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Author Emiliano Fernandez Villalba

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A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Valeria C Gonçalves, María Guillén-Díaz, Elena Aguilar-Moñino, Consuelo Sánchez-Rodrigo, Ana-María González-Cuello, Emiliano Fernández-Villalba, María Trinidad Herrero,

The diurnal rodent <i>Octodon degus</i> (<i>O. degus</i>) is considered an attractive natural model for Alzheimer's disease and other human age-related features. However, it has not been explored so far if the <i>O. degus</i> could be used as a model to study Parkinson's disease. To test this idea, 10 adult male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

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Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.

Valeria C Gonçalves, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Sebastian Martin-Balbuena, Maria Jose da Silva Fernandes, Carla A Scorza, Maria-Trinidad Herrero,

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson's disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421990000]

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Cardiac Tyrosine Hydroxylase Activation and Mb-Comt in Dyskinetic Monkeys

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, José Yuste, Vicente de Pablos, Victor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of the dysautonomic ... Read more >>

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Octodon degus: a natural model of multimorbidity for ageing research.

Lorena Cuenca-Bermejo, Elisa Pizzichini, Ana Maria Gonzalez-Cuello, Maria Egle De Stefano, Emiliano Fernandez-Villalba, María-Trinidad Herrero,

Integrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2020, 64:101204]

Cited: 1 time

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Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.

Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrero,

Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the Substantia Nigra pars compacta (SNpc) and deficit of dopamine in the basal ganglia. These motor symptoms can be preceded by pre-motor symptoms ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2021, :]

Cited: 6 times

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Cardiac Tyrosine Hydroxylase Activation and MB-COMT in Dyskinetic Monkeys 

Lorena Cuenca-Bermejo, Pilar Almela, Pablo Gallo-Soljancic, Jose Yuste, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background: </h4> The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson’s disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of ... Read more >>

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Study of the Link Between Neuronal Death, Glial Response, and MAPK Pathway in Old Parkinsonian Mice.

Ana Luisa Gil-Martinez, Lorena Cuenca-Bermejo, Pablo Gallo-Soljancic, Consuelo Sanchez-Rodrigo, Virginia Izura, Harry W M Steinbusch, Emiliano Fernandez-Villalba, Maria Trinidad Herrero,

<b>Background</b>: Parkinson's disease (PD) is described as an age-related neurodegenerative disorder. However, the vast majority of research is carried out using experimental models of young animals lacking the implications of the decline processes associated with aging. It has been suggested that several molecular pathways are involved in the perpetuation of ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:214]

Cited: 1 time

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Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.

Pilar Almela, Lorena Cuenca-Bermejo, José E Yuste, Cristina Estrada, Vicente de Pablos, Víctor Bautista-Hernández, Emiliano Fernández-Villalba, María-Luisa Laorden, María-Trinidad Herrero,

<h4>Background</h4>Autonomic dysfunction is a well-known dominant symptom in the advanced stages of Parkinson's disease. However, the role of cardiac sympathetic nerves still needs to be elucidated.<h4>Objectives</h4>To evaluate cardiac sympathetic response in Parkinsonian and dyskinetic monkeys.<h4>Methods</h4>Adult male monkeys were divided into 1 of the following 3 groups: controls, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys, and ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(4):698-703]

Cited: 1 time

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Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus.

Cristina Estrada, Lorena Cuenca, Lorena Cano-Fernandez, Ana Luisa Gil-Martinez, Consuelo Sanchez-Rodrigo, Ana Maria González-Cuello, Emiliano Fernandez-Villalba, Maria Trinidad Herrero,

Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory dysfunctions possibly caused by triggers of stress such ... Read more >>

Behav Brain Res (Behavioural brain research)
[2019, 373:112066]

Cited: 1 time

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Local Gastrointestinal Injury Exacerbates Inflammation and Dopaminergic Cell Death in Parkinsonian Mice.

Ana-Luisa Gil-Martínez, Cristina Estrada, Lorena Cuenca, Juan-Antonio Cano, Manuel Valiente, Carlos-Manuel Martínez-Cáceres, Emiliano Fernández-Villalba, María-Trinidad Herrero,

The cause of progressive degeneration in Parkinson's disease is not clear, although, in the last years, different studies have suggested that both brain and peripheral inflammation could play a key role in the progression of this disorder. In our study, we aimed to analyze the effect of an acute inflammation ... Read more >>

Neurotox Res (Neurotoxicity research)
[2019, 35(4):918-930]

Cited: 3 times

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Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice.

Ana Luisa Gil-Martínez, Lorena Cuenca, Cristina Estrada, Consuelo Sánchez-Rodrigo, Emiliano Fernández-Villalba, María Trinidad Herrero,

The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's disease (PD) is an age-related pathology, almost all experimental studies are carried out in young animals. Here, we ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2018, 12:451]

Cited: 4 times

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Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?

Ana-Luisa Gil-Martínez, Lorena Cuenca, Consuelo Sánchez, Cristina Estrada, Emiliano Fernández-Villalba, María Trinidad Herrero,

<h4>Background</h4>Neuroprotective strategies are becoming relevant to slow down dopaminergic cell death and inflammatory processes related to the progressive neurodegeneration in Parkinson's disease (PD). Interestingly, among others, physical activity (PA) or anti-oxidant agents (such as N-acetyl-L-cysteine, NAC) are common therapeutic strategies. Therefore, this study aims to analyze if there is a ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2018, 15(1):328]

Cited: 7 times

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Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease.

Chai K Lim, Francisco J Fernández-Gomez, Nady Braidy, Cristina Estrada, Cristina Costa, Silvia Costa, Alban Bessede, Emiliano Fernandez-Villalba, Anna Zinger, Maria Trinidad Herrero, Gilles J Guillemin,

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. Neuroinflammation leads to microglia activation and release of a large number of proinflammatory mediators. The kynurenine pathway (KP) of tryptophan catabolism ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2017, 155:76-95]

Cited: 39 times

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Retinal aging in the diurnal Chilean rodent (Octodon degus): histological, ultrastructural and neurochemical alterations of the vertical information processing pathway.

Krisztina Szabadfi, Cristina Estrada, Emiliano Fernandez-Villalba, Ernesto Tarragon, Gyorgy Setalo, Virginia Izura, Dora Reglodi, Andrea Tamas, Robert Gabriel, Maria Trinidad Herrero,

The retina is sensitive to age-dependent degeneration. To find suitable animal models to understand and map this process has particular importance. The degu (Octodon degus) is a diurnal rodent with dichromatic color vision. Its retinal structure is similar to that in humans in many respects, therefore, it is well suited ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2015, 9:126]

Cited: 6 times

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Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus.

Ernesto Tarragon, Dolores Lopez, Cristina Estrada, Ana Gonzalez-Cuello, Carmen Ma Ros, Yves Lamberty, Fabien Pifferi, Massimo Cella, Mara Canovi, Giovanna Guiso, Marco Gobbi, Emiliano Fernández-Villalba, Olivier Blin, Regis Bordet, Jill C Richardson, María Trinidad Herrero,

Memory loss is one of the key features of cognitive impairment in either aging, Mild Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are today focused on addressing symptomatology. One of these approved compounds is memantine, a partial NMDA receptor antagonist that has proved its beneficial effects in ... Read more >>

Neuropharmacology (Neuropharmacology)
[2014, 85:206-214]

Cited: 9 times

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Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques.

Carlos Barcia, Carmen María Ros, Carmen María Ros, Francisco Ros-Bernal, Aurora Gómez, Valentina Annese, María Angeles Carrillo-de Sauvage, José Enrique Yuste, Carmen María Campuzano, Vicente de Pablos, Emiliano Fernández-Villalba, María Trinidad Herrero,

Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2013, 261(1-2):60-66]

Cited: 24 times

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Critical evaluation of the anatomical location of the Barrington nucleus: relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus.

Lisette Blanco, Jose Enrique Yuste, María Angeles Carrillo-de Sauvage, Aurora Gómez, Emiliano Fernández-Villalba, Itciar Avilés-Olmos, Patricia Limousin, Ludvic Zrinzo, María Trinidad Herrero,

Deep brain stimulation (DBS) has become the standard surgical procedure for advanced Parkinson's disease (PD). Recently, the pedunculopontine tegmental nucleus (PPN) has emerged as a potential target for DBS in patients whose quality of life is compromised by freezing of gait and falls. To date, only a few groups have ... Read more >>

Neuroscience (Neuroscience)
[2013, 247:351-363]

Cited: 4 times

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Alterations in energy metabolism, neuroprotection and visual signal transduction in the retina of Parkinsonian, MPTP-treated monkeys.

Laura Campello, Julián Esteve-Rudd, Roque Bru-Martínez, María Trinidad Herrero, Emiliano Fernández-Villalba, Nicolás Cuenca, José Martín-Nieto,

Parkinson disease is mainly characterized by the degeneration of dopaminergic neurons in the central nervous system, including the retina. Different interrelated molecular mechanisms underlying Parkinson disease-associated neuronal death have been put forward in the brain, including oxidative stress and mitochondrial dysfunction. Systemic injection of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to monkeys ... Read more >>

PLoS One (PloS one)
[2013, 8(9):e74439]

Cited: 17 times

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CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo.

Maria Angeles Carrillo-de Sauvage, Aurora Gómez, Carmen María Ros, Carmen María Ros, Francisco Ros-Bernal, Eduardo D Martín, Ana Perez-Vallés, José M Gallego-Sanchez, Emiliano Fernández-Villalba, Carlos Barcia, Carlos Barcia, Maria-Trinidad Herrero,

CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the ... Read more >>

PLoS One (PloS one)
[2012, 7(2):e30762]

Cited: 27 times

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Increase of secondary processes of microglial and astroglial cells after MPTP-induced degeneration in substantia nigra pars compacta of non human primates.

Carlos Barcia, Carmen M Ros, María A Carrillo, Francisco Ros, Aurora Gomez, Vicente de Pablos, Victor Bautista-Hernández, Angel Sánchez-Bahillo, Emiliano Fernández Villalba, Maria-Trinidad Herrero,

Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated with dopaminergic cell loss. However, the function of this glial reaction remains unclear. This histological hallmark is also reproduced in ... Read more >>

J Neural Transm Suppl (Journal of neural transmission. Supplementum)
[2009, (73):253-258]

Cited: 3 times

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Inflammatory response in Parkinsonism.

Carlos Barcia, Francisco Ros, María Angeles Carrillo, David Aguado-Llera, Carmen María Ros, Aurora Gómez, Cristina Nombela, Vicente de Pablos, Emiliano Fernández-Villalba, Maria-Trinidad Herrero,

Inflammatory responses have been proposed as important factors in dopaminergic neuro-degeneration in Parkinsonism. Increasing evidence suggests that the alteration of the glial microenvironment induced by neuronal degeneration could be deleterious to the remaining neurons. The activation of microglia/macrophages and reactive astrocytes may have a negative effect on the surrounding parenchyma, ... Read more >>

J Neural Transm Suppl (Journal of neural transmission. Supplementum)
[2009, (73):245-252]

Cited: 3 times

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CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain.

Carlos Barcia, Aurora Gomez, Vicente de Pablos, Emiliano Fernández-Villalba, Chunyan Liu, Kurt M Kroeger, Javier Martín, Andrés Fernández Barreiro, Maria G Castro, Pedro R Lowenstein, Maria-Trinidad Herrero,

The clearance of virally infected cells from the brain is mediated by T cells that engage antigen-presenting cells to form supramolecular activation clusters at the immunological synapse. However, after clearance, the T cells persist at the infection site and remain activated locally. In the present work the long-term interactions of ... Read more >>

J Virol (Journal of virology)
[2008, 82(20):9978-9993]

Cited: 10 times

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Increased plasma levels of TNF-alpha but not of IL1-beta in MPTP-treated monkeys one year after the MPTP administration.

Carlos Barcia, Vicente de Pablos, Víctor Bautista-Hernández, Angel Sánchez-Bahillo, Inmaculada Bernal, Emiliano Fernández-Villalba, Javier Martín, Rafael Bañón, Andrés Fernández-Barreiro, María-Trinidad Herrero,

The cause of Parkinson's disease remains unknown although some evidence suggests that an inflammatory reaction, mediated by cytokines such as TNF-alpha and IL-1beta, is related with dopaminergic degeneration in the brain. In the present work we measured the plasma levels of TNF-alpha and IL-1beta in parkinsonian monkeys one year after ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2005, 11(7):435-439]

Cited: 33 times

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Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure.

Carlos Barcia, Angel Sánchez Bahillo, Emiliano Fernández-Villalba, Víctor Bautista, Máximo Poza Y Poza, Andrés Fernández-Barreiro, Etienne C Hirsch, María-Trinidad Herrero,

Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease. However, it is still not known whether inflammatory changes are responsible for active nerve cell death or if they have a protective role against neurodegeneration. In this ... Read more >>

Glia (Glia)
[2004, 46(4):402-409]

Cited: 117 times

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Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys.

Carlos Barcia, Víctor Bautista, Angel Sánchez-Bahillo, Emiliano Fernández-Villalba, Juana-María Navarro-Ruis, Andrés Fernández Barreiro, Máximo Poza Y Poza, María-Trinidad Herrero,

The aim of this study was to investigate whether prolactin, melatonin and cortisol are altered in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys and if so, whether MPTP may alter the availability of these hormones in chronic experimental parkinsonism. Furthermore, vegetative and sleep disorders have been described in both parkinsonian patients and in MPTP ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2003, 78(2):118-128]

Cited: 22 times

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