Full Text Journal Articles by
Author Emmanuelle Waubant

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Autoimmune Encephalitis in Children: A Case Series at a Tertiary Care Center.

Alice Rutatangwa, Nikita Mittal, Carla Francisco, Kendall Nash, Emmanuelle Waubant,

Autoimmune encephalitis is the third most common cause of encephalitis in children. We provide a detailed account of presenting symptoms, diagnosis, and response to treatment in pediatric autoimmune encephalitis patients evaluated at University of California San Francisco within a 2.5-year period. Eleven were identified: anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis (n = ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820923834]

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Is multiple sclerosis a risk factor for infections?

Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy, Chris Hawkes, Gavin Giovannoni,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[0, :]

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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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The COVID-19 pandemic and the use of MS disease-modifying therapies.

Gavin Giovannoni, Chris Hawkes, Jeannette Lechner-Scott, Michael Levy, Emmanuelle Waubant, Julian Gold,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 39:102073]

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The future of microbiome research in neuroinflammatory disorders.

Emmanuelle Waubant, Anne-Katrin Pröbstel, Michael Levy, Christopher H Hawkes, Gavin Giovannoni, Jeanette Lechner-Scott, Helen Tremlett,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 40:102098]

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Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation.

Pavan Bhargava, Matthew D Smith, Leah Mische, Emily Harrington, Kathryn C Fitzgerald, Kyle Martin, Sol Kim, Arthur Anthony Reyes, Jaime Gonzalez-Cardona, Christina Volsko, Ajai Tripathi, Sonal Singh, Kesava Varanasi, Hannah-Noelle Lord, Keya Meyers, Michelle Taylor, Marjan Gharagozloo, Elias S Sotirchos, Bardia Nourbakhsh, Ranjan Dutta, Ellen M Mowry, Emmanuelle Waubant, Peter A Calabresi,

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including in the CNS and the immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, :]

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Big pharma and social responsibility.

Christopher H Hawkes, Gavin Giovannoni, Michael Levy, Jeanette Lechner-Scott, Emmanuelle Waubant,

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2020, 39:102069]

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Effect of fingolimod on MRI outcomes in patients with paediatric-onset multiple sclerosis: results from the phase 3 PARADIGMS study.

Douglas L Arnold, Brenda Banwell, Amit Bar-Or, Angelo Ghezzi, Benjamin M Greenberg, Emmanuelle Waubant, Gavin Giovannoni, Jerry S Wolinsky, Jutta Gärtner, Kevin Rostásy, Lauren Krupp, Marc Tardieu, Wolfgang Brück, Tracy E Stites, Gregory L Pearce, Dieter A Häring, Martin Merschhemke, Tanuja Chitnis, ,

OBJECTIVE:PARADIGMS demonstrated superior efficacy and comparable safety of fingolimod versus interferon β-1a (IFN β-1a) in paediatric-onset multiple sclerosis (PoMS). This study aimed to report all predefined MRI outcomes from this study. METHODS:Patients with multiple sclerosis (MS) (aged 10-<18 years) were randomised to once-daily oral fingolimod (n=107) or once-weekly intramuscular IFN ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(5):483-492]

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Ageing and multiple sclerosis.

Gavin Giovannoni, Chris H Hawkes, Jeannette Lechner-Scott, Michael Levy, Emmanuelle Waubant,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 38:101953]

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"Is this new medicine going to help me walk again?"

Michael Levy, Emmanuelle Waubant, Christopher Hawkes, Gavin Giovannoni, Jeanette Lechner-Scott,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 37:101875]

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Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline.

Asya I Wallach, Michael Waltz, T Charles Casper, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolanda Harris, Timothy E Lotze, Soe Mar, Manikum Moodley, Jayne M Ness, Mary Rensel, Moses Rodriguez, John W Rose, Teri Schreiner, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, Leigh E Charvet, Lauren B Krupp,

BACKGROUND:Cognitive impairment occurs in approximately one-third of pediatric-onset multiple sclerosis (POMS) patients. The Symbol Digit Modalities Test (SDMT), a widely used cognitive screen in adults, has yet to be incorporated early into the standard care of POMS. OBJECTIVE:To screen for cognitive impairment early in the course of POMS and analyze ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519891984]

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Association Between Breastfeeding and Postpartum Multiple Sclerosis Relapses: A Systematic Review and Meta-analysis.

Kristen M Krysko, Alice Rutatangwa, Jennifer Graves, Ann Lazar, Emmanuelle Waubant,

Importance:Multiple sclerosis (MS) relapses may be increased in the postpartum period, and whether breastfeeding is associated with reduction in the risk of postpartum relapses remains controversial. Objective:To perform a systematic review and meta-analysis to evaluate whether breastfeeding is associated with reduction in postpartum MS relapses compared with not breastfeeding. Data ... Read more >>

JAMA Neurol (JAMA neurology)
[2019, :]

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Grassroot efforts towards diversity in MS care and research: Win-win for patients and science.

Emmanuelle Waubant, Michael Levy, Jeannette Lechner-Scott, Gavin Giovannoni, Christopher Hawkes,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 35:A1-A2]

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Silent symptoms of multiple sclerosis.

Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy, Christopher Hawkes,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 36:101453]

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The multiple sclerosis gut microbiota: A systematic review.

Ali Mirza, Jessica D Forbes, Feng Zhu, Charles N Bernstein, Gary Van Domselaar, Morag Graham, Emmanuelle Waubant, Helen Tremlett,

BACKGROUND:To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS. METHODS:We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008-2018). RESULTS:Of 415 articles identified ten fulfilled criteria. All studies used a case-control design, six ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 37:101427]

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Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis.

Soren Jonzzon, Leena Suleiman, Andrew Yousef, Brenda Young, Janace Hart, Patrick Peschl, Markus Reindl, Kristin L Schaller, Jeffrey L Bennett, Emmanuelle Waubant, Jennifer S Graves,

Limited data exist on isolated optic neuritis in children. We report the clinical features and treatment of pediatric subjects with monophasic and recurrent idiopathic optic neuritis. This retrospective cohort study of patients with isolated optic neuritis identified 10 monophasic and 7 recurrent optic neuritis cases. Monophasic optic neuritis patients were ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(1):77-83]

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Consistent control of disease activity with fingolimod versus IFN β-1a in paediatric-onset multiple sclerosis: further insights from PARADIGMS.

Kumaran Deiva, Peter Huppke, Brenda Banwell, Tanuja Chitnis, Jutta Gärtner, Lauren Krupp, Emmanuelle Waubant, Tracy Stites, Gregory Lewis Pearce, Martin Merschhemke,

BACKGROUND:In PARADIGMS, a double-blind phase III trial in 215 paediatric patients with multiple sclerosis (MS) (10 to <18 years), fingolimod administered for up to 2 years significantly reduced the annualised relapse rate (ARR) and rate of new/newly enlarged T2 (n/neT2) lesions compared with interferon (IFN) β-1a. OBJECTIVES:To investigate (1) differences ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(1):58-66]

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Implementing the 2017 McDonald criteria for the diagnosis of multiple sclerosis.

Frauke Zipp, Jiwon Oh, Yara Dadalti Fragoso, Emmanuelle Waubant,

The latest revision of the McDonald criteria for the diagnosis of multiple sclerosis (MS) was published online in 2017. New features of the criteria, which were designed to facilitate earlier diagnosis of MS, include the recognition of oligoclonal bands in the cerebrospinal fluid as a possible marker of dissemination of ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2019, 15(8):441-445]

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A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children.

Michael Manguinao, Kristen M Krysko, Sai Maddike, Alice Rutatangwa, Carla Francisco, Janace Hart, Janet Chong, Jennifer S Graves, Emmanuelle Waubant,

BACKGROUND:Plasma exchange (PLEX) may improve recovery of acute central nervous system (CNS) demyelinating events related to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), transverse myelitis (TM), acute disseminated encephalomyelitis (ADEM), and MOG-antibody associated demyelination (MOG) if recovery with pulse steroids (PS) is incomplete. Although there is a single randomized ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 35:50-54]

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Editorial on: Eculizumab in aquaporin-4-positive neuromyelitis optica spectrum disorder.

Santiago Pardo, Gavin Giovannoni, Christopher Hawkes, Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 33:A1-A2]

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Introducing the International Women in Multiple Sclerosis network.

Vilija G Jokubaitis, Anne-Katrin Pröbstel, Georgina Arrambide, Fiona Costello, Emmanuelle Waubant,

Lancet Neurol (The Lancet. Neurology)
[2019, 18(6):521]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Pavan Bhargava, Leah Mische, Matthew Smith, Emily Harrington, Kathryn Fitzgerald, Kyle Martin, Sol Kim, Arthur Anthony Reyes, Jaime Gonzalez-Cardona, Christina Volsko, Sonal Singh, Kesava Varanasi, Elias Sotirchos, Bardia Nourbakhsh, Ranjan Dutta, Ellen Mowry, Emmanuelle Waubant, Peter Calabresi,

Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including the CNS and immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, we ... Read more >>

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Three suggestions to decrease the financial burden of MS treatments.

Emmanuelle Waubant, Gavin Giovannoni, Chris Hawkes, Jeanette Lechner-Scott, Michael Levy,

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 30:A1]

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