Full Text Journal Articles by
Author Eliseo A Eugenin

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The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus.

Daniela D'Amico, Silvana Valdebenito, Eliseo A Eugenin,

Only recently, the role of large ionic channels such as Pannexin-1 channels and Connexin hemichannels has been implicated in several physiological and pathological conditions, including HIV infection and associated comorbidities. These channels are in a closed stage in healthy conditions, but in pathological conditions including HIV, Pannexin-1 channels and Connexin ... Read more >>

Purinergic Signal (Purinergic signalling)
[2021, :]

Cited: 0 times

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HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival.

Shaily Malik, Silvana Valdebenito, Daniela D'Amico, Brendan Prideaux, Eliseo A Eugenin,

HIV-associated neurological dysfunction is observed in more than half of the HIV-infected population, even in the current antiretroviral era. The mechanisms by which HIV mediates CNS dysfunction are not well understood but have been associated with the presence of long-lasting HIV reservoirs. In the CNS, macrophage/microglia and a small population ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2021, 206:102157]

Cited: 0 times

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Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions.

Silvana Valdebenito, Shaily Malik, Ross Luu, Olivier Loudig, Megan Mitchell, George Okafo, Krishna Bhat, Brendan Prideaux, Eliseo A Eugenin,

Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14556]

Cited: 0 times

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Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer.

Silvana Valdebenito, Paul Castellano, David Ajasin, Eliseo A Eugenin,

The major barrier to eradicating Human immunodeficiency virus-1 (HIV) infection is the generation of tissue-associated quiescent long-lasting viral reservoirs refractory to therapy. Upon interruption of anti-retroviral therapy (ART), HIV replication can be reactivated. Within the brain, microglia/macrophages and a small population of astrocytes are infected with HIV. However, the role ... Read more >>

J Neurochem (Journal of neurochemistry)
[2021, 158(2):429-443]

Cited: 3 times

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Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread.

George Okafo, Silvana Valdebenito, Maribel Donoso, Ross Luu, David Ajasin, Brendan Prideaux, Santhi Gorantla, Eliseo A Eugenin,

HIV has become a chronic disease despite the effective use of antiretroviral therapy (ART). However, the mechanisms of tissue colonization, viral evolution, generation of viral reservoirs, and compartmentalization are still a matter of debate due to the challenges involved in examining early events of infection at the cellular and molecular ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 205(10):2726-2741]

Cited: 1 time

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Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment.

Silvana Valdebenito, Alessandra Audia, Krishna P L Bhat, George Okafo, Eliseo A Eugenin,

Glioblastoma (GBM) is the most prevalent and aggressive tumor in the central nervous system. Surgical resection followed by concurrent radiotherapy (ionizing radiation [IR]) and temozolomide (TMZ) is the standard of care for GBM. However, a large subset of patients offer resistance or become adapted to TMZ due mainly to the ... Read more >>

iScience (iScience)
[2020, 23(9):101450]

Cited: 5 times

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HIV-1 Tat: Role in Bystander Toxicity.

David Ajasin, Eliseo A Eugenin,

HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its role as the transactivator of HIV transcription is well-established, other non-viral replication-associated functions have been described in several HIV-comorbidities even in the current antiretroviral therapy (ART) era. HIV Tat protein is produced and released ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:61]

Cited: 10 times

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Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland.

Eliseo A Eugenin, Silvana Valdebenito, Anna Maria Gorska, Agustin D Martínez, Marcela Bitran, Juan C Sáez,

Chemical and electrical synapses are the two major communication systems that permit cell-to-cell communication within the nervous system. Although most studies are focused on chemical synapses (glutamate, γ-aminobutyric acid, and other neurotransmitters), clearly both types of synapses interact and cooperate to allow the coordination of several cell functions within the ... Read more >>

J Neurochem (Journal of neurochemistry)
[2019, 151(5):558-569]

Cited: 2 times

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Circulating levels of ATP is a biomarker of HIV cognitive impairment.

Stephani Velasquez, Lisa Prevedel, Silvana Valdebenito, Anna Maria Gorska, Mikhail Golovko, Nabab Khan, Jonathan Geiger, Eliseo A Eugenin,

<h4>Background</h4>In developed countries, Human Immunodeficiency Virus type-1 (HIV-1) infection has become a chronic disease despite the positive effects of anti-retroviral therapies (ART), but still at least half of the HIV infected population shown signs of cognitive impairment. Therefore, biomarkers of HIV cognitive decline are urgently needed.<h4>Methods</h4>We analyze the opening of ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 51:102503]

Cited: 6 times

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Role of cell-to-cell communication in cancer: New features, insights, and directions.

Eliseo A Eugenin,

The current special issue entitled "Role of tunneling nanotubes (TNTs) in carcinogenesis" was designed to discuss the role of cell-to-cell communication, especially TNTs, in cancer pathogenesis. In addition, we discuss the exploitation of TNTs as a potential therapeutic target to prevent and reduce cancer incidence. It is accepted that cell-to-cell ... Read more >>

Cancer Rep (Hoboken) (Cancer reports (Hoboken, N.J.))
[2019, 2(6):e1228]

Cited: 1 time

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The malaria toxin hemozoin induces apoptosis in human neurons and astrocytes: Potential role in the pathogenesis of cerebral malaria.

Eliseo A Eugenin, James A Martiney, Joan W Berman,

Malaria, caused by an intracellular protozoan parasite of the genus Plasmodium, is one of the most important infectious diseases worldwide. In 2017, a total of 219 millions cases were reported with 435,000 deaths related to malaria. A major complication of malaria infection is cerebral malaria (CM), characterized by enhanced blood-brain ... Read more >>

Brain Res (Brain research)
[2019, 1720:146317]

Cited: 4 times

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Toll-like receptor 9 antagonism modulates astrocyte function and preserves proximal axons following spinal cord injury.

Lun Li, Li Ni, Eliseo A Eugenin, Robert F Heary, Stella Elkabes,

Increasing evidence indicates that innate immune receptors play important, yet controversial, roles in traumatic central nervous system (CNS) injury. Despite many advances, the contributions of toll-like receptors (TLRs) to spinal cord injury (SCI) remain inadequately defined. We previously reported that a toll-like receptor 9 (TLR9) antagonist, oligodeoxynucleotide 2088 (ODN 2088), ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2019, 80:328-343]

Cited: 6 times

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HIV infection and latency induce a unique metabolic signature in human macrophages.

Paul Castellano, Lisa Prevedel, Silvana Valdebenito, Eliseo A Eugenin,

Currently, a major barrier to curing HIV infection is the generation of tissue-associated, non-replicating, long-lasting viral reservoirs that are refractory to therapy and can be reactivated upon anti-retroviral therapy interruption. One of these reservoirs are latently HIV-infected macrophages. Here, we show that HIV infection of macrophages results in survival of ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):3941]

Cited: 17 times

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A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation.

Arthur P Ruiz, David O Ajasin, Santhamani Ramasamy, Vera DesMarais, Eliseo A Eugenin, Vinayaka R Prasad,

HIV-1 Tat protein contributes to HIV-neuropathogenesis in several ways including its ability to be taken up by uninfected bystander CNS cells and to activate inflammatory host genes causing synaptic injury. Here, we report that in the globally dominant HIV-1 clade C, Tat displays a naturally occurring polymorphism, R57S, in its ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):3308]

Cited: 3 times

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HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy.

Yonatan Ganor, Fernando Real, Alexis Sennepin, Charles-Antoine Dutertre, Lisa Prevedel, Lin Xu, Daniela Tudor, Bénédicte Charmeteau, Anne Couedel-Courteille, Sabrina Marion, Ali-Redha Zenak, Jean-Pierre Jourdain, Zhicheng Zhou, Alain Schmitt, Claude Capron, Eliseo A Eugenin, Rémi Cheynier, Marc Revol, Sarra Cristofari, Anne Hosmalin, Morgane Bomsel,

Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital mucosal tissues (the main HIV-1 entry portal on sexual transmission). Here, we show, using penile tissues from HIV-1-infected individuals under suppressive combination antiretroviral therapy, ... Read more >>

Nat Microbiol (Nature microbiology)
[2019, 4(4):633-644]

Cited: 77 times

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Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy.

Lisa Prevedel, Nancy Ruel, Paul Castellano, Carla Smith, Shaily Malik, Courtney Villeux, Morgane Bomsel, Susan Morgello, Eliseo A Eugenin,

The major barrier to eradicating human immunodeficiency virus-1 (HIV) infection is the generation and extended survival of HIV reservoirs. In order to eradicate HIV infection, it is essential to detect, quantify, and characterize circulating and tissue-associated viral reservoirs in infected individuals. Currently, PCR-based technologies and Quantitative Viral Outgrowth Assays (Q-VOA) ... Read more >>

Curr Protoc Cell Biol (Current protocols in cell biology)
[2019, 82(1):e64]

Cited: 6 times

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Inflammatory mediators reduce surface PrPc on human BMVEC resulting in decreased barrier integrity.

Bezawit W Megra, Eliseo A Eugenin, Joan W Berman,

The cellular prion protein (PrP<sup>c</sup>) is a surface adhesion molecule expressed at junctions of various cell types including brain microvascular endothelial cells (BMVEC) that are important components of the blood-brain barrier (BBB). PrP<sup>c</sup> is involved in several physiological processes including regulation of epithelial cell barrier function and monocyte migration across ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2018, 98(10):1347-1359]

Cited: 4 times

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Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.

Jansy P Sarathy, Laura E Via, Danielle Weiner, Landry Blanc, Helena Boshoff, Eliseo A Eugenin, Clifton E Barry, Véronique A Dartois,

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance are among the factors driving the long therapy duration. Assays to measure in situ drug susceptibility of Mycobacterium tuberculosis bacteria in pulmonary lesions are needed ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2018, 62(2):]

Cited: 48 times

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Connexin43 Containing Gap Junction Channels Facilitate HIV Bystander Toxicity: Implications in NeuroHIV.

Shaily Malik, Martin Theis, Eliseo A Eugenin,

Human immunodeficiency virus-1 (HIV-1) infection compromises the central nervous system (CNS) in a significant number of infected individuals, resulting in neurological dysfunction that ranges from minor cognitive deficits to frank dementia. While macrophages/microglia are the predominant CNS cells infected by HIV, our laboratory and others have shown that HIV-infected astrocytes, ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2017, 10:404]

Cited: 7 times

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HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim.

Paul Castellano, Lisa Prevedel, Eliseo A Eugenin,

While HIV kills most of the cells it infects, a small number of infected cells survive and become latent viral reservoirs, posing a significant barrier to HIV eradication. However, the mechanism by which immune cells resist HIV-induced apoptosis is still incompletely understood. Here, we demonstrate that while acute HIV infection ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):12866]

Cited: 38 times

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HIV-Associated Cardiovascular Disease: Role of Connexin 43.

Lisa Prevedel, Camilla Morocho, Michael V L Bennett, Eliseo A Eugenin,

Chronic HIV infection due to effective antiretroviral treatment has resulted in a broad range of clinical complications, including accelerated heart disease. Individuals with HIV infection have a 1.5 to 2 times higher incidence of cardiovascular diseases than their uninfected counterparts; however, the underlying mechanisms are poorly understood. To explore the ... Read more >>

Am J Pathol (The American journal of pathology)
[2017, 187(9):1960-1970]

Cited: 4 times

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Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.

Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I Israel, Shunsuke Kimura, Robert B Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A Skeberdis, Ian F Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo,

Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2017, 10:333]

Cited: 69 times

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Role of Connexin and Pannexin containing channels in HIV infection and NeuroAIDS.

Shaily Malik, Eliseo A Eugenin,

Neuron-Glia crosstalk is essential for efficient synaptic communication, cell growth and differentiation, neuronal activity, neurotransmitter recycling, and brain immune response. The master regulators of this neuron-glia communication are connexin containing Gap Junctions (GJs) and Hemichannels (HCs) as well as pannexin HCs. However, the role of these channels under pathological conditions, ... Read more >>

Neurosci Lett (Neuroscience letters)
[2019, 695:86-90]

Cited: 8 times

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The Role of Shed PrPc in the Neuropathogenesis of HIV Infection.

Bezawit W Megra, Eliseo A Eugenin, Joan W Berman,

HIV-1 enters the CNS soon after peripheral infection and causes chronic neuroinflammation and neuronal damage that leads to cognitive impairment in 40-70% of HIV-infected people. The nonpathogenic cellular isoform of the human prion protein (PrP<sup>c</sup>) is an adhesion molecule constitutively expressed in the CNS. Previously, our laboratory showed that shed ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2017, 199(1):224-232]

Cited: 7 times

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The role of connexin and pannexin containing channels in the innate and acquired immune response.

Silvana Valdebenito, Andrea Barreto, Eliseo A Eugenin,

Connexin (Cx) and pannexin (Panx) containing channels - gap junctions (GJs) and hemichannels (HCs) - are present in virtually all cells and tissues. Currently, the role of these channels under physiological conditions is well defined. However, their role in the immune response and pathological conditions has only recently been explored. ... Read more >>

Biochim Biophys Acta Biomembr (Biochimica et biophysica acta. Biomembranes)
[2018, 1860(1):154-165]

Cited: 13 times

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