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Author Eng King Tan

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A microfiber scaffold-based 3D in vitro human neuronal culture model of Alzheimer's disease.

Vivek Damodar Ranjan, Lifeng Qiu, Jolene Wei-Ling Lee, Xuelong Chen, Se Eun Jang, Chou Chai, Kah-Leong Lim, Eng-King Tan, Yilei Zhang, Wei Min Huang, Li Zeng,

Increasing evidence indicates superiority of three-dimensional (3D) in vitro cell culture systems over conventional two-dimensional (2D) monolayer cultures in mimicking native in vivo microenvironments. Tissue-engineered 3D culture models combined with stem cell technologies have advanced Alzheimer's disease (AD) pathogenesis studies. However, existing 3D neuronal models of AD overexpress mutant genes ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(17):4861-4874]

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Neurovascular compression in hemifacial spasm.

Ling-Ling Chan, Eng-King Tan,

Brain (Brain : a journal of neurology)
[2021, :]

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Fist-Edge-Palm (FEP) test has a high sensitivity in differentiating dementia from normal cognition in Parkinson's disease.

Ye Liu, Meng-Yao Qiu, Yu-Lei Zhang, Xiao-Jin Zhang, Daniel Truong, Eng-King Tan, Yun-Cheng Wu,

<h4>Background</h4>The Fist-Edge-Palm (FEP) test takes 0.5-3 min to complete and is highly sensitive in differentiating Alzheimer's disease and frontotemporal dementia from normal cognition, but it has not yet been studied in Parkinson's disease (PD).<h4>Objective</h4>To determine the sensitivity and specificity of the FEP test in screening patients with PD for cognitive impairment ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2021, 429:118060]

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Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations.

Junghyun Jo, Lin Yang, Hoang-Dai Tran, Weonjin Yu, Alfred Xuyang Sun, Ya Yin Chang, Byung Chul Jung, Seung-Jae Lee, Tzuen Yih Saw, Bin Xiao, Audrey Tze Ting Khoo, Lai-Ping Yaw, Jessica Jiaxin Xie, Hidayat Lokman, Wei-Yi Ong, Grace Gui Yin Lim, Kah-Leong Lim, Eng-King Tan, Huck-Hui Ng, Hyunsoo Shawn Je,

<h4>Objective</h4>We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulating α-syn- and Lewy body-related pathologies and the process of neurodegeneration in the hMLO model.<h4>Methods</h4>We generated and ... Read more >>

Ann Neurol (Annals of neurology)
[2021, 90(3):490-505]

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Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.

Ming-Wei Sia, Jia-Nee Foo, Seyed-Ehsan Saffari, Aidan Sheng-Yong Wong, Chiea-Chuen Khor, Jian-Min Yuan, Eng-King Tan, Woon-Puay Koh, Louis Chew-Seng Tan,

<h4>Background</h4>Ethnic-specific genetic risk assessment framework for Parkinson's disease (PD) is lacking for the Asian population.<h4>Objective</h4>We investigated the association of a polygenic risk score (PRS) with PD incidence in a population-based Asian prospective cohort.<h4>Methods</h4>Genetic, dietary, and lifestyle information were prospectively collected from 25,646 participants within the Singapore Chinese Health Study cohort. ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, :]

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Caution in Interpreting Facial Paralysis Data to Understand COVID-19 Vaccination Risks.

Jing Han Ng, Eng King Tan,

JAMA Intern Med (JAMA internal medicine)
[2021, :]

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Genetic Studies of Parkinson's and Alzheimer's Disease in Latinos/Hispanics: New Insights and Challenges.

Eng-King Tan,

Ann Neurol (Annals of neurology)
[2021, 90(3):350-352]

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Case-control study of hypertension and Parkinson's disease.

Yuen-Fann Ng, Ebonne Ng, Ee-Wei Lim, Kumar M Prakash, Louis C S Tan, Eng-King Tan,

We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2021, 7(1):63]

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Functional Neurological Disorders and COVID-19 Vaccination.

Jing-Han Ng, K Ray Chaudhuri, Eng-King Tan,

Ann Neurol (Annals of neurology)
[2021, 90(2):328]

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Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor.

George Zhang Wei, Katherine A Martin, Peter Yuli Xing, Ruchi Agrawal, Luke Whiley, Thomas K Wood, Sophia Hejndorf, Yong Zhi Ng, Jeremy Zhi Yan Low, Janet Rossant, Robert Nechanitzky, Elaine Holmes, Jeremy K Nicholson, Eng-King Tan, Paul M Matthews, Sven Pettersson,

While modulatory effects of gut microbes on neurological phenotypes have been reported, the mechanisms remain largely unknown. Here, we demonstrate that indole, a tryptophan metabolite produced by tryptophanase-expressing gut microbes, elicits neurogenic effects in the adult mouse hippocampus. Neurogenesis is reduced in germ-free (GF) mice and in GF mice monocolonized ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(27):]

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Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease.

Xiaoya Gao, Zifeng Huang, Cailing Feng, Chaohao Guan, Ruidong Li, Haiting Xie, Jian Chen, Mingchun Li, Rongfang Que, Bin Deng, Peihua Cao, Mengyan Li, Jianjun Lu, Yihong Huang, Minzi Li, Weihong Yang, Xiaohua Yang, Chunyan Wen, Xiaomei Liang, Qin Yang, Yin-Xia Chao, Ling-Ling Chan, Midori A Yenari, Kunlin Jin, K Ray Chaudhuri, Jing Zhang, Eng-King Tan, Qing Wang,

<h4>Objective</h4>We aimed to identify key susceptibility gene targets in multiple datasets generated from postmortem brains and blood of Parkinson's disease (PD) patients and healthy controls (HC).<h4>Methods</h4>We performed a multitiered analysis to integrate the gene expression data using multiple-gene chips from 244 human postmortem tissues. We identified hub node genes in ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, 22(4):]

Cited: 3 times

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Seasonal haze: Knowledge gaps and risk perception behaviours.

Jing Han Ng, Eng King Tan,

Ann Acad Med Singap (Annals of the Academy of Medicine, Singapore)
[2021, 50(7):512-513]

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Questions on NOTCH2NLC Repeat Expansions in Parkinson Disease-Reply.

Dongrui Ma, Yi Jayne Tan, Eng-King Tan,

JAMA Neurol (JAMA neurology)
[2021, 78(6):763]

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Clinical correlates of white matter lesions in Parkinson's disease using automated multi-modal segmentation measures.

Eric Fang, Mário João Fartaria, Chu Ning Ann, Bénédicte Maréchal, Tobias Kober, Jie Xin Lim, Leon Qi Rong Ooi, Celeste Chen, Soo Lee Lim, Eng King Tan, Ling Ling Chan,

<h4>Background</h4>Age-related white matter lesions (WML) are common, impact neuronal connectivity, and affect motor function and cognition. In addition to pathological nigrostriatal losses, WML are also common co-morbidities in Parkinson's disease (PD) that affect postural stability and gait. Automated brain volume measures are increasingly incorporated into the clinical reporting workflow to ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2021, 427:117518]

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Unravelling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids.

Jing-Han Ng, Alfred Sun, Hyunsoo Shawn Je, Eng-King Tan,

Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the pathophysiology of COVID-19 in the central nervous system remains unclear. Brain organoid models derived from human pluripotent stem cells are potentially useful for the study of complex physiological and pathological processes associated with severe acute respiratory syndrome ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211015136]

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Gut microbiome modulates Drosophila aggression through octopamine signaling.

Yicong Jia, Shan Jin, Kunkun Hu, Lei Geng, Caihong Han, Ruxue Kang, Yuxin Pang, Erjun Ling, Eng King Tan, Yufeng Pan, Wei Liu,

Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we report that gut microbiome modulates aggressive behaviors in Drosophila. We found that germ-free males showed substantial decrease in inter-male aggression, which could be rescued by microbial re-colonization. These germ-free males are not as competitive as wild-type males ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2698]

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The splenial angle: a novel radiological index for idiopathic normal pressure hydrocephalus.

Ling Ling Chan, Robert Chen, Huihua Li, Amanda J Y Lee, Wei Ying Go, Weiling Lee, Christine Lock, Sumeet Kumar, Adeline S L Ng, Nagaendran Kandiah, Louis C S Tan, Eng King Tan, Nicole C H Keong,

<h4>Objectives</h4>To evaluate the utility of the splenial angle (SA), an axial angular index of lateral ventriculomegaly measured on diffusion tensor MRI color fractional anisotropy maps, in differentiating NPH from Alzheimer's disease (AD), Parkinson's disease (PD), and healthy controls (HC), and post-shunt changes in NPH, compared to Evans' index and callosal ... Read more >>

Eur Radiol (European radiology)
[2021, :]

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Trans-Ethnic Fine-Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease.

Tatsuhiko Naito, Wataru Satake, Kotaro Ogawa, Ken Suzuki, Jun Hirata, Jia Nee Foo, Eng-King Tan, Tatsushi Toda, Yukinori Okada,

<h4>Background</h4>Despite evidence for the role of human leukocyte antigen (HLA) in the genetic predisposition to Parkinson's disease (PD), the complex haplotype structure and highly polymorphic feature of the major histocompatibility complex (MHC) region has hampered a unified insight on the genetic risk of PD. In addition, a majority of the ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, 36(8):1805-1814]

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The role of gut dysbiosis in Parkinson's disease: mechanistic insights andtherapeutic options.

Qing Wang, Yuqi Luo, K Ray Chaudhuri, Richard Reynolds, Eng-King Tan, Sven Pettersson,

Parkinson's disease is a common neurodegenerative disease in which gastrointestinal symptoms may appear prior to motor symptoms. The gut microbiota of patients with Parkinson's disease shows unique changes, which may be used as early biomarkers of disease. Alteration in gut microbiota composition may be related to the cause or effect ... Read more >>

Brain (Brain : a journal of neurology)
[2021, :]

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COVID-19 vaccination and cultural tightness.

Jing-Han Ng, Eng-King Tan,

Psychol Med (Psychological medicine)
[2021, :1-2]

Cited: 1 time

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Two heterozygous progranulin mutations in progressive supranuclear palsy.

Wanlin Yang, Bin Deng, Yu Huang, Jingxing Liu, Zifeng Huang, Zihan Chang, Shuzhen Zhu, Ling-Ling Chan, K Ray Chaudhuri, Eng-King Tan, Qing Wang,

Brain (Brain : a journal of neurology)
[2021, 144(3):e27]

Cited: 2 times

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Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP.

Mei Jiang, Hai-Tao Tu, Ke Zhang, Wei Zhang, Wei-Ping Yu, Jie Xu, Eng-King Tan, Kai-Hua Guo, Li Zeng,

Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Recently, a missense mutation, Asp620Asn (D620N), in VPS35 (PARK17) has been identified as a pathogenic mutation for late-onset autosomal dominant Parkinson's disease (PD). Although PD is characterized by a ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 153:105313]

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Aggregation-induced emission (AIE) nanoparticles labeled human embryonic stem cells (hESCs)-derived neurons for transplantation.

Se Eun Jang, Lifeng Qiu, Xiaolei Cai, Jolene Wei Ling Lee, Wei Zhang, Eng-King Tan, Bin Liu, Li Zeng,

Transplantation of differentiated neurons derived from either human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) is an emerging therapeutic strategy for various neurodegenerative diseases. One important aspect of transplantation is the accessibility to track and control the activity of the stem cells-derived neurons post-transplantation. Recently, the characteristics ... Read more >>

Biomaterials (Biomaterials)
[2021, 271:120747]

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Association study of MCCC1/LAMP3 and DGKQ variants with Parkinson's disease in patients of Malay ancestry.

Jia Lun Lim, Ebonne Yulin Ng, Shen-Yang Lim, Ai Huey Tan, Zariah Abdul-Aziz, Khairul Azmi Ibrahim, Aroma Agape Gopalai, Yi Wen Tay, Yuganthini Vijayanathan, Tzi Shin Toh, Soo Kun Lim, Ping-Chong Bee, Santhi Datuk Puvanarajah, Shanthi Viswanathan, Irene Looi, Thien Thien Lim, Gaik Bee Eow, Wee Kooi Cheah, Eng-King Tan, Azlina Ahmad-Annuar,

<h4>Background</h4>Genome-wide association studies (GWAS) have shown that variants in the 3-methylcrotonyl-CoA carboxylase (MCCC1)/lysosome-associated membrane protein 3 (LAMP3) loci (rs10513789, rs12637471, rs12493050) reduce the risk of Parkinson's disease (PD) in Caucasians, Chinese and Ashkenazi-Jews while the rs11248060 variant in the diacylglycerol kinase theta (DGKQ) gene increases the risk of PD in ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, 42(10):4203-4207]

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"Hot cross bun" is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.

Shuzhen Zhu, Bin Deng, Zifeng Huang, Zihan Chang, Hualin Li, Hui Liu, Yanjun Huang, Ying Pan, Yanping Wang, Yin-Xia Chao, Ling-Ling Chan, Yih-Ru Wu, Eng-King Tan, Qing Wang,

To evaluate the correlation between "hot cross bun" sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P cases. ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2021, 7(1):15]

Cited: 2 times

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