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Author Emanuele Perrone

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Laparoscopic vs. robotic-assisted laparoscopy in endometrial cancer staging: large retrospective single-institution study.

Emanuele Perrone, Ilaria Capasso, Tina Pasciuto, Alessandro Gioè, Salvatore Gueli Alletti, Stefano Restaino, Giovanni Scambia, Francesco Fanfani,

<h4>Objective</h4>The aim of this study is to analyze and draw the potential differences between the robotic-assisted surgery (RS) and the laparoscopy (LPS) in endometrial cancer staging.<h4>Methods</h4>In this single-institution retrospective study we enrolled 1,221 consecutive clinical stage I-III endometrial cancer patients undergone minimally invasive surgical staging. We compared patients treated by ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e45]

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Percutaneous-Assisted versus Laparoscopic Hysterectomy: A Prospective Comparison.

Emanuele Perrone, Cristiano Rossitto, Francesco Fanfani, Stefano Cianci, Anna Fagotti, Stefano Uccella, Giuseppe Vizzielli, Carmine Vascone, Stefano Restaino, Camilla Fedele, Farrah Layla Saleh, Giovanni Scambia, Salvatore Gueli Alletti,

<h4>Objective</h4>To evaluate the feasibility of percutaneous approach, we prospectively compared our experience in percutaneous-assisted hysterectomy (PSS-H) with that in a series of laparoscopic hysterectomies (LPS-Hs).<h4>Methods</h4>In this multicentric cohort study, from May 2015 to October 2017, 160 patients affected by benign and malignant gynecological conditions were considered eligible for minimally invasive ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2020, 85(4):318-326]

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Law and mental health: A bridge between individual neurobiology and the collective organization of behaviors.

Emanuele Perrone, Francesco De Bei, Gianmarco Cristofari,

Mental disorders (MD) or mental symptoms (MS) have multifactorial causes. Today we know much more about the variables that cause individual MD\MS, but in our opinion these characterizations, although essential, are not sufficient to account for the complexity in which we live. For example, they do not explain in a ... Read more >>

Med Hypotheses (Medical hypotheses)
[2020, 144:110004]

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Percutaneous-assisted vs mini-laparoscopic hysterectomy: comparison of ultra-minimally invasive approaches.

Stefano Cianci, Emanuele Perrone, Cristiano Rossitto, Francesco Fanfani, Alessandro Tropea, Antonio Biondi, Giovanni Scambia, Salvatore Gueli Alletti,

To assess the feasibility and the safety of the ultra-minimally invasive (U-MIS) approaches in gynecology, we compared our experience in percutaneous assisted hysterectomy (PSS-H) with a series of 3 mm mini-laparoscopy hysterectomy (m-LPS-H). 126 patients affected by benign and malignant gynecological conditions were considered eligible for minimally invasive hysterectomy: 80 patients ... Read more >>

Updates Surg (Updates in surgery)
[2020, :]

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Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas.

Salvatore Lopez, Emanuele Perrone, Stefania Bellone, Elena Bonazzoli, Burak Zeybek, Chanhee Han, Joan Tymon-Rosario, Gary Altwerger, Gulden Menderes, Anna Bianchi, Luca Zammataro, Aranzazu Manzano, Paola Manara, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Francesco Raspagliesi, Roberto Angioli, Natalia Buza, Pei Hui, Heather M Bond, Alessandro D Santin,

Background:Uterine and ovarian carcinosarcomas (CS) are rare cancers with poor prognosis. Sacituzumab-govitecan (SG) is a new class of antibody-drug-conjugate (ADC) targeting the human-trophoblast-cell-surface marker (Trop-2) conjugated with the active metabolite of irinotecan (SN-38). We evaluated the efficacy of SG against biologically aggressive CS. Methods:Trop-2 expression was evaluated in 10 formalin-fixed-paraffined-embedded ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(5):560-570]

Cited: 2 times

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Sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2, shows cytotoxic activity against poorly differentiated endometrial adenocarcinomas in vitro and in vivo.

Emanuele Perrone, Paola Manara, Salvatore Lopez, Stefania Bellone, Elena Bonazzoli, Aranzazu Manzano, Luca Zammataro, Anna Bianchi, Burak Zeybek, Natalia Buza, Joan Tymon-Rosario, Gary Altwerger, Chanhee Han, Gulden Menderes, Gloria S Huang, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Pei Hui, Peter E Schwartz, Giovanni Scambia, Alessandro D Santin,

Endometrial cancer is the most common gynecologic malignancy in developed countries. The antibody-drug conjugate (ADC) sacituzumab govitecan (SG) targets trophoblast cell-surface antigen-2 (Trop-2) - a cell-surface glycoprotein highly expressed in many epithelial tumors - and delivers the active metabolite of irinotecan SN-38 to Trop-2-positive tumor cells. We evaluated Trop-2 expression ... Read more >>

Mol Oncol (Molecular oncology)
[2020, 14(3):645-656]

Cited: 2 times

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Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38), in Ovarian Cancer.

Emanuele Perrone, Salvatore Lopez, Burak Zeybek, Stefania Bellone, Elena Bonazzoli, Silvia Pelligra, Luca Zammataro, Aranzazu Manzano, Paola Manara, Anna Bianchi, Natalia Buza, Joan Tymon-Rosario, Gary Altwerger, Chanhee Han, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Pei Hui, Peter E Schwartz, Giovanni Scambia, Alessandro D Santin,

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Sacituzumab govitecan (SG) is a novel antibody-drug-conjugate (ADC) targeting trophoblast-antigen-2 (Trop-2), a cell surface glycoprotein highly expressed in many epithelial tumors, to deliver SN-38, the active metabolite of irinotecan. This study aimed to evaluate Trop-2 expression in EOC tissues ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:118]

Cited: 3 times

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In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma.

Chanhee Han, Emanuele Perrone, Burak Zeybek, Stefania Bellone, Joan Tymon-Rosario, Gary Altwerger, Gulden Menderes, Jacqueline Feinberg, Kaitlin Haines, Mariana Espinal Muller Karger, Anna Bianchi, Luca Zammataro, Aranzazu Manzano, Elena Bonazzoli, Paola Manara, Natalia Buza, Pei Hui, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Salvatore Lopez, Alessandro D Santin,

OBJECTIVE:Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer with poor prognosis. Sacituzumab govitecan (SG) is a novel antibody-drug-conjugate (ADC) targeting trophoblast cell-surface antigen 2 (Trop-2), a transmembrane-calcium-signal-transducer, to deliver SN-38, the active metabolite of irinotecan. The objective of this study was to evaluate the expression of Trop-2 ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(2):430-438]

Cited: 2 times

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Cervical carcinomas that overexpress human trophoblast cell-surface marker (Trop-2) are highly sensitive to the antibody-drug conjugate sacituzumab govitecan.

Burak Zeybek, Aranzazu Manzano, Anna Bianchi, Elena Bonazzoli, Stefania Bellone, Natalia Buza, Pei Hui, Salvatore Lopez, Emanuele Perrone, Paola Manara, Luca Zammataro, Gary Altwerger, Chanhee Han, Joan Tymon-Rosario, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Alessandro Santin,

Human trophoblast cell-surface marker (Trop-2) is a surface glycoprotein originally identified in human placental tissue and subsequently found to be highly expressed by various types of human epithelial solid tumors. We investigated the efficacy of sacituzumab govitecan, an antibody-drug conjugate (ADC) comprised of a humanized anti- Trop-2 antibody, conjugated with ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):973]

Cited: 4 times

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Feasibility and perioperative outcomes of percutaneous-assisted laparoscopic hysterectomy: A multicentric Italian experience.

Salvatore Gueli Alletti, Emanuele Perrone, Antonio Cretì, Stefano Cianci, Stefano Uccella, Camilla Fedele, Francesco Fanfani, Stefano Palmieri, Anna Fagotti, Giovanni Scambia, Cristiano Rossitto,

OBJECTIVE:This multicentric prospective phase II study aimed to investigate the feasibility, safety, and efficacy of percutaneous-assisted laparoscopic hysterectomy in terms of perioperative outcomes, feasibility, VAS score, and cosmetic outcomes. STUDY DESIGN:Between May 2015 and October 2017, 382 patients were considered eligible for minimally invasive percutaneous-assisted laparoscopic hysterectomy using Percuvance™, Percutaneous ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 245:181-185]

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Sexual Function following Laparoscopic versus Transvaginal Closure of the Vaginal Vault after Laparoscopic Hysterectomy: Secondary Analysis of a Randomized Trial by the Italian Society of Gynecological Endoscopy Using a Validated Questionnaire.

Stefano Uccella, Vito Andrea Capozzi, Matteo Ricco', Emanuele Perrone, Margherita Zanello, Stefania Ferrari, Pier Carlo Zorzato, Renato Seracchioli, Antonella Cromi, Maurizio Serati, Raffaella Ergasti, Francesco Fanfani, Roberto Berretta, Mario Malzoni, Stefano Cianci, Enrico Vizza, Maurizio Guido, Francesco Legge, Giuseppe Ciravolo, Salvatore Gueli Alletti, Fabio Ghezzi, Massimo Candiani, Giovanni Scambia,

<h4>Study objective</h4>The effect of the different types of vaginal cuff closures on posthysterectomy sexual function has not been investigated in depth. We evaluated if there is a difference between transvaginal versus a laparoscopic closure after total laparoscopic hysterectomy (TLH) on female sexual function, using a validated questionnaire.<h4>Design</h4>Secondary analysis of a ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, 27(1):186-194]

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Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.

Luca Zammataro, Salvatore Lopez, Stefania Bellone, Francesca Pettinella, Elena Bonazzoli, Emanuele Perrone, Siming Zhao, Gulden Menderes, Gary Altwerger, Chanhee Han, Burak Zeybek, Anna Bianchi, Aranzazu Manzano, Paola Manara, Emiliano Cocco, Natalia Buza, Pei Hui, Serena Wong, Antonella Ravaggi, Eliana Bignotti, Chiara Romani, Paola Todeschini, Laura Zanotti, Franco Odicino, Sergio Pecorelli, Carla Donzelli, Laura Ardighieri, Roberto Angioli, Francesco Raspagliesi, Giovanni Scambia, Jungmin Choi, Weilai Dong, Kaya Bilguvar, Ludmil B Alexandrov, Dan-Arin Silasi, Gloria S Huang, Elena Ratner, Masoud Azodi, Peter E Schwartz, Valentina Pirazzoli, Amy L Stiegler, Titus J Boggon, Richard P Lifton, Joseph Schlessinger, Alessandro D Santin,

The prognosis of advanced/recurrent cervical cancer patients remains poor. We analyzed 54 fresh-frozen and 15 primary cervical cancer cell lines, along with matched-normal DNA, by whole-exome sequencing (WES), most of which harboring Human-Papillomavirus-type-16/18. We found recurrent somatic missense mutations in 22 genes (including PIK3CA, ERBB2, and GNAS) and a widespread ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(45):22730-22736]

Cited: 5 times

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PARP-1 activity (PAR) determines the sensitivity of cervical cancer to olaparib.

Anna Bianchi, Salvatore Lopez, Gary Altwerger, Stefania Bellone, Elena Bonazzoli, Luca Zammataro, Aranzazu Manzano, Paola Manara, Emanuele Perrone, Burak Zeybek, Chanhee Han, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Justin Y Newberg, Dean C Pavlick, Julia Elvin, Garrett M Frampton, Peter E Schwartz, Alessandro D Santin,

<h4>Objectives</h4>Cervical cancer (CC) remains a major health problem worldwide. Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutics in ovarian cancer. We explored the preclinical in vitro and in vivo activity of olaparib against multiple primary whole exome sequenced (WES) CC cells lines ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(1):144-150]

Cited: 4 times

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PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers.

Elena Bonazzoli, Emiliano Cocco, Salvatore Lopez, Stefania Bellone, Luca Zammataro, Anna Bianchi, Aranzazu Manzano, Ghanshyam Yadav, Paola Manara, Emanuele Perrone, Kaitlin Haines, Mariana Espinal, Katherine Dugan, Gulden Menderes, Gary Altwerger, Chanhee Han, Burak Zeybek, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Alessandro D Santin,

<h4>Objective</h4>Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutations on the activity of afatinib, in this study we evaluate for the first time ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 153(1):158-164]

Cited: 4 times

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Inguino-abdominal combined approach for laterally extended pelvic resection: a step by step procedure.

Giuseppe Vizzielli, Emanuele Perrone, Alessandro Gioè, Giovanni Tinelli, Giovanni Scambia,

This video article demonstrates an inguino-abdominal combined approach for laterally extended pelvic resection, a major surgical procedure for locally advanced primary or recurrent gynecological cancer infiltrating the pelvic sidewall, for which palliative therapy is the only alternative.1 After local institutional review board approval (protocol No CICOG 02/03/62), we made a ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2019, 29(2):444-445]

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Laparoscopic Pelvic Exenteration With Radical Vaginectomy Using 3-Dimensional Vision and Multifunction Instrument.

Giuseppe Vizzielli, Emanuele Perrone, Sara Pizzacalla, Giovanni Scambia, Alfredo Ercoli,

<h4>Study objective</h4>The video article describes a laparoscopic anterior pelvic exenteration with radical vaginectomy using the 3-dimensional (3D) vision and multifunction instruments.<h4>Methods</h4>This is a step-by-step video presentation of the laparoscopic anterior pelvic exenteration (Canadian Task Force classification III). Although the therapeutic benefit of the PE remains controversial, it is often performed ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(9):1805-1806]

Cited: 0 times

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Robotic video endoscopic inguinal lymphadenectomy (R-VEIL) for vulvar cancer with sentinel node mapping using indocyanine green and near-infrared fluorescence imaging technology.

Angelica Naldini, Giuseppe Vizzielli, Emanuele Perrone, Valerio Gallotta, Giovanni Scambia,

<h4>Objectives</h4>Video endoscopy inguinal lymphadenectomy (VEIL) has emerged as the new frontier for the surgical staging of vulvar cancer (VC) [1, 2]. In this surgical film we show a step-by-step video presentation of a Robotic SLNmapping using ICG (Canadian Task Force classification III). Although the therapeutic benefit of SLN remains controversial ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 150(1):203-204]

Cited: 0 times

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3 mm Senhance robotic hysterectomy: a step towards future perspectives.

Salvatore Gueli Alletti, Emanuele Perrone, Stefano Cianci, Cristiano Rossitto, Giorgia Monterossi, Federica Bernardini, Giovanni Scambia,

J Robot Surg (Journal of robotic surgery)
[2018, 12(3):575-577]

Cited: 3 times

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Single-Institution Propensity-Matched Study to Evaluate the Psychological Effect of Minimally Invasive Interval Debulking Surgery Versus Standard Laparotomic Treatment: From Body to Mind and Back.

Salvatore Gueli Alletti, Giuseppe Vizzielli, Letizia Lafuenti, Barbara Costantini, Anna Fagotti, Camilla Fedele, Stefano Cianci, Emanuele Perrone, Valerio Gallotta, Cristiano Rossitto, Giovanni Scambia,

STUDY OBJECTIVE:To further investigate the psycho-oncologic effect of minimally invasive surgery comparing patients submitted to minimally invasive interval debulking surgery (MI-IDS) with a balanced population treated by standard laparotomy (L-IDS). DESIGN:Single-institution propensity-matched study (Canadian Task Force classification II-2). SETTING:Division of Gynecologic Oncology, "Policlinico A. Gemelli" Foundation, Rome, Italy. PATIENTS:The investigational ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2018, 25(5):816-822]

Cited: 11 times

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Role of blue dye for sentinel lymph node detection in early endometrial cancer.

Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani,

Background:Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as ... Read more >>

Gynecol Surg (Gynecological surgery)
[2017, 14(1):23]

Cited: 3 times

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Laparoscopic vs transvaginal cuff closure after total laparoscopic hysterectomy: a randomized trial by the Italian Society of Gynecologic Endoscopy.

Stefano Uccella, Mario Malzoni, Antonella Cromi, Renato Seracchioli, Giuseppe Ciravolo, Francesco Fanfani, Fevzi Shakir, Salvatore Gueli Alletti, Francesco Legge, Roberto Berretta, Giacomo Corrado, Lucia Casarella, Paolo Donarini, Margherita Zanello, Emanuele Perrone, Baldo Gisone, Enrico Vizza, Giovanni Scambia, Fabio Ghezzi,

BACKGROUND:Vaginal cuff dehiscence following hysterectomy is considered an infrequent but potentially devastating complication. Different possible techniques for cuff closure have been proposed to reduce this threatening adverse event. OBJECTIVE:The aim of the present randomized study was to compare laparoscopic and transvaginal suture of the vaginal vault at the end of ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2018, 218(5):500.e1-500.e13]

Cited: 7 times

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Reply.

Cristiano Rossitto, Salvatore Gueli Alletti, Stefank Cianci, Emanuele Perrone, Giovanni Scambia,

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2017, 24(4):683-684]

Cited: 1 time

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Preoperative Serum Human Epididymis Protein 4 Levels in Early Stage Endometrial Cancer: A Prospective Study.

Francesco Fanfani, Stefano Restaino, Stefania Cicogna, Marco Petrillo, Marcella Montico, Emanuele Perrone, Oriano Radillo, Rossella De Leo, Matteo Ceccarello, Giovanni Scambia, Giuseppe Ricci,

<h4>Objective</h4>The aim of the study was to evaluate the prognostic value of human epididymis protein 4 (HE4) and cancer antigen 125 markers with pathological prognostic factor to complete the preoperative clinical panel and help the treatment planning.<h4>Methods</h4>This prospective multicenter study was conducted in 2 gynecologic oncology centers between 2012 and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2017, 27(6):1200-1205]

Cited: 1 time

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Needleoscopic Conservative Staging of Borderline Ovarian Tumor.

Salvatore Gueli Alletti, Cristiano Rossitto, Emanuele Perrone, Stefano Cianci, Ilaria De Blasis, Anna Fagotti, Giovanni Scambia,

<h4>Study objective</h4>To investigate the safety and technical feasibility of needleoscopic fertility-sparing staging of borderline ovarian tumors.<h4>Design</h4>Video article and review of the literature (Canadian Task Force classification Level III).<h4>Setting</h4>This 29-year-old woman had a right ovarian cyst suspicious for borderline ovarian tumor on preoperative magnetic resonance imaging and ultrasound showing the presence ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2017, 24(4):529-530]

Cited: 5 times

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Total Laparoscopic (S-LPS) versus TELELAP ALF-X Robotic-Assisted Hysterectomy: A Case-Control Study.

Francesco Fanfani, Stefano Restaino, Cristiano Rossitto, Salvatore Gueli Alletti, Barbara Costantini, Giorgia Monterossi, Serena Cappuccio, Emanuele Perrone, Giovanni Scambia,

<h4>Study objective</h4>To compare the feasibility and safety of the TELELAP ALF-X system and standard laparoscopy for total hysterectomy to treat patients with benign and early malignant gynecologic disease.<h4>Design</h4>Single-institution retrospective case-control study (Canadian Task Force classification II-2).<h4>Setting</h4>Catholic University of the Sacred Heart, Rome, Italy.<h4>Patients</h4>Between October 2013 and May 2015, 203 women ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2016, 23(6):933-938]

Cited: 12 times

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