Full Text Journal Articles by
Author Ellen Wang

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Virtual reality for pediatric periprocedural care.

Ellen Wang, James J Thomas, Samuel T Rodriguez, Kristin M Kennedy, Thomas J Caruso,

<h4>Purpose of review</h4>Commercial availability of virtual reality headsets and software has exponentially grown over the last decade as it has become more sophisticated, less expensive, and portable. Although primarily used by the general public for entertainment, virtual reality has been adopted by periprocedural clinicians to improve patient experiences and treatments. ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):284-291]

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Leveraging Virtual Reality and Augmented Reality to Combat Chronic Pain in Youth: Position Paper From the Interdisciplinary Network on Virtual and Augmented Technologies for Pain Management.

Deirdre E Logan, Laura E Simons, Thomas J Caruso, Jeffrey I Gold, Walter Greenleaf, Anya Griffin, Christopher D King, Maria Menendez, Vanessa A Olbrecht, Samuel Rodriguez, Megan Silvia, Jennifer N Stinson, Ellen Wang, Sara E Williams, Luke Wilson,

<h4>Background</h4>Virtual reality (VR) and augmented reality (AR) interventions are emerging as promising tools in the treatment of pediatric chronic pain conditions. However, in this young field, there is little consensus to guide the process of engaging in the development and evaluation of targeted VR-based interventions.<h4>Objective</h4>The INOVATE-Pain (Interdisciplinary Network on Virtual ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2021, 23(4):e25916]

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A type I interferon response defines a conserved microglial state required for effective phagocytosis

Leah Dorman, Phi Nguyen, Caroline Escoubas, Ilia Vainchtein, Yinghong Xiao, Peter Lidsky, Ellen Wang, Sunrae Taloma, Hiromi Nakao-Inoue, Brianna Rivera, Carlo Condello, Raul Andino, Tomasz Nowakowski, Anna Molofsky,

Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the brain environment. We used single cell RNA sequencing to define glial responses in the early postnatal somatosensory cortex after partial whisker lesion, revealing transcriptomic shifts in both astrocytes and microglia during the resulting topographic ... Read more >>

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Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Ellen Q Wang, Vu Le, Melissa O'Gorman, Sakambari Tripathy, Martin E Dowty, Lisy Wang, Bimal K Malhotra,

Abrocitinib, an oral once-daily Janus kinase 1 selective inhibitor, is under development for treatment of atopic dermatitis. This phase 1, nonrandomized, open-label, single-dose study (NCT03626415) investigated the effect of hepatic impairment on pharmacokinetics (PK), safety, and tolerability of abrocitinib and its metabolites after a 200-mg oral dose. Twenty-four subjects with ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2021, :]

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Virtual Reality Augments Movement during Physical Therapy: A Pragmatic Randomized Trial.

Sydney Hemphill, Samuel Rodriguez, Ellen Wang, Kurt Koeppen, Bryn Aitken-Young, Christian Jackson, Laura Simons, Thomas J Caruso,

<h4>Objective</h4>Virtual reality (VR) facilitates physical therapy (PT) via improved engagement. While shown to benefit specific patient populations, such as stroke patients, it is less established in otherwise healthy adults and children receiving outpatient PT. The primary objective was to compare total PT-guided Movement supplemented with VR (PTMVR) to PT guided ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2021, :]

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Sudden anosmia and ageusia in a child: A COVID-19 case report

Ellen Wang, Seckin O. Ulualp, Christopher Liu, Maria Veling,

<h4>Objective</h4> COVID-19 in children has a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. The recognition of COVID-19 in children has been challenging due to overlap with symptoms of common respiratory and gastrointestinal tract infections. We describe isolated sudden anosmia and ageusia as an uncommon ... Read more >>

(Otolaryngology Case Reports)
[2021, 18:100267-100267]

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Virtual Reality Facilitates Engagement in Physical Therapy in the Pediatric CVICU.

Sydney Hemphill, Alan Nguyen, Joann Kwong, Samuel T Rodriguez, Ellen Wang, Thomas J Caruso,

<h4>Purpose</h4>The purpose of this report is to demonstrate the successful application of virtual reality to improve physical therapy in the pediatric cardiovascular intensive care unit. Early mobilization and cognitive stimulation improve morbidity of critically ill children. However, maintaining child engagement with these therapies can be challenging, especially during extended intensive ... Read more >>

Pediatr Phys Ther (Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association)
[2021, 33(1):E7-E9]

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Incidence of and Factors Associated With Prolonged and Persistent Postoperative Opioid Use in Children 0-18 Years of Age.

Andrew Ward, Elizabeth De Souza, Daniel Miller, Ellen Wang, Eric C Sun, Nicholas Bambos, T Anthony Anderson,

<h4>Background</h4>Long-term opioid use has negative health care consequences. Opioid-naïve adults are at risk for prolonged and persistent opioid use after surgery. While these outcomes have been examined in some adolescent and teenage populations, little is known about the risk of prolonged and persistent postoperative opioid use after common surgeries compared ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(4):1237-1248]

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RYK-mediated filopodial pathfinding facilitates midgut elongation.

Sha Wang, James P Roy, Abigail J Tomlinson, Ellen B Wang, Yu-Hwai Tsai, Lisa Cameron, Julie Underwood, Jason R Spence, Katherine D Walton, Steven A Stacker, Deborah L Gumucio, Terry Lechler,

Between embryonic days 10.5 and 14.5, active proliferation drives rapid elongation of the murine midgut epithelial tube. Within this pseudostratified epithelium, nuclei synthesize DNA near the basal surface and move apically to divide. After mitosis, the majority of daughter cells extend a long, basally oriented filopodial protrusion, building a <i>de ... Read more >>

Development (Development (Cambridge, England))
[2020, 147(20):]

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Using Augmented Reality to Reduce Fear and Promote Cooperation During Pediatric Otolaryngologic Procedures.

Thomas J Caruso, Martine Madill, Douglas Sidell, Kara Meister, Ellen Wang, Maria Menendez, Madison N Kist, Samuel Rodriguez,

This case series examines interactive AR during minor otolaryngologic procedures. Although VR has been successfully used for pediatric vascular access, removing children from comforting people in the real world has resulted in patient anxiety. AR offers a potential advantage, utilizing distracting holographic images when patients maintain eye contact with parents. ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, 131(4):E1342-E1344]

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Introduction of the EMR-integrated I-PASS ICU Handoff Tool.

Thomas J Caruso, Felice Su, Ellen Wang,

Pediatr Qual Saf (Pediatric quality & safety)
[2020, 5(4):e334]

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Guidance and Patient Instructions for Proning and Repositioning of Awake, Nonintubated COVID-19 Patients.

Suzanne K Bentley, Laura Iavicoli, David Cherkas, Rikki Lane, Ellen Wang, Maria Atienza, Phillip Fairweather, Stuart Kessler,

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2020, 27(8):787-791]

Cited: 1 time

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Association Between Race and Ethnicity with Intraoperative Analgesic Administration and Initial Recovery Room Pain Scores in Pediatric Patients: a Single-Center Study of 21,229 Surgeries.

Christine G Jette, Julia M Rosenbloom, Ellen Wang, Elizabeth De Souza, T Anthony Anderson,

INTRODUCTION:Perioperative pain may have deleterious effects for all patients. We aim to examine disparities in pain management for children in the perioperative period to understand whether any racial and ethnic groups are at increased risk of poor pain control. METHODS:Medical records from children ≤ 18 years of age who underwent surgery from ... Read more >>

J Racial Ethn Health Disparities (Journal of racial and ethnic health disparities)
[2020, :]

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Association Between Race and Ethnicity in the Delivery of Regional Anesthesia for Pediatric Patients: A Single-Center Study of 3189 Regional Anesthetics in 25,664 Surgeries.

Michael R King, Elizabeth De Souza, Julia M Rosenbloom, Ellen Wang, T Anthony Anderson,

BACKGROUND:Racial and ethnic disparities in health care are well documented in the United States, although evidence of disparities in pediatric anesthesia is limited. We sought to determine whether there is an association between race and ethnicity and the use of intraoperative regional anesthesia at a single academic children's hospital. METHODS:We ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(1):255-262]

Cited: 1 time

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State of the art in clinical decision support applications in pediatric perioperative medicine.

Ellen Wang, B Randall Brenn, Clyde T Matava,

<h4>Purpose of review</h4>The goal of this review is to describe the recent improvements in clinical decision tools applied to the increasingly large and complex datasets in the pediatric ambulatory and inpatient setting.<h4>Recent findings</h4>Clinical decision support has evolved beyond simple static alerts to complex dynamic alerts for: diagnosis, medical decision-making, monitoring ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2020, 33(3):388-394]

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A retrospective cohort study of predictors and interventions that influence cooperation with mask induction in children.

Juan L Marquez, Ellen Wang, Samuel T Rodriguez, Chloe O'Connell, Farrukh Munshey, Curtis Darling, Ban Tsui, Joseph Caruso, Thomas J Caruso,

BACKGROUND:Uncooperative pediatric mask induction is linked to perioperative anxiety. Although some risk factors for uncooperative inductions have been reported, there are no large cohort studies that identify intrinsic patient characteristics associated with cooperation. AIM:The primary aim was to identify patient characteristics associated with cooperative mask inductions. The secondary aim was ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(8):867-873]

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A Quality Improvement Project to Reduce Combination Acetaminophen-opioid Prescriptions to Pediatric Orthopedic Patients.

Thomas J Caruso, Sunny Trivedi, Whitney Chadwick, Shabnam Gaskari, Ellen Wang, Juan Marquez, Sara Lagasse, Madison Bailey, Kevin Shea,

<h4>Background</h4>Acetaminophen-opioid analgesics are among the most commonly prescribed pain medications in pediatric orthopedic patients. However, these combined opioid analgesics do not allow for individual medication titration, which can increase the risk of opioid misuse and hepatoxicity from acetaminophen. The primary aim of this quality improvement project was to alter the ... Read more >>

Pediatr Qual Saf (Pediatric quality & safety)
[2020, 5(3):e291]

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A QUALITY IMPROVEMENT PROJECT TO REDUCE THE USE OF COMBINATION OPIOID/ACETAMINOPHEN MEDICATIONS WITHIN A LARGE HEALTH SYSTEM

Sunny Trivedi, Kevin Shea, Whitney Chadwick, Shabnam Gaskari, Ellen Wang, Thomas Caruso,

<h4>Background:</h4> Combination analgesics are among the most commonly prescribed pain medications in pediatric orthopedic patients. However, combined analgesics do not allow for individual medication titration, which can increase the risk of opioid misuse and hepatoxicity from acetaminophen. Increasingly, the risks of combined analgesics associated with opioid misuse and hepatotoxicity are ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2020, 8(4 suppl3):]

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Programmed Intermittent Bolus Regimen for Erector Spinae Plane Blocks in Children: A Retrospective Review of a Single-Institution Experience.

Farrukh Munshey, Thomas J Caruso, Ellen Y Wang, Ban C H Tsui,

With few published reports on erector spinae plane block use in children, limited guidance on perioperative local anesthetic dosing exists. We present a series of 22 patients who received erector spinae plane catheters with programmed intermittent bolus for various surgeries. Median loading dose of 0.4 mL/kg (interquartile range [IQR], 0.1 ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(3):e63-e66]

Cited: 2 times

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Mobilization and calibration of the HTC VIVE for virtual reality physical therapy.

Sydney Hemphill, Alan Nguyen, Samuel T Rodriguez, Maria Menendez, Ellen Wang, Kiley Lawrence, Thomas J Caruso,

<h4>Aims</h4>The HTC VIVE virtual reality (VR) system is a potential tool for collecting kinematic data during inpatient and outpatient physical therapy (PT). When validated against research-grade systems, the VIVE has a reported translational error between 1.7 mm-2.0 cm. Our purpose was to portabilize the VIVE for room to room PT and validate ... Read more >>

Digit Health (Digital health)
[2020, 6:2055207620950929]

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A Pilot Quality Improvement Project to Reduce Preoperative Fasting Duration in Pediatric Inpatients.

Allison Nye, Erin Conner, Ellen Wang, Whitney Chadwick, Juan Marquez, Thomas J Caruso,

Despite guidelines allowing clear liquids up to 2 hours before anesthesia, preoperative fasting for pediatric inpatients is often unnecessarily prolonged. This delay can lead to prolonged recovery time and increased postoperative pain. Efforts to reduce fasting duration in pediatric surgical patients is an evolving standard in pediatric anesthesiology. The primary ... Read more >>

Pediatr Qual Saf (Pediatric quality & safety)
[2019, 4(6):e246]

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Assessing the Potential Risk of Cross-Reactivity Between Anti-Bococizumab Antibodies and Other Anti-PCSK9 Monoclonal Antibodies.

Ellen Q Wang, Jack F Bukowski, Carla Yunis, Charles L Shear, Paul M Ridker, Pamela F Schwartz, Daniel Baltrukonis,

<h4>Background</h4>Anti-drug antibodies (ADAs) to bococizumab were detected in > 40% of subjects in the SPIRE lipid-lowering trials. The risk of cross-reactivity between anti-bococizumab antibodies and other approved anti-proprotein convertase subtilisin/kexin type-9 (PCSK9) monoclonal antibodies (mAbs) was investigated using a single-assay approach.<h4>Methods</h4>Bococizumab immunogenicity was assessed in SPIRE-HR, a 52-week study. The highest ADA ... Read more >>

BioDrugs (BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy)
[2019, 33(5):571-579]

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A multifaceted quality improvement project improves intraoperative redosing of surgical antimicrobial prophylaxis during pediatric surgery.

Ashley A Colletti, Ellen Wang, Juan L Marquez, Hayden T Schwenk, Calida Yeverino, Paul J Sharek, Thomas J Caruso,

<h4>Background</h4>Accurate intraoperative antibiotic redosing contributes to prevention of surgical site infections in pediatric patients. Ensuring compliance with evolving national guidelines of weight-based, intraoperative redosing of antibiotics is challenging to pediatric anesthesiologists.<h4>Aims</h4>Our primary aim was to increase compliance of antibiotic redoses at the appropriate time and appropriate weight-based dose to 70%. ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(7):705-711]

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Differential Lung Ventilation Using a Bronchial Blocker in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Case Report.

Vidit Bhargava, Ali Arastu, Curtis Darling, Ellen Wang, Saraswati Kache,

We describe a patient with acute on chronic respiratory failure after a cardiac arrest who was cannulated to venoarterial extracorporeal membrane oxygenation. The patient developed right-sided interstitial emphysema with air leak and left-sided hemothorax with secondary atelectasis. A differential lung ventilation strategy was used in which an endotracheal tube was ... Read more >>

A A Pract (A&A practice)
[2019, 13(6):206-210]

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Intraoperative antibiotic redosing compliance and the extended postoperative recovery period: Often overlooked areas that may reduce surgical site infections.

Thomas J Caruso, Ellen Y Wang, Ashley A Colletti, Paul J Sharek,

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(3):290-291]

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