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Author Elias Iosifidis

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Ventilator-associated Events in Children: Controversies and Research Needs.

Elias Iosifidis, Susan Coffin,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(4):e37-e39]

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Management of osteoarticular fungal infections in the setting of immunodeficiency.

Savvas G Papachristou, Elias Iosifidis, Nikolaos V Sipsas, Maria N Gamaletsou, Thomas J Walsh, Emmanuel Roilides,

Introduction: Osteoarticular fungal infections (OAFIs) complicate the clinical course of high-risk patients, including immunosuppressed individuals. Their management, however, despite being intricate, is governed by evidence arising from sub-optimal quality research, such as case series. Guidelines are scarce and when present result in recommendations based on low quality evidence. Furthermore, the ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, 18(5):461-474]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

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Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study.

Adilia Warris, Zoi-Dorothea Pana, Andrea Oletto, Rebecca Lundin, Elio Castagnola, Thomas Lehrnbecher, Andreas H Groll, Emmanuel Roilides, Cecilie T Andersen, Maiken C Arendrup, Valentina Arsic Arsenijevic, Sonia Bianchini, Ulrich von Both, Martin Chmelnik, Tiziana Controzzi, Marieke Emonts, Susanna Esposito, Laura Ferreras-Antolin, Stefanie Henriet, Elias Iosifidis, Adam Irwin, John Kopsidas, Katrien Lagrou, Hermione Lyall, Angela Manzanares Casteleiro, Alessio Mesini, Peter Olbrich, Stephane Paulus, Karen Rokkedal Lausch, Pere Soler-Palacin, Nikos Spyridis, Volker Strenger, Martha Theodoraki, Tom Wolfs, , ,

BACKGROUND:Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. MATERIAL AND METHODS:All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(2):114-120]

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Thiamine Deficiency in a Child with Short Bowel Syndrome and Review.

Ioannis Roilides, Konstantina Vasilaki, Ioannis Xinias, Elias Iosifidis, Charalampos Antachopoulos, Emmanuel Roilides,

Thiamine (vitamin B1) is a water-soluble vitamin that is not endogenously synthesized in humans. It is absorbed by the small intestine, where it is activated. Its active form acts as a coenzyme in many energy pathways. We report a rare case of thiamine deficiency in a 3.5-year old boy with ... Read more >>

Pediatr Gastroenterol Hepatol Nutr (Pediatric gastroenterology, hepatology & nutrition)
[2019, 22(5):493-499]

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Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network.

Grace Li, Julia Anna Bielicki, A S M Nawshad Uddin Ahmed, Mohammad Shahidul Islam, Eitan Naaman Berezin, Clery B Gallacci, Ruth Guinsburg, Carlos Eduardo da Silva Figueiredo, Rosilene Santarone Vieira, Andre Ricardo Silva, Cristiane Teixeira, Paul Turner, Ladin Nhan, Jaime Orrego, Paola Marsela Pérez, Lifeng Qi, Vassiliki Papaevangelou, Pinelope Triantafyllidou, Elias Iosifidis, Emmanuel Roilides, Kosmas Sarafidis, Dasaratha Ramaiah Jinka, Raghuprakash Reddy Nayakanti, Praveen Kumar, Vikas Gautam, Vinayagam Prakash, Arasar Seeralar, Srinivas Murki, Hemasree Kandraju, Sanjeev Singh, Anil Kumar, Leslie Lewis, Jayashree Pukayastha, Sushma Nangia, Yogesha K N, Suman Chaurasia, Harish Chellani, Stephen Obaro, Angela Dramowski, Adrie Bekker, Andrew Whitelaw, Reenu Thomas, Sithembiso Christopher Velaphi, Daynia Elizabeth Ballot, Trusha Nana, Gary Reubenson, Joy Fredericks, Suvaporn Anugulruengkitt, Anongnart Sirisub, Pimol Wong, Sorasak Lochindarat, Suppawat Boonkasidecha, Kanchana Preedisripipat, Tim R Cressey, Pongsatorn Paopongsawan, Pagakrong Lumbiganon, Dounghatai Pongpanut, Pra-Ornsuda Sukrakanchana, Philippa Musoke, Linus Olson, Mattias Larsson, Paul T Heath, Michael Sharland,

OBJECTIVE:To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR). DESIGN:A web-based survey using a REDCap database was circulated ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2020, 105(1):26-31]

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Effects of an Active Surveillance Program and Enhanced Infection Control Measures on Carbapenem-Resistant Gram-Negative Bacterial Carriage and Infections in Pediatric Intensive Care.

Theodoros Karampatakis, Katerina Tsergouli, Elias Iosifidis, Charalampos Antachopoulos, Eleni Volakli, Angeliki Karyoti, Maria Sdougka, Athanassios Tsakris, Emmanuel Roilides,

We evaluated the effects of enhanced infection control measures (ICMs) on carriage and infections of carbapenem-resistant Gram-negative bacteria (CRGNB) in a pediatric intensive care unit. We conducted a quasi-experimental study, including patients with infections of CRGNB retrospectively for 13 months and those participating in an active surveillance program prospectively for ... Read more >>

Microb. Drug Resist. (Microbial drug resistance (Larchmont, N.Y.))
[2019, 25(9):1347-1356]

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Risk factors for carbapenem resistance and outcomes when treating bloodstream infections in a paediatric intensive care unit.

Violetta Magdalini Darda, Elias Iosifidis, Charalampos Antachopoulos, Elena Volakli, Anna Bettina Haidich, Eleni Vagdatli, Maria Sdougka, Emmanuel Roilides,

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2019, 108(10):1923-1924]

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Use of Ceftazidime-avibactam for the Treatment of Extensively drug-resistant or Pan drug-resistant Klebsiella pneumoniae in Neonates and Children <5 Years of Age.

Elias Iosifidis, Elisavet Chorafa, Eleni Agakidou, Aggeliki Kontou, Asimina Violaki, Eleni Volakli, Eleni-Ifigeneia Christou, Charalampos Zarras, Vassiliki Drossou-Agakidou, Maria Sdougka, Emmanuel Roilides,

BACKGROUND:Emergence of extensively drug-resistant (XDR) or pan drug-resistant (PDR) Enterobacteriaceae is a major public threat especially for young patients. Treatment options for these bacteria are extremely limited with no safety data existing for neonates and children. Ceftazidime-avibactam has activity against Gram-negative bacteria producing Klebsiella pneumoniae carbapenemase, but virtually no data ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(8):812-815]

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Forecasting models of infections due to carbapenem-resistant Gram-negative bacteria in an intensive care unit in an endemic area.

Theodoros Karampatakis, Katerina Tsergouli, Elias Iosifidis, Charalampos Antachopoulos, Eleni Mouloudi, Aggeliki Karyoti, Athanassios Tsakris, Emmanuel Roilides,

OBJECTIVES:The aim of this study was to forecast the monthly incidence rates of infections [infections/1000 bed-days (IBD)] due to carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Acinetobacter baumannii (CRAB) and total carbapenem-resistant Gram-negative bacteria (CRGNB) in an endemic intensive care unit (ICU) during the subsequent year (December 2016-December ... Read more >>

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2020, 20:214-218]

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Polyclonal predominance of concurrently producing OXA-23 and OXA-58 carbapenem-resistant Acinetobacter baumannii strains in a pediatric intensive care unit.

Theodoros Karampatakis, Katerina Tsergouli, Lida Politi, Georgia Diamantopoulou, Elias Iosifidis, Charalampos Antachopoulos, Aggeliki Karyoti, Maria Sdougka, Athanassios Tsakris, Emmanuel Roilides,

We report a predominance (64.7%) of polyclonal carbapenem-resistant Acinetobacter baumannii (CRAB) strains concurrently producing OXA-23 and OXA-58 carbapenemases in a pediatric intensive care unit in an endemic area. This is the first report of emergence of such double-OXA CRAB strains in a single unit worldwide. ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2019, 46(3):3497-3500]

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Child Morbidity and Disease Burden in Refugee Camps in Mainland Greece.

Asterios Kampouras, Georgios Tzikos, Eustathios Partsanakis, Konstantinos Roukas, Stefanos Tsiamitros, Dimitrios Deligeorgakis, Elisavet Chorafa, Maria Schoina, Elias Iosifidis,

The crisis conflicts in Syria have forced a lot of people to relocate and live in mainland Greece, where they are hosted in refugee camps. In the present study, our aim was to assess child morbidity and overall disease burden in two camps in northern Greece during a six-month winter ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(3):]

Cited: 1 time

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Invasive Aspergillosis in Pediatric Leukemia Patients: Prevention and Treatment.

Savvas Papachristou, Elias Iosifidis, Emmanuel Roilides,

The purpose of this article is to review and update the strategies for prevention and treatment of invasive aspergillosis (IA) in pediatric patients with leukemia and in patients with hematopoietic stem cell transplantation. The major risk factors associated with IA will be described since their recognition constitutes the first step ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2019, 5(1):]

Cited: 1 time

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The clinical significance of carbapenem-resistant Klebsiella pneumoniae rectal colonization in critically ill patients: from colonization to bloodstream infection.

Konstantina Kontopoulou, Elias Iosifidis, Eleni Antoniadou, Polychronis Tasioudis, Efthymia Petinaki, Ergina Malli, Symeon Metallidis, Alkiviadis Vatopoulos, Nicolaos Malisiovas,

PURPOSE:To highlight the clinical significance of carbapenem-resistant Klebsiella pneumoniae (CRKP) rectal colonization by examining the risk factors for CRKP rectal colonization and subsequent bloodstream infection (BSI) in critically ill patients. METHODOLOGY:Prospective study of CRKP rectal colonization in an intensive care unit (ICU) during a 39-month period. CRKP strains isolated from ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2019, 68(3):326-335]

Cited: 1 time

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Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis.

Magdalini Tsekoura, Maria Ioannidou, Zoi-Dorothea Pana, Anna-Bettina Haidich, Charalampos Antachopoulos, Elias Iosifidis, George Kolios, Emmanuel Roilides,

BACKGROUND:Echinocandins are recommended for the treatment of suspected or confirmed invasive candidiasis (IC) in adults. Less is known about the use of echinocandins for the management of IC in children. The aim of this study was to investigate the overall efficacy and safety of echinocandin class in neonatal and pediatric ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(1):42-49]

Cited: 1 time

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Molecular Epidemiology of Endemic Carbapenem-Resistant Gram-Negative Bacteria in an Intensive Care Unit.

Theodoros Karampatakis, Katerina Tsergouli, Lida Politi, Georgia Diamantopoulou, Elias Iosifidis, Charalampos Antachopoulos, Aggeliki Karyoti, Eleni Mouloudi, Athanassios Tsakris, Emmanuel Roilides,

The molecular epidemiology of endemic carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Acinetobacter baumannii (CRAB) in an intensive care unit located in an endemic area with high rates of resistance was investigated. A CRPA strain producing VIM and KPC concurrently was detected for the first time in ... Read more >>

Microb. Drug Resist. (Microbial drug resistance (Larchmont, N.Y.))
[2019, 25(5):712-716]

Cited: 2 times

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2302. Bloodstream Infections Due to Carbapenem-Resistant Gram-Negative Bacteria in Pediatric Intensive Care Unit (PICU): Risk Factors and Outcomes.

Violetta-Magdalini Darda, Elias Iosifidis, Eleni Volakli, Charalampos Antachopoulos, Anna-Bettina Haidich, Eleni Vagdatli, Maria Sdougka, Emmanuel Roilides,

AbstractBackgroundBloodstream infections (BSI) caused by multidrug-resistant bacteria are associated with poor outcome and increased cost. We investigated risk factors for carbapenem resistance (CR) and outcome associated with the development of BSI due to Gram-negative (GN) bacteria in PICU patients, a very vulnerable population.MethodsWe reviewed the records of 1 month–15 year ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S683-S683]

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): a randomised controlled trial

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul Heath Frcpch, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

Abstract Background The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, were single centre or country, insufficiently powered, evaluated antibiotics not in ... Read more >>

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Advances in the Treatment of Mycoses in Pediatric Patients.

Elias Iosifidis, Savvas Papachristou, Emmanuel Roilides,

The main indications for antifungal drug administration in pediatrics are reviewed as well as an update of the data of antifungal agents and antifungal policies performed. Specifically, antifungal therapy in three main areas is updated as follows: a) Prophylaxis of premature neonates against invasive candidiasis; b) management of candidemia and ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2018, 4(4):]

Cited: 3 times

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Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention.

Elias Iosifidis, Georgia Pitsava, Emmanuel Roilides,

AIM:While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. METHODOLOGY:We conducted a systematic PUBMED analysis (January 1990-January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. ... Read more >>

Future Microbiol (Future microbiology)
[2018, 13:1431-1446]

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Intravenous fosfomycin in patients with liver disease for extensively drug-resistant Gram-negative bacteria.

Athina Pyrpasopoulou, Georgia Pitsava, Elias Iosifidis, George Imvrios, Eleni Massa, Eleni Mouloudi, Ioannis Goulis, Eleni Chatzidrosou, Charalampos Antachopoulos, Ioannis Fouzas, Emmanuel Roilides,

J. Infect. (The Journal of infection)
[2018, 77(5):448-454]

Cited: 0 times

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Recent Advances in the Treatment of Scedosporiosis and Fusariosis.

Matthew W McCarthy, Aspasia Katragkou, Elias Iosifidis, Emmanuel Roilides, Thomas J Walsh,

Species of Scedosporium and Fusarium are considered emerging opportunistic pathogens, causing invasive fungal diseases in humans that are known as scedosporiosis and fusariosis, respectively. These mold infections typically affect patients with immune impairment; however, cases have been reported in otherwise healthy individuals. Clinical manifestations vary considerably, ranging from isolated superficial ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2018, 4(2):]

Cited: 2 times

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Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey.

Ann Versporten, Peter Zarb, Isabelle Caniaux, Marie-Françoise Gros, Nico Drapier, Mark Miller, Vincent Jarlier, Dilip Nathwani, Herman Goossens, ,

BACKGROUND:The Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed to assess antimicrobial prescribing and resistance in hospital inpatients. METHODS:We used a standardised surveillance method to collect detailed data about antimicrobial prescribing and resistance from hospitals worldwide, which were ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2018, 6(6):e619-e629]

Cited: 25 times

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Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management.

Suzanne E Luck, Jantien W Wieringa, Daniel Blázquez-Gamero, Philipp Henneke, Katharina Schuster, Karina Butler, Maria Grazia Capretti, Maria José Cilleruelo, Nigel Curtis, Francesca Garofoli, Paul Heath, Elias Iosifidis, Nigel Klein, Giuseppina Lombardi, Hermione Lyall, Tea Nieminen, Dasja Pajkrt, Vassiliki Papaevangelou, Klara Posfay-Barbe, Laura Puhakka, Emmanuel Roilides, Pablo Rojo, Jesús Saavedra-Lozano, Teshri Shah, Mike Sharland, Harri Saxen, Ann C T M Vossen, ,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2017, 36(12):1205-1213]

Cited: 7 times

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Colistin Use in Neonates and Children With Infections Due to Carbapenem-resistant Bacteria.

Charalampos Antachopoulos, Elias Iosifidis,

Current evidence on the use of colistin in pediatric patients for infections caused by carbapenem-resistant bacteria is based on retrospective case series. The coadministration of colistin with other antimicrobial agents was associated with a relatively low rate of nephrotoxicity and a favorable outcome in >70% of these patients. Further study ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2017, 36(9):905-907]

Cited: 2 times

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