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Author Elif Cadirci

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Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

Duygu Kose, Harun Un, Rustem Anil Ugan, Zekai Halici, Elif Cadirci, Tugba Bal Tastan, Aysenur Kahramanlar,

<h4>Objectives</h4>We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.<h4>Methods</h4>A total of 40 rats were divided into 5 groups with 8 animals in each group. Group 1 (SHAM), control group; Group 2 ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2021, :]

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The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats.

Duygu Köse, Tuğba Nurcan Yüksel, Zekai Halıcı, Elif Çadırcı, Muhammed Ali Gürbüz,

<h4>Objective</h4>We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods.<h4>Materials and methods</h4>In our experimental model, the 32 rats were divided into 4 groups: group 1: control group (HEALTHY); group 2: lipopolysaccharide group (LPS); group 3: LPS ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2021, 53(2):127-131]

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5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.

Irfan Cinar, Busra Sirin, Zekai Halici, Saziye Sezin Palabiyik-Yucelik, Erol Akpinar, Elif Cadirci,

Prostate cancer (PCa) is one of the most common types of cancer seen among men worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation, migration, and invasion in vitro; the presence of 5-HT receptors in cancer cells; and the role of serotonin in tumor development. The most recently discovered ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(6):1205-1213]

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Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation.

Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici,

<h4>Aim</h4>Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.<h4>Main methods</h4>Totally, 48 Balb/C female mice were separated into eight groups (n = 6). ... Read more >>

Life Sci (Life sciences)
[2021, 266:118869]

Cited: 2 times

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Investigation of the Role of Stimulation and Blockade of 5-HT7 Receptors in Ketamine Anesthesia.

Busra Dincer, Zekai Halici, Elif Cadirci,

Although several pieces of evidence have indicated the ability of the serotonin-7 receptor (5-HTR<sub>7</sub>) to modulate N-methyl-<sub>D</sub>-aspartate receptor (NMDAR) activation, the possible impact on ketamine anesthesia has not been examined directly. The purpose of the present study is thus to investigate the possible role of the 5-HTR<sub>7</sub> in ketamine anesthesia ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, 71(5):1095-1111]

Cited: 1 time

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Isolation of Major Compounds and Gastroprotective Activity of Alchemilla Caucasica on Indomethacin Induced Gastric Ulcers in Rats.

Esen Sezen Karaoglan, Yasin Bayir, Abdulmecit Albayrak, Erdem Toktay, Ufuk Ozgen, Cavit Kazaz, Aysenur Kahramanlar, Elif Cadirci,

<h4>Objective</h4>The <i>Alchemilla</i> genus, which belongs to the Rosaceae family, is known as Lady's mantle and is commonly used in traditional medicine. This study was designed to investigate the major metabolites isolation and gastroprotective effects of <i>Alchemilla caucasica</i>.<h4>Materials and methods</h4>Phytochemical studies were carried out using column chromatography on <i>Alchemilla caucasica</i>. The ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(3):249-253]

Cited: 0 times

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Possible contribution of the neprilysin/ACE pathway to sepsis in mice.

Rustem Anil Ugan, Harun Un, Muhammed Ali Gurbuz, Gokce Kaya, Aysenur Kahramanlar, Zeynep Berna Aksakalli-Magden, Zekai Halici, Elif Cadirci,

<h4>Aim</h4>Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.<h4>Main methods</h4>A cecal ligation and puncture (CLP) sepsis model was used to evaluate 10 and 20 mg/kg doses of omapatrilat in ... Read more >>

Life Sci (Life sciences)
[2020, 258:118177]

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LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats.

Ilknur Calik, Muhammed Yayla, Irfan Cinar, Elif Cadirci, Abdulmecit Albayrak, Busra Sirin, Muhammet Calik, Zekai Halici,

<h4>Aim</h4>This study aimed to demonstrate the role of serotonin 7 receptor (5-HT<sub>7</sub>) and the effects of 5-HT<sub>7</sub> agonists and antagonists in an indomethacin-induced gastric ulcer.<h4>Material and method</h4>Male albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT<sub>7</sub> agonist) and SB269970 (5-HT<sub>7</sub> antagonist) were administered at 10 mg/kg as a pre-treatment. One ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(4):893-902]

Cited: 0 times

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Can aprepitant used for nausea and vomiting be good gastrointestinal complaints?

Rustem Anil Ugan, Harun Un, Duygu Kose, Elif Cadirci, Tugba Bal Tastan, Muhammed Yayla, Zekai Halici,

Aprepitant is a selective SP/NK-1 receptor antagonist and used in postoperative and chemotherapeutics induced emesis and vomiting. The aim of our study is to show aprepitant may have beneficial effects on gastrointestinal complaints in cancer patients undergoing chemotherapeutics by indomethacin-induced gastric ulcer model. A total of 48 rats were fasted ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2020, 393(12):2463-2472]

Cited: 0 times

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A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity.

Harun Un, Rustem Anil Ugan, Duygu Kose, Yasin Bayir, Elif Cadirci, Jale Selli, Zekai Halici,

Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induced nephrotoxicity and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 880:173168]

Cited: 4 times

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Regenerative Effect of Resorbable Scaffold Embedded Boron-Nitride/Hydroxyapatite Nanoparticles in Rat Parietal Bone.

Muhammed Yayla, Elif Cadirci, Zekai Halici, Feray Bakan, Nuran Ay, Selami Demirci, Adem Karaman, Fikrettin Sahin,

BN has important roles in several physiological events, including bone growth and immune system. New infection-free cranioplasty and has an osteogenic activities material that are compatible with tissue are being developed. We aimed in our study to examine whether different combinations of Boron-nitride/Hydroxyapatite are embedded into the scaffold in the ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(2):680-691]

Cited: 1 time

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The investigation of possible roles of central 5-HT7 receptors in antipyretic effect mechanism of paracetamol in LPS-induced hyperthermia model of mice.

Duygu Kose, Elif Cadirci, Zekai Halici, Busra Sirin, Busra Dincer,

<h4>Aim</h4>This study aimed to investigate the role of the 5-HT<sub>7</sub> receptor in fever mechanisms and its possible effect on the antipyretic mechanism of paracetamol.<h4>Materials and methods</h4>The study consisted of eight experimental groups and one control group. Group I: healthy, II: LPS, III: LPS + PARA, IV: LPS + AGO, V: LPS + ANTA, VI: LPS + AGO + ANTA, VII: ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2019, 27(6):1169-1178]

Cited: 1 time

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The effects of Beeswax, Olive oil and Butter impregnated bandage on burn wound healing.

Yasin Bayir, Harun Un, Rustem Anil Ugan, Erol Akpinar, Elif Cadirci, Ilknur Calik, Zekai Halici,

<h4>Background</h4>Beeswax, Olive oil and Butter (BOB) are nutritive products that could support wound healing by adsorption to bandage. This study demonstrated the therapeutic effects of BOB on second degree burn.<h4>Methods</h4>Second degree burn model was created in rats. Experimental groups were assigned to Healthy, Burn, Silver Sulfadiazine (SS) and BOB. The ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2019, 45(6):1410-1417]

Cited: 0 times

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Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats.

Irfan Cinar, Busra Sirin, Pelin Aydin, Erdem Toktay, Elif Cadirci, Iclal Halici, Zekai Halici,

<h4>Aims</h4>Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of ... Read more >>

Life Sci (Life sciences)
[2019, 221:327-334]

Cited: 4 times

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Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways.

Tugba Nurcan Yuksel, Muhammed Yayla, Zekai Halici, Elif Cadirci, Beyzagul Polat, Duygu Kose,

Serotonin exerts anti-inflammatory, antioxidant and antiapoptotic effects through 5-HT7 receptors. The present study determined the role of 5-HT7 receptors in glutamate-induced neurotoxicity by using human SH-SY5Y neuroblastoma cells. The cells were pretreated with different concentrations of 5-HT7 receptor agonist LP44 and antagonist SB269970 for 60 min, followed by treatment with glutamate. ... Read more >>

Neurotoxicol Teratol (Neurotoxicology and teratology)
[2019, 72:22-28]

Cited: 2 times

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Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats.

Yasin Bayir, Harun Un, Elif Cadirci, Erol Akpinar, Busra Diyarbakir, Ilknur Calik, Zekai Halici,

Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues ... Read more >>

An Acad Bras Cienc (Anais da Academia Brasileira de Ciencias)
[2019, 91(1):e20180106]

Cited: 1 time

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Urotensin receptors as a new target for CLP induced septic lung injury in mice.

Elif Cadirci, Rustem Anil Ugan, Busra Dincer, Betul Gundogdu, Irfan Cinar, Erol Akpinar, Zekai Halici,

Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in pulmonary, cardiovascular, central nervous, renal and metabolic systems, and especially in inflammatory regions. This study aimed to investigate whether urotensin II (UII) and UII receptor (UTR) ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2019, 392(2):135-145]

Cited: 1 time

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Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.

Fadime Atalay Dumlu, Tuba Aydin, Fehmi Odabasoglu, Ozlem Aydin Berktas, Zerrin Kutlu, Huseyin Serkan Erol, Mesut B Halici, Elif Cadirci, Ahmet Cakir,

<h4>Background</h4>Veratrum, hellebore is an important plant species of the Liliaceae family and jervine is the characteristic steroidal alkaloid constituent of Veratrum album.<h4>Purpose</h4>In the current study, anti-inflammatory and antioxidant effects of jervine isolated from NH<sub>4</sub>OH-benzene extract of V. album rhizomes were investigated on CAR induced paw edema in rats.<h4>Methods/study design</h4>In inflammatory ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 55:191-199]

Cited: 2 times

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The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions.

Rustem Anil Ugan, Elif Cadirci, Zekai Halici, Erdem Toktay, Irfan Cinar,

This study aimed to investigate the potential role of urotensin-II receptors in sepsis-induced lung injury in diabetic mice using urotensin-II receptor agonists and antagonists. A total of 110 male CD1 mice were used in this study. Diabetes was induced by 200mg/kg streptozotocin. One month after diabetes induction, the cecal ligation ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2018, 818:457-469]

Cited: 3 times

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A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: the protective potential of epigallocatechin-3-gallate.

Saziye Sezin Palabiyik, Busra Dincer, Elif Cadirci, Irfan Cinar, Cemal Gundogdu, Beyzagul Polat, Muhammed Yayla, Zekai Halici,

Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its ... Read more >>

Ren Fail (Renal failure)
[2017, 39(1):314-322]

Cited: 2 times

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Sepsis and Septic Shock: Current Treatment Strategies and New Approaches.

Gizem Polat, Rustem Anil Ugan, Elif Cadirci, Zekai Halici,

Sepsis is a complex condition characterized by the simultaneous activation of inflammation and coagulation in response to microbial insult. These events manifest as systemic inflammatory response syndrome or sepsis symptoms through the release of proinflammatory cytokines, procoagulants, and adhesion molecules from immune cells and/or damaged endothelium. Today, sepsis is a ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2017, 49(1):53-58]

Cited: 27 times

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Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.

Beyzagul Polat, Zekai Halici, Elif Cadirci, Emre Karakus, Yasin Bayir, Abdulmecit Albayrak, Deniz Unal,

<h4>Background and aim</h4>Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2017, 43:227-235]

Cited: 11 times

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Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.

Zekai Halici, Beyzagul Polat, Elif Cadirci, Atilla Topcu, Emre Karakus, Duygu Kose, Abdulmecit Albayrak, Yasin Bayir,

<h4>Purpose</h4>Previously blocking the renin angiotensin system (RAAS) has been effective in the prevention of gastric damage. Therefore, the aim of this study was to investigate the effects of aliskiren, and thus, direct renin blockage, in indomethacin-induced gastric damage model.<h4>Methods</h4>Effects of aliskiren were evaluated in indomethacin-induced gastric damage model on Albino ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2016, 258:266-275]

Cited: 5 times

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Evaluation of 5-HT7 Receptor Trafficking on In Vivo and In Vitro Model of Lipopolysaccharide (LPS)-Induced Inflammatory Cell Injury in Rats and LPS-Treated A549 Cells.

Gulsen Ayaz, Zekai Halici, Abdulmecit Albayrak, Emre Karakus, Elif Cadirci,

This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular methods. This study was conducted in two steps. For in vivo studies, 24 female rats were divided into four groups. Group I: healthy; II ... Read more >>

Biochem Genet (Biochemical genetics)
[2017, 55(1):34-47]

Cited: 9 times

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A Comparative Study of the Effects of Intravitreal Anidulafungin, Voriconazole, and Amphotericin B in an Experimental Candida Endophthalmitis Model.

Ergenekon Karagoz, Rustem Anil Ugan, Eyup Duzgun, Elif Cadirci, Sadullah Keles, M Hamidullah Uyanik, Ibrahim Yavan, Vedat Turhan,

<h4>Purpose</h4>To compare the safety and efficacy of intravitreal anidulafungin injection with voriconazole and amphotericin B (Amp B) in an experimental Candida endophthalmitis (CE) model.<h4>Methods</h4>Intravitreal 1 × 10<sup>5</sup> CFU/0.1 ml Candida albicans was injected into the right eyes of 24 New Zealand rabbits, which were divided into 4 groups. Voriconazole 50 ... Read more >>

Curr Eye Res (Current eye research)
[2017, 42(2):225-232]

Cited: 4 times

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