Full Text Journal Articles by
Author Edmund Lau

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Chronic thromboembolic pulmonary hypertension in Australia and New Zealand: An analysis of the PHSANZ registry.

Katherine Kearney, Joshua Gold, Carolyn Corrigan, Kumud Dhital, David Boshell, David Haydock, David McGiffin, Michael Wilson, Nicholas Collins, Rachael Cordina, Nathan Dwyer, John Feenstra, Melanie Lavender, Jeremy Wrobel, Helen Whitford, Trevor Williams, Dominic Keating, Ken Whyte, Tanya McWilliams, Anne Keogh, Geoff Strange, Eugene Kotlyar, James Anderson, Edmund Mt Lau,

<h4>Background and objective</h4>Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition occurring in 2%-4% of patients after acute pulmonary embolism. Pulmonary endarterectomy (PEA) is a potential cure for technically operable disease. The epidemiology and long-term outcomes of CTEPH have not been previously described in Australia and New Zealand.<h4>Methods</h4>Data were extracted ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2021, :]

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Risk of Severe Acute Localized Reactions for Different Intraarticular Hyaluronic Acid Knee Injections in a Real-World Setting.

Kevin L Ong, Jack Farr, Andrew S Gudeman, Iain R Murray, Louis F McIntyre, Charles D Hummer, Wilson Ngai, Edmund Lau, Roy D Altman, Seth L Sherman,

<h4>Objective</h4>Case reports of severe acute localized reactions (SALR) following intraarticular (IA) hyaluronic acid (HA) injections for knee osteoarthritis (OA) have been described. We compared surrogate SALR measures between patients using hylan G-F 20 and specific non-hylan G-F 20 HA products.<h4>Design</h4>Knee OA patients were identified from the Optum Clinformatics dataset (January ... Read more >>

Cartilage (Cartilage)
[2021, :19476035211025815]

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Distinct Roles of Tensile and Compressive Stresses in Graphitizing and Properties of Carbon Nanofibers.

Yujia Liu, Edmund Lau, Dario Mager, Marc J Madou, Maziar Ghazinejad,

It is generally accepted that inducing molecular alignment in a polymer precursor via mechanical stresses influences its graphitization during pyrolysis. However, our understanding of how variations of the imposed mechanics can influence pyrolytic carbon microstructure and functionality is inadequate. Developing such insight is consequential for different aspects of carbon MEMS ... Read more >>

Micromachines (Basel) (Micromachines)
[2021, 12(9):]

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Diagnosis of myositis-associated interstitial lung disease: Utility of the myositis autoantibody line immunoassay.

Adelle S Jee, Matthew J S Parker, Jane F Bleasel, Lauren K Troy, Edmund M Lau, Helen E Jo, Alan K Y Teoh, Susanne Webster, Stephen Adelstein, Tamera J Corte,

<h4>Objectives</h4>The detection of myositis autoantibodies (MA) in patients with interstitial lung disease (ILD) has major implications for diagnosis and management, especially amyopathic and forme frustes of idiopathic inflammatory myositis-associated ILD (IIM-ILD). Use of the MA line immunoblot assay (MA-LIA) in non-rheumatological cohorts remains unvalidated. We assessed the diagnostic performance of ... Read more >>

Respir Med (Respiratory medicine)
[2021, 187:106581]

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Recent trends in revision knee arthroplasty in Germany.

Markus Rupp, Nike Walter, Edmund Lau, Michael Worlicek, Steven M Kurtz, Volker Alt,

We aimed to answer the following questions: (1) How did numbers of revision knee arthroplasty procedures develop in Germany over the last decade compared to primary TKA? (2) How high was the percentage of septic interventions in knee prosthesis revisions? (3) Which treatment strategy was chosen for surgical treatment of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):15479]

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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation.

David Montani, Barbara Girerd, Xavier Jaïs, Pierantonio Laveneziana, Edmund M T Lau, Amir Bouchachi, Sébastien Hascoët, Sven Günther, Laurent Godinas, Florence Parent, Christophe Guignabert, Antoine Beurnier, Denis Chemla, Philippe Hervé, Mélanie Eyries, Florent Soubrier, Gérald Simonneau, Olivier Sitbon, Laurent Savale, Marc Humbert,

<h4>Background</h4>Heritable pulmonary arterial hypertension (PAH) is most commonly due to heterozygous mutations of the <i>BMPR2</i> gene. Based on expert consensus, guidelines recommend annual screening echocardiography in asymptomatic <i>BMPR2</i> mutation carriers. The main objectives of this study were to evaluate the characteristics of asymptomatic <i>BMPR2</i> mutation carriers, assess their risk of ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 58(1):]

Cited: 2 times

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Cryobiopsy for Identification of Usual Interstitial Pneumonia and Other Interstitial Lung Disease Features. Further Lessons from COLDICE, a Prospective Multicenter Clinical Trial.

Wendy A Cooper, Annabelle Mahar, Jeffrey L Myers, Christopher Grainge, Tamera J Corte, Jonathan P Williamson, Michael P Vallely, Simon Lai, Ellie Mulyadi, Paul J Torzillo, Martin J Phillips, Edmund M T Lau, Ganesh Raghu, Lauren K Troy,

<b>Rationale:</b> Transbronchial lung cryobiopsy (TBLC) is an emerging technique for interstitial lung disease diagnosis. Good histopathologic agreement between TBLC and surgical lung biopsy (SLB) was demonstrated in the COLDICE (Cryobiopsy versus Open Lung Biopsy in the Diagnosis of Interstitial Lung Disease Alliance) study; however, diagnostic confidence was frequently lower for ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(10):1306-1313]

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Waitlist and post-transplant outcomes for eisenmenger syndrome: A comparison of transplant strategies.

Katherine Kearney, Edmund M Lau, David Darley, Anitra Romfh, Nicole Bart, Eugene Kotlyar, Don Hayes, Kiran Khush, Anne Keogh,

<h4>Background</h4>End-stage Eisenmenger syndrome (ES) due to unrepaired atrial septal defect (ASD) or ventricular septal defect (VSD) is an indication for lung transplantation (LTx) or heart-lung transplantation (HLTx). Limited evidence exists as to the optimal transplant strategy for this unique population.<h4>Aim</h4>To describe waitlist characteristics and post-transplant outcomes in patients with ES-ASD ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2021, 40(8):841-849]

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Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort.

Adelle S Jee, Matthew J S Parker, Jane F Bleasel, Lauren K Troy, Edmund M Lau, Helen E Jo, Alan K Y Teoh, Stephen Adelstein, Susanne Webster, Tamera J Corte,

<h4>Background and objective</h4>The research term "interstitial pneumonia with autoimmune features" (IPAF) encompasses interstitial lung disease (ILD) patients with autoimmune features not meeting diagnostic criteria for a defined connective tissue disease (CTD). It remains unclear if IPAF is a distinct disease entity with implications for management and prognosis. We describe an ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, 100(9):853-864]

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The isobaric pulmonary arterial compliance in pulmonary hypertension.

Denis Chemla, Emmanuelle Berthelot, Jason Weatherald, Edmund M T Lau, Laurent Savale, Antoine Beurnier, David Montani, Olivier Sitbon, Pierre Attal, David Boulate, Patrick Assayag, Marc Humbert, Philippe Hervé,

Pulmonary hypertension is associated with stiffening of pulmonary arteries which increases right ventricular pulsatile loading. High pulmonary artery wedge pressure (PAWP) in postcapillary pulmonary hypertension (Pc-PH) further decreases pulmonary arterial compliance (PAC) at a given pulmonary vascular resistance (PVR) compared with precapillary pulmonary hypertension, thus responsible for a higher total ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(2):]

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Prevalence of spine degeneration diagnosis by type, age, gender, and obesity using Medicare data.

Chantal S Parenteau, Edmund C Lau, Ian C Campbell, Amy Courtney,

Identifying the prevalence of degenerative spinal pathologies and relevant demographic risk factors is important for understanding spine injury risk, prevention, treatment, and outcome, and for distinguishing acute injuries from degenerative pathologies. Prevalence data in the literature are often based on small-scale studies focused on a single type of pathology. This ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5389]

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Risk Stratification in Pulmonary Arterial Hypertension: Do Not Forget the Patient Perspective.

Marc Humbert, Edmund M T Lau,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(6):675-677]

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Pulmonary Vascular Disease as a Systemic and Multisystem Disease.

Katherine Kearney, Eugene Kotlyar, Edmund M T Lau,

Pulmonary arterial hypertension (PAH) is a disease of progressive pulmonary vascular remodeling due to abnormal proliferation of pulmonary vascular endothelial and smooth muscle cells and endothelial dysfunction. PAH is a multisystem disease with systemic manifestations and complications. This article covers the chronic heart failure syndrome, including the systemic consequences of ... Read more >>

Clin Chest Med (Clinics in chest medicine)
[2021, 42(1):167-177]

Cited: 1 time

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Revision Surgery for Instability After Total Hip Arthroplasty: Does Timing Matter?

Nathanael D Heckmann, JaeWon Yang, Kevin L Ong, Edmund C Lau, Brian C Fuller, Daniel D Bohl, Craig J Della Valle,

<h4>Background</h4>Instability is a common reason for revision surgery after total hip arthroplasty (THA). Recent studies suggest that revisions performed in the early postoperative period are associated with higher complication rates. The purpose of this study is to assess the effect of timing of revision for instability on subsequent complication rates.<h4>Methods</h4>The ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2021, 36(5):1779-1783.e2]

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Intra-Articular Corticosteroid or Hyaluronic Acid Injections Are Not Associated with Periprosthetic Joint Infection Risk following Total Knee Arthroplasty.

Steven M Kurtz, Michael A Mont, Antonia F Chen, Craig Della Valle, Nipun Sodhi, Edmund Lau, Kevin L Ong,

This study evaluated whether the preoperative use and timing of the use of hyaluronic acid (HA) and/or corticosteroid (CS) injections were associated with an increased risk of periprosthetic joint infections (PJIs) following primary total knee arthroplasty (TKA). We tested the hypothesis that preoperative injection of HA or CS within 3 ... Read more >>

J Knee Surg (The journal of knee surgery)
[2021, :]

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Decrease in opioid and intra-articular corticosteroid burden after intra-articular hyaluronic acid for knee osteoarthritis treatment.

Faizan Niazi, Kevin L Ong, Vasco Deon Kidd, Edmund Lau, Steven M Kurtz, Stanley H Dysart, Gerard Malanga,

<b>Aim:</b> We studied changes in opioid prescriptions and corticosteroid injection use for knee osteoarthritis patients before and after intra-articular hyaluronic acid (HA) use and opioid prescriptions before and after knee arthroplasty (KA). <b>Materials & methods:</b> A total of 1,017,578 knee osteoarthritis members were ascertained from a commercial claims database (Health Intelligence Company LLC, IL, USA) ... Read more >>

Pain Manag (Pain management)
[2020, 10(6):387-397]

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Reoperation Risk After Total Elbow Arthroplasty Versus Open Reduction Internal Fixation for Distal Humerus Fractures in Elderly Patients.

Nitin Goyal, Daniel D Bohl, Kevin L Ong, Edmund Lau, Gregory P Nicholson, Robert W Wysocki,

<h4>Objective</h4>To compare reoperation risk after total elbow arthroplasty (TEA) and open reduction internal fixation (ORIF) for intra-articular distal humerus fractures in elderly patients.<h4>Design</h4>Retrospective comparative.<h4>Setting</h4>Five percent Medicare Part B claims database.<h4>Patients</h4>Patients older than 65 years of age with closed distal humerus fractures undergoing TEA or ORIF from 1996 to 2016.<h4>Intervention</h4>TEA and ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2020, 34(9):503-509]

Cited: 1 time

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Knee Osteoarthritis Treatment Costs in the Medicare Patient Population.

Gerard Malanga, Faizan Niazi, Vasco Deon Kidd, Edmund Lau, Steven M Kurtz, Kevin L Ong, Andrew L Concoff,

<h4>Background</h4>Several nonoperative options have been recommended for the treatment of knee osteoarthritis (OA), with varying degrees of evidence. Adhering to the American Academy of Orthopaedic Surgeons clinical practice guidelines has been suggested to decrease direct treatment costs by 45% in the year before knee arthroplasty, but this does not consider ... Read more >>

Am Health Drug Benefits (American health & drug benefits)
[2020, 13(4):144-153]

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Priorities and expectations of patients attending a multidisciplinary interstitial lung disease clinic.

Anna E B McLean, Susanne E Webster, Margaret Fry, Edmund M Lau, Peter Corte, Paul J Torzillo, Lauren K Troy, Helen E Jo, Monika Geis, Jessica E Rhodes, Shannon Cleary, Lissa Spencer, Tamera J Corte,

<h4>Background and objective</h4>The significant and progressive morbidity associated with ILD mean that patients often struggle with the impact of this disease on their QOL and independence. To date, no studies have investigated the importance of multidisciplinary care on patient experience in ILD. We aimed to determine the expectations and priorities ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2021, 26(1):80-86]

Cited: 1 time

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Detection of ctDNA in plasma of patients with clinically localised prostate cancer is associated with rapid disease progression.

Edmund Lau, Patrick McCoy, Fairleigh Reeves, Ken Chow, Michael Clarkson, Edmond M Kwan, Kate Packwood, Helen Northen, Miao He, Zoya Kingsbury, Stefano Mangiola, Michael Kerger, Marc A Furrer, Helen Crowe, Anthony J Costello, David J McBride, Mark T Ross, Bernard Pope, Christopher M Hovens, Niall M Corcoran,

<h4>Background</h4>DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be used as a marker of disease burden as well as to monitor treatment response. Although circulating tumour DNA (ctDNA) measurement has prognostic/predictive value in metastatic prostate cancer, its utility in ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):72]

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Knee OA cost comparison for hyaluronic acid and knee arthroplasty.

Kevin L Ong, Faizan Niazi, Edmund Lau, Michael A Mont, Andrew Concoff, Peter Shaw, Steven M Kurtz,

<h4>Background</h4>Limiting treatment to those recommended by the American Academy of Orthopaedic Surgeon Clinical Practice Guidelines has been suggested to decrease costs by 45% in the year prior to total knee arthroplasty, but this only focuses on expenditures leading up to, but not including, the surgery and not the entire episode ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2020, 15(1):305]

Cited: 2 times

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Inspiratory Muscle Training Improves Inspiratory Muscle Strength and Functional Exercise Capacity in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Pilot Randomised Controlled Study.

Derek Tran, Phillip Munoz, Edmund M T Lau, Jennifer A Alison, Martin Brown, Yizhong Zheng, Patricia Corkery, Keith Wong, Steven Lindstrom, David S Celermajer, Glen M Davis, Rachael Cordina,

<h4>Background</h4>Exercise intolerance is present even in the early stages of pulmonary arterial hypertension (PAH) and is associated with poorer prognosis. Respiratory muscle dysfunction is common and may contribute to exercise limitation. We sought to investigate the effects of inspiratory muscle training (IMT) to improve exercise capacity in PAH.<h4>Methods</h4>Adults with PAH ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2021, 30(3):388-395]

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Pulmonary arterial hypertension with below threshold pulmonary vascular resistance.

Seshika Ratwatte, James Anderson, Geoffrey Strange, Carolyn Corrigan, Nicholas Collins, David S Celermajer, Nathan Dwyer, John Feenstra, Dominic Keating, Eugene Kotlyar, Melanie Lavender, Helen Whitford, Ken Whyte, Trevor Williams, Jeremy P Wrobel, Anne Keogh, Edmund M Lau, ,

Pulmonary vascular resistance (PVR) >3 Wood units is a criterion of the haemodynamic definition of pulmonary arterial hypertension (PAH). However, this cut-off is conservative and arbitrarily defined. Data is lacking on the natural history, response to therapy and survival of patients diagnosed with precapillary pulmonary hypertension (PH) with mild or borderline ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(1):]

Cited: 3 times

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Projections of Primary TKA and THA in Germany From 2016 Through 2040.

Markus Rupp, Edmund Lau, Steven M Kurtz, Volker Alt,

<h4>Background</h4>Future projections for both TKA and THA in the United States and other countries forecast a further increase of already high numbers of joint replacements. The consensus is that in industrialized countries, this increase is driven by demographic changes with more elderly people being less willing to accept activity limitations. ... Read more >>

Clin Orthop Relat Res (Clinical orthopaedics and related research)
[2020, 478(7):1622-1633]

Cited: 12 times

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Methodologies of COLDICE and Cryo-PID studies: details make the difference.

Edmund M T Lau, Christopher Grainge, Jonathan P Williamson, Tamera J Corte, Wendy A Cooper, Martin J Phillips, Paul J Torzillo, Michael P Vallely, Ganesh Raghu, Lauren K Troy,

Ann Transl Med (Annals of translational medicine)
[2020, 8(12):781]

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