Full Text Journal Articles by
Author Emre Karakus

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Sequencing of the Canine Cytochrome P450 CYP2C41 Gene and Genotyping of Its Polymorphic Occurrence in 36 Dog Breeds.

Emre Karakus, Clarissa Prinzinger, Silke Leiting, Joachim Geyer,

Cytochrome P450 (CYP) drug metabolizing enzymes play an important role in efficient drug metabolism and elimination. Many CYPs are polymorphic and, thereby, drug metabolism can vary between individuals. In the case of canine CYP2C41, gene polymorphism was identified. However, as the first available canine genome sequences all were CYP2C41 negative, ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2021, 8:663175]

Cited: 0 times

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The orphan solute carrier SLC10A7 is a novel negative regulator of intracellular calcium signaling.

Emre Karakus, Marie Wannowius, Simon Franz Müller, Silke Leiting, Regina Leidolf, Saskia Noppes, Stefan Oswald, Martin Diener, Joachim Geyer,

SLC10A7 represents an orphan member of the Solute Carrier Family SLC10. Recently, mutations in the human SLC10A7 gene were associated with skeletal dysplasia, amelogenesis imperfecta, and decreased bone mineral density. However, the exact molecular function of SLC10A7 and the mechanisms underlying these pathologies are still unknown. For this reason, the ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7248]

Cited: 2 times

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Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6).

Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto Sánchez-Guijo, Stefan A Wudy, Joachim Geyer,

Estrogens play a pivotal role in the development and proliferation of hormone-dependent breast cancer. Apart from free estrogens, which can directly activate the estrogen receptor (ER) of tumor cells, sulfo-conjugated steroids, which maintain high plasma concentrations even after menopause, first have to be imported into tumor cells by carrier-mediated uptake ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:941]

Cited: 3 times

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Dose-dependent effect of radiation on resorbable blast material titanium implants: an experimental study in rabbits.

Gülnihal Emrem Doğan, Zekai Halici, Emre Karakus, Burak Erdemci, Akgün Alsaran, Irfan Cinar,

<h4>Background</h4>Radiotherapy is a commonly used treatment modality in head and neck cancer; however, it also negatively affects healthy structures. Direct damage to oral soft and hard tissue frequently occurs with radiotherapy. In this study, we aimed to evaluate the effect of radiotherapy on bone surrounding titanium dental implants via biomechanical ... Read more >>

Acta Odontol Scand (Acta odontologica Scandinavica)
[2018, 76(2):130-134]

Cited: 1 time

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Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.

Beyzagul Polat, Zekai Halici, Elif Cadirci, Emre Karakus, Yasin Bayir, Abdulmecit Albayrak, Deniz Unal,

<h4>Background and aim</h4>Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2017, 43:227-235]

Cited: 11 times

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Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.

Zekai Halici, Beyzagul Polat, Elif Cadirci, Atilla Topcu, Emre Karakus, Duygu Kose, Abdulmecit Albayrak, Yasin Bayir,

<h4>Purpose</h4>Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model.<h4>Methods</h4>Effects of aliskiren were evaluated in indomethacin-induced gastric damage model on Albino ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2016, 258:266-275]

Cited: 5 times

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Evaluation of 5-HT7 Receptor Trafficking on In Vivo and In Vitro Model of Lipopolysaccharide (LPS)-Induced Inflammatory Cell Injury in Rats and LPS-Treated A549 Cells.

Gulsen Ayaz, Zekai Halici, Abdulmecit Albayrak, Emre Karakus, Elif Cadirci,

This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular methods. This study was conducted in two steps. For in vivo studies, 24 female rats were divided into four groups. Group I: healthy; II ... Read more >>

Biochem Genet (Biochemical genetics)
[2017, 55(1):34-47]

Cited: 9 times

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Aliskiren - a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS.

Yasin Bayir, Elif Cadirci, Beyzagul Polat, Nurcan Kilic Baygutalp, Abdulmecit Albayrak, Emre Karakus, Harun Un, Mevlut Sait Keles, Fatma Betul Kocak Ozgeris, Erdem Toktay, Mehmet Karaca, Zekai Halici,

The aim of this study was to evaluate the effects of aliskiren, direct renin inhibitor, as an antioxidant and tissue protective agent and evaluate the molecular, biochemical, and histopathological changes in experimental ischemia and ischemia/reperfusion injury in rat ovaries. Forty-eight female rats were randomly divided into eight groups: in Group 1, only sham ... Read more >>

Gynecol Endocrinol (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2016, 32(8):675-683]

Cited: 5 times

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The Immunostimulatory Effect of Lactic Acid Bacteria in a Rat Model.

Murat Karamese, Hakan Aydin, Emin Sengul, Volkan Gelen, Cigdem Sevim, Duran Ustek, Emre Karakus,

<h4>Background</h4>Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics.<h4>Objective</h4>To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels.<h4>Methods</h4>The rats were ... Read more >>

Iran J Immunol (Iranian journal of immunology : IJI)
[2016, 13(3):220-228]

Cited: 9 times

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Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.

Elif Cadirci, Zekai Halici, Muhammed Yayla, Erdem Toktay, Yasin Bayir, Emre Karakus, Atilla Topcu, Basak Buyuk, Abdulmecit Albayrak,

This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30mg/kg ... Read more >>

Peptides (Peptides)
[2016, 82:35-43]

Cited: 5 times

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Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women.

Emine Irge, Zekai Halici, Mehmet Yilmaz, Elif Cadirci, Emre Karakus,

In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2016, 38(2):189-193]

Cited: 1 time

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The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells.

Murat Karamese, Bulent Guvendi, Selina Aksak Karamese, Irfan Cinar, Serpil Can, Huseyin Serkan Erol, Hakan Aydin, Volkan Gelen, Emre Karakus,

<h4>Objectives</h4>In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma ... Read more >>

Iran J Basic Med Sci (Iranian journal of basic medical sciences)
[2016, 19(5):483-489]

Cited: 2 times

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The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats.

Saliha Sena Karcioglu, Saziye Sezin Palabiyik, Yasin Bayir, Emre Karakus, Tolga Mercantepe, Zekai Halici, Abdulmecit Albayrak,

Paracetamol is one of the most popular and widely used analgesic and antipyretic agents, but an overdose can cause hepatotoxicity and lead to acute liver failure. Aliskiren directly inhibits renin which downregulates the renin-angiotensin-aldosterone system (RAAS). Recent findings suggest that RAAS system takes part in the pathogenesis of liver fibrosis. ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2016, 117(3):638-646]

Cited: 5 times

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Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat.

Emre Karakus, Zekai Halici, Abdulmecit Albayrak, Yasin Bayir, Elif Demirci, Ali Aydin, Berna Ozturk-Karagoz, Elif Cadirci, Arif Kursat Ayan, Ali Sahin, Deniz Unal,

This study was performed to evaluate the possible protective effect of two calcium channel blocker's "lacidipine (LAC) and amlodipine (AML)" on bone metabolism in an experimental ovariectomized and inflammation-induced osteoporosis rat model (OVXinf). For the purpose of this study, the rats were divided into eight groups, each containing eight rats: ... Read more >>

Inflammation (Inflammation)
[2016, 39(1):336-346]

Cited: 3 times

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Nephroprotective potential of carnitine against glycerol and contrast-induced kidney injury in rats through modulation of oxidative stress, proinflammatory cytokines, and apoptosis.

Celalettin S Kunak, Rustem A Ugan, Elif Cadirci, Emre Karakus, Beyzagul Polat, Harun Un, Zekai Halici, Murat Saritemur, Hasan T Atmaca, Adem Karaman,

<h4>Objective</h4>Contrast media (CM) are a major cause of nephropathy in high-risk patients. The aim of this study was to examine the effects of carnitine (CAR) in advanced nephrotoxicity due to CM administration in rats with glycerol-induced renal functional disorder.<h4>Methods</h4>40 rats were divided randomly into five groups (n = 8): (1) healthy group; ... Read more >>

Br J Radiol (The British journal of radiology)
[2016, 89(1058):20140724]

Cited: 10 times

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The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist.

Saziye S Palabiyik, Emre Karakus, Erol Akpinar, Zekai Halici, Yasin Bayir, Muhammed Yayla, Duygu Kose,

We aimed to evaluate the possible protective effect of a UTR antagonist and to determine the effect of the antagonist on ALT and AST levels in serum, the mRNA expression level of UTR, tumour necrosis factor-alpha (TNF-α) and IL-1β and SOD activity, GSH and MDA levels in liver tissues, which ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2016, 118(2):150-159]

Cited: 5 times

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The Effects of RAAS Inhibition in Rate Limiting Step by Aliskiren on Testicular Torsion Injury in Rats.

Harun Un, Yasin Bayir, Zekai Halici, Erol Akpinar, Emre Karakus, Akgun Oral, Tevfik Ziypak, Jale Selli,

<h4>Purpose</h4>Testicular torsion is a urological emergency. Failure of timely intervention for this issue leads the testicles to go into necrosis. If left untreated, it can lead to loss of the reproductive organs. The aim of this study was to examine the role of aliskiren in testicular torsion and detorsion injuries.<h4>Materials ... Read more >>

J Urol (The Journal of urology)
[2015, 194(3):828-833]

Cited: 8 times

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Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions.

Ali Aydin, Zekai Halici, Abdulmecit Albayrak, Beyzagul Polat, Emre Karakus, Omer Selim Yildirim, Yasin Bayir, Elif Cadirci, Arif Kursad Ayan, Ahmet Murat Aksakal,

The aim of this study was to examine the effects of carnitine on bone healing in ovariectomy (OVX) and inflammation (INF)-induced osteoporotic rats. The rats were randomly divided into nine groups (n = 8 animals per group): sham-operated (Group 1: SHAM); sham + magnesium silicate (Mg-silicate) (Group 2: SHAM + INF); ovariectomy (Group 3: OVX); ovariectomy + femoral ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2015, 117(3):173-179]

Cited: 7 times

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Study of the boron levels in serum after implantation of different ratios nano-hexagonal boron nitride-hydroxy apatite in rat femurs.

Alptug Atila, Zekai Halici, Elif Cadirci, Emre Karakus, Saziye Sezin Palabiyik, Nuran Ay, Feray Bakan, Sahin Yilmaz,

Boron and its derivatives are effective in bone recovery and osteointegration. However, increasing the boron levels in body liquids may cause toxicity. The aim of our study is to investigate serum boron levels using ICP-MS after implantation of different ratios of nano-hBN-HA composites in rat femurs. All rats were (n=126) ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2016, 58:1082-1089]

Cited: 2 times

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The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain.

Aksak Karamese Selina, Karamese Murat, Karakus Emre, Malkoc Ismail, Unal Bunyami, Gundogdu Cemal,

Estrogen is one of the most important regulators of neuron function. There is a broad consensus that a loss of estrogen is associated with neurodegeneration in the hippocampus which leads to cognitive impairment. Hematopoietic-Pbx-interaction-protein (HPIP) is a novel scaffolding protein which interacts with microtubules and estrogen receptors. In this study, ... Read more >>

Acta Histochem (Acta histochemica)
[2015, 117(8):747-751]

Cited: 3 times

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Boron and Poloxamer (F68 and F127) Containing Hydrogel Formulation for Burn Wound Healing.

Selami Demirci, Ayşegül Doğan, Emre Karakuş, Zekai Halıcı, Atila Topçu, Elif Demirci, Fikrettin Sahin,

Burn injuries, the most common and destructive forms of wounds, are generally accompanied with life-threatening infections, inflammation, reduced angiogenesis, inadequate extracellular matrix production, and lack of growth factor stimulation. In the current study, a new antimicrobial carbopol-based hydrogel formulated with boron and pluronic block copolymers was evaluated for its healing ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2015, 168(1):169-180]

Cited: 14 times

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The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia.

Ozgur Yesilyurt, Melik Seyrek, Serdar Tasdemir, Serdar Kahraman, Mehmet Salih Deveci, Emre Karakus, Zekai Halici, Ahmet Dogrul,

The opioid and non-opioid types of stress-induced analgesia have been well defined. One of the non-opioid type involve the endocannabinoid system. We previously reported that the spinal serotonin 7 receptor (5-HT7) blockers inhibit both morphine and cannabinoid-induced analgesia, thus we hypothesized that descending serotonergic pathways-spinal 5-HT7 receptor loop might contribute ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2015, 762:402-410]

Cited: 9 times

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Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study.

Tevfik Ziypak, Zekai Halici, Erdal Alkan, Erol Akpinar, Beyzagul Polat, Senol Adanur, Elif Cadirci, Irmak Ferah, Yasin Bayir, Emre Karakus, Tolga Mercantepe,

<h4>Purpose</h4>To determine the protective effect of aliskiren on ischemia-reperfusion (I/R) injury in a rat renal (I/R) model.<h4>Methods</h4>Rats were randomly divided into five groups: sham control group; sham control with aliskiren pretreatment; I/R group and I/R with two doses of aliskiren pretreatment. Rats were unilaterally nephrectomized and subjected to 45 min of ... Read more >>

Ren Fail (Renal failure)
[2015, 37(2):343-354]

Cited: 8 times

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The double-edged sword: effects of pregabalin on experimentally induced sciatic nerve transection and crush injury in rats.

Mine Celik, Ahmet Kose, Duygu Kose, Emre Karakus, Erol Akpinar, Muhammed Calik, Aysenur Dostbil, Cagatay Calikoglu, Mehmet Aksoy, Lutfu Ozel,

The aim of this study was to research the effects of pregabalin on experimentally induced peripheral nerve crush injuries in rats.Forty-two adult female Wistar albino rats were divided into seven groups: 1st group: healthy; 2nd group: axonotmesis control; 3rd group: anastomosis control; 4th group: axonotmesis+30 mg/kg of pregabalin; 5th group: axonotmesis+60 mg/kg ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2015, 125(11):845-854]

Cited: 5 times

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Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy.

Murat Saritemur, Harun Un, Elif Cadirci, Emre Karakus, Erol Akpinar, Zekai Halici, Rustem Anil Ugan, Adem Karaman, Hasan Tarik Atmaca,

Contrast medium-induced nephropathy (CIN) remains as a problem with high incidence and mortality rates. The aim of this study is to examine the roles of infliximab (INF) in the glycerol (GLY) and CIN model in rats. The rats were separated into five groups (n=8): Healthy, GLY, GLY+CM, GLY+CM+INF 5mg/kg intraperitoneally ... Read more >>

Environ Toxicol Pharmacol (Environmental toxicology and pharmacology)
[2015, 39(2):577-588]

Cited: 5 times

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