Full Text Journal Articles by
Author Edward Cantu

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Primary graft dysfunction.

Rachel N Criner, Emily Clausen, Edward Cantu,

<h4>Purpose of review</h4>Primary graft dysfunction (PGD) is a devastating complication in the acute postoperative lung transplant period, associated with high short-term mortality and chronic rejection. We review its definition, pathophysiology, risk factors, prevention, treatment strategies, and future research directions.<h4>Recent findings</h4>New analyses suggest donation after circulatory death and donation after brain ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):321-327]

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Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.

Jake G Natalini, Joshua M Diamond, Mary K Porteous, David J Lederer, Keith M Wille, Ann B Weinacker, Jonathan B Orens, Pali D Shah, Vibha N Lama, John F McDyer, Laurie D Snyder, Chadi A Hage, Jonathan P Singer, Lorraine B Ware, Edward Cantu, Michelle Oyster, Laurel Kalman, Jason D Christie, Steven M Kawut, Elana J Bernstein,

<h4>Background</h4>Previous studies have reported similarities in long-term outcomes following lung transplantation for connective tissue disease-associated interstitial lung disease (CTD-ILD) and idiopathic pulmonary fibrosis (IPF). However, it is unknown whether CTD-ILD patients are at increased risk of primary graft dysfunction (PGD), delays in extubation, or longer index hospitalizations following transplant compared ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2021, 40(5):351-358]

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The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.

John P Reilly, Nuala J Meyer, Michael Gs Shashaty, Brian J Anderson, Caroline Ittner, Thomas G Dunn, Brian Lim, Caitlin Forker, Michael P Bonk, Ethan Kotloff, Rui Feng, Edward Cantu, Nilam S Mangalmurti, Carolyn S Calfee, Michael A Matthay, Carmen Mikacenic, Keith R Walley, James Russell, David C Christiani, Mark M Wurfel, Paul N Lanken, Muredach P Reilly, Jason D Christie,

BACKGROUNDThe ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases, including acute respiratory distress syndrome (ARDS). We hypothesized that genetically determined blood subtype A1 is associated with increased risk of ARDS and markers of microvascular dysfunction and coagulation.METHODSWe conducted analyses in 3 cohorts ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(1):]

Cited: 2 times

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A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury.

Changhai Li, Kunal Patel, Zhenxiao Tu, Xiaofeng Yang, Liudmila Kulik, Ali Alawieh, Patterson Allen, Qi Cheng, Caroline Wallace, Jane Kilkenny, Jennie Kwon, Barry Gibney, Edward Cantu, Ashish Sharma, Mauricio Pipkin, Tiago Machuca, Amir Emtiazjoo, Martin Goddard, V Michael Holers, Satish Nadig, Jason Christie, Stephen Tomlinson, Carl Atkinson,

Complement is known to play a role in ischemia and reperfusion injury (IRI). A general paradigm is that complement is activated by self-reactive natural IgM antibodies (nAbs), after they engage postischemic neoepitopes. However, a role for nAbs in lung transplantation (LTx) has not been explored. Using mouse models of LTx, ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, :]

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mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.

Kseniya Obraztsova, Maria C Basil, Ryan Rue, Aravind Sivakumar, Susan M Lin, Alexander R Mukhitov, Andrei I Gritsiuta, Jilly F Evans, Meghan Kopp, Jeremy Katzen, Annette Robichaud, Elena N Atochina-Vasserman, Shanru Li, Justine Carl, Apoorva Babu, Michael P Morley, Edward Cantu, Michael F Beers, David B Frank, Edward E Morrisey, Vera P Krymskaya,

Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin of LAM cells is still unknown. Here, we profile a LAM lung compared to an age- ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5640]

Cited: 1 time

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Preprocurement In Situ Donor Lung Tissue Gene Expression Classifies Primary Graft Dysfunction Risk.

Edward Cantu, Mengying Yan, Yoshikazu Suzuki, Taylor Buckley, Vito Galati, Neha Majeti, Christian A Bermudez, Joshua M Diamond, Jason D Christie, Rui Feng,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(7):1046-1048]

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STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.

Andrew J Paris, Katharina E Hayer, Joseph H Oved, Daphne C Avgousti, Sushila A Toulmin, Jarod A Zepp, William J Zacharias, Jeremy B Katzen, Maria C Basil, Madison M Kremp, April R Slamowitz, Sowmya Jayachandran, Aravind Sivakumar, Ning Dai, Ping Wang, David B Frank, Laurence C Eisenlohr, Edward Cantu, Michael F Beers, Matthew D Weitzman, Edward E Morrisey, G Scott Worthen,

Alveolar epithelial regeneration is essential for recovery from devastating lung diseases. This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and transdifferentiate into type I alveolar pneumocytes (AT1 cells). We used genome-wide analysis of chromatin accessibility and gene expression following acute lung injury to elucidate repair mechanisms. AT2 ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(10):1197-1210]

Cited: 1 time

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Relationship of intraoperative perfusion parameters to the need for immediate extracorporeal support following heart transplantation.

J Trent Magruder, Alexandra Sperry, Pavan Atluri, Christian Bermudez, Edward Cantu, Gerald Broniec, Chloe Choi, Michael A Acker, Marisa Cevasco,

<h4>Purpose</h4>We sought to assess the relationship of intraoperative perfusion parameters while on cardiopulmonary bypass, including oxygen delivery (DO<sub>2</sub>), to the need for ECMO following orthotopic heart transplantation (OHT).<h4>Methods</h4>We included all adult (>18 years old) OHTs performed at our institution since implementation of an electronic perfusion record (March 2019-February 2020). Multi-organ transplants ... Read more >>

Perfusion (Perfusion)
[2020, :267659120958153]

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Local complement activation is associated with primary graft dysfunction after lung transplantation.

Hrishikesh S Kulkarni, Kristy Ramphal, Lina Ma, Melanie Brown, Michelle Oyster, Kaitlyn N Speckhart, Tsuyoshi Takahashi, Derek E Byers, Mary K Porteous, Laurel Kalman, Ramsey R Hachem, Melanie Rushefski, Ja'Nia McPhatter, Marlene Cano, Daniel Kreisel, Masina Scavuzzo, Brigitte Mittler, Edward Cantu, Katrine Pilely, Peter Garred, Jason D Christie, John P Atkinson, Andrew E Gelman, Joshua M Diamond,

BACKGROUNDThe complement system plays a key role in host defense but is activated by ischemia/reperfusion injury (IRI). Primary graft dysfunction (PGD) is a form of acute lung injury occurring predominantly due to IRI, which worsens survival after lung transplantation (LTx). Local complement activation is associated with acute lung injury, but ... Read more >>

JCI Insight (JCI insight)
[2020, 5(17):]

Cited: 2 times

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International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

Tereza Martinu, Angela Koutsokera, Christian Benden, Edward Cantu, Daniel Chambers, Marcelo Cypel, Jeffrey Edelman, Amir Emtiazjoo, Andrew J Fisher, John R Greenland, Don Hayes, David Hwang, Brian C Keller, Erika D Lease, Michael Perch, Masaaki Sato, Jamie L Todd, Stijn Verleden, Jan von der Thüsen, S Samuel Weigt, Shaf Keshavjee, ,

Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx). However, BAL collection and processing are not standardized across LTx centers. This International Society for Heart and Lung Transplantation-supported consensus document on BAL standardization aims to clarify definitions and propose common approaches to improve clinical and ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, :]

Cited: 1 time

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Impact of the elimination of the donation service area on United States lung transplant practices and outcomes at high and low competition centers.

Claire Drolen, Edward Cantu, Hilary J Goldberg, Joshua M Diamond, Andrew Courtwright,

In November 2017, the donation service area (DSA) was removed as the primary unit of US donor lung allocation. Our primary objective was to evaluate the effect of this change on recipient characteristics, the use of pretransplant extracorporeal membrane oxygenation (ECMO), and on index hospitalization length of stay (LOS) and ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(12):3631-3638]

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Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: Results from a multicentric study.

Miguel M Leiva-Juárez, Andreacarola Urso, Elisabet Arango Tomás, David J Lederer, Pablo Sanchez, Bartley Griffith, R Duane Davis, Mani Daneshmand, Matthew Hartwig, Edward Cantu, Michael J Weyant, Christian Bermudez, Jonathan D'Cunha, Tiago Machuca, Thomas Wozniak, William Lynch, Hassan Nemeh, Michael Mulligan, Tae Song, Michael Jessen, Phillip C Camp, Christiano Caldeira, Bryan Whitson, Daniel Kreisel, Danny Ramzy, Frank D'Ovidio,

<h4>Background</h4>Ex vivo lung perfusion (EVLP) allows for a reassessment of lung grafts initially deemed unsuitable for transplantation, increasing the available donor pool; however, this requires a pre- and post-EVLP period of cold ischemic time (CIT). Paucity of data exists on how the sequence of cold normothermic-cold preservations affect outcomes.<h4>Methods</h4>A total ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(9):954-961]

Cited: 2 times

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Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Michaela R Anderson, Imaani Easthausen, Grace Gallagher, Jayaram Udupa, Yubing Tong, Drew Torigian, Joshua Matthew Diamond, Mary Katherine Porteous, Scott M Palmer, Laurie D Snyder, Luke Benvenuto, Meghan Aversa, Selim Arcasoy, John R Greenland, Steven R Hays, Jasleen Kukreja, Edward Cantu, John Shinn Kim, Dympna Gallagher, Matthew R Baldwin, R Graham Barr, David J Lederer, Jason D Christie, Jonathan Paul Singer,

CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was ... Read more >>

Thorax (Thorax)
[2020, 75(9):801-804]

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Multiorgan procurement is associated with a survival benefit after heart transplantation.

Jonathan Trent Magruder, Yoshikazu Suzuki, Alexandra Sperry, Charles R Vasquez, Benjamin Smood, Joshua C Grimm, Pavan Atluri, Christian Bermudez, Michael A Acker, Joyce W Wald, Edward Cantu, Marisa Cevasco,

We assessed the impact of donor multiorgan procurement on survival following orthotopic heart transplantation (OHT). From the UNOS STAR database, we included all adult (≥18 Y) heart transplants (OHT) performed since 2000 and used donor IDs to determine how many other organs were procured from the same donor as the recipient's ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(8):e13901]

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Stratification Risk Analysis in Bridging Patients to Lung Transplant on ECMO: The STABLE Risk Score.

Andreas Habertheuer, Thomas Richards, Federico Sertic, Maria Molina, Prashanth Vallabhajosyula, Yoshikazu Suzuki, Dyenaba Diagne, Edward Cantu, Ibrahim Sultan, Maria M Crespo, Christian A Bermudez,

BACKGROUND:No clinically validated tool exists to predict in-hospital mortality in patients requiring extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation. We generated a quantitative risk assessment tool for these patients. METHODS:Of 822 patients in the United Network for Organ Sharing (UNOS) database who required ECMO as bridge to ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 110(4):1175-1184]

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Lung Innate Lymphoid Cell Composition Is Altered in Primary Graft Dysfunction.

Laurel A Monticelli, Joshua M Diamond, Steven A Saenz, Elia D Tait Wojno, Mary K Porteous, Edward Cantu, David Artis, Jason D Christie,

<b>Rationale:</b> Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation, but the immunologic mechanisms are poorly understood. Innate lymphoid cells (ILC) are a heterogeneous family of immune cells regulating pathologic inflammation and beneficial tissue repair. However, whether changes in donor-derived lung ILC populations ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(1):63-72]

Cited: 3 times

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Early Tacrolimus Concentrations After Lung Transplant Are Predicted by Combined Clinical and Genetic Factors and Associated With Acute Kidney Injury.

Todd A Miano, Judd D Flesch, Rui Feng, Caitlin M Forker, Melanie Brown, Michelle Oyster, Laurel Kalman, Melanie Rushefski, Edward Cantu, Mary Porteus, Wei Yang, A Russel Localio, Joshua M Diamond, Jason D Christie, Michael G S Shashaty,

Tacrolimus exhibits unpredictable pharmacokinetics (PKs) after lung transplant, partly explained by cytochrome P450 (CYP)-enzyme polymorphisms. However, whether exposure variability during the immediate postoperative period affects outcomes is unknown, and pharmacogenetic dosing may be limited by residual PK variability. We estimated adjusted associations between early postoperative tacrolimus concentrations and acute kidney ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2020, 107(2):462-470]

Cited: 4 times

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Upper Respiratory Dysbiosis with a Facultative-dominated Ecotype in Advanced Lung Disease and Dynamic Change after Lung Transplant.

Aurea Simon-Soro, Michael B Sohn, John E McGinniss, Ize Imai, Melanie C Brown, Vincent R Knecht, Aubrey Bailey, Erik L Clarke, Edward Cantu, Hongzhe Li, Kyle Bittinger, Joshua M Diamond, Jason D Christie, Frederic D Bushman, Ronald G Collman,

<b>Rationale:</b> The oropharyngeal microbiome is a primary source of lung microbiota, contributes to lower respiratory infection, and is also a driver of oral health.<b>Objectives:</b> We sought to understand oropharyngeal microbial communities in advanced lung disease, community dynamics after lung transplantation, and ecological features of dysbiosis.<b>Methods:</b> Oropharyngeal wash samples were obtained ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2019, 16(11):1383-1391]

Cited: 1 time

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Discharge frailty following lung transplantation.

Andrew M Courtwright, Derek Zaleski, Michael Tevald, Joe Adler, Jonathan P Singer, Edward E Cantu, Christian A Bermudez, Joshua M Diamond,

<h4>Introduction</h4>Frailty at listing for lung transplant has been associated with waitlist and post-transplant mortality. Frailty trajectories following transplant, however, have been less well characterized, including whether recipient frailty improves. The objective of this study was to identify prevalence and risk factors for frailty at discharge and to evaluate changes in ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(10):e13694]

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Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes.

Astero Klampatsa, Shaun M O'Brien, Jeffrey C Thompson, Abhishek S Rao, Jason E Stadanlick, Marina C Martinez, Maria Liousia, Edward Cantu, Keith Cengel, Edmund K Moon, Sunil Singhal, Evgeniy B Eruslanov, Steven M Albelda,

Given the growing interest and promising preliminary results of immunotherapy in malignant pleural mesothelioma (MPM), it has become important to more fully understand the immune landscape in this tumor. This may be especially relevant in deciding who might benefit most from checkpoint blockade or agonist antibody therapy. Since the phenotype ... Read more >>

Oncoimmunology (Oncoimmunology)
[2019, 8(9):e1638211]

Cited: 7 times

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RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation.

Pitchumani Sivakumar, John Ryan Thompson, Ron Ammar, Mary Porteous, Carly McCoubrey, Edward Cantu, Kandasamy Ravi, Yan Zhang, Yi Luo, Denis Streltsov, Michael F Beers, Gabor Jarai, Jason D Christie,

Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of lung function, remains a fatal disease with a significant unmet medical need. Patients with severe IPF often develop acute exacerbations resulting in the rapid deterioration of lung function, requiring transplantation. Understanding the pathophysiological mechanisms contributing to ... Read more >>

ERJ Open Res (ERJ open research)
[2019, 5(3):]

Cited: 5 times

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Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.

Michaela R Anderson, Jayaram K Udupa, Ethan Edwin, Joshua M Diamond, Jonathan P Singer, Jasleen Kukreja, Steven R Hays, John R Greenland, Anthony Ferrante, Matthew Lippel, Tatiana Blue, Amika McBurnie, Michelle Oyster, Laurel Kalman, Melanie Rushefski, Caiyun Wu, Gargi Pednekar, Wen Liu, Selim Arcasoy, Joshua Sonett, Frank D'Ovidio, Matthew Bacchetta, John D Newell, Drew Torigian, Edward Cantu, Donna L Farber, Jon T Giles, Yubing Tong, Scott Palmer, Lorraine B Ware, Wayne W Hancock, Jason D Christie, David J Lederer,

<h4>Background</h4>Obesity is associated with an increased risk of primary graft dysfunction (PGD) after lung transplantation. The contribution of specific adipose tissue depots is unknown.<h4>Methods</h4>We performed a prospective cohort study of adult lung transplant recipients at 4 U.S. transplant centers. We measured cross-sectional areas of subcutaneous adipose tissue (SAT) and visceral ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2019, 38(12):1246-1256]

Cited: 1 time

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The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study.

Michael G S Shashaty, Caitlin M Forker, Todd A Miano, Qufei Wu, Wei Yang, Michelle L Oyster, Mary K Porteous, Edward E Cantu, Joshua M Diamond, Jason D Christie,

<h4>Background</h4>Prior studies of post-lung transplant acute kidney injury (AKI) have not accounted for confounding effects of primary graft dysfunction (PGD). We sought to test the impact of PGD on AKI risk factors and on the association of AKI with mortality.<h4>Methods</h4>We included patients transplanted at the University of Pennsylvania from 2005-12, ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(10):e13678]

Cited: 2 times

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Aryl-Hydrocarbon Receptor Repressor Gene in Primary Graft Dysfunction after Lung Transplantation.

Michaela R Anderson, Ethan A Edwin, Joshua M Diamond, Anthony Ferrante, Joshua Sonett, Frank D'Ovidio, Selim Arcasoy, Edward Cantu, Jason D Christie, David J Lederer,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2019, 61(2):268-271]

Cited: 0 times

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Postreperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.

Caitlin M Forker, Todd A Miano, John P Reilly, Michelle L Oyster, Mary K Porteous, Edward E Cantu, Lorraine B Ware, Joshua M Diamond, Jason D Christie, Michael G S Shashaty,

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in kidney microcirculatory injury in animal models of AKI. We tested the association of 6-hour postreperfusion plasma levels of ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2019, 19(8):2366-2373]

Cited: 1 time

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