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Author Eberhard Korsching

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Characterization of the first microRNA in human CDH1 that affects cell cycle and apoptosis and indicates breast cancers progression.

Sedigheh Gharbi, Zahra Mohammadi, Maryam Saedi Dezaki, Sadat Dokanehiifard, Shahriar Dabiri, Eberhard Korsching,

The E-cadherin protein (Cadherin 1, gene: CDH1), a master regulator of the human epithelial homeostasis, contributes to the epithelial-mesenchymal transition (EMT) which confers cell migratory features to the cells. The EMT is central to many pathophysiological changes in cancer. Therefore, a better understanding of this regulatory scenario is beneficial for ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2022, :]

Cited: 0 times

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Statins: Complex outcomes but increasingly helpful treatment options for patients.

Niloufar Mohammadkhani, Sedigheh Gharbi, Huda Fatima Rajani, Avishan Farzaneh, Golnoosh Mahjoob, Afsaneh Hoseinsalari, Eberhard Korsching,

Statins are long known class of medicines and the most frequently prescribed drugs in cardiovascular pharmacotherapy, widely ordered not only in patients suffering from dyslipidemia, but also in patients with coronary artery disease, acute coronary syndromes, diabetes mellitus, stroke, hypertension, and chronic kidney disease, with or without coexisting dyslipidemia. However, ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2019, 863:172704]

Cited: 6 times

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Defining a Characteristic Gene Expression Set Responsible for Cancer Stem Cell-Like Features in a Sub-Population of Ewing Sarcoma Cells CADO-ES1.

Marc Hotfilder, Nikhil Mallela, Jochen Seggewiß, Uta Dirksen, Eberhard Korsching,

One of the still open questions in Ewing sarcoma, a rare bone tumor with weak therapeutic options, is to identify the tumor-driving cell (sub) population and to understand the specifics in the biological network of these cells. This basic scientific insight might foster the development of more specific therapeutic target ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(12):]

Cited: 3 times

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Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium.

Werner Boecker, Laura van Horn, Göran Stenman, Christine Stürken, Udo Schumacher, Thomas Loening, Lukas Liesenfeld, Eberhard Korsching, Doreen Gläser, Katharina Tiemann, Igor Buchwalow,

Understanding the mechanisms regulating human mammary epithelium requires knowledge of the cellular constituents of this tissue. Different and partially contradictory definitions and concepts describing the cellular hierarchy of mammary epithelium have been proposed, including our studies of keratins K5 and/or K14 as markers of progenitor cells. Furthermore, we and others ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2018, 98(8):1065-1075]

Cited: 3 times

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miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer.

Nassim Ghorbanmehr, Sedigheh Gharbi, Eberhard Korsching, Mahmood Tavallaei, Behzad Einollahi, Seyed Javad Mowla,

<h4>Background</h4>Early detection of cancers improves patients' survival and decreases the treatment cost. Unfortunately, the current methods for diagnosis of bladder and prostate cancers, two most common urothelial malignancies, suffer from a low sensitivity and specificity. MicroRNAs, as a group of endogenously produced non-coding RNAs, regulate gene expression and their expression ... Read more >>

Prostate (The Prostate)
[2019, 79(1):88-95]

Cited: 20 times

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The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling.

Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz,

<h4>Background</h4>The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and ... Read more >>

Cell Commun Signal (Cell communication and signaling : CCS)
[2018, 16(1):21]

Cited: 8 times

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MicroRNA expression in serum samples of sulfur mustard veterans as a diagnostic gateway to improve care.

Sedigheh Gharbi, Shahriar Khateri, Mohammad Reza Soroush, Mehdi Shamsara, Parisa Naeli, Ali Najafi, Eberhard Korsching, Seyed Javad Mowla,

Sulfur mustard is a vesicant chemical warfare agent, which has been used during Iraq-Iran-war. Many veterans and civilians still suffer from long-term complications of sulfur mustard exposure, especially in their lung. Although the lung lesions of these patients are similar to Chronic Obstructive Pulmonary Disease (COPD), there are some differences ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0194530]

Cited: 9 times

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Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways.

Gesche Frohwitter, Horst Buerger, Paul J VAN Diest, Eberhard Korsching, Johannes Kleinheinz, Thomas Fillies,

Squamous cell carcinoma (SCC) of the oral cavity is a morphological heterogeneous disease. Various cytokeratin (CK) expression patterns with different prognostic values have been described, but little is known concerning the underlying biological cell mechanisms. Therefore, the present study investigated 193 cases of oral SCCs using immunohistochemistry for α/β/γ-catenin, glucose ... Read more >>

Oncol Lett (Oncology letters)
[2016, 12(1):107-113]

Cited: 9 times

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Interlaboratory variability of Ki67 staining in breast cancer.

Cornelia M Focke, Horst Bürger, Paul J van Diest, Kai Finsterbusch, Doreen Gläser, Eberhard Korsching, Thomas Decker, ,

<h4>Background</h4>Postanalytic issues of Ki67 assessment in breast cancers like counting method standardisation and interrater bias have been subject of various studies, but little is known about analytic variability of Ki67 staining between pathology labs. Our aim was to study interlaboratory variability of Ki67 staining in breast cancer using tissue microarrays ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2017, 84:219-227]

Cited: 21 times

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Site-specific gene expression patterns in oral cancer.

Gesche Frohwitter, Horst Buerger, Eberhard Korsching, Paul J van Diest, Johannes Kleinheinz, Thomas Fillies,

<h4>Background</h4>Squamous cell carcinomas (SCCs) are the most prevalent malignant tumours within the head and neck. Evidence exists that distinct genes are differentially regulated in SCCs of the oral cavity compared to other head and neck regions. Given this background, the aim of this study was to investigate whether such tumour ... Read more >>

Head Face Med (Head & face medicine)
[2017, 13(1):6]

Cited: 7 times

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Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.

Werner Boecker, Göran Stenman, Tina Schroeder, Udo Schumacher, Thomas Loening, Lisa Stahnke, Catharina Löhnert, Robert Michael Siering, Arthur Kuper, Vera Samoilova, Markus Tiemann, Eberhard Korsching, Igor Buchwalow,

We contend that knowledge about the cellular composition of normal breast epithelium is a prerequisite for understanding proliferative breast disease. Against this background, we used multicolor immunofluorescence to study normal breast epithelium and two types of intraepithelial proliferative breast lesion for expression of the p63, basal keratin K5, glandular keratin ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2017, 470(5):493-504]

Cited: 5 times

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TMAinspiration: Decode Interdependencies in Multifactorial Tissue Microarray Data.

Florian Boecker, Horst Buerger, Nikhil V Mallela, Eberhard Korsching,

There are no satisfying tools in tissue microarray (TMA) data analysis up to now to analyze the cooperative behavior of all measured markers in a multifactorial TMA approach. The developed tool TMAinspiration is not only offering an analysis option to close this gap but also offering an ecosystem consisting of ... Read more >>

Cancer Inform (Cancer informatics)
[2016, 15:143-149]

Cited: 1 time

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The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.

Heinrich Kovar, James Amatruda, Erika Brunet, Stefan Burdach, Florencia Cidre-Aranaz, Enrique de Alava, Uta Dirksen, Wietske van der Ent, Patrick Grohar, Thomas G P Grünewald, Lee Helman, Peter Houghton, Kristiina Iljin, Eberhard Korsching, Marc Ladanyi, Elizabeth Lawlor, Stephen Lessnick, Joseph Ludwig, Paul Meltzer, Markus Metzler, Jaume Mora, Richard Moriggl, Takuro Nakamura, Theodore Papamarkou, Branka Radic Sarikas, Francoise Rédini, Guenther H S Richter, Claudia Rossig, Keri Schadler, Beat W Schäfer, Katia Scotlandi, Nathan C Sheffield, Anang Shelat, Ewa Snaar-Jagalska, Poul Sorensen, Kimberly Stegmaier, Elizabeth Stewart, Alejandro Sweet-Cordero, Karoly Szuhai, Oscar M Tirado, Franck Tirode, Jeffrey Toretsky, Kalliopi Tsafou, Aykut Üren, Andrei Zinovyev, Olivier Delattre,

Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second "European interdisciplinary Ewing sarcoma research summit" assembled a large group of scientific experts in the field to discuss their latest unpublished findings on the way to the identification of novel therapeutic targets and strategies. ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(8):8613-8624]

Cited: 26 times

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Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease.

Jenny Potratz, Amelie Tillmanns, Philipp Berning, Eberhard Korsching, Christiane Schaefer, Birgit Lechtape, Carolin Schleithoff, Rebekka Unland, Karl-Ludwig Schäfer, Carsten Müller-Tidow, Heribert Jürgens, Uta Dirksen,

Receptor tyrosine kinases (RTKs) have provided molecular targets for the development of novel, prognosis-improving agents in many cancers; however, resistances to these therapies occur. On the cellular level, one resistance mechanism is attributed to functional RTK redundancies and compensatory cross-signaling, leading to perception of RTKs as signaling and target networks. ... Read more >>

Mol Oncol (Molecular oncology)
[2016, 10(5):677-692]

Cited: 21 times

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Genomic heterogeneity of osteosarcoma - shift from single candidates to functional modules.

Kathrin Poos, Jan Smida, Doris Maugg, Gertrud Eckstein, Daniel Baumhoer, Michaela Nathrath, Eberhard Korsching,

Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of common drivers in OS biology. To identify the common molecular mechanisms involved in the maintenance ... Read more >>

PLoS One (PloS one)
[2015, 10(4):e0123082]

Cited: 15 times

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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.

Konstantin Agelopoulos, Günther H S Richter, Eva Schmidt, Uta Dirksen, Kristina von Heyking, Benjamin Moser, Hans-Ulrich Klein, Udo Kontny, Martin Dugas, Kathrin Poos, Eberhard Korsching, Thorsten Buch, Matthias Weckesser, Isabell Schulze, Regina Besoke, Anika Witten, Monika Stoll, Gabriele Köhler, Wolfgang Hartmann, Eva Wardelmann, Claudia Rossig, Daniel Baumhoer, Heribert Jürgens, Stefan Burdach, Wolfgang E Berdel, Carsten Müller-Tidow,

<h4>Purpose</h4>A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2015, 21(21):4935-4946]

Cited: 32 times

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Tracing differences between male and female breast cancer: both diseases own a different biology.

Robert Kornegoor, Paul J van Diest, Horst Buerger, Eberhard Korsching,

<h4>Aims</h4>Male breast cancer (MBC) is a rare and poorly characterized disease. In the present study we used a novel biomathematical model to further characterize MBC and to identify differences between male and female breast cancer (FBC).<h4>Methods and results</h4>A total of 134 cases of MBC were stained immunohistochemically for 13 key ... Read more >>

Histopathology (Histopathology)
[2015, 67(6):888-897]

Cited: 7 times

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New small molecules targeting apoptosis and cell viability in osteosarcoma.

Doris Maugg, Ina Rothenaigner, Kenji Schorpp, Harish Kumar Potukuchi, Eberhard Korsching, Daniel Baumhoer, Kamyar Hadian, Jan Smida, Michaela Nathrath,

Despite the option of multimodal therapy in the treatment strategies of osteosarcoma (OS), the most common primary malignant bone tumor, the standard therapy has not changed over the last decades and still involves multidrug chemotherapy and radical surgery. Although successfully applied in many patients a large number of patients eventually ... Read more >>

PLoS One (PloS one)
[2015, 10(6):e0129058]

Cited: 9 times

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Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation.

Kathrin Poos, Jan Smida, Michaela Nathrath, Doris Maugg, Daniel Baumhoer, Anna Neumann, Eberhard Korsching,

Osteosarcoma (OS) is the most common primary bone cancer exhibiting high genomic instability. This genomic instability affects multiple genes and microRNAs to a varying extent depending on patient and tumor subtype. Massive research is ongoing to identify genes including their gene products and microRNAs that correlate with disease progression and ... Read more >>

Database (Oxford) (Database : the journal of biological databases and curation)
[2014, 2014:]

Cited: 17 times

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How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation.

Kathrin Poos, Jan Smida, Michaela Nathrath, Doris Maugg, Daniel Baumhoer, Eberhard Korsching,

Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affect the expression and function of several genes due to drastic changes in the underlying gene regulatory network. However, we know little about critical gene regulators and their functional consequences on the pathogenesis of OS. Therefore, we aimed ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2013, 9(8):e1003210]

Cited: 46 times

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Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice.

Christa Hohoff, Ali Gorji, Sylvia Kaiser, Edith Willscher, Eberhard Korsching, Oliver Ambrée, Volker Arolt, Klaus-Peter Lesch, Norbert Sachser, Jürgen Deckert, Lars Lewejohann,

The most prominent brain region evaluating the significance of external stimuli immediately after their onset is the amygdala. Stimuli evaluated as being stressful actuate a number of physiological processes as an immediate stress response. Variation in the serotonin transporter gene has been associated with increased anxiety- and depression-like behavior, altered ... Read more >>

PLoS One (PloS one)
[2013, 8(3):e58880]

Cited: 6 times

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Chromosome 16q loss--a genetic key to the understanding of breast carcinogenesis.

Horst Bürger, Mirthe de Boer, Paul J van Diest, Eberhard Korsching,

In the last decade the concepts of breast cancer dedifferentiation and progression have undergone a significant and substantial change. In the past it was widely believed that the detailed associations between genetic and morphological changes defined in the Vogelstein model of colorectal cancer pathogenesis could be transferred to breast carcinogenesis. ... Read more >>

Histol Histopathol (Histology and histopathology)
[2013, 28(3):311-320]

Cited: 6 times

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Is there 'progression through grade' in ductal invasive breast cancer?

Barbara Schymik, Horst Buerger, Annika Krämer, Ulli Voss, Petra van der Groep, Wolfgang Meinerz, Paul J van Diest, Eberhard Korsching,

Recent molecular data pointed towards the possibility of a stepwise dedifferentiation in a subgroup of invasive breast cancer (BC) cases. It was hypothesized that oestrogen receptor positive (ER+) grade 3 (G3) ductal invasive BCs are the end stage of a dedifferentiation process of luminal BC. A progression of luminal A ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2012, 135(3):693-703]

Cited: 11 times

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Origin and differentiation of breast nipple syringoma.

Werner Boecker, Tina Junkers, Michael Reusch, Horst Buerger, Eberhard Korsching, Dieter Metze, Thomas Decker, Thomas Loening, Alina Lange, Vera Samoilova, Igor Buchwalow,

Sci Rep (Scientific reports)
[2012, 2:226]

Cited: 4 times

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Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor binding sites in vivo.

Ronaldo Schuch, Konstantin Agelopoulos, Anna Neumann, Burkhard Brandt, Horst Bürger, Eberhard Korsching,

<h4>Background</h4>Transcription factors (TFs) and their binding sites (TFBSs) play a central role in the regulation of gene expression. It is therefore vital to know how the allocation pattern of TFBSs affects the functioning of any particular gene in vivo. A widely used method to analyze TFBSs in vivo is the ... Read more >>

BMC Res Notes (BMC research notes)
[2012, 5:109]

Cited: 4 times

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