Full Text Journal Articles by
Author Edward F Nash

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Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators - an international survey.

Edward F Nash, Peter G Middleton, Jennifer L Taylor-Cousar,

BACKGROUND:As their long-term prognosis improves, women with CF are increasingly choosing to have children, but the safety of CFTR modulators in pregnancy and breastfeeding is currently unknown. METHODS:A survey was sent to lead clinicians of adult CF centres in Europe, the United Kingdom (UK), United States of America (USA), Australia ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2020, :]

Cited: 0 times

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Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis.

Sally Palser, Sherie Smith, Edward F Nash, Arnav Agarwal, Alan R Smyth,

BACKGROUND:Chronic infection with Pseudomonas aeruginosa (PA) in cystic fibrosis (CF) is a source of much morbidity and mortality. Eradication of early PA infection is possible, but can recur in many individuals. We sought to examine strategies to delay the time to PA recurrence in people with CF. OBJECTIVES:To establish whether ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 12:CD012300]

Cited: 0 times

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An exploration into experiences and attitudes regarding risky health behaviours in an adult cystic fibrosis population.

Rebecca Keyte, Helen Egan, Edward F Nash, Anna Regan, Craig Jackson, Michail Mantzios,

Health risk behaviours (HRBs) are prevalent within the cystic fibrosis (CF) population, and there is a lack of research around what influences their engagement. This research explored beliefs associated with HRBs within an adult CF population using qualitative semi-structured interviews. Participants' beliefs towards their CF and its life impact were ... Read more >>

Psychol Health Med (Psychology, health & medicine)
[2019, :1-7]

Cited: 0 times

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Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Karmel Webb, Andrew Fogarty, David A Barrett, Edward F Nash, Joanna L Whitehouse, Alan R Smyth, Iain Stewart, Alan Knox, Paul Williams, Nigel Halliday, Miguel Cámara, Helen L Barr,

Introduction. Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces intercellular signalling molecules including 2-alkyl-4-quinolones (AQs), which regulate virulence-factor production and biofilm formation in the CF airways. Studies have ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2019, 68(12):1823-1828]

Cited: 0 times

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Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.

Gwyneth Davies, Nicola J Rowbotham, Sherie Smith, Zoe C Elliot, Katie Gathercole, Oli Rayner, Paul A Leighton, Sophie Herbert, Alistair Ja Duff, Suja Chandran, Tracey Daniels, Edward F Nash, Alan R Smyth,

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: "What are effective ways of simplifying the treatment burden of people with CF?" We aimed to summarise the lived experience of treatment burden and suggest research themes aimed at reducing ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2019, :]

Cited: 0 times

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Pragmatic criteria to define chronic pseudomonas aeruginosa infection among adults with cystic fibrosis.

Zhe Hui Hoo, Elizabeth Coates, Chin Maguire, Hannah Cantrill, Nadia Shafi, Edward F Nash, Angela McGowan, Stephen J Bourke, William G Flight, Thomas V Daniels, Julia A Nightingale, Mark I Allenby, Rachael Curley, Martin J Wildman,

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2018, 37(11):2219-2222]

Cited: 1 time

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Improving the care of patients with cystic fibrosis (CF).

Ahsan Aftab Khan, Edward F Nash, Joanna Whitehouse, Rifat Rashid,

The West Midlands Adult Cystic Fibrosis (CF) Centre based at Birmingham Heartlands Hospital provides care for adults with CF in the West Midlands. People with CF are prone to pulmonary exacerbations, which often require inpatient admission for intravenous antibiotics. We observed that the admission process was efficient during working hours ... Read more >>

BMJ Open Qual (BMJ open quality)
[2017, 6(2):e000020]

Cited: 1 time

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The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and healthcare providers.

Nicola J Rowbotham, Sherie Smith, Paul A Leighton, Oli C Rayner, Katie Gathercole, Zoe C Elliott, Edward F Nash, Tracey Daniels, Alistair J A Duff, Sarah Collins, Suja Chandran, Ursula Peaple, Matthew N Hurley, Keith Brownlee, Alan R Smyth,

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Research questions were elicited and then prioritised in successive surveys. A workshop agreed the ... Read more >>

Thorax (Thorax)
[2018, 73(4):388-390]

Cited: 9 times

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Ease of use of tobramycin inhalation powder compared with nebulized tobramycin and colistimethate sodium: a crossover study in cystic fibrosis patients with pulmonary Pseudomonas aeruginosa infection.

James Greenwood, Carsten Schwarz, Urte Sommerwerck, Edward F Nash, Michael Tamm, Weihua Cao, Paul Mastoridis, Laurie Debonnett, Kamal Hamed,

This study assessed the ease of use of tobramycin inhalation powder (TIP) administered via T-326 inhaler versus tobramycin inhalation solution (TIS) and colistimethate sodium (COLI), both administered via nebulizers, for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF).A real-world, open-label, crossover, interventional phase IV ... Read more >>

Ther Adv Respir Dis (Therapeutic advances in respiratory disease)
[2017, 11(7):249-260]

Cited: 1 time

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A prospective pilot study of home monitoring in adults with cystic fibrosis (HOME-CF): protocol for a randomised controlled trial.

Jocelyn Choyce, Karen L Shaw, Alice J Sitch, Hema Mistry, Joanna L Whitehouse, Edward F Nash,

Home monitoring has the potential to detect early pulmonary exacerbations in people with cystic fibrosis (CF), with consequent improvements in health outcomes and healthcare associated costs. This study aims to assess the effects of home monitoring on hospital admissions, quality of life, antibiotic requirements, exacerbation frequency, lung function, nutritional outcomes, ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2017, 17(1):22]

Cited: 1 time

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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium.

Josephine M Bryant, Dorothy M Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen P Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter Gilligan, Charles R Esther, Peadar G Noone, Olivia Giddings, Scott C Bell, Rachel Thomson, Claire E Wainwright, Chris Coulter, Sushil Pandey, Michelle E Wood, Rebecca E Stockwell, Kay A Ramsay, Laura J Sherrard, Timothy J Kidd, Nassib Jabbour, Graham R Johnson, Luke D Knibbs, Lidia Morawska, Peter D Sly, Andrew Jones, Diana Bilton, Ian Laurenson, Michael Ruddy, Stephen Bourke, Ian Cjw Bowler, Stephen J Chapman, Andrew Clayton, Mairi Cullen, Thomas Daniels, Owen Dempsey, Miles Denton, Maya Desai, Richard J Drew, Frank Edenborough, Jason Evans, Jonathan Folb, Helen Humphrey, Barbara Isalska, Søren Jensen-Fangel, Bodil Jönsson, Andrew M Jones, Terese L Katzenstein, Troels Lillebaek, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, Edward F Nash, Christopher O'Brien, Deirdre O'Brien, Chandra Ohri, Caroline S Pao, Daniel Peckham, Felicity Perrin, Audrey Perry, Tania Pressler, Laura Prtak, Tavs Qvist, Ali Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, Noreen West, Joanna Whitehouse, Charles S Haworth, Simon R Harris, Diane Ordway, Julian Parkhill, R Andres Floto,

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals ... Read more >>

Science (Science (New York, N.Y.))
[2016, 354(6313):751-757]

Cited: 106 times

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Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study.

Helen L Barr, Nigel Halliday, David A Barrett, Paul Williams, Douglas L Forrester, Daniel Peckham, Kate Williams, Alan R Smyth, David Honeybourne, Joanna L Whitehouse, Edward F Nash, Jane Dewar, Andrew Clayton, Alan J Knox, Miguel Cámara, Andrew W Fogarty,

BACKGROUND:Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are detectable in the sputum, plasma and urine of adults with CF, suggesting that they have potential as biomarkers ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2017, 16(2):230-238]

Cited: 7 times

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Chest wall motion analysis in healthy volunteers and adults with cystic fibrosis using a novel Kinect-based motion tracking system.

James M Harte, Christopher K Golby, Johanna Acosta, Edward F Nash, Ercihan Kiraci, Mark A Williams, Theodoros N Arvanitis, Babu Naidu,

Respiratory disease is the leading cause of death in the UK. Methods for assessing pulmonary function and chest wall movement are essential for accurate diagnosis, as well as monitoring response to treatment, operative procedures and rehabilitation. Despite this, there is a lack of low-cost devices for rapid assessment. Spirometry is ... Read more >>

Med Biol Eng Comput (Medical & biological engineering & computing)
[2016, 54(11):1631-1640]

Cited: 7 times

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Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.

Helen L Barr, Nigel Halliday, Miguel Cámara, David A Barrett, Paul Williams, Douglas L Forrester, Rebecca Simms, Alan R Smyth, David Honeybourne, Joanna L Whitehouse, Edward F Nash, Jane Dewar, Andrew Clayton, Alan J Knox, Andrew W Fogarty,

Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection.A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained at the start and end of the treatment period. Additional ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2015, 46(4):1046-1054]

Cited: 27 times

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Physical activity in adults with cystic fibrosis receiving intravenous antibiotics in hospital and in the community.

Heena Khiroya, Rebecca Pound, Ushna Qureshi, Catherine Brown, Joanne Barrett, Rifat Rashid, Joanna L Whitehouse, Alice M Turner, Edward F Nash,

INTRODUCTION:Intravenous antibiotic therapy (IVAT) for CF acute pulmonary exacerbations (APE) can be delivered in hospital or in the community. This study aimed to compare physical activity in CF patients receiving hospital and community-delivered IVAT, as well as other health outcomes. MATERIALS AND METHODS:This was a non-randomised parallel group prospective observational ... Read more >>

Open Respir Med J (The open respiratory medicine journal)
[2015, 9:15-21]

Cited: 0 times

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Preferences for Prenatal Tests for Cystic Fibrosis: A Discrete Choice Experiment to Compare the Views of Adult Patients, Carriers of Cystic Fibrosis and Health Professionals.

Melissa Hill, Ranjan Suri, Edward F Nash, Stephen Morris, Lyn S Chitty,

As new technologies enable the development of non-invasive prenatal diagnosis (NIPD) for cystic fibrosis (CF), research examining stakeholder views is essential for the preparation of implementation strategies. Here, we compare the views of potential service users with those of health professionals who provide counselling for prenatal tests. A questionnaire incorporating ... Read more >>

J Clin Med (Journal of clinical medicine)
[2014, 3(1):176-190]

Cited: 5 times

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Abdominal pain in adults with cystic fibrosis.

Edward F Nash, Chandra M Ohri, Anne L Stephenson, Peter R Durie,

Abdominal pain is a common symptom in individuals with cystic fibrosis (CF). As prognosis has improved, CF has changed from a pediatric disease to the current situation wherein most people with CF are adults. With improved survival, the spectrum of pathologies causing abdominal pain in CF has shifted. Despite this, ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2014, 26(2):129-136]

Cited: 4 times

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Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

Julian Tam, Edward F Nash, Felix Ratjen, Elizabeth Tullis, Anne Stephenson,

BACKGROUND:Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions. Respiratory failure, due to recurrent pulmonary infection and inflammation, is the most common cause of mortality. Muco-active therapies (e.g. dornase alfa and nebulized hypertonic saline) may decrease sputum viscosity, increase airway clearance of sputum, reduce infection and inflammation ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2013, (7):CD007168]

Cited: 19 times

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Implications of the current UK welfare reforms for adults with cystic fibrosis.

Edward F Nash, Dominic Kavanagh, Steven Williams, Shiva Bikmalla, Anne Gray, Joanna L Whitehouse,

Clin Med (Lond) (Clinical medicine (London, England))
[2011, 11(6):634]

Cited: 0 times

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Intussusception in adults with cystic fibrosis: a case series with review of the literature.

Edward F Nash, Anne Stephenson, Emma J Helm, Terence Ho, Chandra M Thippanna, Asad Ali, Joanna L Whitehouse, David Honeybourne, Elizabeth Tullis, Peter R Durie,

Dig. Dis. Sci. (Digestive diseases and sciences)
[2011, 56(12):3695-3700]

Cited: 6 times

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"Cepacia syndrome" associated with Burkholderia cepacia (Genomovar I) infection in an adolescent with cystic fibrosis.

Edward F Nash, Ajit Thomas, Richard Whitmill, Rifat Rashid, Bethan Barker, Rosie J Rayner, Joanna L Whitehouse, David Honeybourne,

Pediatr. Pulmonol. (Pediatric pulmonology)
[2011, 46(5):512-514]

Cited: 3 times

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Clinical outcomes of pandemic (H1N1) 2009 influenza (swine flu) in adults with cystic fibrosis.

Edward F Nash, Richard Whitmill, Bethan Barker, Rifat Rashid, Joanna L Whitehouse, David Honeybourne,

Thorax (Thorax)
[2011, 66(3):259]

Cited: 13 times

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Impact of lung transplantation on serum lipids in adults with cystic fibrosis.

Edward F Nash, Anne Stephenson, Emma J Helm, Peter R Durie, Elizabeth Tullis, Lianne G Singer, Cecilia Chaparro,

BACKGROUND: Cystic fibrosis (CF) is an inherited condition that causes progressive respiratory failure and is the third most common indication for adult bilateral lung transplantation. Post-transplant hyperlipidemia commonly affects lung transplant recipients, but the impact of lung transplantation on serum lipids in the adult CF population is not well studied. ... Read more >>

J. Heart Lung Transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2011, 30(2):188-193]

Cited: 12 times

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Prevalence of dyslipidemia in adults with cystic fibrosis.

Bronwen Rhodes, Edward F Nash, Elizabeth Tullis, Paul B Pencharz, Michelle Brotherwood, Annie Dupuis, Anne Stephenson,

BACKGROUND: A high fat calorie diet is advocated for patients with cystic fibrosis (CF) however the lipid profiles of individuals with CF, including those with CF-related diabetes (CFRD), are not well studied. METHODS: We conducted a retrospective review of adult CF patients attending St Michael's Hospital between January 2005 and ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2010, 9(1):24-28]

Cited: 22 times

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Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

Edward F Nash, Anne Stephenson, Felix Ratjen, Elizabeth Tullis,

BACKGROUND:Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions. Respiratory failure, due to recurrent pulmonary infection and inflammation, is the most common cause of mortality. Muco-active therapies (e.g. dornase alfa and nebulized hypertonic saline) may decrease sputum viscosity, increase airway clearance of sputum, reduce infection and inflammation ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2009, (1):CD007168]

Cited: 12 times

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