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Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience.

Alexander T Sougiannis, Brandon N VanderVeen, J Mark Davis, Daping Fan, E Angela Murphy,

Intestinal mucositis remains one of the most debilitating side effects related to chemotherapy. The onset and persistence of mucositis is an intricate physiological process involving cross-communication between the specific chemotherapeutic drug, the immune system, and gut microbes that results in a loss of mucosal integrity leading to gut-barrier dysfunction. Intestinal ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, :]

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Managing clinical trials during COVID-19: experience from a clinical research facility.

Frances Shiely, Jean Foley, Amy Stone, Emma Cobbe, Shaunagh Browne, Ellen Murphy, Maeve Kelsey, Joanne Walsh-Crowley, Joseph A Eustace,

There is a dearth of literature on best practices for managing clinical trials, and little is understood on the role of the clinical trial manager. The COVID-19 pandemic has brought this into focus, and the continuance of clinical trials worldwide has been catapulted into a state of uncertainty as countries ... Read more >>

Trials (Trials)
[2021, 22(1):62]

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The Challenges of Recruitment to a Randomised Trial Registry – What Information Matters to the Patient?

Ellen Murphy, Niamh Shea, Aoife O'Keeffe, Eva Long, Joseph Eustace, Frances Shiely,

<h4>Background: </h4> Randomised controlled trials (RCTs) are the gold standard for demonstrating efficacy of new therapies. Despite this, nephrology trials, especially of patients with end stage renal disease (ESRD) are much fewer in number than other specialties. Recruitment difficulties are cited as a particular challenge. Using registries to conduct RCTs ... Read more >>

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Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study.

Rishi K Gupta, Ewen M Harrison, Antonia Ho, Annemarie B Docherty, Stephen R Knight, Maarten van Smeden, Ibrahim Abubakar, Marc Lipman, Matteo Quartagno, Riinu Pius, Iain Buchan, Gail Carson, Thomas M Drake, Jake Dunning, Cameron J Fairfield, Carrol Gamble, Christopher A Green, Sophie Halpin, Hayley E Hardwick, Karl A Holden, Peter W Horby, Clare Jackson, Kenneth A Mclean, Laura Merson, Jonathan S Nguyen-Van-Tam, Lisa Norman, Piero L Olliaro, Mark G Pritchard, Clark D Russell, James Scott-Brown, Catherine A Shaw, Aziz Sheikh, Tom Solomon, Cathie Sudlow, Olivia V Swann, Lance Turtle, Peter J M Openshaw, J Kenneth Baillie, Malcolm G Semple, Mahdad Noursadeghi, ,

<h4>Background</h4>Prognostic models to predict the risk of clinical deterioration in acute COVID-19 cases are urgently required to inform clinical management decisions.<h4>Methods</h4>We developed and validated a multivariable logistic regression model for in-hospital clinical deterioration (defined as any requirement of ventilatory support or critical care, or death) among consecutively hospitalised adults with ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: outcomes from a national centre in the current era.

Michael Eamon Kelly, Edward Murphy, Alan Martin Keyes, Mohammad Faraz Khan, Jarlath C Bolger, Josh Grundy, John Conneely, John MacHale, John McCaffrey, Ronan Cahill, Brendan Moran, Conor Shields, Jürgen Mulsow,

<h4>Background</h4>Multimodal therapy incorporating cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival for selected patients with colorectal peritoneal metastases (CPMs). Many countries have centralised management of these patients, aiming to improve outcomes. There is ongoing debate on the need for and complications associated with HIPEC administration. We report indications ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2021, :]

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Multiple Site SBRT in Pediatric, Adolescent, and Young Adult Patients With Recurrent and/or Metastatic Sarcoma.

Shireen Parsai, Geoffrey Sedor, Timothy D Smile, Jacob Scott, Allison Ochocki, Nicole Vassil, Stacey Zahler, Lilyana Angelov, Samuel T Chao, Peng Qi, Peter Anderson, Erin S Murphy,

<h4>Background</h4>Stereotactic body radiation therapy (SBRT) is increasingly used for patients with recurrent and or metastatic tumors. Sarcomas are generally considered not sensitive to radiotherapy and SBRT may allow for increased biological effectiveness. We report intermediate outcomes and toxicity for pediatric, adolescent, and young adult patients treated with SBRT to sites ... Read more >>

Am J Clin Oncol (American journal of clinical oncology)
[2021, Publish Ahead of Print:]

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Rewealthization in twenty-first century Western countries: the defining trend of the socioeconomic squeeze of the middle class

Louis Chauvel, Eyal Bar Haim, Anne Hartung, Emily Murphy,

The wealth-to-income ratio (WIR) in many Western countries, particularly in Europe and North America, increased by a factor of two in the last three decades. This represents a defining empirical trend: a rewealthization (from the French repatrimonialisation)—or the comeback of (inherited) wealth primacy since the mid-1990s. For the sociology of social stratification, ... Read more >>

(The Journal of Chinese Sociology)
[2021, 8(1):]

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Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients treated with Pulse - Taper Corticosteroids for Post-infectious Inflammatory Syndrome.

Seher Anjum, Owen Dean, Peter Kosa, M Teresa Magone, Kelly A King, Edmond Fitzgibbon, H Jeff Kim, Chris Zalewski, Elizabeth Murphy, Bridgette Jeanne Billioux, Jennifer Chisholm, Carmen C Brewer, Chantal Krieger, Waleed Elsegeiny, Terri L Scott, Jing Wang, Sally Hunsberger, John E Bennett, Avindra Nath, Kieren A Marr, Bibiana Bielekova, David Wendler, Dima A Hammoud, Peter Williamson,

<h4>Background</h4>Cryptococcal meningoencephalitis (CM) is a major cause of mortality in immunosuppressed patients and previously healthy individuals. In the latter, a post-infectious inflammatory response syndrome (PIIRS) is associated with poor clinical response despite antifungal therapy and negative CSF cultures. Data on effective treatment are limited.<h4>Methods</h4>Between March 2015 and March 2020, 15 ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Managing clinical trials during COVID-19: experience from a clinical research facility

Frances Shiely, Jean Foley, Amy Stone, Emma Cobbe, Shaunagh Browne, Ellen Murphy, Maeve Kelsey, Joanne Walsh-Crowley, Joseph A. Eustace,

There is a dearth of literature on best practices for managing clinical trials, and little is understood on the role of the clinical trial manager. The COVID-19 pandemic has brought this into focus, and the continuance of clinical trials worldwide has been catapulted into a state of uncertainty as countries ... Read more >>

Trials (Trials)
[2021, 22(1):]

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Innovations in Diabetes Care for a Better "New Normal" Beyond COVID-19.

Shivani Agarwal, Michelle L Griffith, Elizabeth J Murphy, Carol Greenlee, Jeffrey Boord, Robert A Gabbay,

The coronavirus disease pandemic has created opportunities for innovation in diabetes care that were not possible before. From the lens of this "new normal" state, we have an opportunity to rapidly implement, test, and iterate models of diabetes care to achieve the quadruple aim of improving medical outcomes, patient experience, ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(1):e377-e381]

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Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre.

Maria Schwarz, Edel J Murphy, Aoife M Foley, David F Woods, Ignacio Abreu Castilla, F Jerry Reen, Stuart G Collins, Fergal O'Gara, Anita R Maguire,

The marine transaminase, P-ω-TA, can be employed for the transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre resulting in formation of ketone products with up to 93% ee. While 4-substituents are tolerated on the tetralin core, the presence ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2021, 19(1):188-198]

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Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection.

Georgios Amanakis, Junhui Sun, Maria M Fergusson, Shane McGinty, Chengyu Liu, Jeffery D Molkentin, Elizabeth Murphy,

<h4>Aims</h4>Cyclophilin-D is a well-known regulator of the mitochondrial permeability transition pore (PTP), the main effector of cardiac ischaemia/reperfusion injury. However, the binding of CypD to the PTP is poorly understood. Cysteine 202 (C202) of CypD is highly conserved among species and can undergo redox-sensitive post-translational modifications. We investigated whether C202 ... Read more >>

Cardiovasc Res (Cardiovascular research)
[2021, 117(1):212-223]

Cited: 2 times

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SARS-CoV-2 testing of 11,884 healthcare workers at an acute NHS hospital trust in England: a retrospective analysis

Aidan Hanrath, Ina Schim van der Loeff, Dennis Lendrem, Kenneth Baker, David Price, Peter McDowall, Kiera McDowall, Sue Cook, Peter Towns, Ulrich Schwab, Adam Evans, Jill Dixon, Jennifer Collins, Shirelle Burton-Fanning, David Saunders, Jayne Harwood, Julie Samuel, Matthias Schmid, Lucia Pareja-Cebrian, Ewan Hunter, Elizabeth Murphy, Yusri Taha, Brendan Payne, Christopher J.A. Duncan,

<h4>ABSTRACT</h4> Healthcare workers (HCWs) are known to be at increased risk of infection with SARS-CoV-2, although whether these risks are equal across all roles is uncertain. Here we report a retrospective analysis of a large real-world dataset obtained from 10 March to 6 July 2020 in an NHS Foundation Trust ... Read more >>

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Evaluation of methods for the reduction of contaminating host reads when performing shotgun metagenomic sequencing of the milk microbiome.

Min Yap, Conor Feehily, Calum J Walsh, Mark Fenelon, Eileen F Murphy, Fionnuala M McAuliffe, Douwe van Sinderen, Paul W O'Toole, Orla O'Sullivan, Paul D Cotter,

Shotgun metagenomic sequencing is a valuable tool for the taxonomic and functional profiling of microbial communities. However, this approach is challenging in samples, such as milk, where a low microbial abundance, combined with high levels of host DNA, result in inefficient and uneconomical sequencing. Here we evaluate approaches to deplete ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21665]

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Ammonia: what adult neurologists need to know.

Rick Meijer, Umesh Vivekananda, Simona Balestrini, Matthew Walker, Robin Lachmann, Johannes Haeberle, Elaine Murphy,

Hyperammonaemia is often encountered in acute neurology and can be the cause of acute or chronic neurological symptoms. Patients with hyperammonaemia may present with seizures or encephalopathy, or may be entirely asymptomatic. The underlying causes are diverse but often straightforward to diagnose, although sometimes require specialist investigations. Haemodialysis or haemo(dia)filtration ... Read more >>

Pract Neurol (Practical neurology)
[2020, :]

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The Acute Effects of 5 Fluorouracil on Skeletal Muscle Resident and Infiltrating Immune Cells in Mice.

Brandon N VanderVeen, Alexander T Sougiannis, Kandy T Velazquez, James A Carson, Daping Fan, E Angela Murphy,

5 fluorouracil (5FU) has been a first-choice chemotherapy drug for several cancer types (e.g., colon, breast, head, and neck); however, its efficacy is diminished by patient acquired resistance and pervasive side effects. Leukopenia is a hallmark of 5FU; however, the impact of 5FU-induced leukopenia on healthy tissue is only becoming ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:593468]

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The multiple effects of aspirin in prostate cancer patients.

S N Joshi, E A Murphy, P Olaniyi, R J Bryant,

Aspirin is a commonly used medication with anti-inflammatory and analgesic properties, and it is widely used to reduce the risk of ischaemic heart disease-related events and/or cerebrovascular accidents. However, there is also evidence from epidemiological and interventional studies to suggest that regular aspirin use can reduce the risk of prostate ... Read more >>

Cancer Treat Res Commun (Cancer treatment and research communications)
[2020, 26:100267]

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GCT-33. A PHASE 2 TRIAL OF RESPONSE-BASED RADIATION THERAPY FOR PATIENTS WITH LOCALIZED CENTRAL NERVOUS SYSTEM GERM CELL TUMORS: A CHILDREN’S ONCOLOGY GROUP (COG) STUDY. IMPACT OF RAPID CENTRAL RADIOTHERAPY REVIEW ON RADIOTHERAPY QUALITY AND PATTERN OF FAILURE FOR NON-GERMINOMATOUS GERM CELL TUMORS

Erin S Murphy, Girish Dhall, Jason Fangusaro, Ute Bartels, Maryam Fouladi, Dennis Shaw, Soumen Khatua, Ashok Panigraphy, Mark Souweidane, Amar Gajjar, Chris Williams-Hughes, Arzu Onar, Shengjie Wu, Daphne Haas-Kogan, Shannon MacDonald,

Abstract <h4>BACKGROUND</h4> COG ACNS 1123 tested reduced radiotherapy (RT) for non-metastatic, non-germinomatous germ cell tumor (NGGCT) patients. The impact of central review on quality of RT and pattern of failure for NGGCT patients is evaluated. <h4>METHODS</h4> Patients who achieved a complete response (CR) or partial response (PR) to induction chemotherapy ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii334-iii334]

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Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.

Yann Le Poul, Yaqun Xin, Liucong Ling, Bettina Mühling, Rita Jaenichen, David Hörl, David Bunk, Hartmann Harz, Heinrich Leonhardt, Yingfei Wang, Elena Osipova, Mariam Museridze, Deepak Dharmadhikari, Eamonn Murphy, Remo Rohs, Stephan Preibisch, Benjamin Prud'homme, Nicolas Gompel,

Developmental enhancers control the expression of genes prefiguring morphological patterns. The activity of an enhancer varies among cells of a tissue, but collectively, expression levels in individual cells constitute a spatial pattern of gene expression. How the spatial and quantitative regulatory information is encoded in an enhancer sequence is elusive. ... Read more >>

Sci Adv (Science advances)
[2020, 6(49):]

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GCT-41. RESPONSE-BASED RADIATION THERAPY IN PATIENTS WITH NEWLY DIAGNOSED CENTRAL NERVOUS SYSTEM LOCALIZED GERMINOMA: A CHILDREN’S ONCOLOGY GROUP (COG) PROSPECTIVE PHASE 2 CLINICAL TRIAL

Ute Bartels, Jason Fangusaro, Dennis Shaw, Aashim Bhatia, Arzu Omar-Thomas, Shengjie Wu, Shannon MacDonald, Erin Murphy, Mark Souweidane, Maryam Fouladi, Amar Gajjar, Girish Dhall, Soumen Khatua,

Abstract <h4>BACKGROUND</h4> The objective of stratum 2 of COG ACNS1123 was to evaluate children and young adults (3–21 years) with localized central nervous system (CNS) germinoma and investigate whether simplified pre-irradiation chemotherapy followed by response based dose-reduced whole ventricular irradiation (WVI) would maintain a high progression-free survival (PFS) while reducing ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii336-iii336]

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Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study.

Thomas M Drake, Annemarie B Docherty, Ewen M Harrison, Jennifer K Quint, Huzaifa Adamali, Sarah Agnew, Suresh Babu, Christopher M Barber, Shaney Barratt, Elisabeth Bendstrup, Stephen Bianchi, Diego Castillo Villegas, Nazia Chaudhuri, Felix Chua, Robina Coker, William Chang, Anjali Crawshaw, Louise E Crowley, Davinder Dosanjh, Christine A Fiddler, Ian A Forrest, Peter M George, Michael A Gibbons, Katherine Groom, Sarah Haney, Simon P Hart, Emily Heiden, Michael Henry, Ling-Pei Ho, Rachel K Hoyles, John Hutchinson, Killian Hurley, Mark Jones, Steve Jones, Maria Kokosi, Michael Kreuter, Laura S MacKay, Siva Mahendran, George Margaritopoulos, Maria Molina-Molina, Philip L Molyneaux, Aiden O'Brien, Katherine O'Reilly, Alice Packham, Helen Parfrey, Venerino Poletti, Joanna C Porter, Elisabetta Renzoni, Pilar Rivera-Ortega, Anne-Marie Russell, Gauri Saini, Lisa G Spencer, Giulia M Stella, Helen Stone, Sharon Sturney, David Thickett, Muhunthan Thillai, Tim Wallis, Katie Ward, Athol U Wells, Alex West, Melissa Wickremasinghe, Felix Woodhead, Glenn Hearson, Lucy Howard, J Kenneth Baillie, Peter J M Openshaw, Malcolm G Semple, Iain Stewart, R Gisli Jenkins, ,

<b>Rationale:</b> The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.<b>Objectives:</b> To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population.<b>Methods:</b> An international multicenter audit of patients with a prior diagnosis ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(12):1656-1665]

Cited: 1 time

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Asymptomatic SARS-CoV-2 Infection and COVID-19 Mortality During an Outbreak Investigation in a Skilled Nursing Facility.

Mahesh C Patel, Lelia H Chaisson, Scott Borgetti, Deborah Burdsall, Rashmi K Chugh, Christopher R Hoff, Elizabeth B Murphy, Emily A Murskyj, Shannon Wilson, Joe Ramos, Lynn Akker, Debra Bryars, Evonda Thomas-Smith, Susan C Bleasdale, Ngozi O Ezike,

<h4>Background</h4>Outbreaks of coronavirus disease 2019 (COVID-19) have been reported in nursing homes and assisted living facilities; however, the extent of asymptomatic and presymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in this high-risk population remains unclear.<h4>Methods</h4>We conducted an investigation of the first known outbreak of SARS-CoV-2 at a skilled ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(11):2920-2926]

Cited: 3 times

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Description and etiology of paleopathological lesions in the type specimen of Parasaurolophus walkeri (Dinosauria: Hadrosauridae), with proposed reconstructions of the nuchal ligament.

Filippo Bertozzo, Fabio Manucci, Matthew Dempsey, Darren H Tanke, David C Evans, Alastair Ruffell, Eileen Murphy,

Paleopathology, or the study of ancient injuries and diseases, can enable the ecology and life history of extinct taxa to be deciphered. Large-bodied ornithopods are the dinosaurs with the highest frequencies of paleopathology reported to-date. Among these, the crested hadrosaurid Parasaurolophus walkeri is one of the most famous, largely due ... Read more >>

J Anat (Journal of anatomy)
[2020, :]

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GCT-42. CLINICAL CHARACTERISTICS OF LOCALIZED CENTRAL NERVOUS SYSTEM NON-GERMINOMATOUS GERM CELL TUMORS (NGGCT) PATIENTS ENROLLED ON ACNS1123 WITH RELAPSE: A CHILDREN’S ONCOLOGY GROUP (COG) STUDY

Girish Dhall, Shengjie Wu, Arzu Onar-Thomas, Dennis Shaw, Shannon MacDonald, Erin Murphy, Soumen Khatua, Ute Bartels, Jason Fangusaro,

Abstract ACNS1123 was a Children’s Oncology Group Phase 2 study that was undertaken to determine whether irradiation could be safely reduced without impacting survival in a subgroup of NGGCT patients. Between May 2012-Jan 2017, 107 eligible patients were accrued to Stratum 1 (NGGCT stratum). Sixty-six (61.7%) patients achieved a complete/partial ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii336-iii336]

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Correction: Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection.

Candelaria Vergara, Priya Duggal, Chloe L Thio, Ana Valencia, Thomas R O'Brien, Rachel Latanich, Winston Timp, Eric O Johnson, Alex H Kral, Alessandra Mangia, James J Goedert, Valeria Piazzola, Shruti H Mehta, Gregory D Kirk, Marion G Peters, Sharyne M Donfield, Brian R Edlin, Michael P Busch, Graeme Alexander, Edward L Murphy, Arthur Y Kim, Georg M Lauer, Raymond T Chung, Matthew E Cramp, Andrea L Cox, Salim I Khakoo, Hugo R Rosen, Laurent Alric, Sarah J Wheelan, Genevieve L Wojcik, David L Thomas, Margaret A Taub,

Genes Immun (Genes and immunity)
[2020, 21(6-8):420]

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