Full Text Journal Articles by
Author Emily E Wing

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Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice.

Franziska Schuster, Gianna Huber, Ines Stölting, Emily E Wing, Kathrin Saar, Norbert Hübner, William A Banks, Walter Raasch,

Obesity is a global health problem and treatment options are still insufficient. When chronically treated with the angiotensin II receptor blocker telmisartan (TEL), rodents do not develop diet-induced obesity (DIO). However, the underlying mechanism for this is still unclear. Here we investigated whether TEL prevents leptin resistance by enhancing leptin ... Read more >>

Pflugers Arch (Pflugers Archiv : European journal of physiology)
[2018, 470(11):1673-1689]

Cited: 3 times

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Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice.

Adam K Walker, Emily E Wing, William A Banks, Robert Dantzer,

Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. Circulating kynurenine is transported into the brain by the large amino transporter LAT1 at the level of the blood-brain barrier. We hypothesized that administration of leucine that has a high affinity for LAT1 should prevent the entry of kynurenine into ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2019, 24(10):1523-1532]

Cited: 16 times

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Antibody blood-brain barrier efflux is modulated by glycan modification.

John M Finke, Kari R Ayres, Ryan P Brisbin, Hali A Hill, Emily E Wing, William A Banks,

<h4>Background</h4>Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are needed to better accomplish this goal. Based on prior evidence, the hypothesis that glycan modification ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2017, 1861(9):2228-2239]

Cited: 11 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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