Full Text Journal Articles by
Author E J Molloy

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Altered inflammasome activation in neonatal encephalopathy persists in childhood.

L A Kelly, M I O'Dea, Z Zareen, A M Melo, E McKenna, T Strickland, V McEneaney, V Donoghue, G Boylan, D Sweetman, J Butler, C Vavasseur, J Miletin, A F El-Khuffash, L A J O'Neill, J J O'Leary, E J Molloy,

Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra and IL-18 are activated by the nucleotide-binding and oligomerization domain (NOD)-, leucine-rich repeat domain (LRR)- and NOD-like receptor protein 3 (NLRP3) inflammasome; furthermore, we aimed to ... Read more >>

Clin Exp Immunol (Clinical and experimental immunology)
[2021, :]

Cited: 0 times

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Carbon dioxide as a drug in neonatology.

E J Molloy, E P Cummins,

Pediatr Res (Pediatric research)
[2021, 89(5):1049-1050]

Cited: 1 time

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Children's Palliative Care; the identified Learning Needs of Paediatricians.

L Whitla, M Devins, E J Molloy, M Twomey, M O'Reilly, J Balfe,

Aim To determine baseline learning needs of Paediatricians in Ireland when caring for children with palliative care needs. Methods A questionnaire based online survey was conducted. Results One hundred and fourteen paediatricians responded to the survey, the majority were Specialist Registrars but almost half were consultant paediatricians (46% n=52). Most ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):95]

Cited: 0 times

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Paediatric Head Injury and Traumatic Brain Injury.

E Ryan, T Bolger, M J Barrett, C Blackburn, I Okafor, R McNamara, E J Molloy,

Aim To determine prevalence of head injury presenting to paediatric emergency departments (PEDs) and characterise by demographics, triage category, disposition neuroimaging or re-attendance. Methods Presentations in 2014 and 2015, with diagnoses of head injury, intracranial bleed, skull fracture including single or re-attendances within 28 days post head injury to all ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):94]

Cited: 0 times

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Vitamin D, Covid-19 and Children.

E J Molloy, N Murphy,

Ir Med J (Irish medical journal)
[2020, 113(4):64]

Cited: 6 times

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Dynamic platelet function on von Willebrand factor is different in preterm neonates and full-term neonates: changes in neonatal platelet function.

J Cowman, N Quinn, S Geoghegan, S Müllers, I Oglesby, B Byrne, M Somers, A Ralph, B Voisin, A J Ricco, E J Molloy, D Kenny,

Essentials It is unclear if platelet function differs between preterm and full-term neonates. Platelet behavior was characterized using a flow-based assay on von Willebrand Factor (VWF). Preterms had increased platelet interaction with VWF and glycoprotein Ibα expression. Platelets from preterm neonates behave differently on VWF compared to full-term neonates.<h4>Summary</h4>Background Very ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2016, 14(10):2027-2035]

Cited: 6 times

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Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation.

C Onwuneme, B Diya, O Uduma, R A McCarthy, N Murphy, M T Kilbane, M J McKenna, E J Molloy,

<h4>Introduction</h4>Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants.<h4>Objective</h4>We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates.<h4>Methods</h4>Serum ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2016, 185(3):683-687]

Cited: 2 times

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Incorporating Teaching in Global Child Health into Irish Medical School Curriculum.

S Geoghegan, A J Nicholson, E J Molloy,

Ir Med J (Irish medical journal)
[2015, 108(7):194]

Cited: 0 times

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Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy.

F M O'Hare, R W G Watson, A O'Neill, A Blanco, V Donoghue, E J Molloy,

Circulating immune cell activation is associated with worse outcome in adult and animal models of brain injury. Our aim was to profile the systemic inflammatory response over the first week of life in infants at risk of neonatal encephalopathy and correlate early neutrophil and monocyte endotoxin and activation responses with ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2016, 29(4):582-589]

Cited: 6 times

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Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo.

H O Eliwan, R W G Watson, S Aslam, I Regan, B Philbin, F M O'Hare, A O'Neill, R Preston, A Blanco, T Grant, B Nolan, O Smith, E J Molloy,

Infection and inflammation can be antecedents of neonatal encephalopathy (NE) and increase the risk of neurological sequelae. Activated protein C (APC) has anti-coagulant and anti-inflammatory effects and provides neuroprotection in brain and spinal cord injury. We examined neutrophil and monocyte responses to lipopolysaccharide (LPS) in infants with NE compared with ... Read more >>

Clin Exp Immunol (Clinical and experimental immunology)
[2015, 179(3):477-484]

Cited: 8 times

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Impact of maternal diet on neonatal anthropometry: a randomized controlled trial.

J M Donnelly, J M Walsh, J Byrne, E J Molloy, F M McAuliffe,

<h4>Objective</h4>Large for gestational age infants are at increased risk of childhood obesity and maternal nutrition impacts birthweight. The aim of this study was to assess the impact of a maternal low glycaemic index (GI) diet on neonatal anthropometry.<h4>Methods</h4>The ROLO (Randomised Control Trial of Low Glycaemic Index Diet in Pregnancy) study ... Read more >>

Pediatr Obes (Pediatric obesity)
[2015, 10(1):52-56]

Cited: 17 times

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Universal perinatal screening for Treponema pallidum: the role of a dedicated infectious diseases team for prevention of mother-to-child transmission.

B Freyne, A Stafford, S Knowles, A O Hora, E J Molloy,

Sex Transm Infect (Sexually transmitted infections)
[2013, 89(7):582]

Cited: 2 times

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Biomarkers of acute kidney injury in neonatal encephalopathy.

D U Sweetman, E J Molloy,

Acute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2013, 172(3):305-316]

Cited: 12 times

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Vitamin D and neonatal immune function.

N Clancy, C Onwuneme, A Carroll, R McCarthy, M J McKenna, N Murphy, E J Molloy,

Vitamin D deficiency is widespread in the neonatal and paediatric population of northern latitudes, particularly in children of African, Middle Eastern and Asian ethnicity. This is associated with diminished immune function and increases the risk of Th1 autoimmune diseases like type 1 diabetes. Epidermiological studies have also shown a link ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2013, 26(7):639-646]

Cited: 16 times

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Seen but not heard: congenital cytomegalovirus.

G Harrison, A Waters, C F De Gascun, M Boyle, S Knowles, E J Molloy,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2012, 97(5):F390]

Cited: 0 times

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Serum magnesium in the first week of life in extremely low birth weight infants.

D Noone, E Kieran, E J Molloy,

<h4>Background</h4>Evidence that antenatal administration of magnesium sulfate (MgSO(4)) to women in preterm labor may confer fetal neuroprotection is growing. MgSO(4) crosses the placenta and can affect the neonate. Magnesium homeostasis in extremely low birth weight (ELBW) infants remains to be clarified.<h4>Objectives</h4>We aimed to assess the natural progression of serum magnesium ... Read more >>

Neonatology (Neonatology)
[2012, 101(4):274-277]

Cited: 5 times

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Efficacy and safety of intravenous Ig and alterations in haematological parameters of infants with isoimmune haemolytic disease.

B Freyne, F M O'Hare, E J Molloy,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2012, 97(1):F76-7]

Cited: 0 times

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Is antenatal screening for syphilis still necessary?

E J Molloy, C Owoeye, S Knowles,

Ir Med J (Irish medical journal)
[2012, 105(2):37-38]

Cited: 0 times

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Cardiac biomarkers in neonatal hypoxic ischaemia.

D Sweetman, K Armstrong, J F A Murphy, E J Molloy,

<h4>Unlabelled</h4>Following a perinatal hypoxic-ischaemic insult, term infants commonly develop cardiovascular dysfunction. Troponin-T, troponin-I and brain natriuretic peptide are sensitive indicators of myocardial compromise. The long-term effects of cardiovascular dysfunction on neurodevelopmental outcome following perinatal hypoxic ischaemia remain controversial. Follow-up studies are warranted to ensure optimal cardiac function in adulthood.<h4>Conclusion</h4>Cardiac biomarkers ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2012, 101(4):338-343]

Cited: 6 times

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Parents' attitudes towards infant safety during air travel.

M Bahari, N Prunty, E J Molloy,

Arch Dis Child (Archives of disease in childhood)
[2011, 96(7):701]

Cited: 0 times

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Neonatal albumin infusions in paediatric intensive care.

E Low, M Healy, E J Molloy,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2010, 95(2):F149]

Cited: 0 times

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Congenital diaphragmatic hernia: neonatal outcomes following referral to a paediatric surgical centre.

J Chukwu, C Iro, V Donoghue, N McCallion, J F Murphy, F Quinn, M Healy, E J Molloy,

Congenital diaphragmatic hernia (CDH) is a rare malformation observed in approximately 1 in 3000 live births. Estimates of postnatal survival range from 50 to 70% despite advances in neonatal care. Antenatal diagnosis is associated with termination of pregnancy in 25-50% pregnancy internationally which may not be reflective of the Irish ... Read more >>

Ir Med J (Irish medical journal)
[2009, 102(8):260-261]

Cited: 3 times

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Do we neglect infant safety during air travel?

M J Barrett, E J Molloy,

Arch Dis Child (Archives of disease in childhood)
[2009, 94(7):562]

Cited: 1 time

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Relationship between vitamin D and alkaline phosphatase in very-low-birthweight infants.

R McCarthy, N McCallion, G Harrison, E J Molloy,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2009, 94(1):F77-8]

Cited: 3 times

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Elevated iron indices in preterm infants: association with male gender.

E J Molloy, A El-Khuffash, A Bieda, M M Jelinek, J Baley,

Elevated iron indices may be underrecognized in preterm infants. Sixty growing, stable preterm infants < 1500 g studied had elevated iron indices, which was especially elevated in male infants. Careful evaluation of iron indices is essential to prevent potential organ injury and unnecessary iron supplementation. ... Read more >>

Am J Perinatol (American journal of perinatology)
[2009, 26(1):7-11]

Cited: 5 times

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