Full Text Journal Articles by
Author Emily A Ricke

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RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance.

Jordan E Vellky, Sean T McSweeney, Emily A Ricke, William A Ricke,

Prostate cancer (CaP) driven by androgen receptor (AR) is treated with androgen deprivation; however, therapy failure results in lethal castration-resistant prostate cancer (CRPC). AR-low/negative (ARL/-) CRPC subtypes have recently been characterized and cannot be targeted by hormonal therapies, resulting in poor prognosis. RNA-binding protein (RBP)/helicase DDX3 (DEAD-box helicase 3 X-linked) ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

Cited: 0 times

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Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.

Jordan E Vellky, Emily A Ricke, Wei Huang, William A Ricke,

Differentiating between indolent and aggressive prostate cancers (CaP) is important to decrease over-treatment and increase survival for men with aggressive disease. Nucleolar prominence is a histologic hallmark of CaP; however, the expression, localization, and functional significance of specific nucleolar proteins has not been thoroughly investigated. Nucleolar protein BOP1 has been ... Read more >>

Am J Pathol (The American journal of pathology)
[2020, :]

Cited: 0 times

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Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.

Petra Popovics, Wisam N Awadallah, Sarah E Kohrt, Thomas C Case, Nicole L Miller, Emily A Ricke, Wei Huang, Marisol Ramirez-Solano, Qi Liu, Chad M Vezina, Robert J Matusik, William A Ricke, Magdalena M Grabowska,

BACKGROUND:Male lower urinary tract symptoms (LUTS) occur in more than half of men above 50 years of age. LUTS were traditionally attributed to benign prostatic hyperplasia (BPH) and therefore the clinical terminology often uses LUTS and BPH interchangeably. More recently, LUTS were also linked to fibrogenic and inflammatory processes. We ... Read more >>

Prostate (The Prostate)
[2020, 80(10):731-741]

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SUN-747 Steroid Hormone Metabolism Mediated Racial Disparity in Men with Benign Prostatic Hyperplasia.

Teresa T Liu, Emily A Ricke, Douglas Strand, Rajiv Dhir, William Allen Ricke,

Abstract Introduction and Objective: Racial disparity in prostate cancer has been well established, with African American (AA) men having higher rates of diagnoses and death from the disease compared to Caucasian American (CA) men. AA men also have a high incidence of benign prostatic hyperplasia (BPH), a disease associated with ... Read more >>

(Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

Cited: 0 times

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Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA.

Kristen S Uchtmann, Julia A Taylor, Barry G Timms, Richard W Stahlhut, Emily A Ricke, Mark R Ellersieck, Frederick S Vom Saal, William A Ricke,

Bisphenol A (BPA) is a contaminant in virtually all Americans. To examine BPA's adverse effects, the FDA-NCTR, NIEHS, and 14 groups of academic scientists formed a consortium: CLARITY-BPA. The purpose of our study was to investigate the effects of a wide range of doses of BPA on fetal development of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 91:131-141]

Cited: 2 times

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Modeling human prostate cancer progression in vitro.

Teresa T Liu, Jonathan A Ewald, Emily A Ricke, Robert Bell, Colin Collins, William A Ricke,

Detailed mechanisms involved in prostate cancer (CaP) development and progression are not well understood. Current experimental models used to study CaP are not well suited to address this issue. Previously, we have described the hormonal progression of non-tumorigenic human prostate epithelial cells (BPH1) into malignant cells via tissue recombination. Here, ... Read more >>

Carcinogenesis (Carcinogenesis)
[2019, 40(7):893-902]

Cited: 1 time

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Incidence of androgen receptor and androgen receptor variant 7 coexpression in prostate cancer.

Jordan E Vellky, Tyler M Bauman, Emily A Ricke, Wei Huang, William A Ricke,

BACKGROUND:Prostate cancer (PRCA) is an androgen-driven disease, where androgens act through the androgen receptor (AR) to induce proliferation and survival of tumor cells. Recently, AR splice variant 7 (ARv7) has been implicated in advanced stages of PRCA and clinical recurrence. With the widespread use of AR-targeted therapies, there has been ... Read more >>

Prostate (The Prostate)
[2019, 79(16):1811-1822]

Cited: 0 times

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Expression and Localization of DDX3 in Prostate Cancer Progression and Metastasis.

Jordan E Vellky, Emily A Ricke, Wei Huang, William A Ricke,

Survival rates decrease significantly when localized prostate cancer (CaP) becomes metastatic, emphasizing the need for improved targeted therapies. DDX3, an RNA helicase, has widespread functions in RNA regulation, in both the nucleus and cytoplasm. Although DDX3 has been implicated as a prognostic marker for many cancers, including primary CaP, its ... Read more >>

Am J Pathol (The American journal of pathology)
[2019, 189(6):1256-1267]

Cited: 1 time

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Tissue-specific quantification and localization of androgen and estrogen receptors in prostate cancer.

Priyanka D Sehgal, Tyler M Bauman, Tristan M Nicholson, Jordan E Vellky, Emily A Ricke, Weiping Tang, Wei Xu, Wei Huang, William A Ricke,

Androgens and estrogens, working together, promote prostate cancer (PRCA) initiation and progression, with androgens acting via androgen receptor (AR) and estrogens acting primarily through estrogen receptor α (ERα). While the interplay between these steroid hormones has been established, the interaction between steroid hormone receptors in prostatic disease remains unstudied. The ... Read more >>

Hum Pathol (Human pathology)
[2019, 89:99-108]

Cited: 3 times

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Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging.

Tyler M Bauman, Emily A Ricke, Sally A Drew, Wei Huang, William A Ricke,

Immunohistochemistry is a commonly used clinical and research lab detection technique for investigating protein expression and localization within tissues. Many semi-quantitative systems have been developed for scoring expression using immunohistochemistry, but inherent subjectivity limits reproducibility and accuracy of results. Furthermore, the investigation of spatially overlapping biomarkers such as nuclear transcription ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (110):]

Cited: 2 times

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Expression and colocalization of β-catenin and lymphoid enhancing factor-1 in prostate cancer progression.

Tyler M Bauman, Chad M Vezina, Emily A Ricke, Richard B Halberg, Wei Huang, Richard E Peterson, William A Ricke,

The purpose of this study was to objectively investigate β-catenin and LEF1 abundance, subcellular localization, and colocalization across benign and staged prostate cancer (PCa) specimens. A tissue microarray containing tumor-adjacent histologically benign prostate tissue (BPT; n = 48 patients), high-grade prostatic intraepithelial neoplasia (HGPIN; n = 25), localized PCa (n ... Read more >>

Hum Pathol (Human pathology)
[2016, 51:124-133]

Cited: 5 times

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In Utero and Lactational TCDD Exposure Increases Susceptibility to Lower Urinary Tract Dysfunction in Adulthood.

William A Ricke, Calvin W Lee, Tyler R Clapper, Andrew J Schneider, Robert W Moore, Kimberly P Keil, Lisa L Abler, Jalissa L Wynder, Arnaldo López Alvarado, Isaac Beaubrun, Jenny Vo, Tyler M Bauman, Emily A Ricke, Richard E Peterson, Chad M Vezina,

Benign prostatic hyperplasia, prostate cancer, and changes in the ratio of circulating testosterone and estradiol often occur concurrently in aging men and can lead to lower urinary tract (LUT) dysfunction. To explore the possibility of a fetal basis for the development of LUT dysfunction in adulthood, Tg(CMV-cre);Nkx3-1(+/-);Pten(fl/+) mice, which are ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2016, 150(2):429-440]

Cited: 9 times

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Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis.

Emily A Ricke, Karin Williams, Yi-Fen Lee, Suzana Couto, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha, William A Ricke,

It has been postulated that prostatic carcinogenesis is androgen dependent and that androgens mediate their effects primarily through epithelial cells; however, definitive proof of androgen hormone action in prostate cancer (PRCA) progression is lacking. Here we demonstrate through genetic loss of function experiments that PRCA progression is androgen dependent and ... Read more >>

Carcinogenesis (Carcinogenesis)
[2012, 33(7):1391-1398]

Cited: 39 times

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Testosterone and 17β-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.

Tristan M Nicholson, Emily A Ricke, Paul C Marker, Joseph M Miano, Robert D Mayer, Barry G Timms, Frederick S vom Saal, Ronald W Wood, William A Ricke,

Benign prostatic hyperplasia (BPH) and bladder outlet obstruction (BOO) are common in older men and can contribute to lower urinary tract symptoms that significantly impact quality of life. Few existing models of BOO and BPH use physiological levels of hormones associated with disease progression in humans in a genetically manipulable ... Read more >>

Endocrinology (Endocrinology)
[2012, 153(11):5556-5565]

Cited: 51 times

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Steroid hormones stimulate human prostate cancer progression and metastasis.

William A Ricke, Kenichiro Ishii, Emily A Ricke, Jeff Simko, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha,

Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of testosterone (T) and estradiol-17beta (E2) that elicit ... Read more >>

Int J Cancer (International journal of cancer)
[2006, 118(9):2123-2131]

Cited: 54 times

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A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout mice.

Stephanie E Mann, Emily A Ricke, Elvina A Torres, Robert N Taylor,

OBJECTIVE: To test the hypothesis that amniotic fluid volume is increased in aquaporin 1 knockout mice. STUDY DESIGN: Transgenic mice deficient in aquaporin 1 protein were generated by targeted gene disruption, as described previously. After a cesarean section was performed, intact, individual gestational sacs were removed from the uterus and ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2005, 192(6):2041-4; discussion 2044-6]

Cited: 24 times

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Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis.

Kathy L Sharpe-Timms, Randy L Zimmer, Emily A Ricke, Marta Piva, Gary M Horowitz,

OBJECTIVE:To evaluate the effects of endometriotic haptoglobin on peritoneal macrophage function. DESIGN:Prospective laboratory study. SETTING:School of medicine. PATIENT(S):Twenty-three women with and without endometriosis. INTERVENTION(S):Peritoneal macrophages cultured without or with haptoglobin. MAIN OUTCOME MEASURE(S):Peritoneal macrophage haptoglobin immunoreactivity, adhesion, and interleukin-6 (IL-6) production. RESULT(S):In vivo, significantly more peritoneal macrophages from women with ... Read more >>

Fertil. Steril. (Fertility and sterility)
[2002, 78(4):810-819]

Cited: 33 times

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Expression and localization of aquaporin 1 and 3 in human fetal membranes.

Stephanie E Mann, Emily A Ricke, Baxoue A Yang, Alan S Verkman, Robert N Taylor,

OBJECTIVES:Aquaporins are a family of water-selective channels that facilitate fluid movement across cell membranes. Specifically, aquaporin 1 (AQP1) and aquaporin 3 (AQP3) have been found to be important in osmotic water movement across membranes. Our goal in this study was (1) to determine whether AQP1 or AQP3 messenger RNA are ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2002, 187(4):902-907]

Cited: 28 times

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