Full Text Journal Articles by
Author Elena Ioana Braicu

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis.

Joanna Baum, Elena Ioana Braicu, Oliver Hunsicker, Ignace Vergote, Nicole Concin, Els Van Nieuwenhuysen, Aarne Feldheiser, Patriciu Achimas-Cadariu, Silvia Darb-Esfahani, Astrid Berger, Bogdan Fetica, Sven Mahner, Andrea Papadia, Linn Wölber, Maria Luisa Gasparri, Adriaan Vanderstichele, Pierluigi Benedetti Panici, Michael D Mueller, Ilary Ruscito, Hannah Woopen, Jalid Sehouli,

<h4>Introduction</h4>Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Secondary malignancies in long-term ovarian cancer survivors: results of the 'Carolin meets HANNA' study.

Hannah Woopen, Carolin Rolf, Elena Ioana Braicu, Nina Buttmann-Schweiger, Benjamin Barnes, Joanna Baum, Klaus Pietzner, Klaus Kraywinkel, Jalid Sehouli,

<h4>Objective</h4>To evaluate the rate of secondary malignancies in long-term survivors with ovarian cancer.<h4>Methods</h4>Long-term survivors with ovarian cancer (survival ≥8 years after initial diagnosis) with multiple malignancies were identified within the Tumorbank Ovarian Cancer and our study 'Carolin meets HANNA - Holistic Analyses of Long-term Survivors with Ovarian Cancer'.<h4>Results</h4>Of a total ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Lymphovascular space invasion and Ki67 as predictors of lymph node metastasis in primary low grade serous ovarian cancer.

Jacek P Grabowski, Joanna Glajzer, Rolf Richter, Helmut Plett, Mustafa-Zelal Muallem, Elena Ioana Braicu, Eliane Taube, Jalid Sehouli,

<h4>Objective</h4>Low grade serous ovarian cancers characterize a unique clinical pattern and likely less frequent incidence of lymphatic metastasis. The expression level of Ki67 is associated with differences in prognosis and therapy outcome. However, its expression in combination with lymphovascular space invasion has not been evaluated in the prediction of lymphatic ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(1):98-103]

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Patients' subjective assessment as a decisive predictor of malignancy in pelvic masses: results of a multicentric, prospective pelvic mass study.

Elisa Koch, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Gerhard Nohe, Bodo Müller, Janine Boeneß-Zaloum, Kerstin Ames, Frank Chen, Carmen Beteta, Kati Hasenbein, Adak Pirmorady, Mathias Zimmermann, Desislava Dimitrova, Rudolf Tauber, Jalid Sehouli, Catherine Linn Knieper, Elena Ioana Braicu,

<h4>Objective</h4>The prognosis for ovarian cancer patients remains poor. A key to maximizing survival rates is early detection and treatment. This requires an accurate prediction of malignancy. Our study seeks to improve the accuracy of prediction by focusing on early subjective assessment of malignancy. We therefore investigated the assessment of patients ... Read more >>

J Psychosom Obstet Gynaecol (Journal of psychosomatic obstetrics and gynaecology)
[2020, :1-6]

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Biological Impact of Unilateral Oophorectomy: Does the Number of Ovaries Really Matter?

Maria Luisa Gasparri, Ilary Ruscito, Elena Ioana Braicu, Jalid Sehouli, Luca Tramontano, Flavia Costanzi, Maria Paola De Marco, Michael D Mueller, Andrea Papadia, Donatella Caserta, Filippo Bellati,

Although unilateral oophorectomies are performed more often than bilateral ones in women of reproductive age, their clinical consequences have been less intensively investigated. Experimental models in animals have shown that compensatory mechanisms occur after a unilateral oophorectomy (UO). This review aims to summarize the available evidence on the biological effects ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2021, 81(3):331-338]

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ESGO-SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers.

Cristiana Sessa, Dominik T Schneider, François Planchamp, Katja Baust, Elena Ioana Braicu, Nicole Concin, Jan Godzinski, W Glenn McCluggage, Daniel Orbach, Patricia Pautier, Fedro A Peccatori, Philippe Morice, Gabriele Calaminus,

The European Society of Gynaecological Oncology and the European Society for Paediatric Oncology jointly developed clinically relevant and evidence-based guidelines for the management of adolescents and young adults aged 15 to 25 years with non-epithelial ovarian cancers, including malignant ovarian germ cell tumours, sex cord-stromal tumours, and small cell carcinoma ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(7):e360-e368]

Cited: 1 time

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Incorporating Parp-inhibitors in Primary and Recurrent Ovarian Cancer: A Meta-analysis of 12 phase II/III randomized controlled trials.

Ilary Ruscito, Filippo Bellati, Isabelle Ray-Coquard, Mansoor Raza Mirza, Andreas du Bois, Maria Luisa Gasparri, Flavia Costanzi, Maria Paola De Marco, Marianna Nuti, Donatella Caserta, Sandro Pignata, Oliver Dorigo, Jalid Sehouli, Elena Ioana Braicu,

BACKGROUND:The second decade of 2000s is witnessing a new ovarian cancer (OC) paradigm shift thanks to the results recently obtained by a new class of targeted agents: the Poly(ADP-ribose)polymerase (PARP)-Inhibitors (PARPi). Aim of this meta-analysis is to analyze available results obtained with PARPi, administered alone or in combination with chemo- ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2020, 87:102040]

Cited: 2 times

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Immunoglobulin G Subclass-Specific Glycosylation Changes in Primary Epithelial Ovarian Cancer.

Marta Wieczorek, Elena Ioana Braicu, Leticia Oliveira-Ferrer, Jahid Sehouli, Véronique Blanchard,

Epithelial ovarian cancer (EOC) was previously shown to be associated with glycosylation changes of total serum and total IgG proteins. However, as a majority of previous studies analyzed released glycan profiles, still little is known about IgG subclass-specific alterations in ovarian cancer. Hence, in this study, we investigated EOC-related glycosylation ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:654]

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Ultrasound and Clinical Preoperative Characteristics for Discrimination Between Ovarian Metastatic Colorectal Cancer and Primary Ovarian Cancer: A Case-Control Study.

Maciej Stukan, Juan Luis Alcazar, Jacek Gębicki, Elizabeth Epstein, Marcin Liro, Alexandra Sufliarska, Sebastian Szubert, Stefano Guerriero, Elena Ioana Braicu, Mariusz Szajewski, Małgorzata Pietrzak-Stukan, Daniela Fischerova,

The aim of this study was to describe the clinical and sonographic features of ovarian metastases originating from colorectal cancer (mCRC), and to discriminate mCRC from primary ovarian cancer (OC). We conducted a multi-institutional, retrospective study of consecutive patients with ovarian mCRC who had undergone ultrasound examination using the International ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 9(4):]

Cited: 1 time

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Dual targeting of estrogen receptor α and estrogen-related receptor α: a novel endocrine therapy for endometrial cancer.

XiaoDan Mao, Binhua Dong, Min Gao, GuanYu Ruan, MeiMei Huang, Elena Ioana Braicu, Jalid Sehouli, PengMing Sun,

Background:Endometrial cancer (EC) is a hormone dependent carcinoma that may involve complex molecular mechanisms. Endocrine therapy by blocking the estrogen and estrogen receptor α (ERα) has been effective in breast cancer, while it is still controversial in EC. Recently, estrogen-related receptor α (ERRα) was proven to be another endocrine therapy ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:6757-6767]

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Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer.

Hagen Kulbe, Raik Otto, Silvia Darb-Esfahani, Hedwig Lammert, Salem Abobaker, Gabriele Welsch, Radoslav Chekerov, Reinhold Schäfer, Duska Dragun, Michael Hummel, Ulf Leser, Jalid Sehouli, Elena Ioana Braicu,

Detection of epithelial ovarian cancer (EOC) poses a critical medical challenge. However, novel biomarkers for diagnosis remain to be discovered. Therefore, innovative approaches are of the utmost importance for patient outcome. Here, we present a concept for blood-based biomarker discovery, investigating both epithelial and specifically stromal compartments, which have been ... Read more >>

Cells (Cells)
[2019, 8(7):]

Cited: 6 times

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Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium.

Jun Guan, Silvia Darb-Esfahani, Rolf Richter, Eliane T Taube, Ilary Ruscito, Sven Mahner, Linn Woelber, Katharina Prieske, Nicole Concin, Ignace Vergote, Els Van Nieuwenhuysen, Patriciu Achimas-Cadariu, Joanna Glajzer, Hannah Woopen, Mandy Stanske, Hagen Kulbe, Carsten Denkert, Jalid Sehouli, Elena Ioana Braicu,

OBJECTIVE:The impact of angiogenesis on long-term survival of high-grade serous ovarian cancer (HGSOC) patients remains unclear. This study investigated whether angiogenic markers correlated with 5-year progression-free survival (PFS) in a large cohort of matched advanced HGSOC tissue samples. METHODS:Tumor samples from 124 primary HGSOC patients were retrospectively collected within the ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2019, 145(4):1063-1073]

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Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer.

Caroline Kreuzinger, Isabel von der Decken, Andrea Wolf, Magdalena Gamperl, Julia Koller, Jasmine Karacs, Stephanie Pfaffinger, Thomas Bartl, Alexander Reinthaller, Christoph Grimm, Christian F Singer, Elena Ioana Braicu, Paula Cunnea, Charlie Gourley, Dominiek Smeets, Bram Boeckx, Diether Lambrechts, Paul Perco, Reinhard Horvat, Els M J J Berns, Dan Cacsire Castillo-Tong,

High grade serous ovarian cancer (HGSOC) is the most frequent type of ovarian cancer. Most patients have primary response to platinum-based chemotherapy but frequently relapse, which leads to patient death. A lack of well documented and characterized patient-derived HGSOC cell lines is so far a major barrier to define tumor ... Read more >>

Cancer Lett (Cancer letters)
[2019, 459:1-12]

Cited: 5 times

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Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.

Anastasia Meshcheryakova, Martin Svoboda, Markus Jaritz, Felicitas Mungenast, Martina Salzmann, Dietmar Pils, Dan Cacsire Castillo-Tong, Gudrun Hager, Andrea Wolf, Elena Ioana Braicu, Jalid Sehouli, Sandrina Lambrechts, Ignace Vergote, Sven Mahner, Peter Birner, Philip Zimmermann, David N Brindley, Georg Heinze, Robert Zeillinger, Diana Mechtcheriakova,

The sphingolipid and lysophosphatidate regulatory networks impact diverse mechanisms attributed to cancer cells and the tumor immune microenvironment. Deciphering the complexity demands implementation of a holistic approach combined with higher-resolution techniques. We implemented a multi-modular integrative approach consolidating the latest accomplishments in gene expression profiling, prognostic/predictive modeling, next generation digital ... Read more >>

Comput Struct Biotechnol J (Computational and structural biotechnology journal)
[2019, 17:537-560]

Cited: 4 times

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Prognostic significance of Ki-67 levels and hormone receptor expression in low-grade serous ovarian carcinoma: an investigation of the Tumor Bank Ovarian Cancer Network.

Jalid Sehouli, Elena Ioana Braicu, Rolf Richter, Carsten Denkert, Paul Jank, Philipp Sebastian Jurmeister, Catarina Alisa Kunze, Jan Budczies, Sylvia Darb-Esfahani, Wolfgang Daniel Schmitt, Alexander Traut, Jacek Grabowski, Eliane Tabea Taube, Helmut Plett,

Low-grade serous ovarian carcinoma (LGSOC) has recently come up as a distinct rare entity of epithelial ovarian cancer. Predictive and prognostic markers are not well studied yet. Because Ki-67 and hormone receptors (HR) have been established as relevant cancer biomarkers in several malignant tumors, we evaluated Ki-67 and HR expression ... Read more >>

Hum Pathol (Human pathology)
[2019, 85:299-308]

Cited: 1 time

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Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer.

PengMing Sun, YiYi Song, DaBin Liu, GuiFen Liu, XiaoDan Mao, BinHua Dong, Elena Ioana Braicu, Jalid Sehouli,

Few studies have examined the potential transcription factor (TF) simultaneously associated with cisplatin resistance and metastasis in ovarian cancer. To assess a related mechanism, a 345-channel protein/DNA array and transcriptional activity ELISA were performed to compare the TF activities in the cisplatin-sensitive SKOV3 and cisplatin-resistant SKOV3-DDP cells and in HO-8910 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13483]

Cited: 6 times

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Clinical Outcome After Completion Surgery in Patients With Ovarian Cancer: The Charite Experience.

Aygun Babayeva, Elena Ioana Braicu, Jacek P Grabowski, Khayal Gasimli, Rolf Richter, Mustafa Zelal Muallem, Jalid Sehouli,

<h4>Objective</h4>The aim of this study was to estimate surgical outcome and survival benefit after completion surgery.<h4>Methods</h4>We evaluated 164 patients with epithelial ovarian cancer who underwent incomplete primary cytoreductive surgery or rather received only staging procedures from January 2000 to December 2014 in outside institutions. Patient-related data were registered in prospective ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(8):1491-1497]

Cited: 2 times

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Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).

Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, Iulia Ignat, Mandy Stanske, Adriaan Vanderstichele, Jacek Glajzer, Hagen Kulbe, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Pierluigi Benedetti Panici, Charlie Gourley, Hani Gabra, Marianna Nuti, Eliane T Taube, Mirjana Kessler, Jalid Sehouli, Silvia Darb-Esfahani, Elena Ioana Braicu,

<h4>Background</h4>High-grade serous ovarian cancer (HGSOC) intratumoural vasculature evolution remains unknown. The study investigated changes in tumour microvessel density (MVD) in a large cohort of paired primary and recurrent HGSOC tissue samples and its impact on patients' clinico-pathological outcome.<h4>Methods</h4>A total of 222 primary (pOC) and recurrent (rOC) intra-patient paired HGSOC were ... Read more >>

Br J Cancer (British journal of cancer)
[2018, 119(3):330-338]

Cited: 2 times

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Sorafenib plus topotecan versus placebo plus topotecan for platinum-resistant ovarian cancer (TRIAS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Radoslav Chekerov, Felix Hilpert, Sven Mahner, Ahmed El-Balat, Philipp Harter, Nikolaus De Gregorio, Claudius Fridrich, Susanne Markmann, Jochem Potenberg, Ralf Lorenz, Guelten Oskay-Oezcelik, Marcus Schmidt, Petra Krabisch, Hans-Joachim Lueck, Rolf Richter, Elena Ioana Braicu, Andreas du Bois, Jalid Sehouli, , ,

<h4>Background</h4>Antiangiogenic therapy has known activity in ovarian cancer. The investigator-initiated randomised phase 2 TRIAS trial assessed the multi-kinase inhibitor sorafenib combined with topotecan and continued as maintenance therapy for platinum-resistant or platinum-refractory ovarian cancer.<h4>Methods</h4>We did a multicentre, double-blind, placebo-controlled, randomised, phase 2 trial at 20 sites in Germany. Patients (≥18 ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2018, 19(9):1247-1258]

Cited: 18 times

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Preoperative CA-125 Value as a Predictive Factor for Postoperative Outcome in First Relapse of Platinum-sensitive Serous Ovarian Cancer.

Asya Parashkevova, Jalid Sehouli, Rolf Richter, Desislava Dimitrova, Elena Ioana Braicu, Mustafa Zelal Muallem,

<h4>Aim</h4>The purpose of the study was to evaluate whether preoperative cancer antigen 125 (CA-125) levels predict outcome of secondary cytoreductive surgery (SCS) in patients with serous recurrent ovarian cancer and whether this could be used as a prognostic factor for progression-free (PFS) and overall (OS) survival.<h4>Patients and methods</h4>A cohort of ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(8):4865-4870]

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The Role of PAR1 Autoantibodies in Patients with Primary Epithelial Ovarian Cancer.

Katrin Kreienbring, Annika Franz, Rolf Richter, Duska Dragun, Harald Heidecke, Dominik Müller, Monika Mentze, Ralf Dechend, Jalid Sehouli, Elena Ioana Braicu,

This study aimed to analyze the predictive, prognostic and diagnostic value of autoantibodies to coagulation factor II thrombin receptor (F2R; protease-activated receptor 1, PAR1) (PAR1-AB) in patients with primary epithelial ovarian cancer (EOC).A total of 197 patients with primary EOC and 200 healthy female blood donors were included in the ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(6):3619-3625]

Cited: 3 times

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Immunobiology of Solid Cancers: Cellular and Molecular Pathways as Potential Diagnostic and Therapeutic Targets.

Ilary Ruscito, Elena Ioana Braicu, Maria Luisa Gasparri, Ilaria Grazia Zizzari,

Biomed Res Int (BioMed research international)
[2018, 2018:6532019]

Cited: 0 times

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The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis.

Ilary Ruscito, Silvia Darb-Esfahani, Hagen Kulbe, Filippo Bellati, Ilaria Grazia Zizzari, Hassan Rahimi Koshkaki, Chiara Napoletano, Donatella Caserta, Aurelia Rughetti, Mirjana Kessler, Jalid Sehouli, Marianna Nuti, Elena Ioana Braicu,

To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics.The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "cancer stem ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2018, 150(1):151-157]

Cited: 3 times

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A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer.

Caroline Kreuzinger, Angelika Geroldinger, Dominiek Smeets, Elena Ioana Braicu, Jalid Sehouli, Julia Koller, Andrea Wolf, Silvia Darb-Esfahani, Korinna Joehrens, Ignace Vergote, Adriaan Vanderstichele, Bram Boeckx, Diether Lambrechts, Hani Gabra, G Bea A Wisman, Fabian Trillsch, Georg Heinze, Reinhard Horvat, Stephan Polterauer, Els Berns, Charles Theillet, Dan Cacsire Castillo-Tong,

<b>Purpose:</b> Most high-grade serous ovarian cancer (HGSOC) patients develop recurrent disease after first-line treatment, frequently with fatal outcome. This work aims at studying the molecular biology of both primary and recurrent HGSOC.<b>Experimental Design:</b> Gene expression profiles of matched primary and recurrent fresh-frozen tumor tissues from 66 HGSOC patients were obtained ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2017, 23(24):7621-7632]

Cited: 7 times

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