion for prostate cancer (PCa) and multiple negative prebiopsies prior to multiparametric magnetic resonance imaging (mpMRI) are still frequently evaluated for an image-guided biopsy and are reported with heterogeneous detection rates. The inclusion of a systematic biopsy (SB) is also still recommended with predominant sampling within the ... Read more >>

Urol. Int. (Urologia internationalis)
[2020, 104(3-4):205-213]

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A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature.

Zhongwei Zhao, Sabine Weickmann, Monika Jung, Michael Lein, Ergin Kilic, Carsten Stephan, Andreas Erbersdobler, Annika Fendler, Klaus Jung,

Within five to ten years after radical prostatectomy (RP), approximately 15-34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR), which is defined as recurrence of serum levels of prostate-specific antigen >0.2 µg/L, indicating probable cancer recurrence. Models using clinicopathological variables for predicting this risk for patients lack accuracy. There ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(10):]

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Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy.

Antonia Franz, Bernhard Ralla, Sabine Weickmann, Monika Jung, Hannah Rochow, Carsten Stephan, Andreas Erbersdobler, Ergin Kilic, Annika Fendler, Klaus Jung,

Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in ccRCC tissue with a focus to evaluate their potential as ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(10):]

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Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas

Yi Xiao, Rosanna Clima, Jonas Felix Busch, Anja Rabien, Ergin Kilic, Sonia Villegas, Seval Türkmen, Bernd Timmermann, Marcella Attimonelli, Klaus Jung, David Meierhofer,

Summary Chromophobe renal cell carcinomas (chRCC) are derived from intercalated cells of the collecting duct system, and are thought to be the malignant counterpart of benign renal oncocytomas. Here, we report the characterization of nine chRCC with adjacent healthy kidney tissues by applying proteome-, transcriptome (TCGA)-, and metabolome profiling. Most ... Read more >>

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Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer.

Jasmin Zeindler, Fiorenzo Angehrn, Raoul Droeser, Silvio Däster, Salvatore Piscuoglio, Charlotte K Y Ng, Ergin Kilic, Robert Mechera, Samuel Meili, Andrej Isaak, Walter P Weber, Simone Muenst, Savas Deniz Soysal,

PURPOSE:Myeloperoxidase (MPO) is an enzyme secreted by neutrophil granulocytes as a result of phagocytosis during inflammation. In colorectal cancer, tumour infiltration by MPO expressing cells has been shown to be independently associated with a favourable prognosis. In this study, we explored the role of MPO-positive cell infiltration and its prognostic ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2019, 177(3):581-589]

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Papillary renal cell carcinomas rewire glutathione metabolism and are deficient in anabolic glucose synthesis

Ayham Alahmad, Vanessa Paffrath, Rosanna Clima, Jonas Felix Busch, Anja Rabien, Ergin Kilic, Sonia Villegas, Bernd Timmermann, Marcella Attimonelli, Klaus Jung, David Meierhofer,

Abstract Papillary renal cell carcinoma (pRCC) is a malignant kidney cancer with a prevalence of 7-20% of all renal tumors. Proteome and metabolome profiles of 19 pRCC and patient-matched healthy kidney controls were used to elucidate the regulation of metabolic pathways and the underlying molecular mechanisms. Glutathione (GSH), a main ... Read more >>

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Lymphatic micrometastases predict biochemical recurrence in patients undergoing radical prostatectomy and pelvic lymph node dissection for prostate cancer.

Andreas Maxeiner, Andreas Grevendieck, Therese Pross, Marc Rudl, Alexander Arnold, Carsten Stephan, Klaus Jung, Kurt Miller, Ergin Kilic, Jonas Busch,

BACKGROUND: Nodal metastasis is a strong prognostic parameter in prostate cancer (PCa). We analysed the detection of micrometastases (miN + ) in initially nodal-negative (pN0) radical prostatectomy specimens from pT2a-c and pT3a PCa patients by immunohistochemistry (IHC). MATERIAL AND METHODS: A total of 2352 lymph nodes of 193 PCa patients were centrally re-examined for ... Read more >>

Aktuelle Urol (Aktuelle Urologie)
[2019, 50(6):612-618]

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Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer.

Robert Mechera, Savas D Soysal, Salvatore Piscuoglio, Charlotte K Y Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A Droeser, Walter P Weber, Simone Muenst,

BACKGROUND:The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the resistance of breast cancer cells to anti-endocrine therapies, and RET expression is assumed to correlate with poor prognosis ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):41]

Cited: 1 time

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miR-9-5p in Nephrectomy Specimens is a Potential Predictor of Primary Resistance to First-Line Treatment with Tyrosine Kinase Inhibitors in Patients with Metastatic Renal Cell Carcinoma.

Bernhard Ralla, Jonas Busch, Anne Flörcken, Jörg Westermann, Zhongwei Zhao, Ergin Kilic, Sabine Weickmann, Monika Jung, Annika Fendler, Klaus Jung,

Approximately 20⁻30% of patients with metastatic renal cell carcinoma (mRCC) in first-line treatment with tyrosine kinase inhibitors (TKIs) do not respond due to primary resistance to this drug. At present, suitable robust biomarkers for prediction of a response are not available. Therefore, the aim of this study was to evaluate ... Read more >>

Cancers (Basel) (Cancers)
[2018, 10(9):]

Cited: 2 times

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Diagnostic and Prognostic Potential of MicroRNA Maturation Regulators Drosha, AGO1 and AGO2 in Urothelial Carcinomas of the Bladder.

Anja Rabien, Nadine Ratert, Anica Högner, Andreas Erbersdobler, Klaus Jung, Thorsten H Ecke, Ergin Kilic,

Bladder cancer still requires improvements in diagnosis and prognosis, because many of the cases will recur and/or metastasize with bad outcomes. Despite ongoing research on bladder biomarkers, the clinicopathological impact and diagnostic function of miRNA maturation regulators Drosha and Argonaute proteins AGO1 and AGO2 in urothelial bladder carcinoma remain unclear. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(6):]

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PBRM1 and VHL expression correlate in human clear cell renal cell carcinoma with differential association with patient's overall survival.

Anica Högner, Hans Krause, Burkhard Jandrig, Mumtaz Kasim, Tom Florian Fuller, Martin Schostak, Andreas Erbersdobler, Andreas Patzak, Ergin Kilic,

OBJECTIVE:To identify the clinicopathological association of PBRM1 (Polybromo-1 gene) and VHL (von Hippel-Lindau gene) expression at mRNA and protein levels in clear cell renal cell carcinoma (ccRCC) and its role in tumor progression. PATIENTS AND METHODS:Immunohistochemical analysis, Western blotting and qPCR analysis of PBRM1 and VHL were performed on fresh-frozen ... Read more >>

Urol. Oncol. (Urologic oncology)
[2018, 36(3):94.e1-94.e14]

Cited: 2 times

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miR-199a-3p and miR-214-3p improve the overall survival prediction of muscle-invasive bladder cancer patients after radical cystectomy.

Thorsten H Ecke, Katja Stier, Sabine Weickmann, Zhongwei Zhao, Laura Buckendahl, Carsten Stephan, Ergin Kilic, Klaus Jung,

To improve the clinical decision-making regarding further treatment management and follow-up scheduling for patients with muscle-invasive bladder cancer (MIBC) after radical cystectomy (RC), a better prediction accuracy of prognosis for these patients is urgently needed. The objective of this study was to evaluate the validity of differentially expressed microRNAs (miRNAs) ... Read more >>

Cancer Med (Cancer medicine)
[2017, 6(10):2252-2262]

Cited: 10 times

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The prostate health index PHI predicts oncological outcome and biochemical recurrence after radical prostatectomy - analysis in 437 patients.

Andreas Maxeiner, Ergin Kilic, Julia Matalon, Frank Friedersdorff, Kurt Miller, Klaus Jung, Carsten Stephan, Jonas Busch,

The purpose of this study was to investigate the Prostate-Health-Index (PHI) for pathological outcome prediction following radical prostatectomy and also for biochemical recurrence prediction in comparison to established parameters such as Gleason-score, pathological tumor stage, resection status (R0/1) and prostate-specific antigen (PSA). Out of a cohort of 460 cases with ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(45):79279-79288]

Cited: 2 times

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Design and fuzzy logic control of an active wrist orthosis.

Ergin Kilic, Erdi Dogan,

People who perform excessive wrist movements throughout the day because of their professions have a higher risk of developing lateral and medial epicondylitis. If proper precautions are not taken against these diseases, serious consequences such as job loss and early retirement can occur. In this study, the design and control ... Read more >>

Proc Inst Mech Eng H (Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine)
[2017, 231(8):728-746]

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Does the Prostate Health Index Depend on Tumor Volume?-A Study on 196 Patients after Radical Prostatectomy.

Frank Friedersdorff, Britt Groß, Andreas Maxeiner, Klaus Jung, Kurt Miller, Carsten Stephan, Jonas Busch, Ergin Kilic,

The Prostate Health Index (PHI) has been used increasingly in the context of prostate cancer (PCa) diagnostics since 2010. Previous studies have shown an association between PHI and a tumor volume of >0.5 cm³. The aim of this study was to investigate the correlation between PHI and tumor volume as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(3):]

Cited: 2 times

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Sertoli cell tumour in a neonate calf: an unusual congenital tumour. A case report.

Théophile Vissiennon, Markus Freick, Ergin Kilic, Thomas Schmidt, Sven Dänicke, Marion Schmicke, Eckard Schneider,

Congenital testicular tumours are seldom reported in bovine species. This case report describes the clinical, sonographical, haematological, pathomorphological and immunohistological features of a Sertoli cell tumour in a neonatal German Holstein calf. Microscopically, the enlarged testicle was composed of neoplastic cells, which were packed in well-formed tubules. The mostly polygonal ... Read more >>

Tierarztl Prax Ausg G Grosstiere Nutztiere (Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere)
[2016, 44(6):371-378]

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Expression and clinicopathological correlations of retinoid acid receptor responder protein 1 in renal cell carcinomas.

Annette Zimpfer, Friedericke Dammert, Aenne Glass, Heike Zettl, Ergin Kilic, Matthias Maruschke, Oliver W Hakenberg, Andreas Erbersdobler,

To evaluate the expression and prognostic value of RARRES1 at protein level in renal cell carcinoma (RCC).Expression profile of RARRES1 was analyzed in 903 documented RCC followed by clinicopathological correlations and survival analysis.RARRES1 expression was seen in 72.5% of RCC. A stronger RARRES1 expression was seen in high grade compared ... Read more >>

Biomark Med (Biomarkers in medicine)
[2016, 10(7):721-732]

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Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma.

Julia Liep, Ergin Kilic, Hellmuth A Meyer, Jonas Busch, Klaus Jung, Anja Rabien,

BACKGROUND:Due to the poor prognosis for advanced renal cell carcinoma (RCC), there is an urgent need for new therapeutic targets and for prognostic markers to identify high risk tumors. MicroRNAs (miRNAs) are frequently dysregulated in tumors, play a crucial role during carcinogenesis and therefore might be promising new biomarkers. In ... Read more >>

PLoS ONE (PloS one)
[2016, 11(6):e0157801]

Cited: 15 times

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Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma.

Hana Mlcochova, Tana Machackova, Anja Rabien, Lenka Radova, Pavel Fabian, Robert Iliev, Katerina Slaba, Alexandr Poprach, Ergin Kilic, Michal Stanik, Martina Redova-Lojova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Klaus Jung, Ondrej Slaby,

Clear-cell renal cell carcinomas (ccRCCs) are genetically heterogeneous tumors presenting diverse clinical courses. Epithelial-mesenchymal transition (EMT) is a crucial process involved in initiation of metastatic cascade. The aim of our study was to identify an integrated miRNA/mRNA signature associated with metastasis and prognosis in ccRCC through targeted approach based on ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:31852]

Cited: 14 times

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The zinc-finger transcription factor SALL4 is frequently expressed in human cancers: association with clinical outcome in squamous cell carcinoma but not in adenocarcinoma of the esophagus.

Ergin Kilic, Pierre Tennstedt, Anica Högner, Patrick Lebok, Guido Sauter, Carsten Bokemeyer, Jakob R Izbicki, Waldemar Wilczak,

SALL4 is a transcription factor originally identified as a homeotic gene essential for organ development. Early studies suggested that SALL4 is a useful marker to identify testicular and ovarian germ cell tumors. The aim of the study was to evaluate the diagnostic potential of SALL4 immunohistochemistry. Immunohistochemical staining was performed ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2016, 468(4):483-492]

Cited: 8 times

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Serum Vitamin D is Not Helpful for Predicting Prostate Cancer Aggressiveness Compared with the Prostate Health Index.

Carsten Stephan, Michael Lein, Julia Matalon, Ergin Kilic, Zhongwei Zhao, Jonas Busch, Klaus Jung,

PURPOSE:We evaluated the usefulness of serum 25-hydroxyvitamin D as a marker of aggressive prostate cancer and for active surveillance compared to PHI (Prostate Health Index). MATERIALS AND METHODS:Of 480 prospectively biopsied men 222 had prostate cancer and 258 had no evidence of malignancy. In all men prostate specific antigen was ... Read more >>

J. Urol. (The Journal of urology)
[2016, 196(3):709-714]

Cited: 3 times

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Significant reduction in positive surgical margin rate after laparoscopic radical prostatectomy by application of the modified surgical margin recommendations of the 2009 International Society of Urological Pathology consensus.

Andreas Maxeiner, Ahmed Magheli, Korinna Jöhrens, Ergin Kilic, Tom Lukas Braun, Carsten Kempkensteffen, Stefan Hinz, Carsten Stephan, Kurt Miller, Jonas Busch,

To verify retrospectively the margin status and analyse the location and characteristics of positive surgical margins (PSMs) in patients undergoing radical prostatectomy (RP), by a central pathology review, based on the consensus conference 2009 updated margin criteria from the International Society of Urological Pathology (ISUP).The detailed PSM characteristics of 441 ... Read more >>

BJU Int. (BJU international)
[2016, 118(5):750-757]

Cited: 3 times

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New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers.

Linda Gummlich, Thilo Kähne, Michael Naumann, Ergin Kilic, Klaus Jung, Wolfgang Dubiel,

Urological cancers are a very common type of cancer worldwide and have alarming high incidence and mortality rates, especially in kidney cancers, illustrate the urgent need for new therapeutic targets. Recent publications point to a deregulated COP9 signalosome (CSN)-cullin-RING ubiquitin-ligase (CRL) pathway which is here considered and investigated as potential ... Read more >>

Int Rev Cell Mol Biol (International review of cell and molecular biology)
[2016, 323:181-229]

Cited: 1 time

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Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p.

Zofia Wotschofsky, Linda Gummlich, Julia Liep, Carsten Stephan, Ergin Kilic, Klaus Jung, Jean-Noel Billaud, Hellmuth-Alexander Meyer,

BACKGROUND:MicroRNAs (miRNAs) regulate gene expression by interfering translation or stability of target transcripts. This interplay between miRNA and their mRNA has been proposed as an important process in cancer development and progression. We have investigated molecular networks impacted by predicted mRNA targets of differentially expressed miRNAs in patients with clear ... Read more >>

PLoS ONE (PloS one)
[2016, 11(2):e0148746]

Cited: 27 times

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Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients.

Hongbiao Lu, Jonas Busch, Monika Jung, Silke Rabenhorst, Bernhard Ralla, Ergin Kilic, Steffen Mergemeier, Nils Budach, Annika Fendler, Klaus Jung,

There is inconsistent information about the clinical usefulness of circulating cell-free DNA (cfDNA) in plasma from clear cell renal cell cancer (RCC) patients. This is attributed to preanalytical, analytical, and clinical factors that were considered as far as possible in this study.cfDNA was extracted from EDTA plasma of healthy people ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2016, 452:109-119]

Cited: 17 times

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