Full Text Journal Articles by
Author Emily P Slater

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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.

Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater,

<h4>Background</h4>Familial pancreatic carcinoma (FPC) is a rare hereditary tumor syndrome with a heterogeneous clinical phenotype. The study of FPC also contributes to a better understanding of the more common sporadic pancreatic ductal adenocarcinoma (PDAC). We report on the past 20 years' experience of the German National Case Collection for Familial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma.

Christian Jaworek, Yesim Verel-Yilmaz, Sarah Driesch, Sarah Ostgathe, Lena Cook, Steffen Wagner, Detlef K Bartsch, Emily P Slater, Jörg W Bartsch,

Pancreatic ductal adenocarcinoma (PDAC) is a cancer type with one of the highest mortalities. The metalloprotease-disintegrin ADAM8 is highly expressed in pancreatic cancer cells and is correlated with an unfavorable patient prognosis. However, no information is available on ADAM8 expression in cells of the tumor microenvironment. We used immunohistochemistry (IHC) ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(2):]

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The Immune Microenvironment in Pancreatic Cancer.

Magdalena Huber, Corinna U Brehm, Thomas M Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke Pogge von Strandmann, Emily P Slater, Jörg W Bartsch, Christian Bauer, Matthias Lauth,

The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor-stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(19):]

Cited: 1 time

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Surgical Management, Preoperative Tumor Localization, and Histopathology of 80 Patients Operated on for Insulinoma.

Mikkel Andreassen, Emma Ilett, Dominik Wiese, Emily P Slater, Marianne Klose, Carsten Palnæs Hansen, Norman Gercke, Seppo W Langer, Andreas Kjaer, Elisabeth Maurer, Birgitte Federspiel, Peter H Kann, Detlef K Bartsch, Ulrich Knigge,

<h4>Introduction</h4>Diagnosis and pathological classification of insulinomas are challenging.<h4>Aim</h4>To characterize localization of tumors, surgery outcomes, and histopathology in patients with insulinoma.<h4>Methods</h4>Patients with surgically resected sporadic insulinoma were included.<h4>Results</h4>Eighty patients were included. Seven had a malignant tumor. A total of 312 diagnostic examinations were performed: endoscopic ultrasonography (EUS; n = 59; sensitivity, ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2019, 104(12):6129-6138]

Cited: 2 times

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Incidental findings in pancreas screening programs for high-risk individuals: Results from three European expert centers.

Isaura S Ibrahim, Catharina Brückner, Alfredo Carrato, Julie Earl, Akin Inderson, Wouter H de Vos Tot Nederveen Cappel, Ioannis Mintziras, Elvira Matthäi, Jens Figiel, Martin Wasser, Hans Moreau, Bert Bonsing, Emily P Slater, Detlef K Bartsch, Hans Fa Vasen,

<h4>Background</h4>Widespread abdominal imaging has led to a substantial increase in the detection of incidentalomas. Currently, an increasing number of centers offer surveillance of the pancreas to individuals at high risk (IARs) of pancreatic ductal adenocarcinoma (PDAC).<h4>Objective</h4>The aims of this study were to evaluate the frequency and type of incidental findings ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2019, 7(5):682-688]

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Chemoprevention with Somatuline© Delays the Progression of Pancreatic Neuroendocrine Neoplasms in a Mouse Model of Multiple Endocrine Neoplasia Type 1 (MEN1).

Caroline L Lopez, Barbara Joos, Detlef K Bartsch, Jerena Manoharan, Max Albers, Emily P Slater, Carmen Bollmann, Sylvia Roth, Aninja Bayer, Volker Fendrich,

<h4>Objective</h4>Long-acting synthetic somatostatin analogues (SSA) are an essential part of the treatment of neuroendocrine neoplasms. We evaluated the chemopreventive effects of a long-acting somatostatin analogue on the development of pancreatic neuroendocrine neoplasms (pNENs) in a genetically engineered MEN1 knockout mouse model.<h4>Materials and methods</h4>Heterozygote MEN1 knockout mice were injected every 28 days ... Read more >>

World J Surg (World journal of surgery)
[2019, 43(3):831-838]

Cited: 0 times

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German National Case Collection for familial pancreatic Cancer (FaPaCa) - acceptance and psychological aspects of a pancreatic cancer screening program.

Frederike S Franke, Elvira Matthäi, Emily P Slater, Christoph Schicker, Johannes Kruse, Detlef K Bartsch,

<h4>Background</h4>Pancreatic cancer screening is recommended to individuals at risk (IAR) of familial pancreatic cancer (FPC) families, but little is known about the acceptance of such screening programs. Thus, the acceptance and psychological aspects of a controlled FPC screening program was evaluated.<h4>Methods</h4>IAR of FPC families underwent comprehensive counseling by a geneticist ... Read more >>

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2018, 16:17]

Cited: 4 times

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ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance.

Catharina Conrad, Julia Benzel, Kristina Dorzweiler, Lena Cook, Uwe Schlomann, Alexander Zarbock, Emily P Slater, Christopher Nimsky, Jörg W Bartsch,

Ectodomain shedding of extracellular and membrane proteins is of fundamental importance for cell-cell communication in neoplasias. A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2019, 133(1):83-99]

Cited: 5 times

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Chemoprevention with Enalapril and Aspirin in Men1(+/T) Knockout Mouse Model.

Jerena Manoharan, Volker Fendrich, Pietro Di Fazio, Carmen Bollmann, Silvia Roth, Barbara Joos, Ioannis Mintziras, Max B Albers, Annette Ramaswamy, Philippe Bertolino, Chang X Zhang, Emily P Slater, Detlef K Bartsch, Caroline L Lopez-Lopez,

Pancreatic neuroendocrine neoplasias (pNEN) are the most common cause of death in adult patients with multiple endocrine neoplasia type 1 (MEN1). So far, only few chemopreventive strategies (e.g., with somatostatin analogues) have been evaluated for MEN1 associated pNENs. In this experimental study on 75 Men1(+/T) knockout mice, the effect of ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2018, 107(3):257-266]

Cited: 1 time

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Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.

Volker Fendrich, Frederike Jendryschek, Saskia Beeck, Max Albers, Matthias Lauth, Farzad Esni, Kristin Heeger, Janina Dengler, Emily P Slater, Julia P N Holler, Aninja Baier, Detlef K Bartsch, Jens Waldmann,

Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In the present study, we used a transgenic murine model of pancreatic cancer to evaluate the ... Read more >>

Oncogene (Oncogene)
[2018, 37(14):1845-1856]

Cited: 3 times

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Overexpression of MicroRNA miR-7-5p Is a Potential Biomarker in Neuroendocrine Neoplasms of the Small Intestine.

Anna E Heverhagen, Nathalie Legrand, Vinona Wagner, Volker Fendrich, Detlef K Bartsch, Emily P Slater,

<h4>Background/aims</h4>Neuroendocrine neoplasms of the small intestine (SI-NENs) constitute 25-30% of all gastroenteropancreatic NEN. These tumors arise from enterochromaffin cells, and little is known about their microRNA (miRNA) expression. The purpose of this study was to characterize the expression of miRNAs in SI-NEN and to determine the potential of miRNAs as ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2018, 106(4):312-317]

Cited: 10 times

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Is Routine Screening of Young Asymptomatic MEN1 Patients Necessary?

Jerena Manoharan, Friedhelm Raue, Caroline L Lopez, Max B Albers, Carmen Bollmann, Volker Fendrich, Emily P Slater, Detlef K Bartsch,

<h4>Background</h4>Recent clinical practice guidelines recommend that routine screening of MEN1 mutation carriers should start at the age of 5 years. The occurrence of clinically relevant MEN1 organ manifestations in children (≤18 years) was evaluated.<h4>Methods</h4>Two prospective collected databases of MEN1 patients (n = 166) who underwent annual screening were retrospectively analyzed for organ manifestations in ... Read more >>

World J Surg (World journal of surgery)
[2017, 41(8):2026-2032]

Cited: 7 times

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Limited Value of Ga-68-DOTATOC-PET-CT in Routine Screening of Patients with Multiple Endocrine Neoplasia Type 1.

Max B Albers, Damiano Librizzi, Caroline L Lopez, Jerena Manoharan, Jonas C Apitzsch, Emily P Slater, Carmen Bollmann, Peter H Kann, Detlef K Bartsch,

<h4>Background</h4>Routine screening is recommended for patients with multiple endocrine neoplasia type 1 (MEN1) to enable early detection and treatment of associated neuroendocrine neoplasms (NEN). Gallium<sup>68</sup>-DOTATOC-Positron emission tomography combined with computed tomography (Ga-68-DOTATOC-PET-CT) is a very sensitive and specific imaging technique for the detection of sporadic neuroendocrine tumors. The present study ... Read more >>

World J Surg (World journal of surgery)
[2017, 41(6):1521-1527]

Cited: 7 times

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Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor.

Caroline Goehringer, Christian Sutter, Matthias Kloor, Johannes Gebert, Emily P Slater, Monika Keller, Irmgard Treiber, Petra Ganschow, Martina Kadmon, Ute Moog,

We report on three brothers affected by pancreatic tumors, all due to different causes, including mutations associated with two different cancer predisposition syndromes in the same individual. In the index patient a germline mutation both in the APC and BRCA2 gene was identified while one affected brother showed the BRCA2 ... Read more >>

Fam Cancer (Familial cancer)
[2017, 16(2):303-309]

Cited: 1 time

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Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.

Hans Vasen, Isaura Ibrahim, Carmen Guillen Ponce, Emily P Slater, Elvira Matthäi, Alfredo Carrato, Julie Earl, Kristin Robbers, Anneke M van Mil, Thomas Potjer, Bert A Bonsing, Wouter H de Vos Tot Nederveen Cappel, Wilma Bergman, Martin Wasser, Hans Morreau, Günter Klöppel, Christoph Schicker, Martin Steinkamp, Jens Figiel, Irene Esposito, Evelina Mocci, Enrique Vazquez-Sequeiros, Alfonso Sanjuanbenito, Maria Muñoz-Beltran, José Montans, Peter Langer, Volker Fendrich, Detlef K Bartsch,

<h4>Purpose</h4>Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Hereditary factors play a role in the development of PDAC in 3% to 5% of all patients. Surveillance of high-risk groups, may facilitate detection of PDAC at an early stage. The aim of this study was to assess whether surveillance aids detection ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2016, 34(17):2010-2019]

Cited: 94 times

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An unusual phenotype of MEN1 syndrome with a SI-NEN associated with a deletion of the MEN1 gene.

Jerena Manoharan, Caroline L Lopez, Karl Hackmann, Max B Albers, Anika Pehl, Peter H Kann, Emily P Slater, Evelin Schröck, Detlef K Bartsch,

<h4>Unlabelled</h4>We report about a young female who developed an unusual and an aggressive phenotype of the MEN1 syndrome characterized by the development of a pHPT, malignant non-functioning pancreatic and duodenal neuroendocrine neoplasias, a pituitary adenoma, a non-functioning adrenal adenoma and also a malignant jejunal NET at the age of 37 ... Read more >>

Endocrinol Diabetes Metab Case Rep (Endocrinology, diabetes & metabolism case reports)
[2016, 2016:160011]

Cited: 1 time

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Bronchopulmonary Neuroendocrine Neoplasms and Their Precursor Lesions in Multiple Endocrine Neoplasia Type 1.

Detlef K Bartsch, Max B Albers, Caroline L Lopez, Jonas C Apitzsch, Eduard M Walthers, Ludger Fink, Volker Fendrich, Emily P Slater, Jens Waldmann, Martin Anlauf,

<h4>Objective</h4>The prevalence and clinical behavior of bronchopulmonary neuroendocrine tumors (bNET) associated with multiple endocrine neoplasia type 1 (MEN1) are not well defined. This study aimed to determine the prevalence, potential precursor lesions and prognosis of bNET in patients with MEN1.<h4>Methods</h4>A database of 75 prospectively collected MEN1 cases was retrospectively analyzed ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2016, 103(3-4):240-247]

Cited: 7 times

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Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.

Urs D Lichtenauer, Guido Di Dalmazi, Emily P Slater, Thomas Wieland, Anne Kuebart, Anett Schmittfull, Thomas Schwarzmayr, Susanne Diener, Dominik Wiese, Wolfgang E Thasler, Martin Reincke, Thomas Meitinger, Matthias Schott, Martin Fassnacht, Detlef K Bartsch, Tim M Strom, Felix Beuschlein,

<h4>Context</h4>Insulinomas represent pancreatic neuroendocrine neoplasms that cause severe morbidity attributed to their often pronounced endocrine activity. Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. Applying next-generation sequencing methods, disease-causing genetic alterations have been identified in ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2015, 100(5):E776-82]

Cited: 19 times

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IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells.

Christin Münzberg, Katharina Höhn, Denis Krndija, Ulrike Maaß, Detlef K Bartsch, Emily P Slater, Franz Oswald, Paul Walther, Thomas Seufferlein, Götz von Wichert,

Hypersecretion is the major symptom of functional neuroendocrine tumours. The mechanisms that contribute to this excessive secretion of hormones are still elusive. A key event in secretion is the exit of secretory products from the Golgi apparatus. ADP-ribosylation factor (Arf) GTPases are known to control vesicle budding and trafficking, and ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2015, 19(5):948-959]

Cited: 4 times

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Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain.

Detlef K Bartsch, Emily P Slater, Max Albers, Richard Knoop, Brunhilde Chaloupka, Caroline L Lopez, Volker Fendrich, Peter H Kann, Jens Waldmann,

<h4>Context</h4>Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in 10%-20% of patients. Causative MEN1 mutations in the interacting domains of the encoded Menin protein directly alter its regulation abilities and may influence the phenotype.<h4>Objective</h4>The objective of the ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2014, 99(11):E2387-91]

Cited: 19 times

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MicroRNA-196a and -196b as Potential Biomarkers for the Early Detection of Familial Pancreatic Cancer.

Emily P Slater, Konstantin Strauch, Susanne Rospleszcz, Annette Ramaswamy, Irene Esposito, Günter Klöppel, Elvira Matthäi, Kristin Heeger, Volker Fendrich, Peter Langer, Detlef K Bartsch,

Screening programs are recommended for individuals at risk (IAR) from families with familial pancreatic cancer (FPC). However, reliable imaging methods or biomarkers for early diagnosis of pancreatic ductal adenocarcinoma (PC) or its precursor lesions are still lacking. The ability of circulating microRNAs (miRNAs) to discriminate multifocal high-grade precursor lesions or ... Read more >>

Transl Oncol (Translational oncology)
[2014, 7(4):464-471]

Cited: 37 times

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LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer.

Emily P Slater, Volker Fendrich, Konstantin Strauch, Susanne Rospleszcz, Annette Ramaswamy, Elvira Mätthai, Brunhilde Chaloupka, Thomas M Gress, Peter Langer, Detlef K Bartsch,

High-risk individuals of familial pancreatic cancer (FPC) families are considered to be good candidates for screening programs to detect early PC or its high-grade precursor lesions, especially pancreatic intraepithelial neoplasia (PanIN) 2/3 lesions. There is a definite need for diagnostic markers as neither reliable imaging methods nor biomarkers are available ... Read more >>

Transl Oncol (Translational oncology)
[2013, 6(2):99-103]

Cited: 15 times

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Variation in precursor lesions of pancreatic cancer among high-risk groups.

Thomas P Potjer, Ingrid Schot, Peter Langer, Johannes T Heverhagen, Martin N J M Wasser, Emily P Slater, Günter Klöppel, Hans M Morreau, Bert A Bonsing, Wouter H de Vos Tot Nederveen Cappel, Mathias Bargello, Thomas M Gress, Hans F A Vasen, Detlef K Bartsch, , ,

<h4>Purpose</h4>Pancreatic ductal adenocarcinoma (PDAC) surveillance programs are currently offered to high-risk individuals aiming to detect precursor lesions or PDAC at an early stage. We assessed differences in frequency and behavior of precursor lesions and PDAC between two high-risk groups.<h4>Experimental design</h4>Individuals with a p16-Leiden germline mutation (N = 116; median age ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2013, 19(2):442-449]

Cited: 22 times

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Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense?

Ralph Schneider, Annette Ramaswamy, Emily P Slater, Detlef K Bartsch, Katja Schlosser,

<h4>Background</h4>Metachronous autotransplantation of cryopreserved parathyroid tissue is a technique for treating postoperative hypoparathyroidism after parathyroid surgery for renal hyperparathyroidism (rHPT). The aim of the present study was to evaluate our institution's experience with metachronous autotransplantation to analyze the role of cryopreservation in the treatment of rHPT and to determine for ... Read more >>

World J Surg (World journal of surgery)
[2012, 36(11):2598-2604]

Cited: 6 times

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Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors.

Volker Fendrich, Katja Maschuw, Johannes Rehm, Malte Buchholz, Julia P Holler, Emily P Slater, Detlef K Bartsch, Jens Waldmann,

<h4>Background</h4>The purpose of the study was to evaluate Sorafenib (BAY 43-9006) derived receptor tyrosine kinase inhibition on tumor progression in murine islet cell tumors. Sorafenib is considered to be a potent inhibitor of tumor angiogenesis and neovascularization in various solid tumors. Rip1Tag2 mice were treated in two different groups according ... Read more >>

ScientificWorldJournal (TheScientificWorldJournal)
[2012, 2012:529151]

Cited: 2 times

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