Full Text Journal Articles by
Author Elizabeth S Higgs

Advertisement

Find full text journal articles






Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials.

Timothy G Buchman, Ruxandra Draghia-Akli, Stacey J Adam, Neil R Aggarwal, Joshua P Fessel, Elizabeth S Higgs, Joseph P Menetski, Sarah W Read, Eric A Hughes, ,

Given the urgent need for coronavirus disease 2019 therapeutics, early in the pandemic the Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership rapidly designed a unique therapeutic agent intake and assessment process for candidate treatments of coronavirus disease 2019. These treatments included antivirals, immune modulators, severe acute ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1963-1973]

Cited: 0 times

View full text PDF listing >>



The impact of the 2014 Ebola epidemic on HIV disease burden and outcomes in Liberia West Africa.

Soka J Moses, Ian Wachekwa, Collin Van Ryn, Greg Grandits, Alice Pau, Moses Badio, Stephen B Kennedy, Michael C Sneller, Elizabeth S Higgs, H Clifford Lane, Mosoka Fallah, Stephen A Migueles, Cavan Reilly,

<h4>Background</h4>Detailed longitudinal studies of HIV-positive individuals in West Africa are lacking. Here the HIV prevalence, incidence, all-cause mortality, and the proportion of individuals receiving treatment with cART in two cohorts of participants in Ebola-related studies are described.<h4>Setting</h4>Individuals of all ages were enrolled and followed at four sites in the area ... Read more >>

PLoS One (PloS one)
[2021, 16(9):e0257049]

Cited: 0 times

View full text PDF listing >>



Advertisement

Community-based hospitals: New partners for government-sponsored clinical research during public health emergencies.

Laura A McNay, Gretchen Arnoczy, Mary Martell, Polly Mock, Mary E Wright, Shelly Simpson, Mary Smolskis, Elizabeth S Higgs,

In the United States, clinical trials of COVID-19 vaccines and therapeutics quickly exhausted available clinical research capacity at large medical centers. The NIAID Division of Clinical Research tapped community hospitals to help fill the gap. ... Read more >>

Vaccine (Vaccine)
[2021, 39(42):6183-6185]

Cited: 0 times

View full text PDF listing >>



Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV): Designing Master Protocols for Evaluation of Candidate COVID-19 Therapeutics.

Lisa LaVange, Stacey J Adam, Judith S Currier, Elizabeth S Higgs, Lora A Reineck, Eric A Hughes, Sarah W Read, ,

Working in an unprecedented time frame, the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership developed and launched 9 master protocols between 14 April 2020 and 31 May 2021 to allow for the coordinated and efficient evaluation of multiple investigational therapeutic agents for COVID-19. The ACTIV master protocols were ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(9):1293-1300]

Cited: 2 times

View full text PDF listing >>



Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

View full text PDF listing >>



PREVAIL IV: A Randomized, Double-Blind, Two-Phase, Phase 2 Trial of Remdesivir versus Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors.

Elizabeth S Higgs, Dehkontee Gayedyu-Dennis, William Fisher, Martha Nason, Cavan Reilly, Abdoul Habib Beavogui, Jamila Aboulhab, Jacqueline Nordwall, Princess Lobbo, Ian Wachekwa, Huyen Cao, Tomas Cihlar, Lisa Hensley, H Clifford Lane,

<h4>Background</h4>Ebola virus RNA persists in the semen of male Ebola survivors for months to years after the acute infection and male-to-female sexual transmission of the virus is well documented. We investigated whether remdesivir can safely reduce persistence of seminal Ebola virus RNA.<h4>Methods</h4>We recruited men with persistent seminal Ebola RNA in ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 1 time

View full text PDF listing >>



Characterization of Ebola Virus-Associated Eye Disease.

Allen O Eghrari, Rachel J Bishop, Robin D Ross, Bionca Davis, Jemma Larbelee, Fred Amegashie, Robert F Dolo, S Grace Prakalapakorn, Catherine Gaisie, Catherine Gargu, Yassah Sosu, Jennie Sackor, Precious Z Cooper, Augustine Wallace, Ruth Nyain, Maima Gray, Famatta Kamara, Bryn Burkholder, Christopher J Brady, Vincent Ray, Kirstin L Tawse, Ian Yeung, James D Neaton, Elizabeth S Higgs, H Clifford Lane, Cavan Reilly, Michael C Sneller, Mosoka P Fallah,

<h4>Importance</h4>Survivors of Ebola virus disease (EVD) may experience ocular sequelae. Comparison with antibody-negative individuals from the local population is required to characterize the disease.<h4>Objective</h4>To assess features of ophthalmic disease specific to EVD.<h4>Design, setting, and participants</h4>This baseline cross-sectional analysis of survivors of EVD and their close contacts was conducted within PREVAIL ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2032216]

Cited: 1 time

View full text PDF listing >>



A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.

, Jens D Lundgren, Birgit Grund, Christina E Barkauskas, Thomas L Holland, Robert L Gottlieb, Uriel Sandkovsky, Samuel M Brown, Kirk U Knowlton, Wesley H Self, D Clark Files, Mamta K Jain, Thomas Benfield, Michael E Bowdish, Bradley G Leshnower, Jason V Baker, Jens-Ulrik Jensen, Edward M Gardner, Adit A Ginde, Estelle S Harris, Isik S Johansen, Norman Markowitz, Michael A Matthay, Lars Østergaard, Christina C Chang, Victoria J Davey, Anna Goodman, Elizabeth S Higgs, Daniel D Murray, Thomas A Murray, Roger Paredes, Mahesh K B Parmar, Andrew N Phillips, Cavan Reilly, Shweta Sharma, Robin L Dewar, Marc Teitelbaum, Deborah Wentworth, Huyen Cao, Paul Klekotka, Abdel G Babiker, Annetine C Gelijns, Virginia L Kan, Mark N Polizzotto, B Taylor Thompson, H Clifford Lane, James D Neaton,

<h4>Background</h4>LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Covid-19.<h4>Methods</h4>In this platform trial of ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(10):905-914]

Cited: 76 times

View full text PDF listing >>



Characterization of an Asymptomatic Cohort of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Individuals Outside of Wuhan, China.

Yubo Wang, Yong He, Jin Tong, Yalan Qin, Ting Xie, Jianghua Li, Jianrong Li, Jianhua Xiang, Yong Cui, Elizabeth S Higgs, Jianglin Xiang,

<h4>Purpose</h4>We aimed to further clarify the epidemiological and clinical characteristics of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.<h4>Methods</h4>We identified close contacts of confirmed coronavirus disease 2019 (COVID-19) cases in northeast Chongqing, China, who were confirmed by real-time reverse transcription polymerase chain reaction-positive (RT-PCR+). We stratified this cohort by ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(16):2132-2138]

Cited: 32 times

View full text PDF listing >>



PREVAIL I Cluster Vaccination Study With rVSVΔG-ZEBOV-GP as Part of a Public Health Response in Liberia.

Fatorma K Bolay, Greg Grandits, H Clifford Lane, Stephen B Kennedy, Melvin P Johnson, Mosoka P Fallah, Barthalomew Wilson, Wissedi S Njoh, Laura A McNay, Lisa E Hensley, Elizabeth S Higgs,

OBJECTIVE:In November 2015, a 15-year-old boy received a diagnosis of Ebola virus disease (EVD) at the John F. Kennedy Medical Center in Monrovia, Liberia. Two additional family members received a diagnosis of EVD. The protocol for a phase 2 placebo-controlled trial of 2 Ebola vaccines was amended and approved; in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2019, 219(10):1634-1641]

Cited: 4 times

View full text PDF listing >>



A Longitudinal Study of Ebola Sequelae in Liberia.

, Michael C Sneller, Cavan Reilly, Moses Badio, Rachel J Bishop, Allen O Eghrari, Soka J Moses, Kumblytee L Johnson, Dehkontee Gayedyu-Dennis, Lisa E Hensley, Elizabeth S Higgs, Avindra Nath, Kaylie Tuznik, Justin Varughese, Kenneth S Jensen, Bonnie Dighero-Kemp, James D Neaton, H Clifford Lane, Mosoka P Fallah,

<h4>Background</h4>Multiple health problems have been reported in survivors of Ebola virus disease (EVD). Attribution of these problems to the disease without a control group for analysis is difficult.<h4>Methods</h4>We enrolled a cohort of EVD survivors and their close contacts and prospectively collected data on symptoms, physical examination findings, and laboratory results. ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(10):924-934]

Cited: 35 times

View full text PDF listing >>



Ring vaccination with rVSV-ZEBOV under expanded access in response to an outbreak of Ebola virus disease in Guinea, 2016: an operational and vaccine safety report.

Pierre-Stéphane Gsell, Anton Camacho, Adam J Kucharski, Conall H Watson, Aminata Bagayoko, Séverine Danmadji Nadlaou, Natalie E Dean, Abdourahamane Diallo, Abdourahmane Diallo, Djidonou A Honora, Moussa Doumbia, Godwin Enwere, Elizabeth S Higgs, Thomas Mauget, Diakite Mory, Ximena Riveros, Fofana Thierno Oumar, Mosoka Fallah, Alhassane Toure, Andrea S Vicari, Ira M Longini, W J Edmunds, Ana Maria Henao-Restrepo, Marie Paule Kieny, Sakoba Kéïta,

<h4>Background</h4>In March, 2016, a flare-up of Ebola virus disease was reported in Guinea, and in response ring vaccination with the unlicensed rVSV-ZEBOV vaccine was introduced under expanded access, the first time that an Ebola vaccine has been used in an outbreak setting outside a clinical trial. Here we describe the ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2017, 17(12):1276-1284]

Cited: 29 times

View full text PDF listing >>



Accelerating Vaccine Development During the 2013-2016 West African Ebola Virus Disease Outbreak.

Elizabeth S Higgs, Sheri A Dubey, Beth A G Coller, Jakub K Simon, Laura Bollinger, Robert A Sorenson, Barthalomew Wilson, Martha C Nason, Lisa E Hensley,

The Ebola virus disease outbreak that began in Western Africa in December 2013 was unprecedented in both scope and spread, and the global response was slower and less coherent than was optimal given the scale and pace of the epidemic. Past experience with limited localized outbreaks, lack of licensed medical ... Read more >>

Curr Top Microbiol Immunol (Current topics in microbiology and immunology)
[2017, 411:229-261]

Cited: 5 times

View full text PDF listing >>



Pregnancy outcomes in Liberian women who conceived after recovery from Ebola virus disease.

Mosoka P Fallah, Laura A Skrip, Bernice T Dahn, Tolbert G Nyenswah, Hilary Flumo, Meekie Glayweon, Tee L Lorseh, Stephen G Kaler, Elizabeth S Higgs, Alison P Galvani,

Lancet Glob Health (The Lancet. Global health)
[2016, 4(10):e678-9]

Cited: 14 times

View full text PDF listing >>



Use of Existing Diagnostic Reverse-Transcription Polymerase Chain Reaction Assays for Detection of Ebola Virus RNA in Semen.

James Pettitt, Elizabeth S Higgs, Rick D Adams, Peter B Jahrling, Lisa E Hensley,

Sexual transmission of Ebola virus in Liberia has now been documented and associated with new clusters in regions previously declared Ebola free. Assays that have Emergency Use Authorization (EUA) and are routinely used to detect Ebola virus RNA in whole blood and plasma specimens at the Liberian Institute for Biomedical ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2016, 213(8):1237-1239]

Cited: 12 times

View full text PDF listing >>



Understanding the role of mHealth and other media interventions for behavior change to enhance child survival and development in low- and middle-income countries: an evidence review.

Elizabeth S Higgs, Allison B Goldberg, Alain B Labrique, Stephanie H Cook, Carina Schmid, Charlotte F Cole, Rafael A Obregón,

Given the high morbidity and mortality among children in low- and middle-income countries as a result of preventable causes, the U.S. government and the United Nations Children's Fund convened an Evidence Summit on Enhancing Child Survival and Development in Lower- and Middle-Income Countries by Achieving Population-Level Behavior Change on June ... Read more >>

J Health Commun (Journal of health communication)
[2014, 19 Suppl 1:164-189]

Cited: 42 times

View full text PDF listing >>



Investigating financial incentives for maternal health: an introduction.

Mary Ellen Stanton, Elizabeth S Higgs, Marge Koblinsky,

Projection of current trends in maternal and neonatal mortality reduction shows that many countries will fall short of the UN Millennium Development Goal 4 and 5. Underutilization of maternal health services contributes to this poor progress toward reducing maternal and neonatal morbidity and mortality. Moreover, the quality of services continues ... Read more >>

J Health Popul Nutr (Journal of health, population, and nutrition)
[2013, 31(4 Suppl 2):1-7]

Cited: 5 times

View full text PDF listing >>



Financial incentives and maternal health: where do we go from here?

Lindsay Morgan, Mary Ellen Stanton, Elizabeth S Higgs, Robert L Balster, Ben W Bellows, Neal Brandes, Alison B Comfort, Rena Eichler, Amanda Glassman, Laurel E Hatt, Claudia M Conlon, Marge Koblinsky,

Health financing strategies that incorporate financial incentives are being applied in many low- and middle-income countries, and improving maternal and neonatal health is often a central goal. As yet, there have been few reviews of such programmes and their impact on maternal health. The US Government Evidence Summit on Enhancing ... Read more >>

J Health Popul Nutr (Journal of health, population, and nutrition)
[2013, 31(4 Suppl 2):8-22]

Cited: 8 times

View full text PDF listing >>



A taxonomy and results from a comprehensive review of 28 maternal health voucher programmes.

Ben W Bellows, Claudia M Conlon, Elizabeth S Higgs, John W Townsend, Matta G Nahed, Karen Cavanaugh, Corinne G Grainger, Jerry Okal, Anna C Gorter,

It is increasingly clear that Millennium Development Goal 4 and 5 will not be achieved in many low- and middle-income countries with the weakest gains among the poor. Recognizing that there are large inequalities in reproductive health outcomes, the post-2015 agenda on universal health coverage will likely generate strategies that ... Read more >>

J Health Popul Nutr (Journal of health, population, and nutrition)
[2013, 31(4 Suppl 2):106-128]

Cited: 12 times

View full text PDF listing >>



Evidence acquisition and evaluation for evidence summit on enhancing provision and use of maternal health services through financial incentives.

Elizabeth S Higgs, Emily Stammer, Rebecca Roth, Robert L Balster,

Recognizing the need for evidence to inform US Government and governments of the low- and middle-income countries on efficient, effective maternal health policies, strategies, and programmes, the US Government convened the Evidence Summit on Enhancing Provision and Use of Maternal Health Services through Financial Incentives in April 2012 in Washington, ... Read more >>

J Health Popul Nutr (Journal of health, population, and nutrition)
[2013, 31(4 Suppl 2):23-35]

Cited: 1 time

View full text PDF listing >>



A comparison of frameworks evaluating evidence for global health interventions.

Jill Luoto, Margaret A Maglione, Breanne Johnsen, Christine Chang, Elizabeth S Higgs, Tanja Perry, Paul G Shekelle,

PLoS Med (PLoS medicine)
[2013, 10(7):e1001469]

Cited: 6 times

View full text PDF listing >>



Neurocysticercosis: neglected but not forgotten.

Christina M Coyle, Siddhartha Mahanty, Joseph R Zunt, Mitchell T Wallin, Paul T Cantey, A Clinton White, Seth E O'Neal, Jose A Serpa, Paul M Southern, Patricia Wilkins, Anne E McCarthy, Elizabeth S Higgs, Theodore E Nash,

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2012, 6(5):e1500]

Cited: 69 times

View full text PDF listing >>



Evidence acquisition and evaluation for a U.S. Government Evidence Summit on Protecting Children Outside Family Care.

Elizabeth S Higgs, Vera M Zlidar, Robert L Balster,

Recognizing the need for evidence to inform policies, strategies, and programs to care for vulnerable children, the U.S. Government convened an Evidence Summit on Protecting Children Outside of Family Care on December 12-13, 2011, in Washington, DC, USA. This paper summarizes the background and methods for the acquisition and evaluation ... Read more >>

Child Abuse Negl (Child abuse & neglect)
[2012, 36(10):689-700]

Cited: 2 times

View full text PDF listing >>



End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease.

Michael G Ison, Menno D de Jong, Kevin J Gilligan, Elizabeth S Higgs, Andrew T Pavia, Jerome Pierson, Frederick G Hayden,

Influenza infection results in substantial morbidity and mortality in hospitalized patients, including those who are immunocompromised or pregnant. Antiviral therapy likely provides considerable benefit to these patients, but few studies have been successfully conducted in these high-risk populations, and no drugs are specifically licensed for treating these subgroups. One of ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2010, 201(11):1654-1662]

Cited: 41 times

View full text PDF listing >>



The ancillary-care obligations of medical researchers working in developing countries.

,

PLoS Med (PLoS medicine)
[2008, 5(5):e90]

Cited: 29 times

View full text PDF listing >>



Advertisement


Disclaimer

1.2245 s