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Author Eleni Nakou

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Imaging Findings of COVID-19-Related Cardiovascular Complications

Eleni Nakou, Estefania De Garate, Kate Liang, Matthew Williams, Dudley J. Pennell, Chiara Bucciarelli-Ducci,

Other than respiratory disease, patients with coronavirus disease 2019 (COVID-19) commonly have cardiovascular manifestations, which are recognised as significant risk factors for increased mortality. COVID-19 patients may present with a wide spectrum of clinical presentations ranging from asymptomatic heart disease detected incidentally by cardiac investigations (troponin, BNP, imaging) to cardiogenic ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

Cited: 0 times

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Atrial fibrillation ablation in heart failure: Findings from the ESC-EHRA EORP Atrial Fibrillation Ablation long-term (AFA LT) registry.

Pier Luigi Temporelli, Elena Arbelo, Cécile Laroche, Carina Blomström-Lundqvist, Paulus Kirchhof, Gregory Y H Lip, Giuseppe Boriani, Eleni Nakou, Aldo P Maggioni, Luigi Tavazzi, ,

<h4>Background</h4>The current practice of atrial fibrillation ablation (AFA) as a treatment option for atrial fibrillation (AF) in patients with heart failure (HF) across Europe, their clinical profiles and outcomes is still undefined.<h4>Methods</h4>The European Society of Cardiology (ESC) led a prospective observational registry of consecutive patients undergoing AFA, in 27 member ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, :]

Cited: 0 times

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Cardiovascular Magnetic Resonance Parametric Mapping Techniques: Clinical Applications and Limitations.

Eleni Nakou, Rishi K Patel, Marianna Fontana, Chiara Bucciarelli-Ducci,

<h4>Purpose of review</h4>Parametric mapping represents a significant innovation in cardiovascular magnetic resonance (CMR) tissue characterisation, allowing the quantification of myocardial changes based on changes on T1, T2 and T2* relaxation times and extracellular volume (ECV). Its clinical use is rapidly expanding, but it requires availability of dedicated equipment as well ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2021, 23(12):185]

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First-Phase Ejection Fraction, a Measure of Preclinical Heart Failure, Is Strongly Associated With Increased Mortality in Patients With COVID-19.

Haotian Gu, Chiara Cirillo, Adam A Nabeebaccus, Zhenxing Sun, Lingyun Fang, Yuji Xie, Ozan Demir, Nishita Desai, Lin He, Qing Lü, Eleni Nakou, Kevin O'Gallagher, Christos Tountas, Apostolia Marvaki, Mark Monaghan, Divaka Perera, Ana Pericao, Matthew Ryan, Hannah Sinclair, Vasileios Stylianidis, Kelly Victor, Bin Wang, Jing Wang, Rui Wang, Chun Wu, Yali Yang, Hongliang Yuan, Danqing Zhang, Yongxing Zhang, Luca Faconti, Alexandros Papachristidis, Li Zhang, Gerald Carr-White, Ajay M Shah, Mingxing Xie, Phil Chowienczyk,

Presence of heart failure is associated with a poor prognosis in patients with coronavirus disease 2019 (COVID-19). The aim of the present study was to examine whether first-phase ejection fraction (EF1), the ejection fraction measured in early systole up to the time of peak aortic velocity, a sensitive measure of ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, 77(6):2014-2022]

Cited: 2 times

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Discrete aortic dissection: the Achilles' heel of emergency cardiovascular medicine.

Eleni S Nakou, Dimitrios Papasaikas, Ranjit Deshpande, Alexandros Papachristidis,

Eur Heart J (European heart journal)
[2020, 41(44):4285]

Cited: 0 times

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Early Left Ventricular Global Longitudinal Strain Deterioration After Aortic Aneurysm Repair: Impact of Aortic Stiffness.

Maria Marketou, George Papadopoulos, Nikolaos Kontopodis, Alexandros Patrianakos, Eleni Nakou, Spyros Maragkoudakis, Gregory Chlouverakis, Stavros Stratakis, Emmanouel Tavlas, Fragiskos Parthenakis, Christos V Ioannou,

<h4>Purpose</h4>To associate the impact of aortic reconstruction using currently available grafts and endografts on pulse wave velocity in patients with abdominal aortic aneurysm (AAA) and to evaluate its effect on early cardiac systolic function indices.<h4>Materials and methods</h4>Seventy-three consecutive patients with AAA (mean age 70±8 years; all men) who underwent open ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2021, 28(2):352-359]

Cited: 1 time

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Cardiovascular disease in women: Executive summary of the expert panel statement of women in cardiology of the hellenic cardiological society.

Christina Chrysohoou, Constantina Aggeli, Catherine Avgeropoulou, Maria Aroni, Maria Bonou, Maria Boutsikou, Stella Brili, Eftyhia Chamodraka, Anna Dagre, Panagiota Flevari, Aikaterini Fountoulaki, Alexandra Frogoudaki, Aggeliki Gkouziouta, Julia Grapsa, Eleni Hatzinikolaou-Kotsakou, Kallirroi Kalantzi, Anastasia Kitsiou, Panagiota Kostakou, Roy Kourea, Paraskevi Koutrolou-Sotiropoulou, Maria Marketou, Sophie Mavrogeni, Katerina K Naka, Maria Nikolaou, Ourania Papazachou, Lida Pieretta Papavasileiou, Eftihia Simeonidou, Artemisia Theopistou, Helen Triantafyllidi, Chrysanthi Trikka, Dorothea Tsekoura, Aphrodite Tzifa, Sophia Vaina, Agathi Rosa Vrettou, Theodora Zaglavara, Genovefa Kolovou, ,

The perception that women represent a low-risk population for cardiovascular (CV) disease (CVD) needs to be reconsidered. Starting from risk factors, women are more likely to be susceptible to unhealthy behaviors and risk factors that have different impact on CV morbidity and mortality as compared to men. Despite the large ... Read more >>

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2020, 61(6):362-377]

Cited: 0 times

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Isolated papillary muscle rupture with nonobstructive coronary artery disease, minimal myocardial infarction, and normal wall motion.

Eleni S Nakou, Konstantinos C Theodoropoulos, Hizbullah Shaikh, George Amin-Youssef, Mark J Monaghan, Alexandros Papachristidis,

Papillary muscle (PM) rupture can usually complicate inferior or posterior myocardial infarctions, but selective PM infarction is extremely rare, and the exact underlying pathophysiological mechanism is not entirely clear. We present a case of PM rupture due to isolated PM infarction in a patient with unobstructed coronary arteries, which could ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2020, 37(11):1855-1859]

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Innovative Transthoracic Echocardiographic Imaging on Prone Ventilated Patients With COVID-19 Using a Transesophageal Probe.

Apostolia Marvaki, Alexandros Papachristidis, Eleni Nakou, Eva Toth, Kevin O'Gallagher, Richard Fisher, Ajay M Shah, Mark J Monaghan,

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2020, 13(11):2465-2467]

Cited: 1 time

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Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype-imaging phenotype study.

João B Augusto, Rocio Eiros, Eleni Nakou, Sara Moura-Ferreira, Thomas A Treibel, Gabriella Captur, Mohammed M Akhtar, Alexandros Protonotarios, Thomas D Gossios, Konstantinos Savvatis, Petros Syrris, Saidi Mohiddin, James C Moon, Perry M Elliott, Luis R Lopes,

<h4>Aims</h4>Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts of arrhythmogenic left ventricular (LV) cardiomyopathy (ALVC) and arrhythmogenic DCM are currently ill-defined. We hypothesized that a distinctive imaging ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2020, 21(3):326-336]

Cited: 20 times

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Short-term effects of angiotensin receptor-neprilysin inhibitors on diastolic strain and tissue doppler parameters in heart failure patients with reduced ejection fraction: A pilot trial.

Eleni S Nakou, Maria E Marketou, Alexandros Patrianakos, Alexandros Protonotarios, Panos E Vardas, Fragiskos I Parthenakis,

<h4>Objective</h4>Although sacubitril/valsartan has recently shown its long-term benefits on morbidity and mortality in symptomatic patients with chronic heart failure with reduced ejection fraction (HFrEF), its short-term effects on diastolic function remain uncertain. We sought to assess 30-day effects of sacubitril/valsartan on left ventricular (LV) diastolic paremeters determined by speckle tracking ... Read more >>

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2020, 61(6):415-418]

Cited: 0 times

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Clinical characteristics of heart failure patients undergoing atrial fibrillation ablation today in Europe. Data from the atrial fibrillation registries of the European Society of Cardiology and the European Heart Rhythm Association.

Pier Luigi Temporelli, Roland R Tilz, Elena Arbelo, Nikolaos Dagres, Cécile Laroche, Harry J Crijns, Carina Blomstrom-Lundqvist, Paulus Kirchhof, Gregory Y H Lip, Giuseppe Boriani, Evengy Pokushalov, Eleni Nakou, Josep Brugada, Luigi Tavazzi,

Eur J Heart Fail (European journal of heart failure)
[2019, 21(5):690-693]

Cited: 2 times

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Troponin-I levels as a potential prognostic biomarker of sacubitril/valsartan treatment response in heart failure with reduced ejection fraction: Who will benefit most?

Eleni S Nakou, Maria E Marketou, Gregory I Chlouverakis, Alexandros P Patrianakos, Panos E Vardas, Fragiskos I Parthenakis,

<h4>Background</h4>Despite robust data on the benefits of sacubitril/valsartan (LCZ696) in patients with chronic heart failure with reduced ejection fraction (HFrEF), there is no evidence yet on prespecified predictive markers of its efficacy. Hypothesis The objective of this study was to identify potential prognostic factors of LCZ696 treatment response.<h4>Methods</h4>We included 48 ... Read more >>

Clin Cardiol (Clinical cardiology)
[2018, 41(12):1548-1554]

Cited: 3 times

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The clinical relevance of drug-drug interaction between co-trimoxazole and sacubitril/valsartan treatment in a heart failure patient: a case report and overview of mechanisms and management in clinical practice.

Eleni S Nakou, Maria E Marketou, Panos E Vardas, Fragiskos I Parthenakis,

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2018, 107(6):524-526]

Cited: 1 time

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Myocardial regeneration therapy in heart failure: Current status and future therapeutic implications in clinical practice.

Marko Banovic, Maja Pusnik-Vrckovnik, Eleni Nakou, Panos Vardas,

Despite multiple treatment regimens the morbidity and mortality of patients with advanced heart failure (HF) have reached pandemic proportions. In an effort to address the root cause of the problem, curative strategies are increasingly being considered. A case in point is the evolution of regenerative medicine technologies aiming to halt ... Read more >>

Int J Cardiol (International journal of cardiology)
[2018, 260:124-130]

Cited: 1 time

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Upgrading or downgrading a cardiac resynchronization therapy device (CRT) device? Gaps and dilemmas in current clinical practice.

Emmanuel N Simantirakis, Eleni S Nakou, Panos E Vardas,

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2018, 20(1):217-218]

Cited: 1 time

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Anticoagulation in heart failure without atrial fibrillation: gaps and dilemmas in current clinical practice.

Roxana-Nicoleta Siliste, Elena-Laura Antohi, Sergey Pepoyan, Eleni Nakou, Panos Vardas,

Data from observational and post-hoc analyses suggest that heart failure (HF) itself may be associated with higher risk of thromboembolic events compared to populations without HF. Although oral anticoagulants (OACs) might be a therapeutic option in individual cases, anticoagulation therapy in HF patients in sinus rhythm is not generally recommended, ... Read more >>

Eur J Heart Fail (European journal of heart failure)
[2018, 20(6):978-988]

Cited: 0 times

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Cardiac resynchronization therapy (CRT) device replacement considerations: upgrade or downgrade? A complex decision in the current clinical setting.

Eleni S Nakou, Emmanuel N Simantirakis, Eleftherios M Kallergis, Konstantinos S Nakos, Panos E Vardas,

There are limited data about the management of patients presenting for elective generator replacements in the setting of previously implanted cardiac resynchronization therapy (CRT) devices that are nearing end-of-life. The individual patient's clinical status and concomitant morbidities may evolve so that considerations may include not only replacement of the pulse ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2017, 19(5):705-711]

Cited: 4 times

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Alterations in the expression of genes related to contractile function and hypertrophy of the left ventricle in chronically paced patients from the right ventricular apex.

Eva G Arkolaki, Emmanuel N Simantirakis, Joanna E Kontaraki, Stavros I Chrysostomakis, Alexandros P Patrianakos, Gregory I Chlouverakis, Eleni S Nakou, Panos E Vardas,

<h4>Aim</h4>Long-term right ventricular apical (RVA) pacing may lead to left ventricular (LV) remodelling and heart failure. This study assessed changes in the expression of genes regulating LV contractile function and hypertrophy, after permanent RVA pacing and investigated whether such changes proceed or even predict LV remodelling.<h4>Methods and results</h4>We enrolled 52 ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2015, 17(10):1563-1570]

Cited: 2 times

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Chronotropic incompetence presenting as sudden sinus slowing during exercise stress test: the pathophysiological mechanisms.

Eleftherios M Kallergis, Eleni S Nakou, Emmanuel N Simantirakis, Panos E Vardas,

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2015, 104(7):611-613]

Cited: 0 times

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New therapeutic options in heart failure. What's on the horizon? An overview.

Eleni S Nakou, Panagiotis E Vardas,

Heart failure is a complex clinical syndrome responsible for high morbidity and mortality in the world. Despite advances in the management of heart failure, the prognosis of these patients remains poor and there is a critical need for new treatment strategies improving the clinical outcomes. New approaches in heart failure ... Read more >>

Int J Cardiol (International journal of cardiology)
[2013, 170(2):95-106]

Cited: 3 times

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Are diabetic patients at increased risk of arrhythmias?

Eleni S Nakou, Hercules Mavrakis, Panos E Vardas,

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2012, 53(5):335-339]

Cited: 9 times

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Efficacy and safety of ezetimibe plus orlistat or rimonabant in statin-intolerant nondiabetic overweight/obese patients with dyslipidemia.

Matilda Florentin, Michael S Kostapanos, Eleni S Nakou, Moses Elisaf, Evangelos N Liberopoulos,

<h4>Aims</h4>To compare the effects of ezetimibe plus orlistat or rimonabant on anthropometric and lipid parameters in nondiabetic statin-intolerant overweight/obese patients with dyslipidemia.<h4>Methods and results</h4>Thirty participants received a hypocaloric diet and were randomized to open-label combination of ezetimibe (10 mg/day) with orlistat (120 mg, 3 times a day with meals; ezetimibe/orlistat ... Read more >>

J Cardiovasc Pharmacol Ther (Journal of cardiovascular pharmacology and therapeutics)
[2009, 14(4):274-282]

Cited: 5 times

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The role of C-reactive protein in atherosclerotic cardiovascular disease: an overview.

Eleni S Nakou, Evangelos N Liberopoulos, Haralampos J Milionis, Moses S Elisaf,

C-reactive protein (CRP) is an acute-phase protein, which has been used in clinical practice as a non specific marker of inflammation. Many studies have shown that CRP is associated with atherosclerotic cardiovascular disease. It is currently unknown if CRP plays an active role as an etiologic factor in cardiovascular disease. ... Read more >>

Curr Vasc Pharmacol (Current vascular pharmacology)
[2008, 6(4):258-270]

Cited: 32 times

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Orlistat-associated adverse effects and drug interactions: a critical review.

Theodosios D Filippatos, Christos S Derdemezis, Irene F Gazi, Eleni S Nakou, Dimitri P Mikhailidis, Moses S Elisaf,

Orlistat, an anti-obesity drug, is a potent and specific inhibitor of intestinal lipases. In light of the recent US FDA approval of the over-the-counter sale of orlistat (60 mg three times daily), clinicians need to be aware that its use may be associated with less well known, but sometimes clinically ... Read more >>

Drug Saf (Drug safety)
[2008, 31(1):53-65]

Cited: 108 times

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