Full Text Journal Articles by
Author Elena Lucas

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Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.

Hao Chen, Elena Lucas, Amanda L Strickland, Kelley Carrick, Katja Gwin, Diego H Castrillon, Glorimar Rivera-Colon, Shuang Niu, Kyle H Molberg, Wenxin Zheng,

BACKGROUND:Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions is often problematic because of the profound morphologic changes induced by progestin and the lack of established diagnostic criteria for progestin-treated residual AH. METHODS:We conducted a longitudinal study of 265 endometrial biopsies ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1429-1439]

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Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.

Nicole C Panarelli, Suntrea T G Hammer, Jingmei Lin, Purva Gopal, ILKe Nalbantoglu, Lili Zhao, Jerome Cheng, Adam J Gersten, Jonathan B McHugh, Vinita Parkash, Elena Lucas, Maria Westerhoff,

The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1381-1388]

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PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Different Types of Tubo-ovarian Carcinoma and Their Prognostic Value in High-grade Serous Carcinoma.

Hao Chen, Kyle Molberg, Amanda L Strickland, Diego H Castrillon, Kelley Carrick, Qingping Jiang, Shuang Niu, Glorimar Rivera-Colon, Katja Gwin, Stacy Hinson, Jayanthi Lea, David S Miller, Wenxin Zheng, Elena Lucas,

The prevalence and significance of programmed death-1 ligand (PD-L1) expression in different types of tubo-ovarian carcinoma have not been well defined. We evaluated PD-L1 expression and CD8 tumor-infiltrating lymphocyte (TIL) density in whole tissue sections of 189 cases of tubo-ovarian carcinoma, including high-grade serous carcinoma (HGSC, n=100), clear cell carcinoma ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(8):1050-1060]

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Pleomorphic neoplasm in a liver: A potential pitfall for misdiagnosis.

Lubna Alattia, Kyle Molberg, Elena Lucas,

Cytojournal (CytoJournal)
[2020, 17:8]

Cited: 0 times

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Cinacalcet treatment experience in hereditary vitamin D resistant rickets.

Jesús Lucas, Jose Luis Badia, Elena Lucas, Ana Remon,

Background Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR). ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(2):313-318]

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Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior.

Glorimar Rivera-Colon, Hao Chen, Shuang Niu, Elena Lucas, Steven Holloway, Kelley Carrick, Katja Gwin, Jayanthi Lea, Wenxin Zheng,

The pattern-based classification system of endocervical adenocarcinoma correlates with nodal metastasis and clinical outcomes, but its application in biopsies is challenging. The aim of this study was the correlation of additional histologic features with patterns of invasion as well as prognosis. A total of 103 specimens from 71 cervical adenocarcinoma ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(2):247-254]

Cited: 1 time

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Effects of Decalcifying Agents of Variable Duration on PD-L1 Immunohistochemistry.

Amanda L Strickland, Sara Blacketer, Kyle Molberg, John Markantonis, Elena Lucas,

OBJECTIVES:To evaluate the effects of decalcifying agents on programmed cell death ligand 1 (PD-L1) immunohistochemistry (IHC). METHODS:Fragments of 10 placentas (high PD-L1 expressor) and 10 lungs (lower PD-L1 expressor) were formalin-fixed and subjected to four decalcifying solutions (EDTA, formic acid/MasterCal IM Plus [FA/MC], 12% HCl, and Decal STAT/23% HCl) for ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2020, 153(2):258-265]

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PI3K Pathway Effectors pAKT and FOXO1 as Novel Markers of Endometrioid Intraepithelial Neoplasia.

Amanda L Strickland, Glorimar Rivera, Elena Lucas, George John, Ileana Cuevas, Diego H Castrillon,

The diagnosis of endometrioid intraepithelial neoplasia (EIN) is challenging owing to limited sampling, hormonal status, and other confounding histologic variables. Markers such as PTEN or PAX2 can delineate EIN in some cases, but are not wholly reliable. Clearly, new markers of EIN are needed. We explored several potential markers of ... Read more >>

Int. J. Gynecol. Pathol. (International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists)
[2019, 38(6):503-513]

Cited: 4 times

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Mismatch Repair Protein Expression in Endometrioid Intraepithelial Neoplasia/Atypical Hyperplasia: Should We Screen for Lynch Syndrome in Precancerous Lesions?

Elena Lucas, Hao Chen, Kyle Molberg, Diego H Castrillon, Glorimar Rivera Colon, Long Li, Stacy Hinson, Joel Thibodeaux, Jayanthi Lea, David S Miller, Wenxin Zheng,

Screening for Lynch syndrome (LS) is routinely performed in patients with endometrial carcinoma. Currently, no screening recommendations exist for LS in precancerous lesions. The study goal was to determine the incidence of abnormal protein expression in endometrioid intraepithelial neoplasia/atypical hyperplasia (EIN/AH). We analyzed mismatch repair (MMR) protein expression by immunohistochemistry ... Read more >>

Int. J. Gynecol. Pathol. (International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists)
[2019, 38(6):533-542]

Cited: 1 time

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Comparison of Dako HercepTest and Ventana PATHWAY Anti-HER2 (4B5) Tests and Their Correlation With Fluorescent In Situ Hybridization in Breast Carcinoma.

Elena Lucas, Seema B Jabbar, Kyle Molberg, Yisheng Fang, Xian-Jin Xie, Sara Blacketer, Sunati Sahoo,

OBJECTIVES:We compared the performance of two Food and Drug Administration-approved HER2 immunohistochemistry (IHC) tests: HercepTest (Dako) and PATHWAY anti-HER2 (4B5) (Ventana). MATERIALS AND METHODS:In total, 180 invasive breast carcinomas previously tested by both HercepTest and fluorescent in situ hybridization (FISH) were retested with 4B5. Three pathologists scored the HER2 IHC ... Read more >>

Appl. Immunohistochem. Mol. Morphol. (Applied immunohistochemistry & molecular morphology : AIMM)
[2019, 27(6):403-409]

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Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ.

Shuang Niu, Kyle Molberg, Joel Thibodeaux, Glorimar Rivera-Colon, Stacy Hinson, Wenxin Zheng, Elena Lucas,

INTRODUCTION:Recognition of adenocarcinoma in situ (AIS) in cervical cytology is challenging. MATERIALS AND METHODS:We calculated the sensitivity and accuracy of Papanicolaou (Pap) tests obtained within 1 year of a histologic diagnosis of AIS from 2007 to 2016. We also correlated it with the coexistence of squamous lesions, calculated the interobserver ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2019, 8(3):141-148]

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Age cutoff for reporting of benign-appearing endometrial cells in Papanicolaou specimens; should it be raised? A 10-year retrospective study from a large county hospital.

Stacy Hinson, Kyle Molberg, Mariam Mir, Melinda Flores, Wenxin Zheng, Elena Lucas,

INTRODUCTION:The recommendation for reporting benign-appearing endometrial cells in Papanicolaou specimens was increased from 40 to 45 years in the 2014 edition of The Bethesda System. Recent studies suggest that increasing the reporting age to 50 years would have no significant negative impact. Reporting of benign endometrial cells may trigger unnecessary ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2019, 8(2):78-83]

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Lung tumor in a young African American patient with sickle trait: Pieces of a puzzle.

Mariam Mir, Michelle Parmley, Kyle Molberg, Stacy Hinson, Joel Thibodeaux, Elena Lucas,

(CytoJournal)
[2018, 15:21]

Cited: 0 times

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Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.

Minfen Zhang, Elena Lucas, Hanzhen Xiong, Shaoyan Liu, Kyle Molberg, Qingping Jiang, Wenxin Zheng,

BACKGROUND:Although cases of cervical squamous cell carcinoma metastatic to the ovary have been previously documented, we report the first case of superficially invasive squamous cell carcinoma metastatic to the ovary. CASE PRESENTATION:A 45-year-old woman with a two-year history of ovarian endometriosis confirmed by ultrasound underwent oophorectomy. On microscopic examination, a ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2018, 11(1):44]

Cited: 2 times

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Effect of Differing Parameters on Irreversible Electroporation in a Porcine Model.

Noah E Canvasser, Aaron H Lay, Ersin Koseoglu, Nicholas Kavoussi, Igor Sorokin, Jeffrey Gahan, Elena Lucas, Jeffrey A Cadeddu,

INTRODUCTION AND OBJECTIVE:Irreversible electroporation (IRE) is a new ablative technology to treat small renal masses. We evaluated differed ablation settings on lesion size and temperature changes in a porcine model. MATERIALS AND METHODS:After Institutional Animal Care and Use Committee approval, 36 laparoscopy-guided and 16 open ablations were performed on 13 ... Read more >>

J. Endourol. (Journal of endourology)
[2018, 32(4):338-343]

Cited: 0 times

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The diagnostic utility of Merkel cell polyomavirus immunohistochemistry in a fine needle aspirate of metastatic Merkel cell carcinoma of unknown primary to the pancreas.

Long Li, Kyle Molberg, Naga Cheedella, Joel Thibodeaux, Stacy Hinson, Elena Lucas,

Merkel cell carcinoma (MCC) is an aggressive skin tumor with a high tendency for metastases. We report a case of MCC initially presenting as axillary and pancreatic metastases. A 33-year-old HIV-positive Hispanic male presented with a history of a rapidly growing axillary mass. A needle core biopsy demonstrated an epithelioid ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2018, 46(1):67-71]

Cited: 2 times

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Poor phenotype-genotype association in a large series of patients with Type III Bartter syndrome.

Alejandro García Castaño, Gustavo Pérez de Nanclares, Leire Madariaga, Mireia Aguirre, Álvaro Madrid, Sara Chocrón, Inmaculada Nadal, Mercedes Navarro, Elena Lucas, Julia Fijo, Mar Espino, Zilac Espitaletta, Víctor García Nieto, David Barajas de Frutos, Reyner Loza, Guillem Pintos, Luis Castaño, , Gema Ariceta,

Type III Bartter syndrome (BS) is an autosomal recessive renal tubule disorder caused by loss-of-function mutations in the CLCNKB gene, which encodes the chloride channel protein ClC-Kb. In this study, we carried out a complete clinical and genetic characterization in a cohort of 30 patients, one of the largest series ... Read more >>

PLoS One (PloS one)
[2017, 12(3):e0173581]

Cited: 9 times

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Metastatic Melanoma to the Bladder: Case Report and Review of the Literature.

Rohit V Patil, Solomon L Woldu, Elena Lucas, Andrew M Quinn, Franto Francis, Vitaly Margulis,

A 49-year-old Caucasian woman presented to the dermatology clinic for follow-up of malignant melanoma with a complaint of painless gross hematuria. Two years prior she was diagnosed with malignant melanoma from a skin lesion on her left flank treated with wide excision, negative axillary sentinel lymph node biopsy, and adjuvant ... Read more >>

(Urology case reports)
[2017, 11:33-36]

Cited: 1 time

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Expulsion of a Uterine Fibroid into the Small Bowel through Uteroenteric Fistula Presenting with Bowel Obstruction after Uterine Fibroid Embolization: Case Report with Histopathologic Correlation.

Anil K Pillai, Jerry Mathew Elias Kovoor, Stephen P Reis, Kimberly Kho, Patrick D Sutphin, Elena Lucas,

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2016, 27(5):762-764]

Cited: 1 time

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Comparative Effects of Irreversible Electroporation, Radiofrequency Ablation, and Partial Nephrectomy on Renal Function Preservation in a Porcine Solitary Kidney Model.

Monica S C Morgan, Asim Ozayar, Elena Lucas, Justin I Friedlander, Nabeel A Shakir, Jeffrey A Cadeddu,

To evaluate kidney function preservation or regeneration and pathological changes post-irreversible electroporation (IRE) in comparison with partial nephrectomy and radiofrequency ablation (RFA) in a solitary kidney porcine model. Tissue ablation using IRE has been reported to spare critical anatomic structures within or near the ablation zone with associated regeneration of ... Read more >>

Urology (Urology)
[2016, 94:281-287]

Cited: 1 time

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Effectiveness of the Godelieve Denys-Struyf (GDS) method in people with low back pain: cluster randomized controlled trial.

María José Díaz-Arribas, Francisco M Kovacs, Ana Royuela, Mónica Fernández-Serrano, Lorena Gutiérrez-Fernández, Oscar San Martín-Pariente, Víctor Abraira, Mabel Ramos-Sánchez, Rosa Llorca-Palomera, Pedro Pardo-Hervás, Mario Gestoso, Gracia Camacho Sánchez-Gil, María Ángeles Elena-Lucas, Raquel Paniagua-de-la-Calle, Isabel Castellanos-López, María Ángeles García-Heredia, Ana Miriam Cerón-Sanz, Basilio Victoria-González, Carmen Monsalve-Martín, José María Duque-Heras, Manuel J Juanes-Hernández, Jana Saura-Contí, Juan Luis Soto-Sáez, Carlos Román-Moraleda, César Ruiz-Arias, Beatriz Martín-Mora, Rubén Escolano-García, José Sebastian Cantero-Bengoechea, Elena García-López, Alicia López-Pelegrín, Elena Padilla-Martin, María Martínez-Rodríguez, Joaquín Casillas-Martín, Javier Jerez-Vázquez, Lucía Barrientos-Gómez, ,

BACKGROUND: The Godelieve Denys-Struyf method (GDS) is a motor learning intervention that may be applied in group or individualized sessions. OBJECTIVE: The study objective was to compare the effectiveness of routine physical therapy, group GDS (GDS-G) sessions, and group and individualized GDS (GDS-I) sessions. DESIGN: This was a cluster randomized ... Read more >>

Phys Ther (Physical therapy)
[2015, 95(3):319-336]

Cited: 2 times

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Genetics of type III Bartter syndrome in Spain, proposed diagnostic algorithm.

Alejandro García Castaño, Gustavo Pérez de Nanclares, Leire Madariaga, Mireia Aguirre, Alvaro Madrid, Inmaculada Nadal, Mercedes Navarro, Elena Lucas, Julia Fijo, Mar Espino, Zilac Espitaletta, Luis Castaño, Gema Ariceta, ,

The p.Ala204Thr mutation (exon 7) of the CLCNKB gene is a "founder" mutation that causes most of type III Bartter syndrome cases in Spain. We performed genetic analysis of the CLCNKB gene, which encodes for the chloride channel protein ClC-Kb, in a cohort of 26 affected patients from 23 families. ... Read more >>

PLoS One (PloS one)
[2013, 8(9):e74673]

Cited: 5 times

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NT-proBNP as a prognostic marker in critically ill patients.

Elena A Lucas, Frank H Wians,

Anesth. Analg. (Anesthesia and analgesia)
[2007, 104(4):998-9; author reply 999-1000]

Cited: 0 times

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PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma.

José-Francisco Garcia, Giovanna Roncador, Juan-Fernando García, Ana-Isabel Sánz, Lorena Maestre, Elena Lucas, Santiago Montes-Moreno, Rebeca Fernandez Victoria, Jorge L Martinez-Torrecuadrara, Teresa Marafioti, David Y Mason, Miguel A Piris,

BACKGROUND AND OBJECTIVES: The positive regulatory domain I (PRDM1) protein or BLIMP-1, belonging to the PRDM gene family of transcriptional repressors, is a key regulator of terminal differentiation in B-lymphocytes and is critical for plasma cell differentiation. DESIGN AND METHODS: Here we document the expression of PRDM1 in normal and ... Read more >>

Haematologica (Haematologica)
[2006, 91(4):467-474]

Cited: 55 times

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Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections.

José-Francisco García, Juan-Fernando García, Lorena Maestre, Elena Lucas, Lydia Sánchez-Verde, Silvia Romero-Chala, Miguel-Angel Piris, Giovanna Roncador,

Genetic immunization can be combined with hybridoma technology to generate high-affinity monoclonal antibodies (MAbs). A new anti-BCL-6 MAb (GI191E/A8) was produced by cloning full-length BCL-6 cDNA into a eukaryotic vector and delivering this into mouse epidermis using a helium gene gun. A comparative study was made of the specificity and ... Read more >>

J. Histochem. Cytochem. (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society)
[2006, 54(1):31-38]

Cited: 9 times

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