Full Text Journal Articles by
Author Elsa Lauwers

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Dementia and COVID-19: a health and research funding crisis.

Liesbeth Aerts, Elsa Lauwers, Bart De Strooper,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(2):90]

Cited: 0 times

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LifeTime and improving European healthcare through cell-based interceptive medicine.

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John C Marioni, Marc A Marti-Renom, Mihai G Netea, Dörthe Nickel, Marcelo Nollmann, Halina R Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Roman-Roman, Philip Rosenstiel, Joachim L Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet, ,

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence ... Read more >>

Nature (Nature)
[2020, 587(7834):377-386]

Cited: 3 times

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Potential human transmission of amyloid β pathology: surveillance and risks.

Elsa Lauwers, Giovanna Lalli, Sebastian Brandner, John Collinge, Veerle Compernolle, Charles Duyckaerts, Gustaf Edgren, Stéphane Haïk, John Hardy, Adel Helmy, Adrian J Ivinson, Zane Jaunmuktane, Mathias Jucker, Richard Knight, Robin Lemmens, I-Chun Lin, Seth Love, Simon Mead, V Hugh Perry, James Pickett, Guy Poppy, Sheena E Radford, Frederic Rousseau, Carol Routledge, Giampietro Schiavo, Joost Schymkowitz, Dennis J Selkoe, Colin Smith, Dietmar R Thal, Tom Theys, Pierre Tiberghien, Peter van den Burg, Philippe Vandekerckhove, Clare Walton, Hans L Zaaijer, Henrik Zetterberg, Bart De Strooper,

Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid β after systemic injections of contaminated growth hormone ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(10):872-878]

Cited: 2 times

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Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites.

Pranesh Padmanabhan, Adekunle T Bademosi, Ravikiran Kasula, Elsa Lauwers, Patrik Verstreken, Frédéric A Meunier,

Communication between cells relies on regulated exocytosis, a multi-step process that involves the docking, priming and fusion of vesicles with the plasma membrane, culminating in the release of neurotransmitters and hormones. Key proteins and lipids involved in exocytosis are subjected to Brownian movement and constantly switch between distinct motion states ... Read more >>

Neuropharmacology (Neuropharmacology)
[2020, 169:107554]

Cited: 2 times

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Hsp90 Mediates Membrane Deformation and Exosome Release.

Elsa Lauwers, Yu-Chun Wang, Rodrigo Gallardo, Rob Van der Kant, Emiel Michiels, Jef Swerts, Pieter Baatsen, Samantha S Zaiter, Shelli R McAlpine, Natalia V Gounko, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken,

Hsp90 is an essential chaperone that guards proteome integrity and amounts to 2% of cellular protein. We now find that Hsp90 also has the ability to directly interact with and deform membranes via an evolutionarily conserved amphipathic helix. Using a new cell-free system and in vivo measurements, we show this amphipathic ... Read more >>

Mol Cell (Molecular cell)
[2018, 71(5):689-702.e9]

Cited: 19 times

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Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye.

Elsa Lauwers, Patrik Verstreken,

Clathrin-mediated endocytosis plays essential roles both during and after development, and loss-of-function mutants affected in this process are mostly not viable. Different approaches have been developed to circumvent this limitation, including resorting to mosaic model organisms. We here describe the use of FLP/FRT-mediated mitotic recombination to generate Drosophila melanogaster having ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2018, 1847:109-119]

Cited: 2 times

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Presynaptic protein homeostasis and neuronal function.

Yu-Chun Wang, Elsa Lauwers, Patrik Verstreken,

Proteome integrity is maintained by a coordinated network of molecular chaperones, by protein degradation machineries and by their regulators. Numerous human pathologies are considered as diseases of compromised protein homeostasis (proteostasis), including neurodegeneration. These are characterized by the accumulation of neuronal protein aggregates and by synaptic defects followed by loss ... Read more >>

Curr Opin Genet Dev (Current opinion in genetics & development)
[2017, 44:38-46]

Cited: 18 times

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Membrane Lipids in Presynaptic Function and Disease.

Elsa Lauwers, Rose Goodchild, Patrik Verstreken,

Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves ... Read more >>

Neuron (Neuron)
[2016, 90(1):11-25]

Cited: 49 times

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Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy.

Valerie Uytterhoeven, Elsa Lauwers, Ine Maes, Katarzyna Miskiewicz, Manuel N Melo, Jef Swerts, Sabine Kuenen, Rafaël Wittocx, Nikky Corthout, Siewert-Jan Marrink, Sebastian Munck, Patrik Verstreken,

Synapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress. To identify membrane-associated machines that can engulf synaptic targets destined for degradation, we performed a large-scale in vitro liposome-based screen followed by functional studies. We identified a presynaptically ... Read more >>

Neuron (Neuron)
[2015, 88(4):735-748]

Cited: 51 times

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Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons.

Sven Vilain, Roeland Vanhauwaert, Ine Maes, Nils Schoovaerts, Lujia Zhou, Sandra Soukup, Raquel da Cunha, Elsa Lauwers, Mark Fiers, Patrik Verstreken,

Modern molecular genetics studies necessitate the manipulation of genes in their endogenous locus, but most of the current methodologies require an inefficient donor-dependent homologous recombination step to locally modify the genome. Here we describe a methodology to efficiently generate Drosophila knock-in alleles by capitalizing on the availability of numerous genomic ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2014, 4(12):2381-2387]

Cited: 8 times

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Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.

Joke Vandewalle, Marion Langen, Marlen Zschätzsch, Bonnie Nijhof, Jamie M Kramer, Hilde Brems, Marijke Bauters, Elsa Lauwers, Mohammed Srahna, Peter Marynen, Patrik Verstreken, Annette Schenck, Bassem A Hassan, Guy Froyen,

We recently reported that duplication of the E3 ubiquitin ligase HUWE1 results in intellectual disability (ID) in male patients. However, the underlying molecular mechanism remains unknown. We used Drosophila melanogaster as a model to investigate the effect of increased HUWE1 levels on the developing nervous system. Similar to the observed ... Read more >>

PLoS One (PloS one)
[2013, 8(11):e81791]

Cited: 9 times

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Correction: Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/β-Catenin Pathway in a Drosophila Model for Intellectual Disability

Joke Vandewalle, Marion Langen, Marlen Zschaetzsch, Bonnie Nijhof, Jamie M. Kramer, Hilde Brems, Marijke Bauters, Elsa Lauwers, Mohammed Srahna, Peter Marynen, Patrik Verstreken, Annette Schenck, Bassem A. Hassan, Guy Froyen,

PLoS One (PloS one)
[2014, 9(1):]

Cited: 0 times

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Nitrogen catabolite repressible GAP1 promoter, a new tool for efficient recombinant protein production in S. cerevisiae.

Fabien Debailleul, Cataldo Trubbia, Nancy Frederickx, Elsa Lauwers, Ahmad Merhi, Jean-Marie Ruysschaert, Bruno André, Cédric Govaerts,

<h4>Background</h4>Decades of work requiring heterologous expression of eukaryotic proteins have shown that no expression system can be considered as the panacea and the appropriate expression strategy is often protein-dependent. In a large number of cases, yeasts have proven to be reliable organisms for heterologous protein expression by combining eukaryotic cellular ... Read more >>

Microb Cell Fact (Microbial cell factories)
[2013, 12:129]

Cited: 3 times

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Chaperoning the synapse--NMNAT protects Bruchpilot from crashing.

Elsa Lauwers, Patrik Verstreken,

EMBO Rep (EMBO reports)
[2013, 14(1):5-6]

Cited: 1 time

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Systematic mutational analysis of the intracellular regions of yeast Gap1 permease.

Ahmad Merhi, Nicolas Gérard, Elsa Lauwers, Martine Prévost, Bruno André,

<h4>Background</h4>The yeast general amino acid permease Gap1 is a convenient model for studying the intracellular trafficking of membrane proteins. Present at the plasma membrane when the nitrogen source is poor, it undergoes ubiquitin-dependent endocytosis and degradation upon addition of a good nitrogen source, e.g., ammonium. It comprises 12 transmembrane domains ... Read more >>

PLoS One (PloS one)
[2011, 6(4):e18457]

Cited: 24 times

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Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease.

Melissa Vos, Elsa Lauwers, Patrik Verstreken,

Cell types rich in mitochondria, including neurons, display a high energy demand and a need for calcium buffering. The importance of mitochondria for proper neuronal function is stressed by the occurrence of neurological defects in patients suffering from a great variety of diseases caused by mutations in mitochondrial genes. Genetic ... Read more >>

Front Synaptic Neurosci (Frontiers in synaptic neuroscience)
[2010, 2:139]

Cited: 88 times

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The ubiquitin code of yeast permease trafficking.

Elsa Lauwers, Zoi Erpapazoglou, Rosine Haguenauer-Tsapis, Bruno André,

Yeast permeases, that act as transporters for nutrients including amino acids, nucleobases and metals, provide a powerful model system for dissecting the physiological control of membrane protein trafficking. Modification of these transporters by ubiquitin is known to target them for degradation in the vacuole, the degradation organelle of fungi. Recent ... Read more >>

Trends Cell Biol (Trends in cell biology)
[2010, 20(4):196-204]

Cited: 144 times

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K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway.

Elsa Lauwers, Christophe Jacob, Bruno André,

A growing number of yeast and mammalian plasma membrane proteins are reported to be modified with K63-linked ubiquitin (Ub) chains. However, the relative importance of this modification versus monoubiquitylation in endocytosis, Golgi to endosome traffic, and sorting into the multivesicular body (MVB) pathway remains unclear. In this study, we show ... Read more >>

J Cell Biol (The Journal of cell biology)
[2009, 185(3):493-502]

Cited: 133 times

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Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination.

Elsa Lauwers, Guido Grossmann, Bruno André,

Current models for plasma membrane organization integrate the emerging concepts that membrane proteins tightly associate with surrounding lipids and that biogenesis of surface proteins and lipids may be coupled. We show here that the yeast general amino acid permease Gap1 synthesized in the absence of sphingolipid (SL) biosynthesis is delivered ... Read more >>

Mol Biol Cell (Molecular biology of the cell)
[2007, 18(8):3068-3080]

Cited: 43 times

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Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB.

Séverine Steuve, Thalie Devosse, Elsa Lauwers, Jean-Marie Vanderwinden, Bruno André, Pierre J Courtoy, Isabelle Pirson,

Rhophilin-2 or p76(RBE), a protein whose expression is induced by the cyclic AMP pathway in thyrocytes, contains several protein-protein interaction domains including HR-1, Bro1 and PDZ domains, and is a partner of RhoB in its GTP-bound form (Eur J Biochem, 269(24): 6241-9, 2002). We here define its subcellular localization and ... Read more >>

Exp Cell Res (Experimental cell research)
[2006, 312(20):3981-3989]

Cited: 8 times

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Association of yeast transporters with detergent-resistant membranes correlates with their cell-surface location.

Elsa Lauwers, Bruno André,

Detergent-resistant membrane (DRM) fractions enriched in ergosterol and sphingolipids can be isolated from yeast cells and have been proposed to represent the biochemical equivalents of lipid rafts. Most yeast plasma membrane proteins studied for their detergent solubility have been found in DRMs, except for the Hxt1 and Gap1 permeases. We ... Read more >>

Traffic (Traffic (Copenhagen, Denmark))
[2006, 7(8):1045-1059]

Cited: 40 times

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