Full Text Journal Articles by
Author Elie Azoulay

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The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.

Greg S Martin, Sandra L Kane-Gill, Vinay Nadkarni, Lauren R Sorce, Lewis J Kaplan, Maurizio Cecconi, Elie Azoulay, Jean-Louis Teboul, Lui Forni, Jozef Kesecioglu,

Crit Care Med (Critical care medicine)
[2021, 49(11):1849-1850]

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Critical care management of chimeric antigen receptor T-cell therapy recipients.

Alexander Shimabukuro-Vornhagen, Boris Böll, Peter Schellongowski, Sandrine Valade, Victoria Metaxa, Elie Azoulay, Michael von Bergwelt-Baildon,

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic treatment concept that is changing the treatment approach to hematologic malignancies. The development of CAR T-cell therapy represents a prime example for the successful bench-to-bedside translation of advances in immunology and cellular therapy into clinical practice. The currently available CAR ... Read more >>

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2021, :]

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A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.

Faraaz Ali Shah, Nuala J Meyer, Derek C Angus, Rana Awdish, Élie Azoulay, Carolyn S Calfee, Gilles Clermont, Anthony C Gordon, Arthur Kwizera, Aleksandra Leligdowicz, John C Marshall, Carmen Mikacenic, Pratik Sinha, Balasubramanian Venkatesh, Hector R Wong, Fernando G Zampieri, Sachin Yende,

<b>Background:</b> Precision medicine focuses on the identification of therapeutic strategies that are effective for a group of patients based on similar unifying characteristics. The recent success of precision medicine in non-critical care settings has resulted from the confluence of large clinical and biospecimen repositories, innovative bioinformatics, and novel trial designs. ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(8):891-901]

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Pattern of Brain Injury in Patients With Thrombotic Thrombocytopenic Purpura in the Precaplacizumab Era.

Adrien Mirouse, Stéphane Legriel, Guillaume Dumas, Guylaine Labro, Agnès Veyradier, Lara Zafrani, Sandrine Valade, Yannick Hourmant, David Boutboul, Michael Darmon, Paul Coppo, Eric Mariotte, Elie Azoulay,

<h4>Objectives</h4>To describe short- and long-term neurologic prognosis of patients with thrombotic thrombocytopenic purpura and to identify clusters associated with evolution.<h4>Design</h4>Prospective French cohort.<h4>Setting</h4>ICU in a reference center.<h4>Patients</h4>All consecutive patients with newly diagnosed thrombocytopenic purpura.<h4>Intervention</h4>Comprehensive clinical, biological, and radiological evaluation at admission. Neurocognitive recovery was assessed using Glasgow Outcome Scale (range 1-5, ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):e931-e940]

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Preempting critical care services for patients with hematological malignancies.

Élie Azoulay, Marcio Soares, Étienne Lengliné,

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1140-1143]

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Reply to Sklar and Yarnell and to Stahl et al.

Guillaume Dumas, Elie Azoulay, Michael Darmon,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(6):739]

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Gastrointestinal bleeding in critically ill immunocompromised patients.

Jennifer Catano, Sophie Caroline Sacleux, Jean-Marc Gornet, Marine Camus, Naike Bigé, Faouzi Saliba, Elie Azoulay, Guillaume Dumas, Lara Zafrani,

<h4>Background</h4>Acute gastrointestinal bleeding (GIB) may be a severe condition in immunocompromised patients and may require intensive care unit (ICU) admission. We aimed to describe the clinical spectrum of critically ill immunocompromised patients with GIB and identify risk factors associated with mortality and severe GIB defined by hemorrhagic shock, hyperlactatemia and/or ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):130]

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Clinical and biological clusters of sepsis patients using hierarchical clustering.

Grégory Papin, Sébastien Bailly, Claire Dupuis, Stéphane Ruckly, Marc Gainnier, Laurent Argaud, Elie Azoulay, Christophe Adrie, Bertrand Souweine, Dany Goldgran-Toledano, Guillaume Marcotte, Antoine Gros, Jean Reignier, Bruno Mourvillier, Jean-Marie Forel, Romain Sonneville, Anne-Sylvie Dumenil, Michael Darmon, Maité Garrouste-Orgeas, Carole Schwebel, Jean-François Timsit, ,

<h4>Background</h4>Heterogeneity in sepsis expression is multidimensional, including highly disparate data such as the underlying disorders, infection source, causative micro-organismsand organ failures. The aim of the study is to identify clusters of patients based on clinical and biological characteristic available at patients' admission.<h4>Methods</h4>All patients included in a national prospective multicenter ICU ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0252793]

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Correction to: Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort.

Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Mégarbane, Anastasia Saade, Gemma Gomà, Eleni Magira, Jean-François Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loïc Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouzé, ,

Crit Care (Critical care (London, England))
[2021, 25(1):284]

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Outcomes in 1096 patients with severe thrombotic thrombocytopenic purpura before the Caplacizumab era.

Andry Van de Louw, Eric Mariotte, Michael Darmon, Austin Cohrs, Douglas Leslie, Elie Azoulay,

<h4>Introduction</h4>Thrombotic thrombocytopenic purpura (TTP) is a diagnostic and therapeutic emergency. Therapeutic plasma exchange (TPE) combined with immunosuppression has been the cornerstone of the initial management. To produce optimal benefits, emerging treatments must be used against a background of best standard of care. Clarifying current uncertainties is therefore crucial.<h4>Methods</h4>The objective of ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0256024]

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Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients.

Dominique D Benoit, Esther N van der Zee, Michael Darmon, An K L Reyners, Victoria Metaxa, Djamel Mokart, Alexander Wilmer, Pieter Depuydt, Andreas Hvarfner, Katerina Rusinova, Jan G Zijlstra, François Vincent, Dimitrios Lathyris, Anne-Pascale Meert, Jacques Devriendt, Emma Uyttersprot, Erwin J O Kompanje, Ruth Piers, Elie Azoulay,

<h4>Background</h4>Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptions of excessive care (PECs) by ICU clinicians in patients with and without cancer.<h4>Methods</h4>This study is a sub-analysis of ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):120]

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Coagulation disorders in patients with severe hemophagocytic lymphohistiocytosis.

Sandrine Valade, Bérangère S Joly, Agnès Veyradier, Jehane Fadlallah, Lara Zafrani, Virginie Lemiale, Amélie Launois, Alain Stepanian, Lionel Galicier, Claire Fieschi, Adrien Mirouse, Jean Jacques Tudesq, Anne-Claire Lepretre, Elie Azoulay, Michael Darmon, Eric Mariotte,

<h4>Background</h4>Coagulation disorders are common in patients with hemophagocytic lymphohistiocytosis (HLH), associated with an increased risk of bleeding and death. We aim to investigate coagulation disorders and their outcome implications in critically ill patients with HLH.<h4>Methods</h4>We prospectively evaluated 47 critically ill patients with HLH (median age of 54 years [42-67]) between ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0251216]

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Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients.

Bérangère S Joly, Michael Darmon, Charlotte Dekimpe, Thibault Dupont, Guillaume Dumas, Elise Yvin, Nicolas Beranger, Karen Vanhoorelbeke, Elie Azoulay, Agnès Veyradier,

<h4>Background</h4>Critically ill patients with coronavirus disease 2019 (COVID-19) are prone to developing macrothrombosis and microthrombosis. COVID-19 has been reported to be rarely associated with thrombotic microangiopathies. A disintegrin and metalloprotease with thrombospondin type I repeats, member 13 (ADAMTS13) severe deficiency, the hallmark of thrombotic thrombocytopenic purpura (TTP), induces the formation ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2021, 19(9):2193-2198]

Cited: 1 time

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Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study.

Muriel Fartoukh, Guillaume Voiriot, Laurent Guérin, Jean Damien Ricard, Alain Combes, Morgane Faure, Sarah Benghanem, Etienne de Montmollin, Yacine Tandjaoui-Lambiotte, Antoine Vieillard-Baron, Eric Maury, Jean-Luc Diehl, Keyvan Razazi, Virginie Lemiale, Pierre Trouiller, Benjamin Planquette, Laurent Savale, Nicholas Heming, Jonathan Marey, , Fabrice Carrat, Nathanael Lapidus, ,

<h4>Purpose</h4>At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.<h4>Materials, patients and methods</h4>We aimed at assessing the relevance of the Assistance Publique-Hôpitaux de Paris (AP-HP) clinical data warehouse for estimating the burden of the influenza epidemic on medical adult critical care ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):117]

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

, Manu Shankar-Hari, Claire L Vale, Peter J Godolphin, David Fisher, Julian P T Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S Benbenishty, Lindsay R Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L De Buyser, Lennie P G Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C Gordon, Richard Haynes, Olivier Hermine, Peter W Horby, Nora K Horick, Kuldeep Kumar, Bart N Lambrecht, Martin J Landray, Lorna Leal, David J Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V Mohan, Michael C Nivens, Jarmo Oksi, Jose A Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V Ramanan, Philippe Ravaud, Pankti D Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H Stone, Garth W Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E Westerweel, Srinivas Murthy, Janet V Diaz, John C Marshall, Jonathan A C Sterne,

<h4>Importance</h4>Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.<h4>Objective</h4>To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.<h4>Data sources</h4>Trials were identified through systematic searches of electronic ... Read more >>

JAMA (JAMA)
[2021, 326(6):499-518]

Cited: 11 times

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Importance of Lung Epithelial Injury in COVID-19-associated Acute Respiratory Distress Syndrome: Value of Plasma Soluble Receptor for Advanced Glycation End-Products.

Natacha Kapandji, Elise Yvin, Magali Devriese, Constance de Margerie-Mellon, Giulia Moratelli, Virginie Lemiale, Matthieu Jabaudon, Elie Azoulay, Jean-Michel Constantin, Guillaume Dumas,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(3):359-362]

Cited: 1 time

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Non-C. difficile Clostridioides Bacteremia in Intensive Care Patients, France.

Guillaume Morel, Guillaume Mulier, Etienne Ghrenassia, Moustafa Abdel Nabey, Yacine Tandjaoui, Achille Kouatchet, Laura Platon, Frédéric Pène, Anne-Sophie Moreau, Amelie Seguin, Damien Contou, Romain Sonneville, David Rousset, Muriel Picard, Guillaume Dumas, Djamel Mokart, Bruno Megarbane, Guillaume Voiriot, Isabelle Oddou, Elie Azoulay, Lucie Biard, Lara Zafrani,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(7):1840-1849]

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Acute Kidney Injury Recovery Patterns in Critically Ill Patients: Results of a Retrospective Cohort Study.

Moustafa Abdel-Nabey, Etienne Ghrenassia, Eric Mariotte, Sandrine Valade, Guillaume Morel, Virginie Lemiale, Lara Zafrani, Elie Azoulay, Michael Darmon,

<h4>Objectives</h4>Acute kidney injury, acute kidney injury severity, and acute kidney injury duration are associated with both short- and long-term outcomes. Despite recent definitions, only few studies assessed pattern of renal recovery and time-dependent competing risks are usually disregarded. Our objective was to describe pattern of acute kidney injury recovery, change ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):e683-e692]

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Correction to: Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure.

Virginie Lemiale, Guillaume Dumas, Alexandre Demoule, Frederic Pène, Achille Kouatchet, Magali Bisbal, Saad Nseir, Laurent Argaud, Loay Kontar, Kada Klouche, Francois Barbier, Amelie Seguin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Vincent Peigne, Christophe Girault, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Alexandre Lautrette, Naike Bige, Jean-Herle Raphalen, Laurent Papazian, Fabrice Bruneel, Christine Lebert, Dominique Benoit, Anne-Pascale Meert, Samir Jaber, Djamel Mokart, Michael Darmon, Elie Azoulay, ,

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):105]

Cited: 0 times

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Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis.

Paul E Verweij, Roger J M Brüggemann, Elie Azoulay, Matteo Bassetti, Stijn Blot, Jochem B Buil, Thierry Calandra, Tom Chiller, Cornelius J Clancy, Oliver A Cornely, Pieter Depuydt, Philipp Koehler, Katrien Lagrou, Dylan de Lange, Cornelia Lass-Flörl, Russell E Lewis, Olivier Lortholary, Peter-Wei Lun Liu, Johan Maertens, M Hong Nguyen, Thomas F Patterson, Bart J A Rijnders, Alejandro Rodriguez, Thomas R Rogers, Jeroen A Schouten, Joost Wauters, Frank L van de Veerdonk, Ignacio Martin-Loeches,

<h4>Purpose</h4>Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated pulmonary aspergillosis (CAPA) are challenging and our aim was to develop practical guidance.<h4>Methods</h4>A group of 28 international experts reviewed current insights in ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):819-834]

Cited: 2 times

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Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis.

Guillaume Dumas, Virginie Lemiale, Nisha Rathi, Andrea Cortegiani, Frédéric Pène, Vincent Bonny, Jorge Salluh, Guillermo M Albaiceta, Marcio Soares, Ayman O Soubani, Emmanuel Canet, Tarik Hanane, Achille Kouatchet, Djamel Mokart, Pia Lebiedz, Melda Türkoğlu, Rémi Coudroy, Kyeongman Jeon, Alexandre Demoule, Sangeeta Mehta, Pedro Caruso, Jean-Pierre Frat, Kuang-Yao Yang, Oriol Roca, John Laffey, Jean-François Timsit, Elie Azoulay, Michael Darmon,

<b>Rationale:</b> Acute respiratory failure (ARF) is associated with high mortality in immunocompromised patients, particularly when invasive mechanical ventilation is needed. Therefore, noninvasive oxygenation/ventilation strategies have been developed to avoid intubation, with uncertain impact on mortality, especially when intubation is delayed. <b>Objectives:</b> We sought to report trends of survival over time ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(2):187-196]

Cited: 1 time

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Systemic autoimmune disorders associated with thrombotic microangiopathy: A cross-sectional analysis from the French National TMA registry: Systemic autoimmune disease-associated TMA.

Nihal Martis, Matthieu Jamme, Corinne Bagnis-Isnard, Claire Pouteil-Noble, Claire Presne, Cécile Vigneau, Steven Grangé, Stéphane Burtey, Jean-Philippe Coindre, Alain Wynckel, Mohamed A Hamidou, Tarik Kanouni, Elie Azoulay, Miguel Hié, Dominique Chauveau, Agnès Veyradier, Eric Rondeau, Paul Coppo, ,

<h4>Context</h4>The management of systemic auto-immune diseases (SAID) -associated thrombotic microangiopathies (TMA) [SAID-TMA] remains debated.<h4>Objectives</h4>To provide a demographic, clinical and therapeutic picture of SAID-TMA.<h4>Methods</h4>A cross-sectional analysis was conducted on adult patients presenting with SAID and TMA from the French National TMA Registry over a 20-year period. Clinical features were extracted and ... Read more >>

Eur J Intern Med (European journal of internal medicine)
[2021, :]

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An Interprofessional Process for the Limitation of Life-Sustaining Treatments at the End of Life in France.

Jacob A Blythe, Nancy Kentish-Barnes, Anne-Sophie Debue, Daniel Dohan, Elie Azoulay, Ken Covinsky, Thea Matthews, J Randall Curtis, Elizabeth Dzeng,

<h4>Context</h4>The provision of potentially non-beneficial life-sustaining treatments (LSTs) remains a challenging problem. In 2005, legislation in France established an interprofessional process by which non-beneficial LSTs could be withheld or withdrawn, permitting exploration of the effects of such a legally-protected process and its implementation.<h4>Objectives</h4>To characterize intensive care unit (ICU) interprofessional team ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2021, :]

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Lived Experiences of Family Members of Patients With Severe COVID-19 Who Died in Intensive Care Units in France.

Nancy Kentish-Barnes, Zoé Cohen-Solal, Lucas Morin, Virginie Souppart, Frédéric Pochard, Elie Azoulay,

<h4>Importance</h4>During the initial surge of the COVID-19 pandemic, family members were often separated from their loved ones admitted to intensive care units (ICUs), with a potential for negative experiences and psychological burden.<h4>Objective</h4>To better understand the experiences of bereaved family members of patients who died in an ICU during the COVID-19 ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2113355]

Cited: 1 time

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Acute kidney injury in SARS-CoV2-related pneumonia ICU patients: a retrospective multicenter study.

Guillaume Geri, Michael Darmon, Lara Zafrani, Muriel Fartoukh, Guillaume Voiriot, Julien Le Marec, Saafa Nemlaghi, Antoine Vieillard-Baron, Elie Azoulay,

<h4>Background</h4>While acute kidney injury (AKI) is frequent in severe SARS-CoV2-related pneumonia ICU patients, few data are still available about its risk factors.<h4>Methods</h4>Retrospective observational study performed in four university affiliated hospitals in Paris. AKI was defined according to the KIDGO guidelines. Factors associated with AKI were picked up using multivariable mixed-effects ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):86]

Cited: 1 time

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