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Author Enrico Alfonsi

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Isolated bulbar palsy after SARS-CoV-2 infection.

Massimiliano Todisco, Enrico Alfonsi, Sebastiano Arceri, Giulia Bertino, Carlo Robotti, Michele Albergati, Matteo Gastaldi, Cristina Tassorelli, Giuseppe Cosentino,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):169-170]

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Electrophysiological features of acute inflammatory demyelinating polyneuropathy associated with SARS-CoV-2 infection

Antonino Uncini, Camillo Foresti, Barbara Frigeni, Storti Benedetta, Maria Cristina Servalli, Stefano Gazzina, Giuseppe Cosentino, Francesca Bianchi, Ubaldo Del Carro, Enrico Alfonsi, Stefano Cotti Piccinelli, Giovanni De Maria, Alessandro Padovani, Massimiliano Filosto, Luigi Ippoliti,

<h4>Objective</h4> To assess whether patients with acute inflammatory demyelinating polyneuropathy (AIDP) associated with SARS-CoV-2 show characteristic electrophysiological features. <h4>Methods</h4> Clinical and electrophysiological findings of 24 patients with SARS-CoV-2 infection and AIDP (S-AIDP) and of 48 control AIDP (C-AIDP) without SARS-CoV-2 infection were compared. <h4>Results</h4> S-AIDP patients more frequently developed respiratory ... Read more >>

Neurophysiol Clin (Neurophysiologie clinique = Clinical neurophysiology)
[2021, :]

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A Rare Syndrome Causing Neurogenic Dysphagia.

Antonio Zito, Paola Bini, Massimiliano Todisco, Giuseppe Cosentino, Simone Mauramati, Matteo Paoletti, Vincenzo Marasco, Enrico Marchioni, Enrico Alfonsi,

Dysphagia (Dysphagia)
[2020, :]

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COVID-19 and Guillain-Barré Syndrome: A Case Report and Review of Literature.

Antonio Zito, Enrico Alfonsi, Diego Franciotta, Massimiliano Todisco, Matteo Gastaldi, Matteo Cotta Ramusino, Mauro Ceroni, Alfredo Costa,

During the recent coronavirus disease 2019 (COVID-19) outbreak in Northern Italy, we observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain-Barré syndrome (GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Similarly to other bacterial and viral infections, dysregulation of the immune system due to ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:909]

Cited: 5 times

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Mutation in RNF170 causes sensory ataxic neuropathy with vestibular areflexia: a CANVAS mimic.

Andrea Cortese, Ilaria Callegari, Riccardo Currò, Elisa Vegezzi, Silvia Colnaghi, Maurizio Versino, Enrico Alfonsi, Giuseppe Cosentino, Enzamaria Valente, Simone Gana, Cristina Tassorelli, Anna Pichiecchio, Alexander M Rossor, Enrico Bugiardini, Antonio Biroli, Daniela Di Capua, Henry Houlden, Mary M Reilly,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(11):1237-1238]

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KCTD17-related myoclonus-dystonia syndrome: clinical and electrophysiological findings of a patient with atypical late onset.

Massimiliano Todisco, Simone Gana, Giuseppe Cosentino, Edoardo Errichiello, Sebastiano Arceri, Micol Avenali, Enza Maria Valente, Enrico Alfonsi,

<h4>Introduction</h4>Myoclonus-dystonia is a rare syndrome typically occurring during childhood or adolescence, mainly due to SGCE pathogenic variants. Early-onset, atypical presentations of myoclonus-dystonia have recently been associated with KCTD17 variants. In these cases, laryngeal involvement was reported in the advanced stages.<h4>Methods</h4>We evaluated a 52-year-old man with myoclonus-dystonia and positive family history. ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 78:129-133]

Cited: 1 time

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Reproducibility and reaction time of swallowing as markers of dysphagia in parkinsonian syndromes.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Massimiliano Todisco, Roberto De Icco, Micol Avenali, Brigida Minafra, Roberta Zangaglia, Francesca Valentino, Claudio Pacchetti, Giulia Bertino, Simone Mauramati, Mauro Fresia, Enrico Alfonsi,

<h4>Objective</h4>To investigate reproducibility and reaction time of oropharyngeal swallowing in patients with Parkinson's disease (PD) and atypical parkinsonisms (APs).<h4>Methods</h4>We enrolled 19 patients with PD, 30 with APs, and 20 healthy subjects. Presence and severity of dysphagia were assessed with clinical and fiberoptic endoscopic evaluations of swallowing. Reproducibility of the oral ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(9):2200-2208]

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Reply to: "Anodal transcranial direct current stimulation and intermittent theta burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation".

Giuseppe Cosentino, Massimiliano Todisco, Enrico Alfonsi,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(8):e13933]

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Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome.

Giuseppe Cosentino, Marcello Romano, Margherita Algeri, Filippo Brighina, Enrico Alfonsi, Cristina Tassorelli, Grazia Crescimanno,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(4):]

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Anodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Giulia Bertino, Roberto De Icco, Massimiliano Todisco, Salvatore Di Marco, Filippo Brighina, Antonio Schindler, Mariangela Rondanelli, Mauro Fresia, Luca Mainardi, Domenico A Restivo, Alberto Priori, Giorgio Sandrini, Enrico Alfonsi,

BACKGROUND:Dysphagia in the elderly, known as presbydysphagia, has become a relevant public health problem in several countries. Swallowing disorders may be a consequence of different neurological disorders (secondary presbydysphagia) or the expression of the aging process itself (primary presbydysphagia). We aimed to test the therapeutic potential of two different non-invasive ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(5):e13791]

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Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype.

Andrea Cortese, Raffaella Lombardi, Chiara Briani, Ilaria Callegari, Luana Benedetti, Fiore Manganelli, Marco Luigetti, Sergio Ferrari, Angelo M Clerici, Girolama Alessandra Marfia, Andrea Rigamonti, Marinella Carpo, Raffaella Fazio, Massimo Corbo, Anna Mazzeo, Fabio Giannini, Giuseppe Cosentino, Elisabetta Zardini, Riccardo Currò, Matteo Gastaldi, Elisa Vegezzi, Enrico Alfonsi, Angela Berardinelli, Ludivine Kouton, Constance Manso, Claudia Giannotta, Pietro Doneddu, Patrizia Dacci, Laura Piccolo, Marta Ruiz, Alessandro Salvalaggio, Chiara De Michelis, Emanuele Spina, Antonietta Topa, Giulia Bisogni, Angela Romano, Sara Mariotto, Giorgia Mataluni, Federica Cerri, Claudia Stancanelli, Mario Sabatelli, Angelo Schenone, Enrico Marchioni, Giuseppe Lauria, Eduardo Nobile-Orazio, Jérôme Devaux, Diego Franciotta,

<h4>Objective</h4>To assess the prevalence and isotypes of anti-nodal/paranodal antibodies to nodal/paranodal proteins in a large chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cohort, compare clinical features in seronegative vs seropositive patients, and gather evidence of their isotype-specific pathogenic role.<h4>Methods</h4>Antibodies to neurofascin-155 (Nfasc155), neurofascin-140/186 (Nfasc140/186), contactin-1 (CNTN1), and contactin-associated protein 1 (Caspr1) were ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(1):]

Cited: 7 times

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Vocal cord electromyographic correlates of stridor in multiple system atrophy phenotypes.

Massimiliano Todisco, Enrico Alfonsi, Ioannis Ugo Isaias, Roberta Zangaglia, Brigida Minafra, Giuseppe Cosentino, Michele Terzaghi, Nicoló Gabriele Pozzi, Raffaele Manni, Claudio Pacchetti,

<h4>Introduction</h4>Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by dysautonomia in combination with parkinsonian and cerebellar signs. Stridor may also occur and it is associated with life-threatening events and poor prognosis. The pathophysiology of stridor in MSA is still debated.<h4>Objective</h4>To define correlations between diurnal electromyographic (EMG) abnormalities of vocal ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 70:31-35]

Cited: 2 times

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Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment.

Pietro Cortelli, Giovanna Calandra-Buonaura, Eduardo E Benarroch, Giulia Giannini, Alex Iranzo, Phillip A Low, Paolo Martinelli, Federica Provini, Niall Quinn, Eduardo Tolosa, Gregor K Wenning, Giovanni Abbruzzese, Pamela Bower, Enrico Alfonsi, Imad Ghorayeb, Tetsutaro Ozawa, Claudio Pacchetti, Nicolò Gabriele Pozzi, Claudio Vicini, Angelo Antonini, Kailash P Bhatia, Jacopo Bonavita, Horacio Kaufmann, Maria Teresa Pellecchia, Nicole Pizzorni, Antonio Schindler, François Tison, Luca Vignatelli, Wassilios G Meissner,

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by a combination of autonomic failure, cerebellar ataxia, and parkinsonism. Laryngeal stridor is an additional feature for MSA diagnosis, showing a high diagnostic positive predictive value, and its early occurrence might contribute to shorten survival. A consensus definition of stridor in ... Read more >>

Neurology (Neurology)
[2019, 93(14):630-639]

Cited: 4 times

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Corrigendum to 'A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis' [Clin. Neurophysiol. 130 (2019) 1017-1024].

Domenico A Restivo, Enrico Alfonsi, Antonino Casabona, Shaheen Hamdy, Cristina Tassorelli, Mariangela Panebianco, Rosario Marchese-Ragona, Angelo Quartarone, Diego Centonze, Antonino Pavone, Mario Stampanoni Bassi,

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2019, 130(10):2013]

Cited: 0 times

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Pisa syndrome in Idiopathic Normal Pressure Hydrocephalus.

Massimiliano Todisco, Nicolò Gabriele Pozzi, Roberta Zangaglia, Brigida Minafra, Domenico Servello, Roberto Ceravolo, Enrico Alfonsi, Alfonso Fasano, Claudio Pacchetti,

<h4>Introduction</h4>Idiopathic Normal Pressure Hydrocephalus (iNPH) is a complex syndrome of ventriculomegaly that can include parkinsonian-like features besides the classical triad of cognitive decline, urinary incontinence, and gait/balance disturbances. Pisa syndrome (PS) is a postural abnormality often associated with parkinsonism and defined as lateral trunk flexion greater than 10° while standing ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2019, 66:40-44]

Cited: 1 time

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A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

Domenico A Restivo, Enrico Alfonsi, Antonino Casabona, Shaheen Hamdy, Cristina Tassorelli, Mariangela Panebianco, Rosario Marchese-Ragona, Angelo Quartarone, Diego Centonze, Antonino Pavone, Mario Stampanoni Bassi,

<h4>Objective</h4>we investigated the effect of anodal transcranial direct current stimulation (tDCS) applied over the pharyngeal motor area in dysphagia associated with multiple sclerosis (MS).<h4>Methods</h4>Eighteen MS patients with dysphagia associated with brainstem involvement were randomized to receive either "real" or "sham" tDCS.<h4>Primary outcome</h4>The Penetration/Aspiration Scale (PAS).<h4>Secondary outcomes</h4>changes in electromyographic (EMG) parameters ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2019, 130(6):1017-1024]

Cited: 0 times

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OnabotulinumtoxinA Reduces Temporal Pain Processing at Spinal Level in Patients with Lower Limb Spasticity.

Roberto De Icco, Armando Perrotta, Eliana Berra, Marta Allena, Enrico Alfonsi, Stefano Tamburin, Mariano Serrao, Giorgio Sandrini, Cristina Tassorelli,

Spasticity is a muscle tone disorder associated with different neurological conditions. Spasticity could be associated with pain, high disability, poor functional recovery, and reduced quality of life. Botulinum neurotoxin type A (BoNT-A) is considered a first-line treatment for spasticity and, more recently, it also represents a therapeutic option for various ... Read more >>

Toxins (Basel) (Toxins)
[2019, 11(6):]

Cited: 1 time

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Subclinical dysphagia in task-specific mouth tremor triggered by drinking.

Mario Stampanoni Bassi, Sara Casciato, Luana Gilio, Luigi Pavone, Daniele Cafolla, Elisabetta Sforza, Enrico Alfonsi, Ilaria Simonelli, Giancarlo Di Gennaro, Diego Centonze, Ennio Iezzi,

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2019, 130(8):1289-1291]

Cited: 0 times

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Botulinum toxin A modifies nociceptive withdrawal reflex in subacute stroke patients.

Elena Alvisi, Mariano Serrao, Carmela Conte, Enrico Alfonsi, Cristina Tassorelli, Paolo Prunetti, Silvano Cristina, Armando Perrotta, Francesco Pierelli, Giorgio Sandrini,

Brain Behav (Brain and behavior)
[2018, 8(12):e01162]

Cited: 1 time

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Botulinum toxin A modifies nociceptive withdrawal reflex in subacute stroke patients.

Elena Alvisi, Mariano Serrao, Carmela Conte, Enrico Alfonsi, Cristina Tassorelli, Paolo Prunetti, Silvano Cristina, Armando Perrotta, Francesco Pierelli, Giorgio Sandrini,

<h4>Objectives</h4>The aims of this study were to evaluate the pattern of the nociceptive withdrawal reflex (NWR) of the upper limb at rest and after injection of Botulinum toxin type A (BoNT-A) in poststroke subacute hemiparetic patients.<h4>Methods</h4>Fourteen patients with poststroke subacute hemiparesis underwent clinical and instrumental evaluation and BoNT-A injection. Painful ... Read more >>

Brain Behav (Brain and behavior)
[2018, 8(9):e01069]

Cited: 2 times

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A pilot study assessing T1-weighted muscle MRI in amyotrophic lateral sclerosis (ALS).

Luca Diamanti, Enrico Alfonsi, Ottavia Eleonora Ferraro, Cristina Cereda, Orietta Pansarasa, Stefano Bastianello, Anna Pichiecchio,

The authors set out to study the role of T1-weighted muscle MRI in the diagnostic phase of ALS, comparing images from ten patients and nine age-matched healthy controls (HCs). All subjects underwent MRI of 68 muscles in the hands, paraspinal regions and lower limbs; the images were semi-quantitatively scored. Atrophy ... Read more >>

Skeletal Radiol (Skeletal radiology)
[2019, 48(4):569-575]

Cited: 3 times

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Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer: A case report and review of the literature.

Luca Diamanti, Erica Quaquarini, Giulia Berzero, Paola Bini, Matteo Gastaldi, Diego Franciotta, Enrico Alfonsi, Mauro Ceroni, Mara Frascaroli, Antonio Bernardo, Enrico Marchioni,

Paraneoplastic neurological syndromes are very rare and often associated to breast, ovarian and small cells lung cancers. Paraneoplastic motor neuron diseases (MNDs) are even rarer, and frequently described in patients with breast cancer. We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2018, 172:141-142]

Cited: 0 times

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Spasmodic Dysphonia in Multiple Sclerosis Treatment With Botulin Toxin A: A Pilot Study.

Arianna Di Stadio, Evanthia Bernitsas, Domenico Antonio Restivo, Enrico Alfonsi, Rosario Marchese-Ragona,

OBJECTIVES:This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. MATERIALS AND METHODS:This is a pilot study on three relapsing-remitting MS patients with SD and ... Read more >>

J Voice (Journal of voice : official journal of the Voice Foundation)
[2019, 33(4):550-553]

Cited: 0 times

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Predictors of outcome in a large retrospective cohort of patients with transverse myelitis.

Matteo Gastaldi, Enrico Marchioni, Paola Banfi, Valeria Mariani, Laura Di Lodovico, Roberto Bergamaschi, Enrico Alfonsi, Paola Borrelli, Ottavia Eleonora Ferraro, Elisabetta Zardini, Anna Pichiecchio, Andrea Cortese, Patrick Waters, Mark Woodhall, Mauro Ceroni, Marco Mauri, Diego Franciotta,

<h4>Background</h4>Transverse myelitis (TM) is an inflammatory disorder that can be idiopathic or associated with central nervous system autoimmune/dysimmune inflammatory diseases, connective tissue autoimmune diseases, or post-infectious neurological syndromes. Prognosis of initial TM presentations is uncertain.<h4>Objective</h4>To identify outcome predictors in TM.<h4>Methods</h4>Retrospective study on isolated TM at onset. Scores ⩾3 on the ... Read more >>

Mult Scler (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(13):1743-1752]

Cited: 1 time

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Effects of More-Affected vs. Less-Affected Motor Cortex tDCS in Parkinson's Disease.

Giuseppe Cosentino, Francesca Valentino, Massimiliano Todisco, Enrico Alfonsi, Rosaria Davì, Giovanni Savettieri, Brigida Fierro, Marco D'Amelio, Filippo Brighina,

<b>Objective</b>: To evaluate therapeutic potential of different montages of transcranial direct current stimulation (tDCS) in Parkinson's Disease (PD) patients with asymmetric motor symptoms. <b>Materials and Methods</b>: Fourteen patients with asymmetric PD underwent, while on treatment, seven separate sessions including electrophysiological and clinical evaluation at baseline and after anodal, cathodal and ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2017, 11:309]

Cited: 5 times

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