Full Text Journal Articles by
Author Elaine S Jaffe

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Epstein-Barr Virus-negative Marginal Zone Lymphoma as an Uncommon Form of Monomorphic Posttransplant Lymphoproliferative Disorder.

Pallavi Galera, Richard Flavin, Natasha M Savage, Annapurna Saksena, Shunyou Gong, Huan-You Wang, Niall Swan, Liqiang Xi, Mark Raffeld, Stefania Pittaluga, Elaine S Jaffe,

Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent hosts in the current WHO Classification. Low-grade B-cell neoplasms have historically been excluded from this category, although rare reports of marginal zone lymphoma (MZL) ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1340-1352]

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The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy.

Caoimhe Egan, Justin Lack, Shannon Skarshaug, Thu Anh Pham, Zied Abdullaev, Liqiang Xi, Svetlana Pack, Stefania Pittaluga, Elaine S Jaffe, Mark Raffeld,

Histiocytic sarcoma and tumors with dendritic cell differentiation (HDT) are uncommon neoplasms often with an aggressive clinical course that may occur in association with another hematologic malignancy or mediastinal germ cell tumor (secondary HDT, sHDT). Previous studies have shown mutations in the RAS/MAPK pathway in HDT and have demonstrated a ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, :]

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Anaplastic large-cell lymphoma (ALK-negative)-related heart failure and recurrence after heart transplantation.

Christopher Felicelli, Nicolas Lopez-Hisijos, Reeba Omman, Daniel Shepherd, Vijayalakshmi Ananthanarayanan, Ameet R Kini, Rhett P Ketterling, Joseph J Maleszewski, Elaine S Jaffe, Sucha Nand, Joshua Newman, Ashish Haryani, Max Liebo, Kamran M Mirza,

J. Heart Lung Transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(10):1156-1158]

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CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma.

Rena R Xian, Yi Xie, Lisa M Haley, Raluca Yonescu, Aparna Pallavajjala, Stefania Pittaluga, Elaine S Jaffe, Amy S Duffield, Chad M McCall, Shereen M F Gheith, Christopher D Gocke,

The diffuse variant of follicular lymphoma (dFL) is a rare variant of FL lacking t(14;18) that was first described in 2009. In this study, we use a comprehensive approach to define unifying pathologic and genetic features through gold-standard pathologic review, FISH, SNP-microarray, and next-generation sequencing of 16 cases of dFL. ... Read more >>

Blood Cancer J (Blood cancer journal)
[2020, 10(6):69]

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Reply to M. Romero et al.

Elaine S Jaffe, Andrew L Feldman, Philippe Gaulard, Roberto N Miranda, Aliyah R Sohani,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(24):2819-2820]

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Treatment of HIV-associated Primary CNS Lymphoma with Antiretroviral Therapy, Rituximab, and High-Dose Methotrexate.

Kathryn Lurain, Thomas S Uldrick, Ramya Ramaswami, Mark Polizzotto, Priscila Goncalves, Anaida Widell, Seth M Steinberg, Elaine S Jaffe, Stefania Pittaluga, Hao-Wei Wang, Constance Yuan, Mary Anne Tamula, Staci Martin, Pamela L Wolters, Jomy George, Richard F Little, Robert Yarchoan,

Blood (Blood)
[2020, :]

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Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.

Mark Roschewski, Kieron Dunleavy, Jeremy S Abramson, Bayard L Powell, Brian K Link, Prapti Patel, Philip J Bierman, Deepa Jagadeesh, Ronald T Mitsuyasu, David Peace, Peter R Watson, Wahid T Hanna, Christopher Melani, Andrea N Lucas, Seth M Steinberg, Stefania Pittaluga, Elaine S Jaffe, Jonathan W Friedberg, Brad S Kahl, Richard F Little, Nancy L Bartlett, Michelle A Fanale, Ariela Noy, Wyndham H Wilson,

PURPOSE:Burkitt lymphoma is an aggressive B-cell lymphoma curable with dose-intensive chemotherapy derived from pediatric leukemia regimens. Treatment is acutely toxic with late sequelae. We hypothesized that dose-adjusted etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, and rituximab (DA-EPOCH-R) may obviate the need for highly dose-intensive chemotherapy in adults with Burkitt lymphoma. METHODS:We conducted ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(22):2519-2529]

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T-cell and NK-cell neoplasms of the gastrointestinal tract - recurrent themes, but clinical and biological distinctions exist.

Elaine S Jaffe,

Haematologica (Haematologica)
[2020, 105(7):1760-1762]

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An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract.

Rahul Krishnan, Kari Ring, Eli Williams, Craig Portell, Elaine S Jaffe, Alejandro A Gru,

Natural killer (NK) cell enteropathy is a lymphoproliferative disorder, initially described by Mansoor and colleagues, that presents in the gastrointestinal tract, and is often mistaken for extranodal NK/T-cell lymphoma on first assessment. This population of cells in this process have an NK-cell phenotype (CD3, CD56, CD2, CD7), lacks evidence of ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(4):561-565]

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Lymphoma Classification.

Laurence de Leval, Elaine S Jaffe,

Twenty-five years after the Revised European American Classification of Lymphoid Neoplasms classification was published, its principle of an integrative approach to disease definition based on several parameters still prevails and has been adopted and expanded in the following World Health Organization classifications of tumors of the hematopoietic organs. The latest ... Read more >>

Cancer J (Cancer journal (Sudbury, Mass.))
[2020, 26(3):176-185]

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Expansion of PD1-positive T Cells in Nodal Marginal Zone Lymphoma: A Potential Diagnostic Pitfall.

Caoimhe Egan, Camille Laurent, Julie C Alejo, Stefano Pileri, Elias Campo, Steven H Swerdlow, Miguel Piris, Wing C Chan, Roger Warnke, Randy D Gascoyne, Liqiang Xi, Mark Raffeld, Stefania Pittaluga, Elaine S Jaffe,

The diagnosis of nodal marginal zone lymphoma (NMZL) can be challenging, with the differential diagnosis including other low-grade B-cell lymphomas, reactive hyperplasia, and even some cases of peripheral T-cell lymphoma (PTCL). PTCL may have a perifollicular growth pattern mimicking NMZL. We and others have noted an atypical distribution of T-follicular ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(5):657-664]

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Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma.

Stefania Pittaluga, Alina Nicolae, George W Wright, Christopher Melani, Mark Roschewski, Seth Steinberg, DaWei Huang, Louis M Staudt, Elaine S Jaffe, Wyndham H Wilson,

Mediastinal gray zone lymphoma (MGZL) has immunopathologic features between classical Hodgkin lymphoma (cHL) and primary mediastinal thymic B-cell lymphoma (PMBL), leading to uncertainty regarding its biological relationship to these entities. We performed gene expression profiling from patients with MGZL (20), cHL (18), and PMBL (17) and show MGZL clusters between ... Read more >>

Blood Cancer Discov (Blood cancer discovery)
[2020, 1(2):155-161]

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Best Practices Guideline for the Pathologic Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma.

Elaine S Jaffe, Binita S Ashar, Mark W Clemens, Andrew L Feldman, Philippe Gaulard, Roberto N Miranda, Aliyah R Sohani, Timothy Stenzel, Sung W Yoon,

PURPOSE:To provide guidelines for the accurate pathologic diagnosis of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), the preoperative evaluation of the patient with suspected BIA-ALCL, and the pathologic evaluation of the capsulectomy specimen. METHODS:To better inform patients and healthcare providers about BIA-ALCL, we convened to review diagnostic procedures used in ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(10):1102-1111]

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Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.

Christopher Melani, Elaine S Jaffe, Wyndham H Wilson,

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven B-cell lymphoproliferative disease (LPD). This disease is hypothesized to result from defective immune surveillance of EBV, with most patients showing evidence of immune dysfunction, despite no known primary immunodeficiency. Pathologically, LYG is graded by the number and density of EBV+ atypical ... Read more >>

Blood (Blood)
[2020, 135(16):1344-1352]

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Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte-predominant Hodgkin lymphoma.

Joo Y Song, Caoimhe Egan, Alyssa C Bouska, Weiwei Zhang, Qiang Gong, Girish Venkataraman, Alex F Herrera, Lu Chen, Rebecca Ottesen, Joyce C Niland, Victoria Bedell, Maria Valle-Catuna, Joyce Murata-Collins, Dennis D Weisenburger, Javeed Iqbal, Elaine S Jaffe, Wing C Chan,

Leukemia (Leukemia)
[2020, 34(8):2238-2242]

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18F-FDG PET Imaging Features of Patients With Autoimmune Lymphoproliferative Syndrome.

Jorge A Carrasquillo, Clara C Chen, Susan Price, Millie Whatley, Nilo A Avila, Stefania Pittaluga, Elaine S Jaffe, V Koneti Rao,

INTRODUCTION:Autoimmune lymphoproliferative syndrome (ALPS) is a rare immune dysregulatory condition, usually presenting in childhood with massive lymphadenopathy, splenomegaly, and an increased incidence of lymphoma. Methods to differentiate between benign ALPS adenopathy and lymphoma are needed. To this end, we evaluated the usefulness of FDG PET. METHODS:We prospectively evaluated 76 ALPS/ALPS-like ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2019, 44(12):949-955]

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Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.

Catalina Amador, Timothy C Greiner, Tayla B Heavican, Lynette M Smith, Karen Tatiana Galvis, Waseem Lone, Alyssa Bouska, Francesco D'Amore, Martin Bjerregaard Pedersen, Stefano Pileri, Claudio Agostinelli, Andrew L Feldman, Andreas Rosenwald, German Ott, Anja Mottok, Kerry J Savage, Laurence de Leval, Philippe Gaulard, Soon Thye Lim, Choon Kiat Ong, Sarah L Ondrejka, Joo Song, Elias Campo, Elaine S Jaffe, Louis M Staudt, Lisa M Rimsza, Julie Vose, Dennis D Weisenburger, Wing C Chan, Javeed Iqbal,

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell malignancies; approximately one-third of cases are designated as PTCL-not otherwise specified (PTCL-NOS). Using gene-expression profiling (GEP), we have previously defined 2 major molecular subtypes of PTCL-NOS, PTCL-GATA3 and PTCL-TBX21, which have distinct biological differences in oncogenic pathways and prognosis. ... Read more >>

Blood (Blood)
[2019, 134(24):2159-2170]

Cited: 5 times

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Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.

Joan Enric Ramis-Zaldivar, Blanca Gonzalez-Farré, Olga Balagué, Verónica Celis, Ferran Nadeu, Julia Salmerón-Villalobos, Mara Andrés, Idoia Martin-Guerrero, Marta Garrido-Pontnou, Ayman Gaafar, Mariona Suñol, Carmen Bárcena, Federico Garcia-Bragado, Maitane Andión, Daniel Azorín, Itziar Astigarraga, Maria Sagaseta de Ilurdoz, Constantino Sábado, Soledad Gallego, Jaime Verdú-Amorós, Rafael Fernandez-Delgado, Vanesa Perez, Gustavo Tapia, Anna Mozos, Montserrat Torrent, Palma Solano-Páez, Alfredo Rivas-Delgado, Ivan Dlouhy, Guillem Clot, Anna Enjuanes, Armando López-Guillermo, Pallavi Galera, Matthew J Oberley, Alanna Maguire, Colleen Ramsower, Lisa M Rimsza, Leticia Quintanilla-Martinez, Elaine S Jaffe, Elías Campo, Itziar Salaverria,

Pediatric large B-cell lymphomas (LBCLs) share morphological and phenotypic features with adult types but have better prognosis. The higher frequency of some subtypes such as LBCL with IRF4 rearrangement (LBCL-IRF4) in children suggests that some age-related biological differences may exist. To characterize the genetic and molecular heterogeneity of these tumors, ... Read more >>

Blood (Blood)
[2020, 135(4):274-286]

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Constipated plasma cells in extranodal marginal zone lymphoma of the lung.

Jinjun Cheng, Elaine S Jaffe,

Blood (Blood)
[2019, 134(24):2226]

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Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting.

Jeffrey I Cohen, Keiji Iwatsuki, Young-Hyeh Ko, Hiroshi Kimura, Irini Manoli, Koichi Ohshima, Stefania Pittaluga, Leticia Quintanilla-Martinez, Elaine S Jaffe,

Epstein-Barr virus (EBV) normally infects B cells, but in some persons the virus infects T or NK cells. Infection of B cells can result in infectious mononucleosis, and the virus is associated with several B cell malignancies including Hodgkin lymphoma, Burkitt lymphoma, and diffuse large B cell lymphoma. Infection of ... Read more >>

Leuk. Lymphoma (Leukemia & lymphoma)
[2020, 61(4):808-819]

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Diagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities.

Charles Van Slambrouck, Jooryung Huh, Cheolwon Suh, Joo Y Song, Madhu P Menon, Aliyah R Sohani, Amy S Duffield, Reva C Goldberg, Paola Dama, Kazuma Kiyotani, James Godfrey, Carrie Fitzpatrick, Justin Kline, Sonali M Smith, Elaine S Jaffe, Sylvia Hartmann, Girish Venkataraman,

Although the distinction of classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma using morphology and immunostains is straightforward in most instances, occasional cases pose diagnostic challenge. We sought to determine the utility of the novel YE361 STAT6 rabbit monoclonal antibody in Hodgkin lymphoma and diagnostically challenging B- and T-cell ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(5):834-845]

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Navigating the cutaneous B-cell lymphomas: avoiding the rocky shoals.

Elaine S Jaffe,

In recent years great progress has been made in understanding the classification of lymphomas. The integration of morphologic, clinical, immunophenotypic, and molecular features provides a rational basis for defining disease entities and has led to worldwide consensus. Hematopathologists and dermatopathologists have worked together to define those lymphomas that are present ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(Suppl 1):96-106]

Cited: 1 time

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18F-FDG PET Imaging Features of Patients With Autoimmune Lymphoproliferative Syndrome.

Jorge A Carrasquillo, Clara C Chen, Susan Price, Millie Whatley, Nilo A Avila, Stefania Pittaluga, Elaine S Jaffe, V Koneti Rao,

INTRODUCTION:Autoimmune lymphoproliferative syndrome (ALPS) is a rare immune dysregulatory condition, usually presenting in childhood with massive lymphadenopathy, splenomegaly, and an increased incidence of lymphoma. Methods to differentiate between benign ALPS adenopathy and lymphoma are needed. To this end, we evaluated the usefulness of FDG PET. METHODS:We prospectively evaluated 76 ALPS/ALPS-like ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2019, :]

Cited: 0 times

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Novel markers in pediatric-type follicular lymphoma.

Claudio Agostinelli, Ayse U Akarca, Alan Ramsay, Hasan Rizvi, Manuel Rodriguez-Justo, Sabine Pomplun, Ian Proctor, Elena Sabattini, David Linch, Stephen Daw, Stefania Pittaluga, Stefano A Pileri, Elaine S Jaffe, Leticia Quintanilla-Martinez, Teresa Marafioti,

The aim of this study was to review the histopathological, phenotypic, and molecular characteristics of pediatric-type follicular lymphoma (PTFL) and to assess the diagnostic value of novel immunohistochemical markers in distinguishing PTFL from follicular hyperplasia (FH). A total of 13 nodal PTFLs were investigated using immunohistochemistry, fluorescence in situ hybridization ... Read more >>

Virchows Arch. (Virchows Archiv : an international journal of pathology)
[2019, 475(6):771-779]

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Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Caoimhe Egan, Alina Nicolae, Justin Lack, Hye-Jung Chung, Shannon Skarshaug, Thu Anh Pham, Winnifred Navarro, Zied Abdullaev, Nadine S Aguilera, Liqiang Xi, Svetlana Pack, Stefania Pittaluga, Elaine S Jaffe, Mark Raffeld,

Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of a previous hematologic malignancy or mediastinal germ cell tumor. Here, we performed whole exome sequencing and RNA-sequencing (RNA-Seq) on 21 archival cases of primary histiocytic sarcoma. We identified a high number of genetic ... Read more >>

Haematologica (Haematologica)
[2020, 105(4):951-960]

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