Full Text Journal Articles by
Author E Scott Halstead

Advertisement

Find full text journal articles








Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model.

Todd M Umstead, Eranda Kurundu Hewage, Margaret Mathewson, Sarah Beaudoin, Zissis C Chroneos, Ming Wang, E Scott Halstead,

Inhaled granulocyte/macrophage colony-stimulating factor (GM-CSF) shows promise as a therapeutic to treat viral and bacterial pneumonia, but no mouse model of inhaled GM-CSF has been described. We sought to 1) develop a mouse model of aerosolized recombinant mouse GM-CSF administration and 2) investigate the protection conferred by inhaled GM-CSF during ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2020, 318(4):L571-L579]

Cited: 0 times

View full text PDF listing >>



DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis.

Dennis W Simon, E Scott Halstead, Sam Davila, Kate F Kernan, Robert S B Clark, Gregory Storch, Joseph A Carcillo,

OBJECTIVE:To evaluate the relationship between detection of DNA viruses, ferritin, and outcomes in children with severe sepsis. STUDY DESIGN:We enrolled 75 pediatric patients with severe sepsis admitted to a tertiary care children's hospital. Plasma ferritin was measured within 48 hours of diagnosis and subsequently twice weekly. Herpes simplex type 1, human ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 213:82-87.e2]

Cited: 0 times

View full text PDF listing >>



Advertisement

Advances in Pediatric Sepsis and Shock.

E Scott Halstead,

J Pediatr Intensive Care (Journal of pediatric intensive care)
[2019, 8(1):1-2]

Cited: 0 times

View full text PDF listing >>



No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.

Katie Park, Lindsay C Trout, Cong Xu, Ming Wang, Robert F Tamburro, E Scott Halstead,

OBJECTIVES:To determine the relationship between theophylline trough levels and urine output in critically ill children administered aminophylline as adjunctive diuretic therapy. DESIGN:Retrospective cohort study. SETTING:The PICU of a tertiary care children's hospital. PATIENTS:A mixed population of medical/surgical including postoperative cardiothoracic surgery patients less than 18 years old. INTERVENTIONS:Electronic medical records ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):e425-e432]

Cited: 0 times

View full text PDF listing >>



GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization.

E Scott Halstead, Todd M Umstead, Michael L Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C Chroneos,

BACKGROUND:Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza infection in mice, but the mechanisms of protection and treatment efficacy have not been established. METHODS:Mice were ... Read more >>

Respir. Res. (Respiratory research)
[2018, 19(1):3]

Cited: 7 times

View full text PDF listing >>



Viral DNAemia and Immune Suppression in Pediatric Sepsis.

Sam Davila, E Scott Halstead, Mark W Hall, Allan Doctor, Russell Telford, Richard Holubkov, Joseph A Carcillo, Gregory A Storch, ,

OBJECTIVES:Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN:Retrospective analysis of a prospective cohort study. PATIENTS:Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:This study was performed as an ancillary investigation to a single-center ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(1):e14-e22]

Cited: 2 times

View full text PDF listing >>



An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections.

Eranda M K Kurundu Hewage, Debbie Spear, Todd M Umstead, Sanmei Hu, Ming Wang, Pak Kin Wong, Zissis C Chroneos, E Scott Halstead, Neal J Thomas,

Bloodstream infections are major contributing factors of morbidity and mortality among children. Precise and timely identification of causative agents can improve the clinical management and outcome of the infection, potentially saving lives. Electrochemical biosensors previously described by Gao et al. (2017) have the potential to deliver greater speed and discrimination. ... Read more >>

SLAS Technol (SLAS technology)
[2017, 22(6):616-625]

Cited: 3 times

View full text PDF listing >>



Intrapulmonary Percussive Ventilation as an Airway Clearance Technique during Venoarterial Extracorporeal Life Support in an Infant with Pertussis.

Conrad Krawiec, Ken Ballinger, E Scott Halstead,

Initiation of extracorporeal life support (ECLS) is often followed by complete opacification of pulmonary parenchyma and volume loss. The optimal mechanical ventilator management and lung recruitment strategy of a pediatric patient requiring extracorporeal membrane oxygenation is not known. We present a case of a 4-week old infant who developed a ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2017, 5:99]

Cited: 0 times

View full text PDF listing >>



Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.

Joseph A Carcillo, E Scott Halstead, Mark W Hall, Trung C Nguyen, Ron Reeder, Rajesh Aneja, Bita Shakoory, Dennis Simon, ,

OBJECTIVES:We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis. DESIGN:Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple organ failure (whole blood ex ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(6):513-523]

Cited: 11 times

View full text PDF listing >>



A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis.

Joseph A Carcillo, Katherine Sward, E Scott Halstead, Russell Telford, Adria Jimenez-Bacardi, Bita Shakoory, Dennis Simon, Mark Hall, ,

OBJECTIVES:We tested the hypothesis that a C-reactive protein and ferritin-based systemic inflammation contingency table can track mortality risk in pediatric severe sepsis. DESIGN:Prospective cohort study. SETTING:Tertiary PICU. PATIENTS:Children with 100 separate admission episodes of severe sepsis were enrolled. INTERVENTIONS:Blood samples were attained on day 2 of sepsis and bi-weekly for ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2017, 18(2):143-150]

Cited: 9 times

View full text PDF listing >>



Plasma Mitochondrial DNA--a Novel DAMP in Pediatric Sepsis.

Valentina Di Caro, Thomas D Walko, R Aaron Bola, John D Hong, Diana Pang, Victor Hsue, Alicia K Au, E Scott Halstead, Joseph A Carcillo, Robert S B Clark, Rajesh K Aneja,

Mitochondrial DNA (mtDNA) is a novel danger-associated molecular pattern that on its release into the extracellular milieu acts via toll-like receptor-9, a pattern recognition receptor of the immune system. We hypothesized that plasma mtDNA concentrations will be elevated in septic children, and these elevations are associated with an increase in ... Read more >>

Shock (Shock (Augusta, Ga.))
[2016, 45(5):506-511]

Cited: 11 times

View full text PDF listing >>



Lethal influenza infection: Is a macrophage to blame?

E Scott Halstead, Zissis C Chroneos,

Alveolar macrophages (AMs) are critical for immunity against influenza A virus (IAV) infection. Depletion, hyporeactivity, and disruption of AM development and differentiation are all associated with lethal IAV infection. AMs drive the innate immune response that limits IAV infection. AMs are crucial for steady-state homeostasis of pulmonary surfactant, and in ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2015, 13(12):1425-1428]

Cited: 4 times

View full text PDF listing >>



SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.

Linlin Yang, Marykate Carrillo, Yuchieh M Wu, Susan L DiAngelo, Patricia Silveyra, Todd M Umstead, E Scott Halstead, Michael L Davies, Sanmei Hu, Joanna Floros, Francis X McCormack, Neil D Christensen, Zissis C Chroneos,

The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-A plays an important role in pulmonary immunity by enhancing opsonization and clearance of pathogens and by modulating macrophage inflammatory responses. Alternative splicing of the Myo18A gene ... Read more >>

PLoS ONE (PloS one)
[2015, 10(5):e0126576]

Cited: 6 times

View full text PDF listing >>



Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*.

Dennis W Simon, Rajesh Aneja, Joseph A Carcillo, E Scott Halstead,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2014, 15(5):486-488]

Cited: 11 times

View full text PDF listing >>



Severe cardiomyopathy in an infant after iatrogenic fosphenytoin overdose.

Melissa Grageda, Ashish P Saini, Lindsay C Trout, Stephen E Cyran, E Scott Halstead,

Clin Pediatr (Phila) (Clinical pediatrics)
[2014, 53(8):791-793]

Cited: 1 time

View full text PDF listing >>



Rapid onset of hippocampal atrophy in febrile-infection related epilepsy syndrome (FIRES).

Debra L Byler, Melissa R Grageda, E Scott Halstead, Sangam Kanekar,

Febrile infection-related epilepsy syndrome (FIRES) is a catastrophic and usually refractory epilepsy syndrome that occurs after a febrile illness in previously normal children. The pathogenesis of the syndrome is unknown, and the diagnosis is typically made by exclusion after an exhaustive negative workup for central nervous system infections and autoimmune ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2014, 29(4):545-549]

Cited: 1 time

View full text PDF listing >>



Reduced frequency of CD56 dim CD16 pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients.

E Scott Halstead, Joseph A Carcillo, Bastian Schilling, Robert J Greiner, Theresa L Whiteside,

BACKGROUND: Sepsis continues to be a leading cause of death in infants and children. Natural killer (NK) cells serve as a bridge between innate and adaptive immunity, yet their role in pediatric sepsis has not been well characterized. METHODS: We tested the hypothesis that decreased NK cell cytotoxicity is a ... Read more >>

Pediatr. Res. (Pediatric research)
[2013, 74(4):427-432]

Cited: 10 times

View full text PDF listing >>



IL-15 enhances survival and function of HIV-specific CD8+ T cells.

Yvonne M Mueller, Paul M Bojczuk, E Scott Halstead, Alfred H J Kim, James Witek, John D Altman, Peter D Katsikis,

HIV-specific CD8(+) T cells are prone to undergo apoptosis, and this may affect their ability to control HIV infection. Because CD8-mediated immune responses play a key role in controlling HIV infection, enhancing the survival and effector function of HIV-specific CD8(+) T cells may augment their ability to control HIV virus. ... Read more >>

Blood (Blood)
[2003, 101(3):1024-1029]

Cited: 76 times

View full text PDF listing >>



In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.

E Scott Halstead, Yvonne M Mueller, John D Altman, Peter D Katsikis,

Given the key role CD8+ T cells play in controlling viral infection, strategies to enhance these responses may have important clinical applications. We found that in vivo CD137 stimulation with an agonistic monoclonal antibody enhanced the primary CD8+ T cell response to influenza type A viral infection in mice. Stimulation ... Read more >>

Nat. Immunol. (Nature immunology)
[2002, 3(6):536-541]

Cited: 88 times

View full text PDF listing >>





Advertisement

Disclaimer
0.9869 s