Full Text Journal Articles by
Author Ena Wang

Advertisement

Find full text journal articles






Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion.

Keli L Hippen, Scott N Furlan, Rahul Roychoudhuri, Ena Wang, Yigang Zhang, Mark J Osborn, Sarah C Merkel, Sophia Hani, Margaret L MacMillan, Frank Cichocki, Jeffrey S Miller, John E Wagner, Nicholas P Restifo, Leslie S Kean, Bruce R Blazar,

<h4>Background aims</h4>Adoptive transfer of suppressive CD4+CD25+ thymic regulatory T cells (tTregs) can control auto- and alloimmune responses but typically requires in vitro expansion to reach the target cell number for efficacy. Although the adoptive transfer of expanded tTregs purified from umbilical cord blood ameliorates graft-versus-host disease in patients receiving hematopoietic ... Read more >>

Cytotherapy (Cytotherapy)
[2021, 23(8):704-714]

Cited: 1 time

View full text PDF listing >>



MicroRNA Expression Profile Distinguishes Glioblastoma Stem Cells from Differentiated Tumor Cells.

Sara Tomei, Andrea Volontè, Shilpa Ravindran, Stefania Mazzoleni, Ena Wang, Rossella Galli, Cristina Maccalli,

Glioblastoma (GBM) represents the most common and aggressive tumor of the brain. Despite the fact that several studies have recently addressed the molecular mechanisms underlying the disease, its etiology and pathogenesis are still poorly understood. GBM displays poor prognosis and its resistance to common therapeutic approaches makes it a highly ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(4):]

Cited: 1 time

View full text PDF listing >>



Advertisement

Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges.

Alessandra Cesano, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, Sergio Rutella,

The development of strongly predictive validated biomarkers is essential for the field of immuno-oncology (IO) to advance. The highly complex, multifactorial data sets required to develop these biomarkers necessitate effective, responsible data-sharing efforts in order to maximize the scientific knowledge and utility gained from their collection. While the sharing of ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

Cited: 1 time

View full text PDF listing >>



Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges.

Sergio Rutella, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, Alessandra Cesano,

The sharing of clinical trial data and biomarker data sets among the scientific community, whether the data originates from pharmaceutical companies or academic institutions, is of critical importance to enable the development of new and improved cancer immunotherapy modalities. Through data sharing, a better understanding of current therapies in terms ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

Cited: 4 times

View full text PDF listing >>



Improving the therapeutic index in adoptive cell therapy: key factors that impact efficacy.

Ena Wang, Alessandra Cesano, Lisa H Butterfield, Francesco Marincola,

The therapeutic index (TI) is a quantitative assessment of a drug safety proportional to its effectiveness. The estimation is intuitive when the engagement of the product with its target is dependent on stable chemistry and predictable pharmacokinetics as is the case for small molecules or antibodies. But for therapeutics with ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

Cited: 4 times

View full text PDF listing >>



Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated

Muna Al Hashmi, Seetharama Konduru, Lee Silcock, Lotfi Chouchane, Valentina Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco Marincola, Sara Tomei,

BACKGROUND. Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS. DNA and RNA mutation status were assessed in 15 melanoma cell lines by Sanger sequencing and RNA-seq. ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated.

Muna Al Hashmi, Konduru S Sastry, Lee Silcock, Lotfi Chouchane, Valentina Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco M Marincola, Sara Tomei,

<h4>Background</h4>Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation.<h4>Methods</h4>DNA and RNA mutation status was assessed in 15 melanoma cell lines by Sanger sequencing and RNA-seq. We tested the ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):192]

Cited: 1 time

View full text PDF listing >>



Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response.

Jessica Roelands, Wouter Hendrickx, Gabriele Zoppoli, Raghvendra Mall, Mohamad Saad, Kyle Halliwill, Giuseppe Curigliano, Darawan Rinchai, Julie Decock, Lucia G Delogu, Tolga Turan, Josue Samayoa, Lotfi Chouchane, Alberto Ballestrero, Ena Wang, Pascal Finetti, Francois Bertucci, Lance D Miller, Jerome Galon, Francesco M Marincola, Peter J K Kuppen, Michele Ceccarelli, Davide Bedognetti,

<h4>Background</h4>An immune active cancer phenotype typified by a T helper 1 (Th-1) immune response has been associated with increased responsiveness to immunotherapy and favorable prognosis in some but not all cancer types. The reason of this differential prognostic connotation remains unknown.<h4>Methods</h4>To explore the contextual prognostic value of cancer immune phenotypes, ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

Cited: 15 times

View full text PDF listing >>



Functional Genome Profiling to Understand Cancer Immune Responsiveness.

Ena Wang, Davide Bedognetti, Francesco M Marincola,

It has been almost two decades since we first proposed the use of minimally invasive serial biopsies to dissect the biology underlining cancer immune responsiveness (CIR) by looking for predictors of response, understanding mechanisms of action (MOA) of therapeutics and documenting strategies adopted by tumor cells to escape immune recognition. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2055:231-244]

Cited: 0 times

View full text PDF listing >>



The Biology of Immune-Active Cancers and Their Regulatory Mechanisms.

Davide Bedognetti, Alessandra Cesano, Francesco M Marincola, Ena Wang,

The development of cancer results from the evolutionary balance between the proliferating aptitude of cancer cells and the response of the host's tissues. Some cancers are characterized by genetic instability dependent upon impaired DNA repair mechanisms that lead to the chaotic disruption of multiple cellular functions often in excess of ... Read more >>

Cancer Treat Res (Cancer treatment and research)
[2020, 180:149-172]

Cited: 0 times

View full text PDF listing >>



Monoallelic expression in melanoma.

Lee Silcock, Hakeem Almabrazi, Younes Mokrab, Puthen Jithesh, Muna Al-Hashmi, Nicola James, Rebecca Mathew, Valentina Mattei, Davide Bedognetti, Francesca Lessi, Ramzi Temanni, Barbara Seliger, Rashid Al-Ali, Francesco M Marincola, Ena Wang, Sara Tomei,

<h4>Background</h4>Monoallelic expression (MAE) is a frequent genomic phenomenon in normal tissues, however its role in cancer is yet to be fully understood. MAE is defined as the expression of a gene that is restricted to one allele in the presence of a diploid heterozygous genome. Constitutive MAE occurs for imprinted ... Read more >>

J Transl Med (Journal of translational medicine)
[2019, 17(1):112]

Cited: 1 time

View full text PDF listing >>



Conditional activation of immune-related signatures and prognostic significance: a pan-cancer analysis

Jessica Roelands, Wouter Hendrickx, Raghvendra Mall, Mohamad Saad, Kyle Halliwill, Gabriele Zoppoli, Giuseppe Curigliano, Darawan Rinchai, Julie Decock, Lucia Delogu, Lotfi Chouchane, Ena Wang, Peter Kuppen, Pascal Finetti, Francois Bertucci, Lance Miller, Jerome Galon, Francesco Marincola, Michele Ceccarelli, Davide Bedognetti,

<h4>Background</h4> It is becoming clear that tumor immune T cell infiltration and its functional orientation have substantial effect on cancer progression, influencing both response to therapy and prognosis. In this pan-cancer study, the previously described Immunologic Constant of Rejection (ICR) signature is used to define opposing immune phenotypes (i.e., immuneactive ... Read more >>

()
[, :]

Cited: 2 times

View full text PDF listing >>



Tailoring cells for clinical needs: Meeting report from the Advanced Therapy in Healthcare symposium (October 28-29 2017, Doha, Qatar).

Sara Deola, Bella S Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M Abdelalim, Goran Petrovski, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S Wels, Stephen P Hunger, Ena Wang, Francesco M Marincola, , Cristina Maccalli, Chiara Cugno,

New technologies and therapies designed to facilitate development of personalized treatments are rapidly emerging in the field of biomedicine. Strikingly, the goal of personalized medicine refined the concept of therapy by developing cell-based therapies, the so-called "living drugs". Breakthrough advancements were achieved in this regard in the fields of gene ... Read more >>

J Transl Med (Journal of translational medicine)
[2018, 16(1):276]

Cited: 1 time

View full text PDF listing >>



The immunologic constant of rejection classification refines the prognostic value of conventional prognostic signatures in breast cancer.

François Bertucci, Pascal Finetti, Ines Simeone, Wouter Hendrickx, Ena Wang, Francesco M Marincola, Patrice Viens, Emilie Mamessier, Michele Ceccarelli, Daniel Birnbaum, Davide Bedognetti,

<h4>Background</h4>The immunologic constant of rejection (ICR) is a broad phenomenon of Th-1 immunity-mediated, tissue-specific destruction.<h4>Methods</h4>We tested the prognostic value of a 20-gene ICR expression signature in 8766 early breast cancers.<h4>Results</h4>Thirty-three percent of tumours were ICR1, 29% ICR2, 23% ICR3, and 15% ICR4. In univariate analysis, ICR4 was associated with a ... Read more >>

Br J Cancer (British journal of cancer)
[2018, 119(11):1383-1391]

Cited: 15 times

View full text PDF listing >>



Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy).

Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A Davies, Reinhard Dummer, Soldano Ferrone, Thomas F Gajewski, Claus Garbe, Jason J Luke, Francesco M Marincola, Giuseppe Masucci, Janice M Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A Postow, Stephen P Schoenberger, Ena Wang, Magdalena Thurin,

Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape was revolutionised with the approval of the anti-cytotoxic T-lymphocyte-associated protein-4 checkpoint inhibitor ipilimumab and the selective BRAF kinase inhibitor vemurafenib, both of which ... Read more >>

J Transl Med (Journal of translational medicine)
[2018, 16(1):207]

Cited: 3 times

View full text PDF listing >>



Tumor mutational burden is a determinant of immune-mediated survival in breast cancer.

Alexandra Thomas, Eric D Routh, Ashok Pullikuth, Guangxu Jin, Jing Su, Jeff W Chou, Katherine A Hoadley, Cristin Print, Nick Knowlton, Michael A Black, Sandra Demaria, Ena Wang, Davide Bedognetti, Wendell D Jones, Gaurav A Mehta, Michael L Gatza, Charles M Perou, David B Page, Pierre Triozzi, Lance D Miller,

Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly immunogenic or inherently immune-resistant tumors would guide development of therapeutic strategies in breast cancer. Genomic, transcriptomic and clinical data from The Cancer Genome Atlas ... Read more >>

Oncoimmunology (Oncoimmunology)
[2018, 7(10):e1490854]

Cited: 67 times

View full text PDF listing >>



A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification

Jessica Roelands, Julie Decock, Sabri Boughorbel, Darawan Rinchai, Cristina Maccalli, Michele Ceccarelli, Michael Black, Cris Print, Jeff Chou, Scott Presnell, Charlie Quinn, Puthen Jithesh, Najeeb Syed, Salha B.J. Al Bader, Shahinaz Bedri, Ena Wang, Francesco Marincola, Damien Chaussabel, Peter Kuppen, Lance Miller, Davide Bedognetti, Wouter Hendrickx,

The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opportunity in the biomedical field. To facilitate and stimulate utilization of these datasets, we have recently developed an interactive data browsing ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Vitamin D and the Pathophysiology of Inflammatory Skin Diseases.

Meenakshi Umar, Konduru S Sastry, Fatima Al Ali, Moza Al-Khulaifi, Ena Wang, Aouatef I Chouchane,

<h4>Background</h4>Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain ... Read more >>

Skin Pharmacol Physiol (Skin pharmacology and physiology)
[2018, 31(2):74-86]

Cited: 23 times

View full text PDF listing >>



Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells.

Francesco Marras, Anna Casabianca, Federica Bozzano, Maria Libera Ascierto, Chiara Orlandi, Antonio Di Biagio, Emanuele Pontali, Chiara Dentone, Giancarlo Orofino, Laura Nicolini, Lucia Taramasso, Mauro Magnani, Francesco M Marincola, Ena Wang, Lorenzo Moretta, Andrea De Maria,

The size of lentiviral DNA reservoirs reflects the effectiveness of immune responses against lentiviruses. So far, abundant information has been gathered on the control of HIV-1 replication. Understanding the innate mechanisms contributing to containment of the HIV DNA reservoir, however, are only partly clarified and are relevant to guiding interventions ... Read more >>

J Virol (Journal of virology)
[2017, 91(23):]

Cited: 14 times

View full text PDF listing >>



The MAPK hypothesis: immune-regulatory effects of MAPK-pathway genetic dysregulations and implications for breast cancer immunotherapy.

Davide Bedognetti, Jessica Roelands, Julie Decock, Ena Wang, Wouter Hendrickx,

With the advent of checkpoint inhibition, immunotherapy has revolutionized the clinical management of several cancers, but has demonstrated limited efficacy in mammary carcinoma. Transcriptomic profiling of cancer samples defined distinct immunophenotypic categories characterized by different prognostic and predictive connotations. In breast cancer, genomic alterations leading to the dysregulation of mitogen-activated ... Read more >>

Emerg Top Life Sci (Emerging topics in life sciences)
[2017, 1(5):429-445]

Cited: 6 times

View full text PDF listing >>



Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.

Jessica Roelands, Peter J K Kuppen, Louis Vermeulen, Cristina Maccalli, Julie Decock, Ena Wang, Francesco M Marincola, Davide Bedognetti, Wouter Hendrickx,

The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(10):]

Cited: 40 times

View full text PDF listing >>



The need for a network to establish and validate predictive biomarkers in cancer immunotherapy.

Giuseppe V Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A Fox, Ena Wang, Francesco M Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H Butterfield, Lisa Villabona, Magdalena Thurin, Michael A Postow, Paul M Sondel, Sandra Demaria, Sanjiv Agarwala, Paolo A Ascierto,

Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints inhibitors. Despite success in a variety of malignancies, responses typically only occur in a small percentage of patients for any ... Read more >>

J Transl Med (Journal of translational medicine)
[2017, 15(1):223]

Cited: 8 times

View full text PDF listing >>



Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling.

Konduru S Sastry, Aouatef Ismail Chouchane, Ena Wang, George Kulik, Francesco M Marincola, Lotfi Chouchane,

Cancer stem cells (CSCs) are increasingly considered to be responsible for tumor initiation, metastasis and drug resistance. The drug resistance mechanisms activated in CSCs have not been thoroughly investigated. Although neuropeptides such as vasoactive intestinal peptide (VIP) can promote tumor growth and activate antiapoptotic signaling in differentiated cancer cells, it ... Read more >>

Cell Death Dis (Cell death & disease)
[2017, 8(6):e2844]

Cited: 6 times

View full text PDF listing >>



A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification.

Jessica Roelands, Julie Decock, Sabri Boughorbel, Darawan Rinchai, Cristina Maccalli, Michele Ceccarelli, Michael Black, Cris Print, Jeff Chou, Scott Presnell, Charlie Quinn, Puthen Jithesh, Najeeb Syed, Salha B J Al Bader, Shahinaz Bedri, Ena Wang, Francesco M Marincola, Damien Chaussabel, Peter Kuppen, Lance D Miller, Davide Bedognetti, Wouter Hendrickx,

The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opportunity in the biomedical field. To facilitate and stimulate utilization of these datasets, we have recently developed an interactive data browsing ... Read more >>

F1000Res (F1000Research)
[2017, 6:296]

Cited: 5 times

View full text PDF listing >>



Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis.

Wouter Hendrickx, Ines Simeone, Samreen Anjum, Younes Mokrab, François Bertucci, Pascal Finetti, Giuseppe Curigliano, Barbara Seliger, Luigi Cerulo, Sara Tomei, Lucia Gemma Delogu, Cristina Maccalli, Ena Wang, Lance D Miller, Francesco M Marincola, Michele Ceccarelli, Davide Bedognetti,

Cancer immunotherapy is revolutionizing the clinical management of several tumors, but has demonstrated limited activity in breast cancer. The development of more effective treatments is hindered by incomplete knowledge of the genetic determinant of immune responsiveness. To fill this gap, we mined copy number alteration, somatic mutation, and expression data ... Read more >>

Oncoimmunology (Oncoimmunology)
[2017, 6(2):e1253654]

Cited: 59 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1282 s