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Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection.

Naoyuki Ueda, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, C Nelson Hayes, Michiya Yokozaki, Kazuaki Chayama,

BACKGROUND:Evaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several limitations. The aim of this study was to determine correlations among METAVIR scores and FibroScan, Virtual-Touch tissue quantification ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2020, 20(1):314]

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Increase of non- HBV, non- HCV related hepatocellular carcinoma -Over 20 years single institution study-

Yuko Nagaoki, Hideyuki Hyogo, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Yuno Nishida, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Daiki Miki, Michio Imamura, Shoichi Takahashi, Kazuaki Chayama, Hiroshi Aikata,

Abstract Background: We previously reported the trends of etiologies of hepatocellular carcinoma (HCC) between 1995 and 2009. By updating this study, we aimed to evaluate the incidence of HCC with non- hepatitis B viral and non- hepatitis C viral (NBNC) etiologies and explore the clinical characteristics, also. Methods: Consecutive 2171 ... Read more >>

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Liver fibrosis assessments using FibroScan, Virtual-Touch tissue quantification, the FIB-4 index, and Mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection

Naoyuki Ueda, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, C.NELSON HAYES, Michiya Yokozaki, Kazuaki Chayama,

Abstract BackgroundEvaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several limitations. The aim of this study was to determine correlations among METAVIR scores and FibroScan, Virtual-Touch tissue ... Read more >>

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Real-world efficacy of sofosbuvir plus velpatasvir therapy for patients with hepatitis C virus-related decompensated cirrhosis.

Kazuki Ohya, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C Nelson Hayes, Nami Mori, Shintaro Takaki, Keiji Tsuji, Yasuyuki Aisaka, Tomokazu Ishitobi, Yoshio Katamura, Hideaki Kodama, Yoshitaka Nabeshima, Keiichi Masaki, Yohji Honda, Takashi Moriya, Hirotaka Kohno, Hiroshi Kohno, Kazuaki Chayama,

AIM:Combination therapy with sofosbuvir (SOF) plus velpatasvir (VEL) is approved for patients with hepatitis C virus (HCV)-related decompensated cirrhosis. We analyzed the real-world efficacy of SOF/VEL therapy. METHODS:Thirty-three patients with HCV-related decompensated cirrhosis (25 and eight patients with Child B and C, respectively) were treated with SOF/VEL for 12 weeks. The ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, :]

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Analysis of Post-Progression Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib.

Yuwa Ando, Tomokazu Kawaoka, Yosuke Suehiro, Kenji Yamaoka, Yumi Kosaka, Shinsuke Uchikawa, Kenichiro Kodama, Kei Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Takayuki Fukuhara, Nami Mori, Shintaro Takaki, Keiji Tsuji, Michihiro Nonaka, Hideyuki Hyogo, Yasuyuki Aisaka, Keiichi Masaki, Yoji Honda, Takashi Moriya, Noriaki Naeshiro, Takahiro Azakami, Shoichi Takahashi, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata,

BACKGROUND:Although a strong antitumor effect of lenvatinib (LEN) has been noted for patients with unresectable hepatocellular carcinoma (HCC), there are still no reports on the prognosis for patients with disease progression after first-line LEN therapy. METHODS:Patients (n = 141) with unresectable HCC, Child-Pugh class A liver function, and an Eastern ... Read more >>

Oncology (Oncology)
[2020, :1-11]

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Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients.

Yuko Nagaoki, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, C Nelson Hayes, Kazuaki Chayama, Hiroshi Aikata,

AIM:We analyzed the impact of hepatitis C virus eradication by direct-acting antiviral (DAA) therapy on the risk of development of hepatocellular carcinoma (HCC), prognosis, and portal hypertension in patients with liver cirrhosis. METHODS:The rate of HCC development and overall survival after achievement of sustained virological response (SVR) in 173 DAA-treated ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, :]

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Trends in Hepatic Functional Reserve of Patients with Hepatocellular Carcinoma Treated with Tyrosine Kinase Inhibitors.

Shinsuke Uchikawa, Tomokazu Kawaoka, Yuwa Ando, Kenji Yamaoka, Yumi Kosaka, Yosuke Suehiro, Yasutoshi Fujii, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Shoichi Takahashi, Kazuaki Chayama, Hiroshi Aikata,

OBJECTIVE:Functional hepatic reserve is important when considering sequential tyrosine kinase inhibitor (TKI) therapy for patients with advanced hepatocellular carcinoma (HCC). We assessed albumin-bilirubin (ALBI) score and Child-Pugh class as indices of liver function during sorafenib and lenvatinib treatment. METHODS:A total of 212 patients with advanced HCC and Child-Pugh class A ... Read more >>

Oncology (Oncology)
[2020, :1-7]

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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

Andrea J Pruijssers, Amelia S George, Alexandra Schäfer, Sarah R Leist, Lisa E Gralinksi, Kenneth H Dinnon, Boyd L Yount, Maria L Agostini, Laura J Stevens, James D Chappell, Xiaotao Lu, Tia M Hughes, Kendra Gully, David R Martinez, Ariane J Brown, Rachel L Graham, Jason K Perry, Venice Du Pont, Jared Pitts, Bin Ma, Darius Babusis, Eisuke Murakami, Joy Y Feng, John P Bilello, Danielle P Porter, Tomas Cihlar, Ralph S Baric, Mark R Denison, Timothy P Sheahan,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for broad-spectrum antiviral countermeasures against SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV) potently inhibits SARS-CoV-2 replication in human lung cells ... Read more >>

Cell Rep (Cell reports)
[2020, 32(3):107940]

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Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

Andrea Pruijssers, Amelia George, Alexandra Schäfer, Sarah Leist, Lisa Gralinksi, Kenneth Dinnon, Boyd Yount, Maria Agostini, Laura Stevens, James Chappell, Xiaotao Lu, Tia Hughes, Kendra Gully, David Martinez, Ariane Brown, Rachel Graham, Jason Perry, Venice Du Pont, Jared Pitts, Bin Ma, Darius Babusis, Eisuke Murakami, Joy Feng, John Bilello, Danielle Porter, Tomas Cihlar, Ralph Baric, Mark Denison, Timothy Sheahan,

SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 as the causative agent of the novel pandemic viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for safe, broad-spectrum antiviral countermeasures against SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV), a monophosphoramidate ... Read more >>

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Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir.

Ting Wang, Darius Babusis, Yeojin Park, Congrong Niu, Cynthia Kim, Xiaofeng Zhao, Bing Lu, Bin Ma, Robert C Muench, Diana Sperger, Adrian S Ray, Eisuke Murakami,

Sofosbuvir (SOF) is a nucleotide prodrug which has been used as a backbone for the clinical treatment of hepatitis C viral infection. Because sofosbuvir undergoes complex first pass metabolism, including metabolic activation to form its pharmacologically active triphosphate (GS-331007-TP) to inhibit the viral RNA polymerase in the liver, it is ... Read more >>

Drug Metab. Pharmacokinet. (Drug metabolism and pharmacokinetics)
[2020, 35(3):334-340]

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Incidence of microsatellite instability-high hepatocellular carcinoma among Japanese patients and response to pembrolizumab.

Tomokazu Kawaoka, Yuwa Ando, Masami Yamauchi, Yosuke Suehiro, Kenji Yamaoka, Yumi Kosaka, Yasutomo Fuji, Shinsuke Uchikawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Shoichi Takahashi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata,

AIM:Pembrolizumab has been quickly approved in many countries for the treatment of patients with unresectable or metastatic, microsatellite instability-high (MSI-H) solid tumors, which have progressed following previous treatment and who have no satisfactory alternative treatment options. We aimed to determine the incidence of MSI-H tumors in Japanese patients with advanced ... Read more >>

Hepatol. Res. (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(7):885-888]

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Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability.

Yuwa Ando, Masami Yamauchi, Yosuke Suehiro, Kenji Yamaoka, Yumi Kosaka, Yasutomo Fuji, Shinsuke Uchikawa, Kenichiro Kodama, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Shoichi Takahashi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata,

Hepatocellular carcinoma (HCC) has limited systemic treatment options and a poor prognosis. The immune checkpoint inhibitor pembrolizumab was recently approved for the treatment of solid tumors with microsatellite instability (MSI). However, its clinical utility for the management of HCC remains to be clarified. Here, we present a case of unresectable ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(5):867-872]

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Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.

Kana Daijo, Takashi Nakahara, Yuki Inagaki, Maiko Nanba, Yuno Nishida, Shinsuke Uchikawa, Kenichiro Kodama, Kazuki Oya, Kei Morio, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, C Nelson Hayes, Michio Imamura, Hiroshi Aikata, Hidenori Ochi, Kazuaki Chayama,

BACKGROUND AND AIM:The most important prognostic factor for non-alcoholic steatohepatitis (NASH) is liver fibrosis. The aim of this study is to examine clinical parameters involved in pathological progression in NASH patients who underwent repeated liver biopsy and to analyze the response to treatment with respect to NASH-related single nucleotide polymorphisms ... Read more >>

J. Gastroenterol. Hepatol. (Journal of gastroenterology and hepatology)
[2020, 35(8):1412-1419]

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A case of advanced HCC treated with lenvatinib after hepatic arterial infusion chemotherapy combined with radiation therapy treatment for portal vein tumor thrombosis in the main trunk.

Yumi Kosaka, Tomokazu Kawaoka, Hiroshi Aikata, Yosuke Suehiro, Kenji Yamaoka, Yuwa Ando, Maiko Namba, Yasue Takeuchi, Yasutomo Fujii, Shinsuke Uchikawa, Kenichiro Kodama, Kazuki Oya, Kei Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yasutaka Baba, Kazuo Awai, Tomoki Kimura, Yasushi Nagata, Kazuaki Chayama,

We report a 46-year-old male patient with functional liver damage due to hepatitis B virus infection. A 12 cm hepatocellular carcinoma (HCC) in the left lobe and portal venous tumor thrombosis (PVTT) with vp4 (portal vein tumor thrombosis in the main trunk) were detected by computed tomography (CT). He underwent hepatic ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(5):839-843]

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Preoperative PET-CT is useful for predicting recurrent extrahepatic metastasis of hepatocellular carcinoma after resection.

Kei Morio, Tomokazu Kawaoka, Hiroshi Aikata, Maiko Namba, Shinsuke Uchikawa, Kenichiro Kodama, Kazuki Ohya, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yuko Nakamura, Motonori Akagi, Kazuo Awai, Tsuyoshi Kobayashi, Hideki Ohdan, Kazuaki Chayama,

PURPOSE:In recent years, it has been reported that use of 18F-FDG PET-CT can reveal the degree of hepatocellular carcinoma malignancy. We evaluate the ability of a preoperative 18F-FDG PET-CT to predict the recurrence of extrahepatic metastasis of HCC after surgery. METHODS:We retrospectively examined 67 patients who received 18F-FDG PET-CT prior ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 124:108828]

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Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection.

Kazuki Ohya, Tomokazu Kawaoka, Michio Imamura, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Akira Hiramatsu, Masataka Tsuge, Hiroshi Aikata, Kazuaki Chayama,

Although direct-acting antivirals (DAAs) have significantly increased the sustained virological response (SVR) rates in chronic hepatitis C virus (HCV)-infected adult patients, the efficacy and safety for children remain unclear. We herein report three HCV-infected children who received DAA treatment. The patients were girls 10-13 years old who had been infected ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, 59(7):941-944]

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Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report.

Yosuke Tamura, Tomokazu Kawaoka, Hiroshi Aikata, Maiko Namba, Yasutomo Fujii, Kei Morio, Eisuke Murakami, Masami Yamauchi, Akira Hiramatsu, Takashi Nakahara, Michio Imamura, Tatsuya Maruhashi, Tsuyoshi Kobayashi, Hideki Ohdan, Tomoki Kimura, Yasushi Nagata, Kouji Arihiro, Kazuaki Chayama,

A 76-year-old man was diagnosed with multiple hepatocellular carcinomas (HCCs). He underwent right lobectomy and partial resection of the liver after transcatheter arterial embolization at our hospital. The pathology report was moderately differentiated HCC (fT4N0M0 Stage Iva, Vp1, Vv0). Follow-up CT revealed a lesion in the right ventricle 3 years after ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(3):421-427]

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Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.

Julie Farand, Jeffrey E Kropf, Peter Blomgren, Jianjun Xu, Aaron C Schmitt, Zachary E Newby, Ting Wang, Eisuke Murakami, Ona Barauskas, Jawahar Sudhamsu, Joy Y Feng, Anita Niedziela-Majka, Brian E Schultz, Karen Schwartz, Serge Viatchenko-Karpinski, Dmytro Kornyeyev, Adam Kashishian, Peidong Fan, Xiaowu Chen, Eric B Lansdon, Michael O Ports, Kevin S Currie, William J Watkins, Gregory T Notte,

We describe the discovery of three structurally differentiated potent and selective MTH1 inhibitors and their subsequent use to investigate MTH1 as an oncology target, culminating in target (in)validation. Tetrahydronaphthyridine 5 was rapidly identified as a highly potent MTH1 inhibitor (IC50 = 0.043 nM). Cocrystallization of 5 with MTH1 revealed the ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2020, 11(3):358-364]

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Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy.

Yuhei Saito, Michio Imamura, Takuro Uchida, Mitsutaka Osawa, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Masahiro Serikawa, Hiroshi Aikata, Hiromi Abe-Chayama, C Nelson Hayes, Kazuaki Chayama,

Ribavirin (RBV) induces nucleotide (nt) substitutions in hepatitis C virus (HCV) genome nonstructural (NS) regions. Although emergence of drug resistance-associated variants is associated with direct-acting antiviral treatment failure, the effect of RBV on genome substitutions in such patients is unknown. Genotype 1b HCV subgenomic replicon cells were treated with RBV ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, 92(2):210-218]

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Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.

Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill Smith, Yurong Lai,

Induction potentials of the pregnane X receptor (PXR) activator rifampin (RIF) on transporter genes [e.g., organic anion-transporting polypeptides (OATPs)] are still in its infancy or remain controversial in the field. The present investigations characterized changes in transporter gene expression by RIF in sandwich-cultured hepatocytes from multiple donors of human and ... Read more >>

Drug Metab. Dispos. (Drug metabolism and disposition: the biological fate of chemicals)
[2019, 47(12):1433-1442]

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Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy.

Kazuki Ohya, Michio Imamura, Mitsutaka Osawa, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Akira Hiramatsu, Masataka Tsuge, Hiroshi Aikata, Clair Nelson Hayes, Kazuaki Chayama,

Although NS3/4 protease inhibitor glecaprevir (GLE) plus NS5A inhibitor pibrentasvir (PIB) therapy has a high efficacy for chronic hepatitis C virus (HCV)-infected patients with hemodialysis, some patients fail to respond to the therapy. Here, we report a hemodialysis genotype 2 HCV-infected patient who achieved sustained virological response (SVR) by 12 weeks ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(2):267-270]

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Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis.

Maiko Namba, Akira Hiramatsu, Hiroshi Aikata, Kenichiro Kodama, Shinsuke Uchikawa, Kazuki Ohya, Kei Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Michio Imamura, Kazuaki Chayama,

BACKGROUND:This study investigated time-course changes in skeletal muscle volume per year with tolvaptan in patients with refractory ascites that was unresponsive to loop diuretics and aldosterone antagonists. METHODS:This retrospective study included 42 patients who received tolvaptan for refractory ascites and/or hepatic edema and underwent computed tomography (CT) before and ≥ 3 months ... Read more >>

J. Gastroenterol. (Journal of gastroenterology)
[2020, 55(2):217-226]

Cited: 2 times

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Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy.

Kazuki Ohya, Tomokazu Kawaoka, Maiko Namba, Shinsuke Uchikawa, Kenichiro Kodama, Kei Morio, Takashi Nakahara, Eisuke Murakami, Akira Hiramatsu, Masataka Tsuge, Masami Yamauchi, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata,

We aimed to investigate the early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated with lenvatinib. This retrospective study included 23 patients with advanced hepatocellular carcinoma who were able to receive lenvatinib continuously for at least 1 week. We compared their ammonia levels (NH3), ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12101]

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Correlation between Early Tumor Marker Response and Imaging Response in Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib.

Kenichiro Kodama, Tomokazu Kawaoka, Maiko Namba, Shinsuke Uchikawa, Kazuki Ohya, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Akira Hiramatsu, Michio Imamura, Kazuaki Chayama, Hiroshi Aikata,

AIM:This study investigated early tumor marker response and treatment response in patients with advanced hepatocellular carcinoma (HCC) treated with lenvatinib. METHODS:Twenty patients with advanced HCC who received lenvatinib were enrolled in this retrospective study. α-Fetoprotein (AFP) and des-γ-carboxyprothrombin (DCP) levels were measured before treatment as well as 2 and 4 ... Read more >>

Oncology (Oncology)
[2019, 97(2):75-81]

Cited: 6 times

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Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice.

Mitsutaka Osawa, Takuro Uchida, Michio Imamura, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe-Chayama, C Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Yuji Ishida, Chise Tateno, Yohei Miyayama, Makoto Hijikata, Kazuaki Chayama,

Combination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy for patients who acquired potent NS5A inhibitor resistance-associated variants (RAVs) as a result of failure to respond to previous direct-acting antiviral (DAA) therapies is unclear. We investigated the efficacy ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2019, 100(7):1123-1131]

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