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Author Eduard Langenegger

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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.

Samantha Budhram, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree Naidoo, Santhi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P Habineza, Priya Israel, Serantha Foolchand, Nomandla V Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S Mojela, Elizabeth J van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C Ngene, Ongombe Lunda, Sylvia N Cebekhulu, Siva Moodley, Mama-Asu Koranteng-Peprah, Emmanuel M C Ati, Salome Maswime, Laura M Yates,

<h4>Objective</h4>To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.<h4>Methods</h4>A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.<h4>Results</h4>A total ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

Cited: 0 times

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PROVE-Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia.

Lina Bergman, Karl Bergman, Eduard Langenegger, Ashley Moodley, Stephanie Griffith-Richards, Johan Wikström, David Hall, Lloyd Joubert, Philip Herbst, Sonja Schell, Teelkien van Veen, Michael Belfort, Stephen Y C Tong, Susan Walker, Roxanne Hastie, Catherine Cluver,

Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a focus on phenotyping severe ... Read more >>

Cells (Cells)
[2021, 10(4):]

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Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration.

Jean B Nachega, Nadia A Sam-Agudu, Samantha Budhram, Taha E Taha, Valerie Vannevel, Priya Somapillay, Daniel Katuashi Ishoso, Michel Tshiasuma Pipo, Christian Bongo-Pasi Nswe, John Ditekemena, Birhanu T Ayele, Rhoderick N Machekano, Onesmus W Gachuno, John Kinuthia, Nancy Mwongeli, Musa Sekikubo, Philippa Musoke, Evans Kofi Agbeno, Lawal W Umar, Mukanire Ntakwinja, Denis M Mukwege, Emily R Smith, Eduard J Mills, John Otokoye Otshudiema, Placide Mbala-Kingebeni, Jean-Marie N Kayembe, Don Jethro Mavungu Landu, Jean-Jacques Muyembe Tamfum, Alimuddin Zumla, Eduard J Langenegger, Lynne M Mofenson, For The AFREhealth Covid-Research Collaboration Working Group,

In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2020, :]

Cited: 4 times

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Intrapartum Basal Ganglia-Thalamic Pattern Injury and Radiologically Termed "Acute Profound Hypoxic-Ischemic Brain Injury" Are Not Synonymous.

Johan Smith, Regan Solomons, Lindi Vollmer, Eduard J Langenegger, Jan W Lotz, Savvas Andronikou, John Anthony, Ronald van Toorn,

<h4>Objective</h4> Human cases of acute profound hypoxic-ischemic (HI) injury (HII), in which the insult duration timed with precision had been identified, remains rare, and there is often uncertainty of the prior state of fetal health.<h4>Study design</h4> A retrospective analysis of 10 medicolegal cases of neonatal encephalopathy-cerebral palsy survivors who sustained intrapartum HI ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

Cited: 1 time

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Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa.

Andrew Boulle, Mary-Ann Davies, Hannah Hussey, Muzzammil Ismail, Erna Morden, Ziyanda Vundle, Virginia Zweigenthal, Hassan Mahomed, Masudah Paleker, David Pienaar, Yamanya Tembo, Charlene Lawrence, Washiefa Isaacs, Hlengani Mathema, Derick Allen, Taryn Allie, Jamy-Lee Bam, Kasturi Buddiga, Pierre Dane, Alexa Heekes, Boitumelo Matlapeng, Themba Mutemaringa, Luckmore Muzarabani, Florence Phelanyane, Rory Pienaar, Catherine Rode, Mariette Smith, Nicki Tiffin, Nesbert Zinyakatira, Carol Cragg, Frederick Marais, Vanessa Mudaly, Jacqueline Voget, Jody Davids, Francois Roodt, Nellis van Zyl Smit, Alda Vermeulen, Kevin Adams, Gordon Audley, Kathleen Bateman, Peter Beckwith, Marc Bernon, Dirk Blom, Linda Boloko, Jean Botha, Adam Boutall, Sean Burmeister, Lydia Cairncross, Gregory Calligaro, Cecilia Coccia, Chadwin Corin, Remy Daroowala, Joel A Dave, Elsa De Bruyn, Martin De Villiers, Mimi Deetlefs, Sipho Dlamini, Thomas Du Toit, Wilhelm Endres, Tarin Europa, Graham Fieggan, Anthony Figaji, Petro Frankenfeld, Elizabeth Gatley, Phindile Gina, Evashan Govender, Rochelle Grobler, Manqoba Vusumuzi Gule, Christoff Hanekom, Michael Held, Alana Heynes, Sabelo Hlatswayo, Bridget Hodkinson, Jeanette Holtzhausen, Shakeel Hoosain, Ashely Jacobs, Miriam Kahn, Thania Kahn, Arvin Khamajeet, Joubin Khan, Riaasat Khan, Alicia Khwitshana, Lauren Knight, Sharita Kooverjee, Rene Krogscheepers, Jean Jacque Kruger, Suzanne Kuhn, Kim Laubscher, John Lazarus, Jacque Le Roux, Scott Lee Jones, Dion Levin, Gary Maartens, Thina Majola, Rodgers Manganyi, David Marais, Suzaan Marais, Francois Maritz, Deborah Maughan, Simthandile Mazondwa, Luyanda Mbanga, Nomonde Mbatani, Bulewa Mbena, Graeme Meintjes, Marc Mendelson, Ernst Möller, Allison Moore, Babalwa Ndebele, Marc Nortje, Ntobeko Ntusi, Funeka Nyengane, Chima Ofoegbu, Nectarios Papavarnavas, Jonny Peter, Henri Pickard, Kent Pluke, Peter J Raubenheimer, Gordon Robertson, Julius Rozmiarek, A Sayed, Matthias Scriba, Hennie Sekhukhune, Prasun Singh, Elsabe Smith, Vuyolwethu Soldati, Cari Stek, Robert van den Berg, Le Roux van der Merwe, Pieter Venter, Barbra Vermooten, Gerrit Viljoen, Santhuri Viranna, Jonno Vogel, Nokubonga Vundla, Sean Wasserman, Eddy Zitha, Vanessa Lomas-Marais, Annie Lombard, Katrin Stuve, Werner Viljoen, De Vries Basson, Sue Le Roux, Ethel Linden-Mars, Lizanne Victor, Mark Wates, Elbe Zwanepoel, Nabilah Ebrahim, Sa'ad Lahri, Ayanda Mnguni, Thomas Crede, Martin de Man, Katya Evans, Clint Hendrikse, Jonathan Naude, Moosa Parak, Patrick Szymanski, Candice Van Koningsbruggen, Riezaah Abrahams, Brian Allwood, Christoffel Botha, Matthys Henndrik Botha, Alistair Broadhurst, Dirkie Claasen, Che Daniel, Riyaadh Dawood, Marie du Preez, Nicolene Du Toit, Kobie Erasmus, Coenraad F N Koegelenberg, Shiraaz Gabriel, Susan Hugo, Thabiet Jardine, Clint Johannes, Sumanth Karamchand, Usha Lalla, Eduard Langenegger, Eize Louw, Boitumelo Mashigo, Nonte Mhlana, Chizama Mnqwazi, Ashley Moodley, Desiree Moodley, Saadiq Moolla, Abdurasiet Mowlana, Andre Nortje, Elzanne Olivier, Arifa Parker, Chané Paulsen, Hans Prozesky, Jacques Rood, Tholakele Sabela, Neshaad Schrueder, Nokwanda Sithole, Sthembiso Sithole, Jantjie J Taljaard, Gideon Titus, Tian Van Der Merwe, Marije van Schalkwyk, Luthando Vazi, Abraham J Viljoen, Mogamat Yazied Chothia, Vanessa Naidoo, Lee Alan Wallis, Mumtaz Abbass, Juanita Arendse, Rizqa Armien, Rochelle Bailey, Muideen Bello, Rachel Carelse, Sheron Forgus, Nosi Kalawe, Saadiq Kariem, Mariska Kotze, Jonathan Lucas, Juanita McClaughlin, Kathleen Murie, Leilah Najjaar, Liesel Petersen, James Porter, Melanie Shaw, Dusica Stapar, Michelle Williams, Linda Aldum, Natacha Berkowitz, Raakhee Girran, Kevin Lee, Lenny Naidoo, Caroline Neumuller, Kim Anderson, Kerrin Begg, Lisa Boerlage, Morna Cornell, Renée de Waal, Lilian Dudley, René English, Jonathan Euvrard, Pam Groenewald, Nisha Jacob, Heather Jaspan, Emma Kalk, Naomi Levitt, Thoko Malaba, Patience Nyakato, Gabriela Patten, Helen Schneider, Maylene Shung King, Priscilla Tsondai, James Van Duuren, Nienke van Schaik, Lucille Blumberg, Cheryl Cohen, Nelesh Govender, Waasila Jassat, Tendesayi Kufa, Kerrigan McCarthy, Lynn Morris, Nei-Yuan Hsiao, Ruan Marais, Jon Ambler, Olina Ngwenya, Richard Osei-Yeboah, Leigh Johnson, Reshma Kassanjee, Tsaone Tamuhla,

<h4>Background</h4>Risk factors for COVID-19 death in sub-Saharan Africa and the effects of HIV and tuberculosis on COVID-19 outcomes are unknown.<h4>Methods</h4>We conducted a population cohort study using linked data from adults attending public sector health facilities in the Western Cape, South Africa. We used Cox-proportional hazards models adjusted for age, sex, ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 95 times

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Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

Sudhir Venkatesan, Puja R Myles, Kirsty J Bolton, Stella G Muthuri, Tarig Al Khuwaitir, Ashish P Anovadiya, Eduardo Azziz-Baumgartner, Tahar Bajjou, Matteo Bassetti, Bojana Beovic, Barbara Bertisch, Isabelle Bonmarin, Robert Booy, Victor H Borja-Aburto, Heinz Burgmann, Bin Cao, Jordi Carratala, Tserendorj Chinbayar, Catia Cilloniz, Justin T Denholm, Samuel R Dominguez, Pericles A D Duarte, Gal Dubnov-Raz, Sergio Fanella, Zhancheng Gao, Patrick Gérardin, Maddalena Giannella, Sophie Gubbels, Jethro Herberg, Anjarath Lorena Higuera Iglesias, Peter H Hoeger, Xiao Yun Hu, Quazi T Islam, Mirela F Jiménez, Gerben Keijzers, Hossein Khalili, Gabriela Kusznierz, Ilija Kuzman, Eduard Langenegger, Kamran B Lankarani, Yee-Sin Leo, Romina P Libster, Rita Linko, Faris Madanat, Efstratios Maltezos, Abdullah Mamun, Toshie Manabe, Gokhan Metan, Auksė Mickiene, Dragan Mikić, Kristin G I Mohn, Maria E Oliva, Mehpare Ozkan, Dhruv Parekh, Mical Paul, Barbara A Rath, Samir Refaey, Alejandro H Rodríguez, Bunyamin Sertogullarindan, Joanna Skręt-Magierło, Ayper Somer, Ewa Talarek, Julian W Tang, Kelvin To, Dat Tran, Timothy M Uyeki, Wendy Vaudry, Tjasa Vidmar, Paul Zarogoulidis, , Jonathan S Nguyen-Van-Tam,

<h4>Background</h4>The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear.<h4>Methods</h4>We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 221(3):356-366]

Cited: 1 time

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A blueprint to establish a four-bed obstetric critical care unit in the labor ward of a central hospital.

Eduard J Langenegger, Gerhard B Theron, David R Hall, Camilo Bello, Maria Fernanda Escobar Vidarte, ,

Patients at risk of organ dysfunction or with established organ dysfunction should be referred to central or tertiary-level hospitals. However, even in central hospitals, intensive care unit (ICU) beds are often unavailable, which may contribute to maternal deaths. One pragmatic solution is to establish obstetric critical care units (OCCUs) in ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2019, 146(1):29-35]

Cited: 1 time

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The impact of an obstetrician-led, labor ward critical care unit: A prospective comparison of outcomes before and after establishment.

Eduard J Langenegger, D R Hall, F Mattheyse, J Harvey,

<h4>Objective</h4>To investigate the outcomes of critically ill obstetric patients managed in a obstetric critical care unit in South Africa.<h4>Methods</h4>Patients with severe maternal morbidity managed in the labor ward of Tygerberg Hospital were studied over three months before the establishment of the obstetrician-led obstetric critical care unit. One year later, patients ... Read more >>

Obstet Med (Obstetric medicine)
[2020, 13(3):132-136]

Cited: 0 times

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Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

Stella G Muthuri, Sudhir Venkatesan, Puja R Myles, Jo Leonardi-Bee, Wei Shen Lim, Abdullah Al Mamun, Ashish P Anovadiya, Wildo N Araújo, Eduardo Azziz-Baumgartner, Clarisa Báez, Carlos Bantar, Mazen M Barhoush, Matteo Bassetti, Bojana Beovic, Roland Bingisser, Isabelle Bonmarin, Victor H Borja-Aburto, Bin Cao, Jordi Carratala, María R Cuezzo, Justin T Denholm, Samuel R Dominguez, Pericles A D Duarte, Gal Dubnov-Raz, Marcela Echavarria, Sergio Fanella, James Fraser, Zhancheng Gao, Patrick Gérardin, Maddalena Giannella, Sophie Gubbels, Jethro Herberg, Anjarath L Higuera Iglesias, Peter H Hoeger, Matthias Hoffmann, Xiaoyun Hu, Quazi T Islam, Mirela F Jiménez, Amr Kandeel, Gerben Keijzers, Hossein Khalili, Gulam Khandaker, Marian Knight, Gabriela Kusznierz, Ilija Kuzman, Arthur M C Kwan, Idriss Lahlou Amine, Eduard Langenegger, Kamran B Lankarani, Yee-Sin Leo, Rita Linko, Pei Liu, Faris Madanat, Toshie Manabe, Elga Mayo-Montero, Allison McGeer, Ziad A Memish, Gokhan Metan, Dragan Mikić, Kristin G I Mohn, Ahmadreza Moradi, Pagbajabyn Nymadawa, Bulent Ozbay, Mehpare Ozkan, Dhruv Parekh, Mical Paul, Wolfgang Poeppl, Fernando P Polack, Barbara A Rath, Alejandro H Rodríguez, Marilda M Siqueira, Joanna Skręt-Magierło, Ewa Talarek, Julian W Tang, Antoni Torres, Selda H Törün, Dat Tran, Timothy M Uyeki, Annelies van Zwol, Wendy Vaudry, Daiva Velyvyte, Tjasa Vidmar, Paul Zarogoulidis, , Jonathan S Nguyen-Van-Tam,

<h4>Background</h4>The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.<h4>Methods</h4>A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2016, 10(3):192-204]

Cited: 29 times

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Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.

Stella G Muthuri, Sudhir Venkatesan, Puja R Myles, Jo Leonardi-Bee, Tarig S A Al Khuwaitir, Adbullah Al Mamun, Ashish P Anovadiya, Eduardo Azziz-Baumgartner, Clarisa Báez, Matteo Bassetti, Bojana Beovic, Barbara Bertisch, Isabelle Bonmarin, Robert Booy, Victor H Borja-Aburto, Heinz Burgmann, Bin Cao, Jordi Carratala, Justin T Denholm, Samuel R Dominguez, Pericles A D Duarte, Gal Dubnov-Raz, Marcela Echavarria, Sergio Fanella, Zhancheng Gao, Patrick Gérardin, Maddalena Giannella, Sophie Gubbels, Jethro Herberg, Anjarath L Higuera Iglesias, Peter H Hoger, Xiaoyun Hu, Quazi T Islam, Mirela F Jiménez, Amr Kandeel, Gerben Keijzers, Hossein Khalili, Marian Knight, Koichiro Kudo, Gabriela Kusznierz, Ilija Kuzman, Arthur M C Kwan, Idriss Lahlou Amine, Eduard Langenegger, Kamran B Lankarani, Yee-Sin Leo, Rita Linko, Pei Liu, Faris Madanat, Elga Mayo-Montero, Allison McGeer, Ziad Memish, Gokhan Metan, Auksė Mickiene, Dragan Mikić, Kristin G I Mohn, Ahmadreza Moradi, Pagbajabyn Nymadawa, Maria E Oliva, Mehpare Ozkan, Dhruv Parekh, Mical Paul, Fernando P Polack, Barbara A Rath, Alejandro H Rodríguez, Elena B Sarrouf, Anna C Seale, Bunyamin Sertogullarindan, Marilda M Siqueira, Joanna Skręt-Magierło, Frank Stephan, Ewa Talarek, Julian W Tang, Kelvin K W To, Antoni Torres, Selda H Törün, Dat Tran, Timothy M Uyeki, Annelies Van Zwol, Wendy Vaudry, Tjasa Vidmar, Renata T C Yokota, Paul Zarogoulidis, , Jonathan S Nguyen-Van-Tam,

<h4>Background</h4>Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2014, 2(5):395-404]

Cited: 256 times

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Severe acute respiratory infection with influenza A (H1N1) during pregnancy.

Eduard Langenegger, Andrn Coetzee, Samier Jacobs, Alrisah le Roux, Gerhard Theron,

S Afr Med J (South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde)
[2009, 99(10):713-4, 716]

Cited: 3 times

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