Full Text Journal Articles by
Author E Wesley Ely

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Patient and Family Engagement in Critical Illness: Erratum.

Cheryl Misak, Margaret Herridge, E Wesley Ely, Alison Clay, Mark E Mikkelsen,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1195]

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Establishing Medicaid incentives for liberating nursing home patients from ventilators.

Laura M Keohane, Matthew F Mart, E Wesley Ely, Pikki Lai, Audrey Cheng, Anil N Makam, David G Stevenson,

Chronic ventilator use in Tennessee nursing homes surged following 2010 increases in respiratory care payment rates. Tennessee's Medicaid program implemented multiple policies between 2014 and 2017 to promote ventilator liberation in 11 nursing homes, including quality reporting, on-site monitoring, and pay-for-performance incentives. Using repeated cross-sectional analysis of Medicare and Medicaid ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, :]

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Prospective Validation of the Preschool Confusion Assessment Method for the ICU to Screen for Delirium in Infants Less Than 6 Months Old.

Marguerite O Canter, Yasas C Tanguturi, Jo Ellen Wilson, Stacey R Williams, Sylvia A Exum, Hiren M Umrania, Kristina A Betters, Rameela Raman, E Wesley Ely, Pratik P Pandharipande, D Catherine Fuchs, Heidi A B Smith,

<h4>Objectives</h4>ICU delirium is a predictor of greater morbidity and higher mortality in the pediatric population. The diagnostic obstacles and validity of delirium monitoring among neonates and young infants have yet to be fully delineated. We sought to validate the Preschool Confusion Assessment Method for the ICU in neonates and young ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):e902-e909]

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IL-6 Inhibition Reduces Neuronal Injury in a Murine Model of Ventilator-induced Lung Injury.

Nicklaus A Sparrow, Faizan Anwar, Ambart E Covarrubias, Padmesh S Rajput, Mohammad Harun Rashid, Peyton L Nisson, Michael M Gezalian, Shahed Toossi, Maranatha O Ayodele, S Ananth Karumanchi, E Wesley Ely, Shouri Lahiri,

Mechanical ventilation is a known risk factor for delirium, a cognitive impairment characterized by dysfunction of the frontal cortex and hippocampus. Although IL-6 is upregulated in mechanical ventilation-induced lung injury (VILI) and may contribute to delirium, it is not known whether the inhibition of systemic IL-6 mitigates delirium-relevant neuropathology. To ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, 65(4):403-412]

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Changes in Use of Respiratory Support for Preterm Infants in the US, 2008-2018.

L Dupree Hatch, Reese H Clark, Waldemar A Carlo, Ann R Stark, E Wesley Ely, Stephen W Patrick,

<h4>Importance</h4>In preterm infants, mechanical ventilation (MV) is associated with adverse pulmonary and neurodevelopmental outcomes. Multiple randomized clinical trials over the past 2 decades have shown the effectiveness of early noninvasive ventilation (NIV) in decreasing the use of MV in preterm infants. The epidemiologic factors associated with respiratory support in US ... Read more >>

JAMA Pediatr (JAMA pediatrics)
[2021, 175(10):1017-1024]

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Predicting brain function status changes in critically ill patients via Machine learning.

Chao Yan, Cheng Gao, Ziqi Zhang, Wencong Chen, Bradley A Malin, E Wesley Ely, Mayur B Patel, You Chen,

<h4>Objective</h4>In intensive care units (ICUs), a patient's brain function status can shift from a state of acute brain dysfunction (ABD) to one that is ABD-free and vice versa, which is challenging to forecast and, in turn, hampers the allocation of hospital resources. We aim to develop a machine learning model ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2021, 28(11):2412-2422]

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Patient and Family Engagement in Critical Illness.

Cheryl Misak, Margaret Herridge, E Wesley Ely, Alison Clay, Mark E Mikkelsen,

Crit Care Med (Critical care medicine)
[2021, 49(9):1389-1401]

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Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.

Vincent C Marconi, Athimalaipet V Ramanan, Stephanie de Bono, Cynthia E Kartman, Venkatesh Krishnan, Ran Liao, Maria Lucia B Piruzeli, Jason D Goldman, Jorge Alatorre-Alexander, Rita de Cassia Pellegrini, Vicente Estrada, Mousumi Som, Anabela Cardoso, Sujatro Chakladar, Brenda Crowe, Paulo Reis, Xin Zhang, David H Adams, E Wesley Ely, ,

<h4>Background</h4>Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties. This study evaluates the efficacy and safety of baricitinib in combination with standard of care for the treatment of hospitalised adults with COVID-19.<h4>Methods</h4>In this phase 3, double-blind, randomised, placebo-controlled trial, participants were enrolled from 101 centres across ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

Cited: 2 times

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Medicine at Its Finest.

E Wesley Ely,

Chest (Chest)
[2021, 160(3):1149-1150]

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Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial.

Claudia D Spies, Cornelia Knaak, Mandy Mertens, Wolf-Rüdiger Brockhaus, Anna Shadenok, Janine Wiebach, Kevin Kunzmann, Aarne Feldheiser, Johann Pratschke, Olga Müller, Valesca Kipping, Maria Fabian, Wiltrud Abels, Friedrich Borchers, Levent Akyüz, E Wesley Ely, Klaus-Dieter Wernecke, David Krishna Menon, Sophie K Piper,

<h4>Background</h4>Anecdotally, cholinergic stimulation has been used to treat delirium and reduce cognitive dysfunction.<h4>Objective</h4>The aim of this investigation was to evaluate whether physostigmine reduced the incidence of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in patients undergoing liver resection.<h4>Design</h4>This was a double-blind, randomised, placebo-controlled trial. Between 11 August 2009 and ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(9):943-956]

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ICU Survivorship-The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness.

Matthew F Mart, Brenda T Pun, Pratik Pandharipande, James C Jackson, E Wesley Ely,

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized treatment for these fragile patients. As the specialty has grown, it has achieved ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(8):1227-1240]

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[Disorientation and delirium assessment : A secondary analysis of a prospective, observational study].

Ulf Guenther, Mirko Wolke, Hans-Christian Hansen, Nicole Feldmann, Anja Diers, Oliver Dewald, E Wesley Ely, Andreas Weyland,

Disorientation may present as a warning sign of developing delirium. The most commonly used delirium assessment tool in Germany, the Confusion Assessment Method for Intensive Care Unit (CAM-ICU), does not rate "disorientation", since intubated patients cannot communicate verbally. However, the majority of German ICU patients are not orally intubated, so they ... Read more >>

Med Klin Intensivmed Notfmed (Medizinische Klinik, Intensivmedizin und Notfallmedizin)
[2021, :]

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Cryptococcal Meningitis Causing Refractory Hemichorea-Hemiballismus Treated With Pallidotomy.

Kevin G Buell, Brian P Vickers, Karen C Bloch, Amy E Brown, Peter Hedera, Walter Jermakowicz, Peter E Konrad, E Wesley Ely,

We report a case of a 31-year-old immunocompetent male who presented with altered mental status and agitation requiring intubation. As sedation was weaned, he demonstrated choreiform movements with associated hemiballismus of the right upper and lower extremities, and he was ultimately diagnosed with cryptococcal meningitis. The patient's chorea did not ... Read more >>

Cureus (Cureus)
[2021, 13(7):e16493]

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Delirium in critical illness: clinical manifestations, outcomes, and management.

Joanna L Stollings, Katarzyna Kotfis, Gerald Chanques, Brenda T Pun, Pratik P Pandharipande, E Wesley Ely,

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the intensive care unit (ICU), duration of delirium is independently predictive of excess death, length of stay, cost of care, and acquired dementia. There are numerous neurotransmitter/functional and/or injury-causing hypotheses rather than a unifying mechanism for ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1089-1103]

Cited: 1 time

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Pseudodelirium: Psychiatric Conditions to Consider on the Differential for Delirium.

Jo Ellen Wilson, Patricia Andrews, Aspen Ainsworth, Kamalika Roy, E Wesley Ely, Mark A Oldham,

<h4>Objective</h4>The phenotypes of several psychiatric conditions can very closely resemble delirium; the authors describe such presentations as pseudodelirium. However, because the clinical management of these conditions differs markedly from that of delirium, prompt differentiation is essential. The authors provide an educational review to assist clinicians in identifying and managing psychiatric ... Read more >>

J Neuropsychiatry Clin Neurosci (The Journal of neuropsychiatry and clinical neurosciences)
[2021, :appineuropsych20120316]

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Protocolized Postextubation Respiratory Support to Prevent Reintubation: A Randomized Clinical Trial.

Jonathan D Casey, Erin M Vaughan, Bradley D Lloyd, Peter A Billas, Karen E Jackson, Eric J Hall, Alexandra H Toporek, Kevin G Buell, Ryan M Brown, Roger K Richardson, J Craig Rooks, Reagan B Buie, Li Wang, Christopher J Lindsell, E Wesley Ely, Wesley H Self, Gordon R Bernard, Todd W Rice, Matthew W Semler,

<b>Rationale:</b> Respiratory support (noninvasive ventilation or high-flow nasal cannula) applied at the time of extubation has been reported to reduce reintubation rates, but concerns regarding effectiveness have limited uptake into practice.<b>Objectives:</b> To determine if providing postextubation respiratory support to all patients undergoing extubation in a medical ICU would decrease the ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(3):294-302]

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Long-Term Outcomes in ICU Patients with Delirium: A Population-based Cohort Study.

Kirsten M Fiest, Andrea Soo, Chel Hee Lee, Daniel J Niven, E Wesley Ely, Christopher J Doig, Henry T Stelfox,

<b>Rationale:</b> Delirium is common in the ICU and portends worse ICU and hospital outcomes. The effect of delirium in the ICU on post-hospital discharge mortality and health resource use is less well known. <b>Objectives:</b> To estimate mortality and health resource use 2.5 years after hospital discharge in critically ill patients ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(4):412-420]

Cited: 1 time

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Delirium-related distress in the ICU: A qualitative meta-synthesis of patient and family perspectives and experiences.

Leanne M Boehm, Abigail C Jones, Abeer A Selim, Claudia Virdun, Cornelia F Garrard, Rachel L Walden, E Wesley Ely, Annmarie Hosie,

<h4>Background</h4>Better understanding of patient and family member experiences of delirium and related distress during critical care is required to inform the development of targeted nonpharmacologic interventions.<h4>Objective</h4>To examine and synthesize qualitative data on patient and family member delirium experiences and relieving factors in the Intensive Care Unit (ICU).<h4>Design</h4>We conducted a systematic ... Read more >>

Int J Nurs Stud (International journal of nursing studies)
[2021, 122:104030]

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Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions.

Alan H Morris, Brian Stagg, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Antonio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha S Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon D Truwit, Jay Steingrub, R Duncan Hite, Douglas F Willson, Jerry J Zimmerman, Vinay M Nadkarni, Adrienne Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang H Lee, Bennett P deBoisblanc, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, David W Grainger, Willard H Dere, Alan S Crandall, Julio C Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Ognjen Gajic, Brian Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Derek Angus, Michael R Pinsky, Brent James, Donald Berwick,

Clinical decision-making is based on knowledge, expertise, and authority, with clinicians approving almost every intervention-the starting point for delivery of "All the right care, but only the right care," an unachieved healthcare quality improvement goal. Unaided clinicians suffer from human cognitive limitations and biases when decisions are based only on ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2021, 28(6):1330-1344]

Cited: 1 time

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The burden they bear: A scoping review of physician empathy in the intensive care unit.

Jessica Bunin, Emily Shohfi, Holly Meyer, E Wesley Ely, Lara Varpio,

<h4>Purpose</h4>Research shows that physician empathy can improve patients' reporting of symptoms, participation in care, compliance, and satisfaction; however, success in harnessing these advantages in the ICU hinges on a myriad of contextual factors. This study describes the current state of knowledge about intensivists' empathy.<h4>Methods</h4>A scoping review was conducted across six ... Read more >>

J Crit Care (Journal of critical care)
[2021, 65:156-163]

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Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness.

Matthew F Mart, Timothy D Girard, Jennifer L Thompson, Hannah Whitten-Vile, Rameela Raman, Pratik P Pandharipande, Daren K Heyland, E Wesley Ely, Nathan E Brummel,

<h4>Background and aims</h4>Risk factors for poor outcomes after critical illness are incompletely understood. While nutritional risk is associated with mortality in critically ill patients, its association with disability, cognitive, and health-related quality of life is unclear in survivors of critical illness. This study's objective was to determine whether greater nutritional ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2021, 40(6):3868-3874]

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Risk factors for delirium among hospitalized patients in Zambia.

Justin K Banerdt, Kondwelani Mateyo, Yan Yan, Dandan Liu, Yi Zuo, Chiara Di Gravio, Julia C Thome, Elisabeth D Riviello, Deanna Saylor, E Wesley Ely, Douglas C Heimburger,

<h4>Objective</h4>To identify risk factors for delirium among hospitalized patients in Zambia.<h4>Methods</h4>We conducted a prospective cohort study at the University Teaching Hospital in Lusaka, Zambia, from October 2017 to April 2018. We report associations of exposures including sociodemographic and clinical factors with delirium over the first three days of hospital admission, ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249097]

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Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies.

Rameela Raman, Wencong Chen, Michael O Harhay, Jennifer L Thompson, E Wesley Ely, Pratik P Pandharipande, Mayur B Patel,

<h4>Background</h4>In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has delirium (i.e., brain dysfunction) during their critical care stay is associated with the presence and severity of long-term ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2021, 21(1):97]

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Statistical analysis plan for the Surgery for Cancer with Option of Palliative Care Expert (SCOPE) trial: a randomized controlled trial of a specialist palliative care intervention for patients undergoing surgery for cancer.

Onur M Orun, Myrick C Shinall, Aimee Hoskins, Ellis Morgan, Mohana Karlekar, Sara F Martin, E Wesley Ely, Rameela Raman,

<h4>Background</h4>The impact of specialist palliative care intervention in patients undergoing surgery for cancer has not been studied extensively. The SCOPE randomized controlled trial will investigate the effect of specialist palliative care intervention in cancer patients undergoing surgery for selected abdominal malignancies. The study protocol of the SCOPE Trial was published ... Read more >>

Trials (Trials)
[2021, 22(1):314]

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Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study.

Christopher G Hughes, Christina J Hayhurst, Pratik P Pandharipande, Matthew S Shotwell, Xiaoke Feng, Jo Ellen Wilson, Nathan E Brummel, Timothy D Girard, James C Jackson, E Wesley Ely, Mayur B Patel,

<h4>Background</h4>The temporal association of delirium during critical illness with mortality is unclear, along with the associations of hypoactive and hyperactive motoric subtypes of delirium with mortality. We aimed to evaluate the relationship of delirium during critical illness, including hypoactive and hyperactive motoric subtypes, with mortality in the hospital and after ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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