Full Text Journal Articles by
Author Emmi Rotgers

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

Cited: 0 times

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Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis.

Emmi Rotgers, Sheyla Cisneros-Montalvo, Mirja Nurmio, Jorma Toppari,

Maintenance of the differentiated state and cell cycle exit in adult Sertoli cells depends on tumor suppressor retinoblastoma protein (RB, also known as RB1). We have previously shown that RB interacts with transcription factor E2F3 in the mouse testis. Here, we investigated how <i>E2f3</i> contributes to adult Sertoli cell proliferation ... Read more >>

J Cell Sci (Journal of cell science)
[2019, 132(14):]

Cited: 2 times

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At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad.

Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao,

The reproductive endocrine systems are vastly different between males and females. This sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. Most gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the ... Read more >>

Endocr Rev (Endocrine reviews)
[2018, 39(5):739-759]

Cited: 15 times

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From the Cover: Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice.

Erica Ungewitter, Emmi Rotgers, Tanika Bantukul, Yasuhiko Kawakami, Grace E Kissling, Humphrey Hung-Chang Yao,

Intrauterine exposure to phthalates is known to cause disorders of male reproductive function including androgen insufficiency, decreased fertility, and germ cell defects in rodents. In this study, we set out to investigate the effects of intrauterine exposure to di-(2-ethylhexyl)-phthalate (DEHP) on fetal development of the B6:129S4 mouse strain. Time-mated pregnant ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2017, 157(1):8-19]

Cited: 4 times

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CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures.

Ashutosh Trehan, Emmi Rotgers, Eleanor T Coffey, Ilpo Huhtaniemi, Adolfo Rivero-Müller,

<h4>Background</h4>G protein-coupled receptors (GPCRs) represent a physiologically and pharmacologically important family of receptors that upon coupling to GαS stimulate cAMP production catalyzed by adenylyl cyclase. Thus, developing assays to monitor cAMP production is crucial to screen for ligands in studies of GPCR signaling. Primary cell cultures represent a more robust ... Read more >>

Cell Commun Signal (Cell communication and signaling : CCS)
[2014, 12:70]

Cited: 6 times

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