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Author Enno D Wildschut

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Hyperoxia in pediatric severe traumatic brain injury (TBI): a comparison of patient classification by cutoff versus cumulative (area-under-the-curve) analysis.

Naomi Ketharanathan, Rogier C J De Jonge, Ilse Klouwen, Enno D Wildschut, Irwin K M Reiss, Dick Tibboel, Iain K M Haitsma, Corinne M P Buysse,

OBJECTIVE:Hyperoxia is associated with adverse outcome in severe traumatic brain injury (TBI). This study explored differences in patient classification of oxygen exposure by PaO2 cutoff and cumulative area-under-the-curve (AUC) analysis. METHODS:Retrospective, explorative study including children (<18 years) with accidental severe TBI (2002-2015). Oxygen exposure analysis used three PaO2 cutoff values and ... Read more >>

Brain Inj (Brain injury)
[2020, :1-7]

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Recovery of cefazolin and clindamycin in in vitro pediatric CPB systems.

Gerdien A Zeilmaker-Roest, Annewil van Saet, Marloes P J van Hoeven, Birgit C P Koch, Joost van Rosmalen, Martina Kinzig, Fritz Söergel, Enno D Wildschut, Robert J Stolker, Dick Tibboel, Ad J J C Bogers,

Cardiopulmonary bypass (CPB) is often necessary for congenital cardiac surgery, but CPB can alter drug pharmacokinetic parameters resulting in underdosing. Inadequate plasma levels of antibiotics could lead to postoperative infections with increased morbidity. The influence of pediatric CPB systems on cefazolin and clindamycin plasma levels is not known. We have ... Read more >>

Artif Organs (Artificial organs)
[2020, 44(4):394-401]

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Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Genny Raffaeli, Pavla Pokorna, Karel Allegaert, Fabio Mosca, Giacomo Cavallaro, Enno D Wildschut, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. As the survival and the overall outcome of patients rely on the treatment and reversal of the underlying disease, effective and preferentially evidence-based pharmacotherapy is crucial to target recovery. Currently limited data exist ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:360]

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In Vitro Recovery of Sufentanil, Midazolam, Propofol, and Methylprednisolone in Pediatric Cardiopulmonary Bypass Systems.

Annewil van Saet, Gerdien A Zeilmaker-Roest, Marloes P J van Hoeven, Birgit C P Koch, Joost van Rosmalen, Martina Kinzig, Fritz Sörgel, Enno D Wildschut, Robert J Stolker, Dick Tibboel, Ad J J C Bogers,

OBJECTIVES:To evaluate in vitro drug recovery in cardiopulmonary bypass (CPB) systems used for pediatric cardiac surgery. DESIGN:Observational in vitro study. SETTING:Single-center university hospital. PARTICIPANTS:In vitro CPB systems used for pediatric cardiac surgery. INTERVENTIONS:Three full neonatal, infant, and pediatric CPB systems were primed according to hospital protocol and kept running for ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, 34(4):972-980]

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The Sublingual Microcirculation Throughout Neonatal and Pediatric Extracorporeal Membrane Oxygenation Treatment: Is It Altered by Systemic Extracorporeal Support?

Özge Erdem, Jan Willem Kuiper, Joost van Rosmalen, Robert Jan Houmes, Enno D Wildschut, Can Ince, Dick Tibboel,

Background: Extracorporeal membrane oxygenation (ECMO) treatment alleviates systemic cardiorespiratory failure. However, it is unclear whether ECMO also improves microcirculatory function, as the microcirculation can be disturbed despite normal systemic hemodynamics. We therefore aimed to study the sublingual microcirculation (SMC) throughout neonatal and pediatric ECMO treatment. We hypothesized that the SMC ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:272]

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Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Naomi Ketharanathan, Yumi Yamamoto, Ursula K Rohlwink, Enno D Wildschut, Ron A A Mathôt, Elizabeth C M de Lange, Saskia N de Wildt, Andrew C Argent, Dick Tibboel, Anthony A Figaji,

Evidence-based analgosedation in severe pediatric traumatic brain injury (pTBI) management is lacking, and improved pharmacological understanding is needed. This starts with increased knowledge of factors controlling the pharmacokinetics (PK) of unbound drug at the target site (brain) and related drug effect(s). This prospective, descriptive study tested a pediatric physiology-based pharmacokinetic ... Read more >>

J. Neurotrauma (Journal of neurotrauma)
[2019, 36(1):111-117]

Cited: 1 time

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In Vitro Adsorption of Analgosedative Drugs in New Extracorporeal Membrane Oxygenation Circuits.

Genny Raffaeli, Karel Allegaert, Birgit Koch, Giacomo Cavallaro, Fabio Mosca, Dick Tibboel, Enno D Wildschut,

OBJECTIVE:Evaluate drug disposition of sedatives and analgesics in the Xenios/Novalung extracorporeal membrane oxygenation circuits. DESIGN:In vitro experimental study. SETTING:Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. SUBJECTS:Nine closed-loop extracorporeal membrane oxygenation circuits, made up of the iLA Activve console with four different iLA Activve kits: two X-lung kits, two ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(5):e251-e258]

Cited: 3 times

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Intravenous morphine versus intravenous paracetamol after cardiac surgery in neonates and infants: a study protocol for a randomized controlled trial.

Gerdien A Zeilmaker-Roest, Joost van Rosmalen, Monique van Dijk, Erik Koomen, Nicolaas J G Jansen, Martin C J Kneyber, Sofie Maebe, Greet van den Berghe, Dirk Vlasselaers, Ad J J C Bogers, Dick Tibboel, Enno D Wildschut,

BACKGROUND:Morphine is worldwide the analgesic of first choice after cardiac surgery in children. Morphine has unwanted hemodynamic and respiratory side effects. Therefore, post-cardiac surgery patients may potentially benefit from a non-opioid drug for pain relief. A previous study has shown that intravenous (IV) paracetamol is effective and opioid-sparing in children ... Read more >>

Trials (Trials)
[2018, 19(1):318]

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Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.

Gerda A Zeilmaker-Roest, Annewil van Saet, Joost van Rosmalen, Soma Bahmany, Antony van Dijk, Enno D Wildschut, Dick Tibboel, Ad J J C Bogers,

<label>BACKGROUND</label>Use of donor blood in congenital cardiac surgery increases the risk for post-operative morbidity and mortality. To reduce the need for allogenic blood transfusion a technique for peri-operative mechanical red cell salvage is applied. Blood from the operation site is collected in a reservoir, processed, passed through a lipophilic filter ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2018, 13(1):64]

Cited: 0 times

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Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Gerdien A Zeilmaker, Paula Pokorna, Paola Mian, Enno D Wildschut, Catherijne A J Knibbe, Elke H J Krekels, Karel Allegaert, Dick Tibboel,

Adequate postoperative analgesia in pediatric patients in the intensive care unit (ICU) matters, since untreated pain is associated with negative outcomes. Compared to routine postoperative patients, children undergoing hypothermia (HT) or extracorporeal membrane oxygenation (ECMO), or recovering after cardiac surgery likely display non-maturational differences in pharmacokinetics (PK) and pharmacodynamics (PD). ... Read more >>

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2018, 14(4):417-428]

Cited: 5 times

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Risk Factors of Impaired Neuropsychologic Outcome in School-Aged Survivors of Neonatal Critical Illness.

Lisette Leeuwen, Raisa M Schiller, André B Rietman, Joost van Rosmalen, Enno D Wildschut, Robert Jan M Houmes, Dick Tibboel, Hanneke IJsselstijn,

OBJECTIVE:Until now, long-term outcome studies have focused on general cognitive functioning and its risk factors following neonatal extracorporeal membrane oxygenation and/or congenital diaphragmatic hernia. However, it is currently unknown which neuropsychological domains are most affected in these patients and which clinical variables can be used to predict specific neuropsychological problems. ... Read more >>

Crit. Care Med. (Critical care medicine)
[2018, 46(3):401-410]

Cited: 4 times

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An international survey of management of pain and sedation after paediatric cardiac surgery.

Gerdien A Zeilmaker-Roest, Enno D Wildschut, Monique van Dijk, Brian J Anderson, Cormac Breatnach, Ad J J C Bogers, Dick Tibboel, ,

The mainstay of pain treatment after paediatric cardiac surgery is the use of opioids. Current guidelines for its optimal use are based on small, non-randomised clinical trials, and data on the pharmacokinetics (PK) and pharmacodynamics (PD) of opioids are lacking. This study aims at providing an overview of international hospital ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2017, 1(1):e000046]

Cited: 1 time

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Risk and relevance of open lung biopsy in pediatric ECMO patients: the Dutch experience.

Robert Jan Houmes, Chantal A Ten Kate, Enno D Wildschut, Rob M Verdijk, René M H Wijnen, Ivo de Blaauw, Dick Tibboel, Arno F van Heijst,

Open lung biopsy can help differentiate between reversible and irreversible lung disease and may guide therapy. To assess the risk-benefit ratio of this procedure in pediatric extracorporeal membrane oxygenation (ECMO) patients, we reviewed data of all patients who underwent an open lung biopsy during ECMO in one of the two ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2017, 52(3):405-409]

Cited: 3 times

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Morphine treatment for neonatal abstinence syndrome: huge dosing variability underscores the need for a better clinical study design.

Paola Mian, Dick Tibboel, Enno D Wildschut, John N van den Anker, Karel Allegaert,

INTRODUCTION:At present, morphine is the most commonly used first-line therapy to treat Neonatal Abstinence Syndrome (NAS). Unfortunately, there is still lack of evidence and consensus to guide pharmacologic therapy for NAS. In this review, we provide an overview on dosing regimens of morphine currently reported to treat NAS, with the ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2019, 71(3):263-286]

Cited: 1 time

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Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration.

Niina Kleiber, Ron A A Mathôt, Maurice J Ahsman, Enno D Wildschut, Dick Tibboel, Saskia N de Wildt,

AIMS:Clonidine is used for sedation in the paediatric intensive care unit. Extracorporeal membrane oxygenation (ECMO) provides temporary support if respiratory and cardiac function is threatened. ECMO influences the pharmacokinetics of drugs. Clonidine during paediatric ECMO cannot be effectively titrated as PK data are lacking. The aim of this study is ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2017, 83(6):1227-1239]

Cited: 6 times

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Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

Pieter L A Fraaij, Enno D Wildschut, Robert J Houmes, Corien M Swaan, Christian J Hoebe, H C C de Jonge, Paulien Tolsma, Isme de Kleer, Suzan D Pas, Bas B Oude Munnink, My V T Phan, Theo M Bestebroer, R Shanty Roosenhoff, Jeroen J A van Kampen, Matthew Cotten, Nancy Beerens, Ron A M Fouchier, Johannes H van den Kerkhof, Aura Timen, Marion P Koopmans,

In October 2016, a severe infection with swine influenza A(H1N1) virus of the Eurasian avian lineage occurred in a child with a previous history of eczema in the Netherlands, following contact to pigs. The patient's condition deteriorated rapidly and required life support through extracorporeal membrane oxygenation. After start of oseltamivir ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2016, 21(48):]

Cited: 4 times

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Loop diuretics are an independent risk factor for acute kidney injury in children on extracorporeal membrane oxygenation with pre-emptive continuous hemofiltration.

Alexandra J M Zwiers, Karlien Cransberg, Joost van Rosmalen, Enno D Wildschut, Dick Tibboel, Saskia N de Wildt,

Intensive Care Med (Intensive Care Medicine)
[2014, 40(4):627-628]

Cited: 3 times

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Brain injury associated with neonatal extracorporeal membrane oxygenation in the Netherlands: a nationwide evaluation spanning two decades.

Marlou M A Raets, Jeroen Dudink, Hanneke Ijsselstijn, Arno F J van Heijst, Maarten H Lequin, Robert Jan Houmes, Enno D Wildschut, Irwin K M Reiss, Paul Govaert, Dick Tibboel,

OBJECTIVE: To determine the prevalence of and to classify ultrasound-proven brain injury during neonatal extracorporeal membrane oxygenation in The Netherlands. DESIGN: Retrospective nationwide study (Rotterdam and Nijmegen), spanning two decades. SETTING: Level III university hospitals. SUBJECTS: All neonates who underwent neonatal extracorporeal membrane oxygenation from 1989 to 2010. INTERVENTIONS: None. ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2013, 14(9):884-892]

Cited: 18 times

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Insufficient serum caspofungin levels in a paediatric patient on ECMO.

Birgit C P Koch, Enno D Wildschut, Anna L de Goede, Matthijs de Hoog, Roger J M Brüggemann,

Caspofungin, aechinocandin, is a relatively new lipophilic antifungal drug. Little is known concerning the pharmacokinetics of caspofungin in children. Extracorporeal membrane oxygenation (ECMO) allows prolonged cardiopulmonary support in patients with life-threatening respiratory or cardiac failure. Pharmacokinetics may be altered by ECMO. We describe the case of a paediatric patient on ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2012, 2:23-24]

Cited: 4 times

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Effect of hypothermia and extracorporeal life support on drug disposition in neonates.

Enno D Wildschut, Saskia N de Wildt, Ron A A Mâthot, I K M Reiss, Dick Tibboel, John Van den Anker,

Extracorporeal membrane oxygenation (ECMO) is a valuable treatment modality in neonates with reversible cardiopulmonary failure in therapy-resistant pulmonary hypertension after perinatal asphyxia, septic shock or ECMO cardiopulmonary resuscitation. Neonates with severe perinatal asphyxia are currently treated with therapeutic hypothermia to improve neurological outcome. Consequently, therapeutic hypothermia may be indicated in ... Read more >>

Semin Fetal Neonatal Med (Seminars in fetal & neonatal medicine)
[2013, 18(1):23-27]

Cited: 10 times

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The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children.

Enno D Wildschut, Annewil van Saet, Pavla Pokorna, Maurice J Ahsman, John N Van den Anker, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2012, 59(5):1183-1204]

Cited: 16 times

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Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates.

Maurice J Ahsman, Manon Hanekamp, Enno D Wildschut, Dick Tibboel, Ron A A Mathot,

Midazolam is used to sedate children during extracorporeal membrane oxygenation (ECMO). Pharmacokinetic changes are expected because of extracorporeal circulation and maturation. We present a population pharmacokinetic model for midazolam and its major metabolites in neonates during venoarterial ECMO.We studied 20 neonates on venoarterial ECMO, with a median postnatal age of ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2010, 49(6):407-419]

Cited: 39 times

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Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation.

Maurice J Ahsman, Enno D Wildschut, Dick Tibboel, Ron A Mathot,

Extracorporeal membrane oxygenation (ECMO) is used to temporarily sustain cardiac and respiratory function in critically ill infants but can cause pharmacokinetic changes necessitating dose modifications. Cefotaxime (CTX) is used to prevent and treat infections during ECMO, but the current dose regimen is based on pharmacokinetic data obtained for non-ECMO patients. ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2010, 54(5):1734-1741]

Cited: 26 times

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Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support.

Enno D Wildschut, Matthijs de Hoog, Maurice J Ahsman, Dick Tibboel, Albert D M E Osterhaus, Pieter L A Fraaij,

INTRODUCTION: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children. METHODOLOGY: Steady state 0-12 hour pharmacokinetic sampling was performed in new influenza A (H1N1) infected children treated with oseltamivir while on ECMO support. Cmax, Cmin and AUC(0-12 h) were ... Read more >>

PLoS ONE (PloS one)
[2010, 5(6):e10938]

Cited: 25 times

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Sildenafil exposure in neonates with pulmonary hypertension after administration via a nasogastric tube.

Maurice J Ahsman, Bregje C Witjes, Enno D Wildschut, Ilona Sluiter, Arnold G Vulto, Dick Tibboel, Ron A Mathot,

OBJECTIVE: To describe the pharmacokinetics and exposure of oral sildenafil (SIL) in neonates (2-5 kg) with pulmonary hypertension (PH). DESIGN: We included 11 neonates (body weight 2-5 kg, postnatal age 2-121 days) who received SIL and extracorporeal membrane oxygenation (ECMO) treatment for PH. SIL capsules were given via a nasogastric ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2010, 95(2):F109-14]

Cited: 20 times

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