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The efficacy of human papillomavirus vaccination in young Japanese girls: the interim results of the OCEAN study.

Kosuke Hiramatsu, Yutaka Ueda, Asami Yagi, Akiko Morimoto, Tomomi Egawa-Takata, Satoshi Nakagawa, Eiji Kobayashi, Toshihiro Kimura, Tadashi Kimura, Ryoko Minekawa, Yumiko Hori, Kazuaki Sato, Eiichi Morii, Tomio Nakayama, Yoshimichi Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Masaki Mandai, Jyunko Saito, Yorihiko Horikoshi, Tetsu Takagi, Takayuki Enomoto, Kentaro Shimura,

Human papillomavirus (HPV) vaccine has been used to prevent chronic HPV infection, which accounts for cervical cancer. Japanese Ministry of Health, Labor and Welfare (MHLW) conducted an HPV vaccination campaign in 2010 and the Obstetrical Gynecological Society of Osaka initiated a multicenter, prospective cohort study in Osaka, Japan - OCEAN ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2021, :1-5]

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An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara,

Aicardi-Goutières syndrome (AGS) is a congenital inflammatory disorder accompanied by overactivated type I IFN signaling and encephalopathy with leukodystrophy and intracranial calcification. To date, none of the mouse models carrying an AGS-causative mutation has mimicked such brain pathology. Here, we established a mutant mouse model carrying a K948N point mutation, ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, :]

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Mitochondria govern histone acetylation in colorectal cancer.

Kenji Ohshima, Ryo Oi, Satoshi Nojima, Eiichi Morii,

Cancer cells have an altered metabolic state that supports their growth, for example, aerobic glycolysis, known as the Warburg effect. Colorectal cancer cells have been reported to exhibit the Warburg effect and mainly rely on glycolysis for progression and have dysfunctional mitochondria. So far, how mitochondrial function influences the properties ... Read more >>

J Pathol (The Journal of pathology)
[2021, :]

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Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling.

Kenji Ohshima, Ryo Oi, Daisuke Okuzaki, Daisuke Motooka, Masakazu Shinohara, Satoshi Nojima, Eiichi Morii,

<h4>Background</h4>The mechanisms underlying metastasis of colorectal cancer (CRC) remain unclear. C14orf159 is a mitochondrial matrix protein converting D-glutamate to 5-oxo-D-proline. Other metabolic functions of C14orf159, especially on mitochondrial metabolism, and its contribution to CRC metastasis, are not elucidated.<h4>Methods</h4>Metabolome analysis by gas chromatography-mass spectrometry, RNA-sequencing analysis, flow cytometry, migration and invasion ... Read more >>

Br J Cancer (British journal of cancer)
[2021, :]

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PIK3CA Mutation Correlates With mTOR Pathway Expression But Not Clinical and Pathological Features in Fibro-Adipose Vascular Anomaly (FAVA)

Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa, Eiichi Morii,

<h4>Background: </h4> Fibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA ) gene were identified at a frequency of 62.5% in FAVA cases. The PIK3CA mutations excessively activate mammalian target of rapamycin (mTOR) pathway, which ... Read more >>

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Nicotinamide N-methyltransferase is related to MELF pattern invasion in endometrioid carcinoma.

Shinichiro Tahara, Satoshi Nojima, Kenji Ohshima, Yumiko Hori, Kazuaki Sato, Masako Kurashige, Takahiro Matsui, Daisuke Okuzaki, Eiichi Morii,

Grade 1 (G1) endometrioid carcinoma (EC) is relatively a good prognosis. However, in a minority of cases, G1 shows an aggressive histological pattern known as the microcystic, elongated, and fragmented (MELF) pattern. We previously reported that EC with high expression levels of S100A4 and serum deprivation-response protein (SDPR) was related to ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(23):8630-8640]

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The Japanese Society of Pathology Practical Guidelines on the handling of pathological tissue samples for cancer genomic medicine.

Yutaka Hatanaka, Takeshi Kuwata, Eiichi Morii, Yae Kanai, Hitoshi Ichikawa, Takashi Kubo, Kanako C Hatanaka, Kazuko Sakai, Kazuto Nishio, Satoshi Fujii, Wataru Okamoto, Takayuki Yoshino, Atsushi Ochiai, Yoshinao Oda,

Clinical cancer genomic testing based on next-generation sequencing can help select genotype-matched therapy and provide diagnostic and prognostic information. Pathological tissue from malignant tumors obtained during routine practice are frequently used for genomic testing. This article is aimed to standardize the proper handling of pathological specimens in practice for genomic ... Read more >>

Pathol Int (Pathology international)
[2021, 71(11):725-740]

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APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation.

Teruyuki Kobayashi, Tomoki Makino, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Eiichi Morii, Hidetoshi Eguchi, Yuichiro Doki,

<h4>Background</h4>Mutations in p53, identified in 90% of oesophageal squamous cell carcinoma (ESCC), are associated with unfavourable prognosis and chemo-resistance. APR-246 induces apoptosis by restoring transcriptional ability of mutant p53, and may be a promising therapeutic agent to overcome chemo-resistance in ESCC.<h4>Methods</h4>In ESCC cell lines differing in p53 status, we performed ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 125(11):1523-1532]

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Polycythemia Vera Associated with Pulmonary Hypertension and Diffuse Large B-Cell Lymphoma: A Case Report.

Satoshi Kameda, Fusako Sera, Kazuaki Sato, Masako Kurashige, Shuichiro Higo, Tomohito Ohtani, Akihiro Tsuboi, Shungo Hikoso, Eiichi Morii, Osamu Yamaguchi, Keiko Yamauchi-Takihara, Yasushi Sakata,

BACKGROUND Myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), are associated with pulmonary hypertension (PH) and malignant lymphomas. Although the underlying mechanisms have not been completely clarified, it has been suggested that the Janus kinase 2 (JAK2) mutation, which is frequently identified in PV, can be involved in the development and/or ... Read more >>

Am J Case Rep (The American journal of case reports)
[2021, 22:e932956]

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Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.

Takahiro Amano, Hideki Iijima, Shinichiro Shinzaki, Taku Tashiro, Shuko Iwatani, Mizuki Tani, Yuriko Otake, Takeo Yoshihara, Aya Sugimoto, Satoshi Egawa, Shinjiro Yamaguchi, Kazuo Kinoshita, Manabu Araki, Motohiro Hirao, Yuko Sakakibara, Satoshi Hiyama, Hiroyuki Ogawa, Koji Nagaike, Jun Murata, Masato Komori, Yorihide Okuda, Takashi Kizu, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Hidekazu Takahashi, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara,

<h4>Background</h4>The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizumab and to explore immunohistochemical markers that can predict the efficacy of bevacizumab for patients with mDJA.<h4>Methods</h4>This multicentre study included patients with histologically ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):978]

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Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis.

Kazuhiro Kozumi, Takahiro Kodama, Hiroki Murai, Sadatsugu Sakane, Olivier Govaere, Simon Cockell, Daisuke Motooka, Naruyasu Kakita, Yukinori Yamada, Yasuteru Kondo, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Ann K Daly, Quentin M Anstee, Tomohide Tatsumi, Eiichi Morii, Tetsuo Takehara,

<h4>Background and aims</h4>NAFLD is the most common liver disease worldwide. NASH, the progressive form of NAFLD, and advanced fibrosis are associated with poor outcomes. We searched for their noninvasive biomarkers.<h4>Approach and results</h4>Global RNA sequencing of liver tissue from 98 patients with biopsy-proven NAFLD was performed. Unsupervised hierarchical clustering well distinguished ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(5):2452-2466]

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Bcl-2-negative IGH-BCL2 translocation-negative follicular lymphoma of the thyroid differs genetically and epigenetically from Bcl-2-positive IGH-BCL2 translocation-positive follicular lymphoma.

Yuichiro Hamamoto, Yoji Kukita, Masanori Kitamura, Masako Kurashige, Hiroaki Masaie, Shigeo Fuji, Jun Ishikawa, Keiichiro Honma, Tomoko Wakasa, Hitoshi Hanamoto, Mitsuyoshi Hirokawa, Ayana Suzuki, Eiichi Morii, Shin-Ichi Nakatsuka,

<h4>Aims</h4>Follicular lymphoma (FL), comprising a minor subset of primary thyroid lymphomas, is divided into two groups based on Bcl-2 expression and IGH-BCL2 translocation. The clinicopathological features exhibited by Bcl-2-negative IGH-BCL2 translocation-negative FL of the thyroid (Bcl-2<sup>-</sup> /IGH-BCL2<sup>-</sup> tFL) are different from those of conventional FL; however, its lymphomagenesis remains unclear. ... Read more >>

Histopathology (Histopathology)
[2021, 79(4):521-532]

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Immunoscore Signatures in Surgical Specimens and Tumor-Infiltrating Lymphocytes in Pretreatment Biopsy Predict Treatment Efficacy and Survival in Esophageal Cancer.

Toshiki Noma, Tomoki Makino, Kenji Ohshima, Keijiro Sugimura, Hiroshi Miyata, Keiichiro Honma, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Eiichi Morii, Hidetoshi Eguchi, Yuichiro Doki,

<h4>Objectives</h4>Tumor-infiltrating lymphocytes (TILs) have long been recognized as playing an important role in tumor immune microenvironment. Lately, the Immunoscore (IS) has been proposed as a new method of quantifying the number of TILs in association with patient survival in several cancer types.<h4>Methods</h4>In 300 preoperatively untreated esophageal cancer (EC) patients who ... Read more >>

Ann Surg (Annals of surgery)
[2021, :]

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Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus.

Tomoki T Mitani, Goichi Beck, Kansuke Kido, Rika Yamashita, Yuki Yonenobu, Takuya Ogawa, Chizu Saeki, Tatsusada Okuno, Seiichi Nagano, Eiichi Morii, Masato Hasegawa, Yuko Saito, Shigeo Murayama, Hideki Mochizuki,

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease; transactivation response DNA-binding protein of 43 kDa (TDP-43) and iron accumulation are supposed to play a crucial role in the pathomechanism of the disease. Here, we report an unusual case of a patient with ALS who presented with speech apraxia as an ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2021, 41(4):324-331]

Cited: 1 time

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Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report.

Satoshi Nojima, Masaharu Kohara, Hiroshi Harada, Hitomi Kajikawa, Katsutoshi Hirose, Shin-Ichi Nakatsuka, Yukinobu Nakagawa, Kaori Oya, Yasuo Fukuda, Kazuhide Matsunaga, Narikazu Uzawa, Manabu Fujimoto, Satoru Toyosawa, Eiichi Morii,

Clear cell carcinoma (CCC) is a rare epithelial malignant tumor of the salivary glands. It is characterized by tumor cells with clear cytoplasm, hyalinized stroma, and most importantly the fusion genes EWSR1-ATF1, EWSR1-CREM, and EWSR1-PLAG1. Break-apart FISH has been performed for multiple CCC cases, but direct sequencing analysis has been ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2021, :]

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An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke.

Takaya Kitano, Yumiko Hori, Shuhei Okazaki, Yuki Shimada, Takanori Iwamoto, Hideaki Kanki, Shintaro Sugiyama, Tsutomu Sasaki, Hajime Nakamura, Naoki Oyama, Taku Hoshi, Goichi Beck, Hiroki Takai, Shunji Matsubara, Hiroya Mizuno, Hirotake Nishimura, Ryo Tamaki, Junichi Iida, Jiro Iba, Masaaki Uno, Haruhiko Kishima, Hiroaki Fushimi, Satoshi Hattori, Shigeo Murayama, Eiichi Morii, Manabu Sakaguchi, Yoshiki Yagita, Takeshi Shimazu, Hideki Mochizuki, Kenichi Todo,

<h4>Background</h4> Thrombosis is a dynamic process, and a thrombus undergoes physical and biochemical changes that may alter its response to reperfusion therapy. This study assessed whether thrombus age influenced reperfusion quality and outcomes after mechanical thrombectomy for cerebral embolism.<h4>Methods</h4> We retrospectively evaluated 185 stroke patients and thrombi that were collected during mechanical ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, :]

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Adult-Onset Biotinidase Deficiency Induces Acutely Progressing Leukoencephalopathy.

Goichi Beck, Daisuke Hirozawa, Keiichiro Honma, Kousuke Baba, Hisae Sumi, Eiichi Morii, Shigeo Murayama, Hideki Mochizuki,

Neurol Clin Pract (Neurology. Clinical practice)
[2021, 11(3):e383-e386]

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Durable response of chemotherapy for cancer of unknown primary with unfavorable subset developed in retroperitoneal space.

Atsuki Matsukawa, Taigo Kato, Fuki Kondo, Keisuke Kawasaki, Atsunari Kawashima, Hiroshi Kiuchi, Ryoichi Imamura, Motohide Uemura, Shinichiro Fukuhara, Eiichi Morii, Norio Nonomura,

<h4>Introduction</h4>Carcinoma of unknown primary site is a heterogeneous group of cancer that is defined by the presence of metastatic disease with no identified primary tumor at initial presentation. Carcinoma of unknown primary site patients with unfavorable subsets particularly show poor prognosis with a median survival of 6-9 months with the treatment ... Read more >>

IJU Case Rep (IJU case reports)
[2021, 4(4):255-258]

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Intraocular Endoscopy Resolved Tube Occlusion of an Ahmed Glaucoma Valve.

Rumi Kawashima, Keita Baba, Kenji Matsushita, Takeshi Soma, Masako Kurashige, Daisuke Umeda, Makoto Nakamura, Eiichi Morii, Kohji Nishida,

We report a case in which intraocular endoscopy clarified the cause of Ahmed glaucoma valve (AGV) failure with a cloudy cornea. A 42-year-old patient with glaucoma underwent AGV implant surgery to treat secondary glaucoma due to chronic iridocyclitis in his left eye. After AGV, he developed bullous keratopathy (BK) in ... Read more >>

Case Rep Ophthalmol (Case reports in ophthalmology)
[2021, 12(2):706-711]

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A deep learning system to diagnose the malignant potential of urothelial carcinoma cells in cytology specimens.

Satoshi Nojima, Kei Terayama, Saeko Shimoura, Sachiko Hijiki, Norio Nonomura, Eiichi Morii, Yasushi Okuno, Kazutoshi Fujita,

<h4>Background</h4>Although deep learning algorithms for clinical cytology have recently been developed, their application to practical assistance systems has not been achieved. In addition, whether deep learning systems (DLSs) can perform diagnoses that cannot be performed by pathologists has not been fully evaluated.<h4>Methods</h4>The authors initially obtained low-power field cytology images from ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2021, :]

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Primary Alveolar Soft Part Sarcoma of Cheek: Report of a Case and Review of the Literature.

Katsutoshi Hirose, Kohei Naniwa, Yu Usami, Masaharu Kohara, Toshihiro Uchihashi, Susumu Tanaka, Saori Yamada, Yuri Iwamoto, Shumei Murakami, Kaori Oya, Yasuo Fukuda, Yumiko Hori, Eiichi Morii, Satoru Toyosawa,

Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma characterized by an alveolar or organoid arrangement of polygonal tumour cells separated by fibrovascular septa. A specific fusion gene [ASPS critical region 1 (ASPSCR1)-TFE3] was detected in ASPS. Despite being a slow-growing tumour without pain and dysfunction, ASPS is ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2021, 15(4):1426-1431]

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Identification of CXCL12-abundant reticular cells in human adult bone marrow.

Kazunari Aoki, Masako Kurashige, Michiko Ichii, Kei Higaki, Tatsuki Sugiyama, Takashi Kaito, Wataru Ando, Nobuhiko Sugano, Takashi Sakai, Hirohiko Shibayama, , Akifumi Takaori-Kondo, Eiichi Morii, Yuzuru Kanakura, Takashi Nagasawa,

A population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells or leptin receptor-expressing cells, are the major cellular component of niches for haematopoietic stem cells (HSCs) in murine bone marrow. CAR cells are characterized by several salient features, including much higher expression of CXCL12, stem cell ... Read more >>

Br J Haematol (British journal of haematology)
[2021, 193(3):659-668]

Cited: 2 times

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Vascular Endothelial Growth Factor-A is an Immunohistochemical Biomarker for the Efficacy of Bevacizumab-containing Chemotherapy for Duodenal and Jejunal Adenocarcinoma

Takahiro Amano, Hideki Iijima, Shinichiro Shinzaki, Taku Tashiro, Shuko Iwatani, Mizuki Tani, Yuriko Otake, Takeo Yoshihara, Aya Sugimoto, Satoshi Egawa, Shinjiro Yamaguchi, Kazuo Kinoshita, Manabu Araki, Motohiro Hirao, Yuko Sakakibara, Satoshi Hiyama, Hiroyuki Ogawa, Koji Nagaike, Jun Murata, Masato Komori, Yorihide Okuda, Takashi Kizu, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Hidekazu Takahashi, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara,

<h4>Background: </h4> The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizumab and to explore immunohistochemical markers that can predict the efficacy of bevacizumab for patients with mDJA. <h4>Methods: </h4>: This multicentre ... Read more >>

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Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

Shigeru Miyagawa, Takuji Kawamura, Emiko Ito, Maki Takeda, Hiroko Iseoka, Junya Yokoyama, Akima Harada, Noriko Mochizuki-Oda, Yukiko Imanishi-Ochi, Junjun Li, Masao Sasai, Fumiyo Kitaoka, Masaki Nomura, Naoki Amano, Tomoko Takahashi, Hiromi Dohi, Eiichi Morii, Yoshiki Sawa,

<h4>Aims</h4> Cardiomyocyte-derived induced pluripotent stem cells (iPSCs) may represent a promising therapeutic strategy for severely damaged myocardium. This study aimed to assess the efficacy and safety of clinical grade human iPSC-derived cardiomyocyte (hiPSC-CM) patches and conduct a pre-clinical proof-of-concept analysis. <h4>Methods and results</h4> A clinical grade hiPSC line was established ... Read more >>

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Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers.

Tsuyoshi Takashima, Daiki Taniyama, Naoya Sakamoto, Maika Yasumoto, Ryuichi Asai, Takuya Hattori, Ririno Honma, Pham Quoc Thang, Shoichi Ukai, Ryota Maruyama, Kenji Harada, Kazuya Kuraoka, Kazuaki Tanabe, Atsuo T Sasaki, Hideki Ohdan, Eiichi Morii, Junko Murai, Wataru Yasui,

<h4>Background</h4>Although unresectable or recurrent gastric cancers (GC) are frequently treated with platinum-based chemotherapy, response to treatment remains unpredictable. Because Schlafen 11 (SLFN11) is recently identified as a critical determinant of platinum sensitivity, we investigated the potential clinical utility of SLFN11 in the treatment of GC.<h4>Methods</h4>We analysed the correlation between SLFN11 ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 125(1):65-77]

Cited: 5 times

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