Full Text Journal Articles by
Author E M Thompson


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Prognostic Importance of Pathological Fractures in Osteosarcomas.

G A Sheridan, L Mellon, E M Thompson, G M O'Kane, G C O'Toole,

Aims To investigate whether pathological fractures impact on osteosarcoma patient prognosis in Ireland. Methods This was a retrospective study over 22 years in a National Orthopaedic Oncology Centre. There were 117 nonfracture cases and 15 fracture cases. Outcome measures included 5 and 10 year event-free (EFS) and overall survival (OS). ... Read more >>

Ir Med J (Irish medical journal)
[2020, 112(10):1021]

Cited: 0 times

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Cardiac Leiomyosarcoma in a Cat Presenting for Bilateral Renal Neoplasia.

M E Schreeg, B J Evans, J Allen, M C Lewis, E Luckring, M Evola, D K Richard, K Piner, E M Thompson, D B Adin, D A Tokarz,

A 10-year-old neutered female domestic longhair cat was presented to a tertiary care veterinary hospital for evaluation of a right renal mass that was identified incidentally on abdominal radiographs and classified further as a sarcoma based on fine needle aspiration cytology. Further diagnostic workup, including ultrasound and cytology, identified a ... Read more >>

J Comp Pathol (Journal of comparative pathology)
[2019, 168:19-24]

Cited: 0 times

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Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

G M Cunniffe, P J Díaz-Payno, J S Ramey, O R Mahon, A Dunne, E M Thompson, F J O'Brien, D J Kelly,

Limitations associated with demineralised bone matrix and other grafting materials have motivated the development of alternative strategies to enhance the repair of large bone defects. The growth plate (GP) of developing limbs contain a plethora of growth factors and matrix cues which contribute to long bone growth, suggesting that biomaterials ... Read more >>

Eur Cell Mater (European cells & materials)
[2017, 33:130-142]

Cited: 6 times

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Use of lumbar laminoplasty vs. laminotomy for transection of the filum terminale does not affect early complication rates or postoperative course.

M J Strong, E M Thompson, N Roundy, N R Selden,

Various techniques are used for spinal cord untethering. The purpose of this study was to compare patient characteristics, postoperative course, and early complications after laminotomy vs. laminoplasty for transection of the filum terminale for tethered cord release.Retrospective analysis of clinical and magnetic resonance imaging data was undertaken for all patients ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2015, 31(4):597-601]

Cited: 3 times

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Local adaptation for body color in Drosophila americana.

P J Wittkopp, G Smith-Winberry, L L Arnold, E M Thompson, A M Cooley, D C Yuan, Q Song, B F McAllister,

Pigmentation is one of the most variable traits within and between Drosophila species. Much of this diversity appears to be adaptive, with environmental factors often invoked as selective forces. Here, we describe the geographic structure of pigmentation in Drosophila americana and evaluate the hypothesis that it is a locally adapted ... Read more >>

Heredity (Edinb) (Heredity)
[2011, 106(4):592-602]

Cited: 29 times

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Growth, behavior, and clinical findings in 27 patients with Kabuki (Niikawa-Kuroki) syndrome.

S M White, E M Thompson, A Kidd, R Savarirayan, A Turner, D Amor, M B Delatycki, M Fahey, A Baxendale, S White, E Haan, K Gibson, J L Halliday, A Bankier,

This study was undertaken to document the phenotype of Kabuki (Niikawa-Kuroki) syndrome in patients from Australia and New Zealand, with particular emphasis on growth patterns, behavior, and relationship between head circumference and intellectual level. Data on 27 children and adults with Kabuki (Niikawa-Kuroki) syndrome from Australia and New Zealand were ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2004, 127A(2):118-127]

Cited: 32 times

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PEHO and PEHO-like syndromes: report of five Australian cases.

M J Field, P Grattan-Smith, S M Piper, E M Thompson, E A Haan, M Edwards, S James, I Wilkinson, L C Adès,

PEHO syndrome is a rare progressive infantile encephalopathy with onset within the first few months of life. Few patients fulfilling the diagnostic criteria for PEHO syndrome have been reported outside Finland. Affected infants have facial dysmorphism and suffer from severe hypotonia, profound mental retardation, convulsions (often with a hypsarrhythmic EEG ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2003, 122A(1):6-12]

Cited: 13 times

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Mutation analysis in the MECP2 gene and genetic counselling for Rett syndrome.

H Gill, J P Cheadle, J Maynard, N Fleming, S Whatley, T Cranston, E M Thompson, H Leonard, M Davis, J Christodoulou, O Skjeldal, F Hanefeld, A Kerr, A Tandy, D Ravine, A Clarke,

J. Med. Genet. (Journal of medical genetics)
[2003, 40(5):380-384]

Cited: 11 times

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A sebaceous cyst with a difference: Dermatobia hominis.

L J Harbin, M Khan, E M Thompson, R D Goldin,

Dermatobia hominis causes furuncular myiasis and is endemic to South America. This report describes a case in a young woman who had recently visited Belize, highlighting the importance of clinical history (including travel history) and close liaison between pathologist and surgeon. ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2002, 55(10):798-799]

Cited: 9 times

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Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation.

F Zhao, C G Weismann, M Satoda, M E Pierpont, E Sweeney, E M Thompson, B D Gelb,

To elucidate further the role, in normal development and in disease pathogenesis, of TFAP2B, a transcription factor expressed in neuroectoderm, we studied eight patients with Char syndrome and their families. Four novel mutations were identified, three residing in the basic domain, which is responsible for DNA binding, and a fourth ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2001, 69(4):695-703]

Cited: 46 times

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Association of mesangial IgM with IgM deposits in the macula densa: an indication of non-specific macromolecule transport rather than immune reactant?

E M Thompson, D J Evans,

BACKGROUND:We observed IgM deposits in the macula densa of the distal convoluted tubule in some renal biopsies with mesangial IgM deposits and did a systematic study to investigate the frequency of this phenomenon. We compared the findings with those in IgA disease. METHODS:A total of 30 renal biopsies with either ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2001, 16(9):1910-1913]

Cited: 1 time

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Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice.

M E Haywood, T J Vyse, A McDermott, E M Thompson, A Ida, M J Walport, S Izui, B J Morley,

Retroviral envelope glycoprotein gp70 is present in the sera of immunologically normal and autoimmune-prone strains of mice. However, only lupus-prone mice spontaneously develop gp70-anti-gp70 immune complexes (gp70IC), and these have been implicated in the development of nephritis. We investigated the genetic factors that affect the production of both free serum ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2001, 167(3):1728-1733]

Cited: 21 times

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Asymptomatic maternal myasthenia as a cause of the Pena-Shokeir phenotype.

L A Brueton, S M Huson, P M Cox, I Shirley, E M Thompson, P R Barnes, J Price, J Newsom-Davis, A Vincent,

We report six sibs with arthrogryposis multiplex congenita and a Pena-Shokeir phenotype, born to a healthy woman who was discovered to have asymptomatic myasthenia gravis (MG). This is the first report of anti-acetylcholine receptor (AChR) antibodies causing fetal akinesia/hypokinesia sequence in the offspring of an asymptomatic mother. ... Read more >>

Am J Med Genet (American journal of medical genetics)
[2000, 92(1):1-6]

Cited: 27 times

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The KBG syndrome.

S F Smithson, E M Thompson, A G McKinnon, I S Smith, R M Winter,

We report on two boys with a combination of short stature, a broad face, macrodontia and developmental delay. These features suggest that they have the KBG syndrome, a rare but distinctive phenotype. The pattern of inheritance remains uncertain and both autosomal dominant and X-linked recessive inheritance should be considered in ... Read more >>

Clin. Dysmorphol. (Clinical dysmorphology)
[2000, 9(2):87-91]

Cited: 9 times

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Type IV phosphodiesterase inhibitor is effective in prevention and treatment of experimental crescentic glomerulonephritis.

F W Tam, J Smith, S Agarwal, A M Karkar, D Morel, E M Thompson, C D Pusey,

Tumour necrosis factor alpha (TNF-alpha) has an important role in acute glomerular inflammation. Rolipram, a type IV phosphodiesterase inhibitor, has multiple anti-inflammatory effects including inhibition of TNF-alpha synthesis.We investigated the effects of rolipram in prevention and delayed treatment of crescentic glomerulonephritis in Wistar Kyoto rats. Glomerulonephritis was induced by injection ... Read more >>

Nephron (Nephron)
[2000, 84(1):58-66]

Cited: 14 times

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Cerebral cortical dysplasia and digital constriction rings in Adams-Oliver syndrome.

R Savarirayan, E M Thompson, K J Abbott, M H Moore,

Adams-Oliver syndrome (AOS) is characterised by aplasia cutis congenita of the scalp and variable degrees of terminal transverse limb defects. Short fingers and hypoplastic nails also occur in this predominantly autosomal dominant syndrome which displays marked variability of expression and lack of penetrance in some cases. We describe a boy ... Read more >>

Am J Med Genet (American journal of medical genetics)
[1999, 86(1):15-19]

Cited: 19 times

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Development of scarring and renal failure in a rat model of crescentic glomerulonephritis.

F W Tam, J Smith, D Morel, A M Karkar, E M Thompson, H T Cook, C D Pusey,

BACKGROUND:The aim of this study was to develop and characterize a rat model of crescentic glomerulonephritis which progresses to glomerulosclerosis and renal failure. METHODS:Glomerulonephritis was induced in Wistar Kyoto rats by a single injection of rabbit anti-glomerular basement membrane antiserum. Albuminuria and serum creatinine were monitored. Kidneys were examined, from ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[1999, 14(7):1658-1666]

Cited: 42 times

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Preferential nuclear location of a transgene does not depend on its transcriptional activity during early mouse development.

E M Thompson, J P Renard,

Changes in chromatin structure play an important role in regulation of the HSP70.1 gene during mouse preimplantation development. Using in situ PCR we have now examined whether the spatial organization of an HSP70.1 luciferase transgene within the nucleus is also a factor in regulating its expression. The transgene showed a ... Read more >>

Chromosoma (Chromosoma)
[1998, 107(5):321-329]

Cited: 0 times

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High mobility group 1 (HMG1) protein in mouse preimplantation embryos.

F Spada, A Brunet, Y Mercier, J P Renard, M E Bianchi, E M Thompson,

High mobility group 1 protein (HMG1) has traditionally been considered a structural component of chromatin, possibly similar in function to histone H1. In fact, at the onset of Xenopus and Drosophila development, HMG1 appears to substitute for histone H1: HMG1 is abundant when histone H1 is absent after the midblastula ... Read more >>

Mech Dev (Mechanisms of development)
[1998, 76(1-2):57-66]

Cited: 15 times

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The causes of sporadic and 'senile' chorea.

J D Warren, F Firgaira, E M Thompson, C S Kneebone, P C Blumbergs, P D Thompson,

BACKGROUND:Although 'senile' chorea is commonly listed in the differential diagnosis of chorea, the condition is poorly defined. Indeed, the existence of such an entity is debated. There are few contemporary prospective studies of sporadic chorea in the elderly. METHODS:Detailed prospective study of patients presenting with undiagnosed chorea over a three ... Read more >>

Aust N Z J Med (Australian and New Zealand journal of medicine)
[1998, 28(4):429-431]

Cited: 10 times

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Prediction of transgene integration by noninvasive bioluminescent screening of microinjected bovine embryos.

M Menck, Y Mercier, E Campion, R B Lobo, Y Heyman, J P Renard, E M Thompson,

Transgenesis in domestic species, as a research tool and in biotechnological applications, has been limited by the expense of producing transgenic offspring by standard microinjection techniques. A major factor is the inefficiency of maintaining large numbers of recipient females, when a high percentage of these carry nontransgenic fetuses. There are ... Read more >>

Transgenic Res (Transgenic research)
[1998, 7(5):331-341]

Cited: 19 times

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Systemic lupus erythematosus, thrombocytopenia, microangiopathic haemolytic anaemia and anti-CD36 antibodies.

R al-Shahi, J C Mason, R Rao, C Hurd, E M Thompson, D O Haskard, K A Davies,

Thrombocytopenia in patients with acute systemic lupus erythematosus (SLE) frequently presents the clinician with considerable diagnostic and therapeutic difficulties. In this Grand Round, we present a 48-yr-old woman with a 7 yr history of lupus, who presented with acute proliferative glomerulonephritis and nephrotic syndrome, pneumonia, profound hypocomplementaemia and a severe ... Read more >>

Br J Rheumatol (British journal of rheumatology)
[1997, 36(7):794-798]

Cited: 4 times

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Does medical audit lead to explicit standards? Experience with thrombolysis in four UK hospitals.

M B Robinson, E M Thompson, N A Black,

The setting of explicit standards against specific criteria is a recognized part of the medical audit cycle, but often in practice it has been neglected, implicit judgements being used instead. The conduct of a study to evaluate audit among physicians in four UK district general hospitals provided an opportunity to ... Read more >>

J Manag Med (Journal of management in medicine)
[1997, 11(2-3):190-199]

Cited: 0 times

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Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.

M Botto, E Theodoridis, E M Thompson, H L Beynon, D Briggs, D A Isenberg, M J Walport, K A Davies,

An allotypic variant of Fc gamma RIIa, Fc gamma RIIa-HR (Fc gamma RIIa-R131), has been shown in vitro to reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was to determine whether this allotypic variant was associated with susceptibility to SLE and the development ... Read more >>

Clin. Exp. Immunol. (Clinical and experimental immunology)
[1996, 104(2):264-268]

Cited: 75 times

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Selective renal transplantation in primary hyperoxaluria type 1.

A R Allen, E M Thompson, G Williams, R W Watts, C D Pusey,

Primary hyperoxaluria type I (PHI) is a cause of end-stage renal disease in young people. It is caused by deficient activity of hepatic peroxisomal alanine:glyoxylate aminotransferase (AGT), which results in hyperoxalemia and hyperoxaluria. The consequent urolithiasis and nephrocalcinosis result in renal impairment, with further reduction in oxalate excretion and eventual ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[1996, 27(6):891-895]

Cited: 7 times

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