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Author Elizabeth A Stephenson

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Loss of Ventricular Pre-excitation During Non-invasive Testing Does Not Exclude High-Risk Accessory Pathways: A Multicenter Study of WPW in Children.

Carolina A Escudero, Scott R Ceresnak, Kathryn K Collins, Robert H Pass, Peter F Aziz, Andrew D Blaufox, Michel Cabrera Ortega, Bryan C Cannon, Mitchell Cohen, Brynn E Dechert, Anne M Dubin, Kara S Motonaga, Michael R Epstein, Christopher C Erickson, Steven B Fishberger, Gregory J Gates, Christine A Capone, Lynn Nappo, Naomi J Kertesz, Jeffrey J Kim, Santiago O Valdes, Peter Kubuš, Ian H Law, Jennifer Maldonado, Jeremy P Moore, James C Perry, Shubhayan Sanatani, Stephen P Seslar, Ira Shetty, Frank J Zimmerman, Jonathan R Skinner, Luciana Marcondes, Elizabeth A Stephenson, Hiroko Asakai, Ronn E Tanel, Orhan Uzun, Susan P Etheridge, Christopher Janson,

BACKGROUND:Abrupt loss of ventricular pre-excitation on non-invasive evaluation, or non-persistent pre-excitation, in Wolff-Parkinson-White syndrome (WPW) is thought to indicate a low risk of life-threatening events. OBJECTIVE:To compare accessory pathway (AP) characteristics and occurrences of sudden cardiac arrest (SCA) and rapidly conducted pre-excited atrial fibrillation (RC-AF) in patients with non-persistent and ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, :]

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A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy.

Anastasia Miron, Myriam Lafreniere-Roula, Chun-Po Steve Fan, Katey R Armstrong, Andreea Dragulescu, Tanya Papaz, Cedric Manlhiot, Beth Kaufman, Ryan J Butts, Letizia Gardin, Elizabeth A Stephenson, Taylor S Howard, Peter F Aziz, Seshadri Balaji, Virginie Beauséjour Ladouceur, Lee N Benson, Steven D Colan, Justin Godown, Heather T Henderson, Jodie Ingles, Aamir Jeewa, John L Jefferies, Ashwin K Lal, Jacob Mathew, Emilie Jean-St-Michel, Michelle Michels, Stephanie J Nakano, Iacopo Olivotto, John J Parent, Alexandre C Pereira, Christopher Semsarian, Robert D Whitehill, Samuel G Wittekind, Mark W Russell, Jennifer Conway, Marc E Richmond, Chet Villa, Robert G Weintraub, Joseph W Rossano, Paul F Kantor, Carolyn Y Ho, Seema Mital,

Background: Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop and validate a SCD risk prediction model in pediatric HCM to guide SCD prevention strategies. Methods: In an international multi-center observational cohort study, phenotype-positive patients with isolated ... Read more >>

Circulation (Circulation)
[2020, :]

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ACC/AHA/ASE/HRS/ISACHD/SCAI/SCCT/SCMR/SOPE 2020 Appropriate Use Criteria for Multimodality Imaging During the Follow-Up Care of Patients With Congenital Heart Disease: A Report of the American College of Cardiology Solution Set Oversight Committee and Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Pediatric Echocardiography.

Ritu Sachdeva, Anne Marie Valente, Aimee K Armstrong, Stephen C Cook, B Kelly Han, Leo Lopez, George K Lui, Sarah S Pickard, Andrew J Powell, Nicole M Bhave, Ritu Sachdeva, Anne Marie Valente, Sarah S Pickard, Jeanne M Baffa, Puja Banka, Scott B Cohen, Julie S Glickstein, Joshua P Kanter, Ronald J Kanter, Yuli Y Kim, Alaina K Kipps, Larry A Latson, Jeannette P Lin, David A Parra, Fred H Rodriguez, Elizabeth V Saarel, Shubhika Srivastava, Elizabeth A Stephenson, Karen K Stout, Ali N Zaidi,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2020, 75(6):657-703]

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Prevalence, predictors and complications with defibrillation threshold testing in pediatric patients: Results from the NCDR.

Jordan M Prutkin, Yongfei Wang, Carolina A Escudero, Elizabeth A Stephenson, Karl E Minges, Jeptha P Curtis, Jonathan C Hsu,

BACKGROUND:There are little data about the prevalence and safety of DFT testing in pediatric populations. We analyzed the predictors and outcomes of defibrillation threshold (DFT) testing at the time of implantable cardioverter-defibrillator (ICD) implant and factors associated with inadequate defibrillation safety margin (DSM) in pediatric patients. METHODS:We performed a retrospective ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, 305:44-49]

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Family screening for hypertrophic cardiomyopathy: Is it time to change practice guidelines?

Myriam Lafreniere-Roula, Yoav Bolkier, Laura Zahavich, Jacob Mathew, Kristen George, Judith Wilson, Elizabeth A Stephenson, Leland N Benson, Cedric Manlhiot, Seema Mital,

AIMS:Current guidelines recommend initiating family screening for hypertrophic cardiomyopathy (HCM) after age 10 or 12 years unless early screening criteria are met. The aim was to evaluate if current screening guidelines miss early onset disease. METHODS AND RESULTS:Children who underwent family screening for HCM before age 18 years were analysed. Major cardiac ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(45):3672-3681]

Cited: 1 time

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Catheter ablation of supraventricular tachycardia after tricuspid valve surgery in patients with congenital heart disease: A multicenter comparative study.

Jeremy P Moore, Roberto G Gallotti, Anca Chiriac, Christopher J McLeod, Elizabeth A Stephenson, Khadijah Maghrabi, Frank A Fish, Orhan U Kilinc, David Bradley, Ulrich Krause, Seshadri Balaji, Kevin M Shannon,

BACKGROUND:Tricuspid valve (TV) surgery is often required for adult congenital heart disease (ACHD), but may hinder catheter ablation when an artificial material or imbricated tissue covers the tricuspid annulus. OBJECTIVE:The purpose of this study was to determine the outcomes of catheter ablation after TV surgery in a large ACHD cohort. ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(1):58-65]

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Riata lead failure in pediatric and congenital heart disease patients.

Carolina A Escudero, Douglas Y Mah, Christina Y Miyake, Elizabeth A Stephenson, Martin J LaPage, Peter Kubuš, Mitchell I Cohen, Joseph Atallah,

BACKGROUND:Implantable cardioverter defibrillator (ICD) lead failures occur at higher rates in pediatric and congenital heart disease (CHD) patients. OBJECTIVE:To determine the rate and timing of Riata lead failure in pediatric and CHD patients. METHODS:This was a retrospective, multicenter cohort study of pediatric patients and adults with CHD with implantation of ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2019, 30(3):320-325]

Cited: 0 times

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SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups.

Alban-Elouen Baruteau, Florence Kyndt, Elijah R Behr, Arja S Vink, Matthias Lachaud, Anna Joong, Jean-Jacques Schott, Minoru Horie, Isabelle Denjoy, Lia Crotti, Wataru Shimizu, Johan M Bos, Elizabeth A Stephenson, Leonie Wong, Dominic J Abrams, Andrew M Davis, Annika Winbo, Anne M Dubin, Shubhayan Sanatani, Leonardo Liberman, Juan Pablo Kaski, Boris Rudic, Sit Yee Kwok, Claudine Rieubland, Jacob Tfelt-Hansen, George F Van Hare, Béatrice Guyomarc'h-Delasalle, Nico A Blom, Yanushi D Wijeyeratne, Jean-Baptiste Gourraud, Hervé Le Marec, Junichi Ozawa, Véronique Fressart, Jean-Marc Lupoglazoff, Federica Dagradi, Carla Spazzolini, Takeshi Aiba, David J Tester, Laura A Zahavich, Virginie Beauséjour-Ladouceur, Mangesh Jadhav, Jonathan R Skinner, Sonia Franciosi, Andrew D Krahn, Mena Abdelsayed, Peter C Ruben, Tak-Cheung Yung, Michael J Ackerman, Arthur A Wilde, Peter J Schwartz, Vincent Probst,

Aims:To clarify the clinical characteristics and outcomes of children with SCN5A-mediated disease and to improve their risk stratification. Methods and results:A multicentre, international, retrospective cohort study was conducted in 25 tertiary hospitals in 13 countries between 1990 and 2015. All patients ≤16 years of age diagnosed with a genetically confirmed SCN5A ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(31):2879-2887]

Cited: 1 time

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Electrocardiograms in Healthy North American Children in the Digital Age.

Elizabeth V Saarel, Suzanne Granger, Jonathan R Kaltman, L LuAnn Minich, Martin Tristani-Firouzi, Jeffrey J Kim, Kathleen Ash, Sabrina S Tsao, Charles I Berul, Elizabeth A Stephenson, David G Gamboa, Felicia Trachtenberg, Peter Fischbach, Victoria L Vetter, Richard J Czosek, Tiffanie R Johnson, Jack C Salerno, Nicole B Cain, Robert H Pass, Ilana Zeltser, Eric S Silver, Joshua R Kovach, Mark E Alexander, ,

BACKGROUND:Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2018, 11(7):e005808]

Cited: 0 times

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Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study.

Susan P Etheridge, Carolina A Escudero, Andrew D Blaufox, Ian H Law, Brynn E Dechert-Crooks, Elizabeth A Stephenson, Anne M Dubin, Scott R Ceresnak, Kara S Motonaga, Jonathan R Skinner, Luciana D Marcondes, James C Perry, Kathryn K Collins, Stephen P Seslar, Michel Cabrera, Orhan Uzun, Bryan C Cannon, Peter F Aziz, Peter Kubuš, Ronn E Tanel, Santiago O Valdes, Sara Sami, Naomi J Kertesz, Jennifer Maldonado, Christopher Erickson, Jeremy P Moore, Hiroko Asakai, LuAnn Mill, Mark Abcede, Zebulon Z Spector, Shaji Menon, Mark Shwayder, David J Bradley, Mitchell I Cohen, Shubhayan Sanatani,

OBJECTIVES:This study sought to characterize risk in children with Wolff-Parkinson-White (WPW) syndrome by comparing those who had experienced a life-threatening event (LTE) with a control population. BACKGROUND:Children with WPW syndrome are at risk of sudden death. METHODS:This retrospective multicenter pediatric study identified 912 subjects ≤21 years of age with WPW syndrome, ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2018, 4(4):433-444]

Cited: 5 times

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Hemodynamic effects of sustained postoperative cardiac resynchronization therapy in infants after repair of congenital heart disease: Results of a randomized clinical trial.

Mark K Friedberg, Steven M Schwartz, Hargen Zhang, Christine Chiu-Man, Cedric Manlhiot, Maria V Ilina, Glen Van Arsdell, Joel A Kirsh, Brian W McCrindle, Elizabeth A Stephenson,

It is unknown whether continuous cardiac resynchronization therapy (CRT) can lead to sustained improvement in hemodynamics after surgery for congenital heart disease (CHD).We investigated whether CRT improves cardiac index (CI) and blood pressure in infants after biventricular repair of CHD.We randomized infants younger than 4 months after biventricular CHD surgery ... Read more >>

Heart Rhythm (Heart Rhythm)
[2017, 14(2):240-247]

Cited: 2 times

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A Clinical Risk Score to Improve the Diagnosis of Tachycardia-Induced Cardiomyopathy in Childhood.

Jeremy P Moore, Shuo Wang, Erin L Albers, Jack C Salerno, Elizabeth A Stephenson, Maully J Shah, Andreas Pflaumer, Richard J Czosek, Jason M Garnreiter, Kathryn Collins, Andrew L Papez, Shubhayan Sanatani, Nicole B Cain, Prince J Kannankeril, James C Perry, Ravi Mandapati, Jennifer N A Silva, Seshadri Balaji, Kevin M Shannon,

Tachycardia-induced cardiomyopathy (TIC) is a treatable cause of heart failure in children, but there is little information as to which clinical variables best discriminate TIC from other forms of cardiomyopathy. TIC cases with dilated cardiomyopathy (DC) from 16 participating centers were identified and compared with controls with other forms of ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2016, 118(7):1074-1080]

Cited: 2 times

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Classic-pattern dyssynchrony and electrical activation delays in pediatric dilated cardiomyopathy.

Daniel Forsha, Cameron Slorach, Ching Kit Chen, Elizabeth A Stephenson, Niels Risum, Christoph Hornik, Galen Wagner, Luc Mertens, Piers Barker, Joseph Kisslo, Mark K Friedberg,

BACKGROUND: Progressive heart failure leading to transplantation or death is common in pediatric dilated cardiomyopathy (DCM), and treatment options are limited. Select children with DCM have improved after cardiac resynchronization therapy (CRT), but predicting response is challenging. Nonetheless, considering the frequency of death or transplantation in this population, identifying any ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2014, 27(9):956-964]

Cited: 6 times

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Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy.

Jeremy P Moore, Payal A Patel, Kevin M Shannon, Erin L Albers, Jack C Salerno, Maya A Stein, Elizabeth A Stephenson, Shaun Mohan, Maully J Shah, Hiroko Asakai, Andreas Pflaumer, Richard J Czosek, Melanie D Everitt, Jason M Garnreiter, Anthony C McCanta, Andrew L Papez, Carolina Escudero, Shubhayan Sanatani, Nicole B Cain, Prince J Kannankeril, Andras Bratincsak, Ravi Mandapati, Jennifer N A Silva, Kenneth R Knecht, Seshadri Balaji,

Tachycardia-induced cardiomyopathy (TIC) carries significant risk of morbidity and mortality, although full recovery is possible. Little is known about the myocardial recovery pattern.The purpose of this study was to determine the time course and predictors of myocardial recovery in pediatric TIC.An international multicenter study of pediatric TIC was conducted. Children ... Read more >>

Heart Rhythm (Heart rhythm)
[2014, 11(7):1163-1169]

Cited: 16 times

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Mutation location effect on severity of phenotype during exercise testing in type 1 long-QT syndrome: impact of transmembrane and C-loop location.

Zachary W M Laksman, Robert M Hamilton, Priya Chockalingam, Emily Ballantyne, Elizabeth A Stephenson, Gil J Gross, Lorne J Gula, George J Klein, Arthur A M Wilde, Andrew D Krahn,

BACKGROUND: Targeted mutation site-specific differences have correlated C-loop missense mutations with worse outcomes and increased benefit of beta-blockers in LQT1. This observation has implicated the C-loop region as being mechanistically important in the altered response to sympathetic stimulation known to put patients with LQT1 at risk of syncope and sudden ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2013, 24(9):1015-1020]

Cited: 9 times

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The Canadian experience with Durata and Riata ST Optim defibrillator leads: a report from the Canadian Heart Rhythm Society Device Committee.

Matthew T Bennett, Andrew C T Ha, Derek V Exner, Stanley K K Tung, Ratika Parkash, Sean Connors, Benoit Coutu, Eugene Crystal, Jean Champagne, Francois Philippon, Raymond Yee, Elizabeth A Stephenson, Pablo B Nery, Vidal Essebag, Shubhayan Sanatani, Damian Redfearn, Andrew D Krahn, Jeffrey S Healey,

The St. Jude Medical Riata family of implantable cardioverter-defibrillator (ICD) leads has demonstrated a high rate of externalized conductors and electrical failure.Given similar design elements of Durata to Riata, the purpose of this study was to assess the rates of failure of the Riata ST Optim and Durata lead families ... Read more >>

Heart Rhythm (Heart rhythm)
[2013, 10(10):1478-1481]

Cited: 6 times

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It is all in the timing: mechanical and electrical dyssynchrony in hypoplastic left heart syndrome.

Elizabeth A Stephenson,

Heart Rhythm (Heart rhythm)
[2012, 9(12):2016-2017]

Cited: 0 times

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Comparison of Fontan survivors with and without pacemakers: a report from the Pediatric Heart Network Fontan Cross-Sectional Study.

Richard V Williams, Thomas Travison, Jonathan R Kaltman, Frank Cecchin, Steven D Colan, Salim F Idriss, Minmin Lu, Renee Margossian, John H Reed, Eric S Silver, Elizabeth A Stephenson, Victoria L Vetter, ,

Although many Fontan patients undergo pacemaker placement, there are few studies characterizing this population. Our purpose was to compare clinical characteristics, functional status and measures of ventricular performance in Fontan patients with and without a pacemaker.The National Heart, Lung, and Blood Institute funded Pediatric Heart Network Fontan Cross-Sectional Study characterized ... Read more >>

Congenit Heart Dis (Congenital heart disease)
[2013, 8(1):32-39]

Cited: 12 times

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Update on the use and outcomes of implantable cardioverter defibrillators in pediatric patients.

Christian J Turner, Elizabeth A Stephenson,

The vast majority of implantable cardioverter defibrillators (ICDs) continue to be implanted in the adult population. Accordingly, manufacturers develop devices and leads primarily for the adult population. Whilst the number of ICDs implanted in children is small in comparison, the potential benefits are large to this group. It is a ... Read more >>

Curr Treat Options Cardiovasc Med (Current treatment options in cardiovascular medicine)
[2012, 14(5):435-442]

Cited: 2 times

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The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants.

Shubhayan Sanatani, James E Potts, John H Reed, J Philip Saul, Elizabeth A Stephenson, Karen A Gibbs, Charles C Anderson, Andrew S Mackie, Pamela S Ro, Svjetlana Tisma-Dupanovic, Ronald J Kanter, Anjan S Batra, Anne Fournier, Andrew D Blaufox, Harinder R Singh, Bertrand A Ross, Kenny K Wong, Yaniv Bar-Cohen, Brian W McCrindle, Susan P Etheridge,

BACKGROUND: Supraventricular tachycardia (SVT) is one of the most common conditions requiring emergent cardiac care in children, yet its management has never been subjected to a randomized controlled clinical trial. The purpose of this study was to compare the efficacy and safety of the 2 most commonly used medications for ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2012, 5(5):984-991]

Cited: 28 times

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Nonphysiologic noise early after defibrillator implantation in Canada: incidence and implications: a report from the Canadian Heart Rhythm Society Device Committee.

Vidal Essebag, Jean Champagne, David H Birnie, Atul Verma, Jeffrey S Healey, Christopher S Simpson, Teresa Kus, Bernard Thibault, Iqwal Mangat, Stanley Tung, Laurence Sterns, Derek V Exner, Ted Davies, Benoit Coutu, Eugene Crystal, Elizabeth A Stephenson, Sean Connors, Felix Ayala Paredes, Ratika Parkash, Andrew D Krahn,

Following recent cases of nonphysiologic noise noted early after defibrillator implantation, the Canadian Heart Rhythm Society Device Committee decided to evaluate the implications of this problem.To determine the incidence and consequences of nonphysiologic noise early after defibrillator implantation.The Canadian Heart Rhythm Society Device Committee surveyed all Canadian defibrillator implanting centers ... Read more >>

Heart Rhythm (Heart rhythm)
[2012, 9(3):378-382]

Cited: 1 time

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The effect of NavX on fluoroscopy times in pediatric catheter ablation.

Wilson Kwong, Andrea L Neilson, Christine C Chiu, Gil J Gross, Robert M Hamilton, Luc Soucie, Elizabeth A Stephenson, Joel A Kirsh,

Catheter ablation is the established curative therapy for pediatric tachyarrhythmias. However, exposure to ionizing radiation from fluoroscopy during the procedure is of concern to both patients and caregivers. We sought to assess the impact of an impedance-based three-dimensional navigation system (NavX(TM), Endocardial Solutions, Inc., St. Paul, MN) on pediatric catheter ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2012, 33(1):123-126]

Cited: 16 times

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Arrhythmias in a contemporary fontan cohort: prevalence and clinical associations in a multicenter cross-sectional study.

Elizabeth A Stephenson, Minmin Lu, Charles I Berul, Susan P Etheridge, Salim F Idriss, Renee Margossian, John H Reed, Ashwin Prakash, Lynn A Sleeper, Victoria L Vetter, Andrew D Blaufox, ,

Our aim was to examine the prevalence of arrhythmias and identify independent associations of time to arrhythmia development.Since introduction of the Fontan operation in 1971, long-term results have steadily improved with newer modifications. However, atrial arrhythmias are frequent and contribute to ongoing morbidity and mortality. Data are lacking regarding the ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2010, 56(11):890-896]

Cited: 64 times

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Diagnosis-specific characteristics of ventricular tachycardia in children with structurally normal hearts.

Samuel Wang, Wei Zhu, Robert M Hamilton, Joel A Kirsh, Elizabeth A Stephenson, Gil J Gross,

Improved mechanistic insights and clinical tools provide increasing diagnostic refinement for ventricular tachycardia in young patients with structurally normal hearts, yielding potentially important prognostic and management implications.The purpose of this study was to survey the clinical characteristics and outcomes of otherwise healthy children with ventricular tachycardia (VT) who were classified ... Read more >>

Heart Rhythm (Heart rhythm)
[2010, 7(12):1725-1731]

Cited: 14 times

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Formation of a national network for rapid response to device and lead advisories: The Canadian Heart Rhythm Society Device Advisory Committee.

Andrew D Krahn, Christopher S Simpson, Ratika Parkash, Raymond Yee, Jean Champagne, Jeffrey S Healey, Doug Cameron, Bernard Thibault, Iqwal Mangat, Stanley Tung, Laurence Sterns, David H Birnie, Derek V Exner, Soori Sivakumaran, Ted Davies, Benoit Coutu, Eugene Crystal, Kevin Wolfe, Atul Verma, Elizabeth A Stephenson, Shubhayan Sanatani, Robert Gow, Sean Connors, Felix Ayala Paredes, Mike Turabian, Teresa Kus, Vidal Essebag, Martin Gardner,

The Canadian Heart Rhythm Society (CHRS) Device Advisory Committee was commissioned to respond to advisories regarding cardiac rhythm device and lead performance on behalf of the CHRS. In the event of an advisory, the Chair uses an e-mail network to disseminate advisory information to Committee members broadly representative of the ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2009, 25(7):403-405]

Cited: 3 times

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