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How well do clinical and demographic characteristics predict Patient Health Questionnaire-9 scores among patients with treatment-resistant major depressive disorder in a real-world setting?

Jennifer Voelker, Kruti Joshi, Ella Daly, Eros Papademetriou, David Rotter, John J Sheehan, Harsh Kuvadia, Xing Liu, Anandaroop Dasgupta, Ravi Potluri,

<h4>Objectives</h4>To create and validate a model to predict depression symptom severity among patients with treatment-resistant depression (TRD) using commonly recorded variables within medical claims databases.<h4>Methods</h4>Adults with TRD (here defined as > 2 antidepressant treatments in an episode, suggestive of nonresponse) and ≥ 1 Patient Health Questionnaire (PHQ)-9 record on or after the index TRD ... Read more >>

Brain Behav (Brain and behavior)
[2021, :e02000]

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Long Chain Omega-3 Fatty Acid Intervention in Ageing Adults at Risk of Dementia Following Repeated Head Trauma. Low-level Support or an Opportunity for an Unanswered Question?

C S Patch, E L Hill-Yardin, L Ryan, E Daly, A J Pearce,

Emerging evidence of brain injury on risk of neurodegenerative diseases such as Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) have resulted in interest in therapeutic potential of omega-3 fatty acids (n-3FA). We conducted a systematic review of n-3FA therapeutic efficacy for ageing adults at risk of AD/CTE following a ... Read more >>

J Prev Alzheimers Dis (The journal of prevention of Alzheimer's disease)
[2021, 8(1):29-32]

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Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine

Robert Wichers, James Findon, Auke Jelsma, Vincent Giampietro, Vladimira Stoencheva, Dene Roberton, Clodagh Murphy, Sarah Blainey, Grainne McAlonan, Christine Ecker, Katya Rubia, Declan Murphy, Eileen Daly,

<h4>Background: </h4> : Autism spectrum disorder (ASD) is associated with deficits in executive functioning (EF), and these have been suggested to contribute to core as well as co-occuring psychiatric symptoms. The biological basis of these deficits is unknown but may include the serotonergic system, which is involved in both regulating ... Read more >>

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Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

, , , , , , Yash Patel, Nadine Parker, Jean Shin, Derek Howard, Leon French, Sophia I Thomopoulos, Elena Pozzi, Yoshinari Abe, Christoph Abé, Alan Anticevic, Martin Alda, Andre Aleman, Clara Alloza, Silvia Alonso-Lana, Stephanie H Ameis, Evdokia Anagnostou, Andrew A McIntosh, Celso Arango, Paul D Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Rosa Ayesa-Arriola, Geor Bakker, Nerisa Banaj, Tobias Banaschewski, Cibele E Bandeira, Alexandr Baranov, Núria Bargalló, Claiton H D Bau, Sarah Baumeister, Bernhard T Baune, Mark A Bellgrove, Francesco Benedetti, Alessandro Bertolino, Premika S W Boedhoe, Marco Boks, Irene Bollettini, Caterina Del Mar Bonnin, Tiana Borgers, Stefan Borgwardt, Daniel Brandeis, Brian P Brennan, Jason M Bruggemann, Robin Bülow, Geraldo F Busatto, Sara Calderoni, Vince D Calhoun, Rosa Calvo, Erick J Canales-Rodríguez, Dara M Cannon, Vaughan J Carr, Nicola Cascella, Mara Cercignani, Tiffany M Chaim-Avancini, Anastasia Christakou, David Coghill, Annette Conzelmann, Benedicto Crespo-Facorro, Ana I Cubillo, Kathryn R Cullen, Renata B Cupertino, Eileen Daly, Udo Dannlowski, Christopher G Davey, Damiaan Denys, Christine Deruelle, Annabella Di Giorgio, Erin W Dickie, Danai Dima, Katharina Dohm, Stefan Ehrlich, Benjamin A Ely, Tracy Erwin-Grabner, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Mar Fatjó-Vilas, Jennifer M Fedor, Kate D Fitzgerald, Judith M Ford, Thomas Frodl, Cynthia H Y Fu, Janice M Fullerton, Matt C Gabel, David C Glahn, Gloria Roberts, Tinatin Gogberashvili, Jose M Goikolea, Ian H Gotlib, Roberto Goya-Maldonado, Hans J Grabe, Melissa J Green, Eugenio H Grevet, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Amalia Guerrero-Pedraza, Raquel E Gur, Ruben C Gur, Shlomi Haar, Bartholomeus C M Haarman, Jan Haavik, Tim Hahn, Tomas Hajek, Benjamin J Harrison, Neil A Harrison, Catharina A Hartman, Heather C Whalley, Dirk J Heslenfeld, Derrek P Hibar, Eva Hilland, Yoshiyuki Hirano, Tiffany C Ho, Pieter J Hoekstra, Liesbeth Hoekstra, Sarah Hohmann, L E Hong, Cyril Höschl, Marie F Høvik, Fleur M Howells, Igor Nenadic, Maria Jalbrzikowski, Anthony C James, Joost Janssen, Fern Jaspers-Fayer, Jian Xu, Rune Jonassen, Georgii Karkashadze, Joseph A King, Tilo Kircher, Matthias Kirschner, Kathrin Koch, Peter Kochunov, Gregor Kohls, Kerstin Konrad, Bernd Krämer, Axel Krug, Jonna Kuntsi, Jun Soo Kwon, Mikael Landén, Nils I Landrø, Luisa Lazaro, Irina S Lebedeva, Elisabeth J Leehr, Sara Lera-Miguel, Klaus-Peter Lesch, Christine Lochner, Mario R Louza, Beatriz Luna, Astri J Lundervold, Frank P MacMaster, Luigi A Maglanoc, Charles B Malpas, Maria J Portella, Rachel Marsh, Fiona M Martyn, David Mataix-Cols, Daniel H Mathalon, Hazel McCarthy, Colm McDonald, Genevieve McPhilemy, Susanne Meinert, José M Menchón, Luciano Minuzzi, Philip B Mitchell, Carmen Moreno, Pedro Morgado, Filippo Muratori, Clodagh M Murphy, Declan Murphy, Benson Mwangi, Leila Nabulsi, Akiko Nakagawa, Takashi Nakamae, Leyla Namazova, Janardhanan Narayanaswamy, Neda Jahanshad, Danai D Nguyen, Rosa Nicolau, Ruth L O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Nils Opel, Roel A Ophoff, Bob Oranje, Victor Ortiz García de la Foz, Bronwyn J Overs, Yannis Paloyelis, Christos Pantelis, Mara Parellada, Paul Pauli, Maria Picó-Pérez, Felipe A Picon, Fabrizio Piras, Federica Piras, Kerstin J Plessen, Edith Pomarol-Clotet, Adrian Preda, Olga Puig, Yann Quidé, Joaquim Radua, J Antoni Ramos-Quiroga, Paul E Rasser, Lisa Rauer, Janardhan Reddy, Ronny Redlich, Andreas Reif, Liesbeth Reneman, Jonathan Repple, Alessandra Retico, Vanesa Richarte, Anja Richter, Pedro G P Rosa, Katya K Rubia, Ryota Hashimoto, Matthew D Sacchet, Raymond Salvador, Javier Santonja, Kelvin Sarink, Salvador Sarró, Theodore D Satterthwaite, Akira Sawa, Ulrich Schall, Peter R Schofield, Anouk Schrantee, Jochen Seitz, Mauricio H Serpa, Esther Setién-Suero, Philip Shaw, Devon Shook, Tim J Silk, Kang Sim, Schmitt Simon, Helen Blair Simpson, Aditya Singh, Antonin Skoch, Norbert Skokauskas, Jair C Soares, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Filip Spaniel, Stephen M Lawrie, Emily R Stern, S Evelyn Stewart, Yoichiro Takayanagi, Henk S Temmingh, David F Tolin, David Tomecek, Diana Tordesillas-Gutiérrez, Michela Tosetti, Anne Uhlmann, Therese van Amelsvoort, Nic J A van der Wee, Steven J A van der Werff, Neeltje E M van Haren, Guido A van Wingen, Alasdair Vance, Javier Vázquez-Bourgon, Daniela Vecchio, Ganesan Venkatasubramanian, Eduard Vieta, Oscar Vilarroya, Yolanda Vives-Gilabert, Aristotle N Voineskos, Henry Völzke, Georg G von Polier, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Andrea S Weideman, Katharina Wittfeld, Daniel H Wolf, Mon-Ju Wu, T T Yang, Kun Yang, Yuliya Yoncheva, Je-Yeon Yun, Yuqi Cheng, Marcus V Zanetti, Georg C Ziegler, Barbara Franke, Martine Hoogman, Jan K Buitelaar, Daan van Rooij, Ole A Andreassen, Christopher R K Ching, Dick J Veltman, Lianne Schmaal, Dan J Stein, Odile A van den Heuvel, Jessica A Turner, Theo G M van Erp, Zdenka Pausova, Paul M Thompson, Tomáš Paus,

<h4>Importance</h4>Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.<h4>Objective</h4>To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2021, 78(1):47-63]

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Influences on HPV vaccination across levels of the social ecological model: perspectives from state level stakeholders.

Grace Ryan, Lejla Avdic, Eliza Daly, Natoshia Askelson, Paige E Farris, Jackilen Shannon, Annie-Laurie McRee, Jessica Hanson, DenYelle Baete Kenyon, Laura Seegmiller,

Nationally, human papillomavirus (HPV) vaccination rates fall short of the Healthy People 2020 goal of 80% completion. Although strategies to increase these rates exist, low rates persist. We used concept mapping with state-level stakeholders to better understand barriers and facilitators to HPV vaccination. Concept mapping is a participatory research process ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-8]

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Association of depression symptom severity with short-term risk of an initial hospital encounter in adults with major depressive disorder

Jennifer Voelker, Kun Wang, Wenze Tang, Jinghua He, Ella Daly, Christopher Pericone, John Sheehan,

<h4>Background: </h4> Despite the availability of pharmacologic and nonpharmacologic treatment options, depression continues to be one of the leading causes of disability worldwide. This study evaluated whether depression symptom severity, as measured by PHQ-9 score, of patients diagnosed with MDD is associated with short-term risk of a hospital encounter (ER ... Read more >>

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Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder.

Caroline Mann, Tim Schäfer, Anke Bletsch, Maria Gudbrandsen, Eileen Daly, John Suckling, Edward T Bullmore, Michael V Lombardo, Meng-Chuan Lai, Michael C Craig, , Simon Baron-Cohen, Declan G M Murphy, Christine Ecker,

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer-specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Bottom trawling noise: Are fishing vessels polluting to deeper acoustic habitats?

Eoghan Daly, Martin White,

The impact of bottom trawling noise was quantified on two surrounding marine acoustic habitats using fixed mooring acoustic recorders. Noise during trawling activity is shown to be considerably louder than ambient noise and a nearby underway research vessel. Estimated source levels were above cetacean damage thresholds. Measurements at a submarine ... Read more >>

Mar Pollut Bull (Marine pollution bulletin)
[2020, 162:111877]

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Clinically Meaningful Changes on Depressive Symptom Measures and Patient-Reported Outcomes in Patients with Treatment-Resistant Depression.

Ibrahim Turkoz, Larry Alphs, Jaskaran Singh, Carol Jamieson, Ella Daly, May Shawi, John J Sheehan, Madhukar H Trivedi, A John Rush,

<h4>Objective</h4>To use the Clinical Global Impression-Severity (CGI-S) scale to estimate clinically meaningful and clinically substantial changes as measured using the Montgomery-Åsberg Depression Rating Scale (MADRS), the Sheehan Disability Scale (SDS), and the Patient Health Questionnaire-9 (PHQ-9) in patients with treatment-resistant depression (TRD).<h4>Methods</h4>Pooled data were derived from two 4-week, randomized, active-controlled ... Read more >>

Acta Psychiatr Scand (Acta psychiatrica Scandinavica)
[2020, :]

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Economic burden of treatment-resistant depression in privately insured US patients with co-occurring anxiety disorder and/or substance use disorder.

Maryia Zhdanava, Harsh Kuvadia, Kruti Joshi, Ella Daly, Dominic Pilon, Carmine Rossi, Laura Morrison, Patrick Lefebvre, Craig Nelson,

<h4>Objective</h4>To assess the burden of treatment-resistant depression (TRD) among privately insured patients with anxiety disorder and/or substance use disorders (SUD).<h4>Methods</h4>Adults <65 years old were identified in the Optum Health Care Solutions Inc. database (July 2009-March 2017). Among those with major depressive disorder (MDD) and antidepressant use, patients who initiated a third ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2020, :1-11]

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Brain morphometry in 22q11.2 deletion syndrome: an exploration of differences in cortical thickness, surface area, and their contribution to cortical volume.

M Gudbrandsen, E Daly, C M Murphy, C E Blackmore, M Rogdaki, C Mann, A Bletsch, L Kushan, C E Bearden, D G M Murphy, M C Craig, Christine Ecker,

22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion in humans, with a heterogenous clinical presentation including medical, behavioural and psychiatric conditions. Previous neuroimaging studies examining the neuroanatomical underpinnings of 22q11.2DS show alterations in cortical volume (CV), cortical thickness (CT) and surface area (SA). The aim of this study was ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18845]

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Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.

Robert W Davies, Ania M Fiksinski, Elemi J Breetvelt, Nigel M Williams, Stephen R Hooper, Thomas Monfeuga, Anne S Bassett, Michael J Owen, Raquel E Gur, Bernice E Morrow, Donna M McDonald-McGinn, Ann Swillen, Eva W C Chow, Marianne van den Bree, Beverly S Emanuel, Joris R Vermeesch, Therese van Amelsvoort, Celso Arango, Marco Armando, Linda E Campbell, Joseph F Cubells, Stephan Eliez, Sixto Garcia-Minaur, Doron Gothelf, Wendy R Kates, Kieran C Murphy, Clodagh M Murphy, Declan G Murphy, Nicole Philip, Gabriela M Repetto, Vandana Shashi, Tony J Simon, Damiàn Heine Suñer, Stefano Vicari, Stephen W Scherer, , Carrie E Bearden, Jacob A S Vorstman,

The 22q11.2 deletion syndrome (22q11DS) is associated with a 20-25% risk of schizophrenia. In a cohort of 962 individuals with 22q11DS, we examined the shared genetic basis between schizophrenia and schizophrenia-related early trajectory phenotypes: sub-threshold symptoms of psychosis, low baseline intellectual functioning and cognitive decline. We studied the association of ... Read more >>

Nat Med (Nature medicine)
[2020, 26(12):1912-1918]

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Comments to Drs. Gastaldon, Raschi, Kane, Barbui, and Schoretsanitis.

Teodora Doherty, Ella J Daly, Janice Miller, Vanina Popova, M Soledad Cepeda, Wayne C Drevets, Carla M Canuso,

Psychother Psychosom (Psychotherapy and psychosomatics)
[2020, :1-2]

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A systematic review of the effects of educational interventions on knowledge and attitudes towards concussion for people involved in sport - Optimising concussion education based on current literature.

Caomhan Conaghan, Ed Daly, Alan J Pearce, Doug A King, Lisa Ryan,

Educational interventions aimed at increasing concussion knowledge and attitudes are designed according to different frameworks. The aim of this systematic review of the literature was to determine the effects of educational interventions on concussion knowledge and attitudes, while providing recommendations for future research in the area of concussion education interventions. ... Read more >>

J Sports Sci (Journal of sports sciences)
[2020, :1-16]

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Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.

Anke Bletsch, Tim Schäfer, Caroline Mann, Derek S Andrews, Eileen Daly, Maria Gudbrandsen, Amber N V Ruigrok, Robert Dallyn, Rafael Romero-Garcia, Meng-Chuan Lai, Michael V Lombardo, Michael C Craig, John Suckling, Edward T Bullmore, Simon Baron-Cohen, , Declan G M Murphy, Flavio Dell'Acqua, Christine Ecker,

Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray-white matter (GWM) boundary, represent a crucial feature ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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The impact of stormwater biofilter design and operational variables on nutrient removal - a statistical modelling approach.

Kefeng Zhang, Yizhou Liu, Ana Deletic, David T McCarthy, Belinda E Hatt, Emily G I Payne, Gayani Chandrasena, Yali Li, Tracey Pham, Behzad Jamali, Edoardo Daly, Tim D Fletcher, Anna Lintern,

Biofiltration systems can help mitigate the impact of urban runoff as they can treat, retain and attenuate stormwater. It is important to select the optimal design characteristics of biofilters (e.g., vegetation, filter media depth) to ensure high treatment performance. Operational conditions (e.g., infiltration rate) can also lead to significant changes ... Read more >>

Water Res (Water research)
[2021, 188:116486]

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Increased excitation-inhibition balance due to a loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction

Shekib Jami, Scott Cameron, Jonathan Wong, Emily Daly, Kimberley McAllister, John Gray,

There is substantial evidence that both NMDA receptor (NMDAR) hypofunction and dysfunction of GABAergic neurotransmission contribute to schizophrenia, though the relationship between these pathophysiological processes remains largely unknown. While models using cell-type-specific genetic deletion of NMDARs have been informative, they display overly pronounced phenotypes extending beyond those of schizophrenia. Here, ... Read more >>

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Patterns of Cortical Folding Associated with Autistic Symptoms in Carriers and Noncarriers of the 22q11.2 Microdeletion.

Maria Gudbrandsen, Caroline Mann, Anke Bletsch, Eileen Daly, Clodagh M Murphy, Vladimira Stoencheva, Charlotte E Blackmore, Maria Rogdaki, Leila Kushan, Carrie E Bearden, Declan G M Murphy, Michael C Craig, Christine Ecker,

22q11.2 deletion syndrome (22q11.2DS) is a genetic condition accompanied by a range of psychiatric manifestations, including autism spectrum disorder (ASD). It remains unknown, however, whether these symptoms are mediated by the same or distinct neural mechanisms as in idiopathic ASD. Here, we examined differences in lGI associated with ASD in ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(10):5281-5292]

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Self-reported review of the value of esketamine in patients with treatment-resistant depression: Understanding the patient experience in the STRIVE Study.

H Lynn Starr, Jill Abell, Allyson Larish, Sandy Lewis, Carla DeMuro, Jagadish Gogate, Carol Jamieson, Ella Daly, Naim Zaki, Michelle Kramer,

Esketamine nasal spray (ESK) is indicated, in conjunction with an oral antidepressant (OAD), for the management of treatment-resistant depression (TRD) in adults. Select US-based patients from an open-label, long-term extension safety study of ESK (NCT02782104) participated in this study through semi-structured interviews. The study evaluated patient-reported early health changes related ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 293:113376]

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Economic Burden of Treatment-Resistant Depression in Privately Insured U.S. Patients with Physical Conditions.

Maryia Zhdanava, Harsh Kuvadia, Kruti Joshi, Ella Daly, Dominic Pilon, Carmine Rossi, Laura Morrison, Patrick Lefebvre, Craig Nelson,

<h4>Background</h4>Little is known about the economic burden of treatment-resistant depression (TRD) in patients with physical conditions.<h4>Objective</h4>To assess health care resource utilization (HRU) and costs, work loss days, and related costs in patients with TRD and physical conditions versus patients with the same conditions and non-TRD major depressive disorder (MDD) or ... Read more >>

J Manag Care Spec Pharm (Journal of managed care & specialty pharmacy)
[2020, 26(8):996-1007]

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Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups.

Premika S W Boedhoe, Daan van Rooij, Martine Hoogman, Jos W R Twisk, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Anatoly Anikin, Alan Anticevic, Celso Arango, Paul D Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Tobias Banaschewski, Alexander Baranov, Marcelo C Batistuzzo, Sarah Baumeister, Ramona Baur-Streubel, Marlene Behrmann, Mark A Bellgrove, Francesco Benedetti, Jan C Beucke, Joseph Biederman, Irene Bollettini, Anushree Bose, Janita Bralten, Ivanei E Bramati, Daniel Brandeis, Silvia Brem, Brian P Brennan, Geraldo F Busatto, Sara Calderoni, Anna Calvo, Rosa Calvo, Francisco X Castellanos, Mara Cercignani, Tiffany M Chaim-Avancini, Kaylita C Chantiluke, Yuqi Cheng, Kang Ik K Cho, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I Cubillo, Anders M Dale, Sara Dallaspezia, Eileen Daly, Damiaan Denys, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Alysa E Doyle, Sarah Durston, Eric A Earl, Christine Ecker, Stefan Ehrlich, Benjamin A Ely, Jeffrey N Epstein, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Jennifer Fedor, Xin Feng, Jamie D Feusner, Jackie Fitzgerald, Kate D Fitzgerald, Jean-Paul Fouche, Christine M Freitag, Egill A Fridgeirsson, Thomas Frodl, Matt C Gabel, Louise Gallagher, Tinatin Gogberashvili, Ilaria Gori, Patricia Gruner, Deniz A Gürsel, Shlomi Haar, Jan Haavik, Geoffrey B Hall, Neil A Harrison, Catharina A Hartman, Dirk J Heslenfeld, Yoshiyuki Hirano, Pieter J Hoekstra, Marcelo Q Hoexter, Sarah Hohmann, Marie F Høvik, Hao Hu, Chaim Huyser, Neda Jahanshad, Maria Jalbrzikowski, Anthony James, Joost Janssen, Fern Jaspers-Fayer, Terry L Jernigan, Dmitry Kapilushniy, Bernd Kardatzki, Georgii Karkashadze, Norbert Kathmann, Christian Kaufmann, Clare Kelly, Sabin Khadka, Joseph A King, Kathrin Koch, Gregor Kohls, Kerstin Konrad, Masaru Kuno, Jonna Kuntsi, Gerd Kvale, Jun Soo Kwon, Luisa Lázaro, Sara Lera-Miguel, Klaus-Peter Lesch, Liesbeth Hoekstra, Yanni Liu, Christine Lochner, Mario R Louza, Beatriz Luna, Astri J Lundervold, Charles B Malpas, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Paulo Mattos, Hazel McCarthy, Jane McGrath, Mitul A Mehta, José M Menchón, Maarten Mennes, Mauricio Moller Martinho, Pedro S Moreira, Astrid Morer, Pedro Morgado, Filippo Muratori, Clodagh M Murphy, Declan G M Murphy, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Leyla Namazova-Baranova, Janardhanan C Narayanaswamy, Rosa Nicolau, Joel T Nigg, Stephanie E Novotny, Erika L Nurmi, Eileen Oberwelland Weiss, Ruth L O'Gorman Tuura, Kirsten O'Hearn, Joseph O'Neill, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Mara Parellada, Paul Pauli, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Kerstin J Plessen, Olga Puig, J Antoni Ramos-Quiroga, Y C Janardhan Reddy, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G P Rosa, Katya Rubia, Oana Georgiana Rus, Yuki Sakai, Anouk Schrantee, Lena Schwarz, Lizanne J S Schweren, Jochen Seitz, Philip Shaw, Devon Shook, Tim J Silk, H Blair Simpson, Norbert Skokauskas, Juan Carlos Soliva Vila, Anastasia Solovieva, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R Stern, Michael C Stevens, S Evelyn Stewart, Gustavo Sudre, Philip R Szeszko, Leanne Tamm, Margot J Taylor, David F Tolin, Michela Tosetti, Fernanda Tovar-Moll, Aki Tsuchiyagaito, Theo G M van Erp, Guido A van Wingen, Alasdair Vance, Ganesan Venkatasubramanian, Oscar Vilarroya, Yolanda Vives-Gilabert, Georg G von Polier, Susanne Walitza, Gregory L Wallace, Zhen Wang, Thomas Wolfers, Yuliya N Yoncheva, Je-Yeon Yun, Marcus V Zanetti, Fengfeng Zhou, Georg C Ziegler, Kathrin C Zierhut, Marcel P Zwiers, , , , Paul M Thompson, Dan J Stein, Jan Buitelaar, Barbara Franke, Odile A van den Heuvel,

<h4>Objective</h4>Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.<h4>Methods</h4>Structural T<sub>1</sub>-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, 177(9):834-843]

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Corrigendum to: Patterns of Cortical Folding Associated with Autistic Symptoms in Carriers and Noncarriers of the 22q11.2 Microdeletion.

Maria Gudbrandsen, Caroline Mann, Anke Bletsch, Eileen Daly, Clodagh M Murphy, Vladimira Stoencheva, Charlotte E Blackmore, Maria Rogdaki, Leila Kushan, Carrie E Bearden, Declan G M Murphy, Michael C Craig, Christine Ecker,

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(9):5191]

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Managing Esketamine Treatment Frequency Toward Successful Outcomes: Analysis of Phase 3 Data.

Michel Nijs, Ewa Wajs, Leah Aluisio, Ibrahim Turkoz, Ella Daly, Adam Janik, Stephane Borentain, Jaskaran B Singh, Allitia DiBernardo, Frank Wiegand,

<h4>Background</h4>Esketamine nasal spray was recently approved for treatment-resistant depression. The current analysis evaluated the impact of symptom-based treatment frequency changes during esketamine treatment on clinical outcomes.<h4>Methods</h4>This is a post-hoc analysis of an open-label, long-term (up to 1 year) study of esketamine in patients with treatment-resistant depression (SUSTAIN 2). During a ... Read more >>

Int J Neuropsychopharmacol (The international journal of neuropsychopharmacology)
[2020, 23(7):426-433]

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Relapse prevention in treatment-resistant major depressive disorder with rapid-acting antidepressants.

Jaskaran B Singh, Maggie Fedgchin, Ella J Daly, Wayne C Drevets,

Major depressive disorder (MDD) is the leading cause of disability worldwide and reduces life expectancy. Achieving and sustaining remission from depression is challenging after initial improvement of an acute episode with an antidepressant, especially for patients whose depressive episodes have proven treatment-resistant in response to conventional antidepressant pharmacotherapy. While standard ... Read more >>

Adv Pharmacol (Advances in pharmacology (San Diego, Calif.))
[2020, 89:237-259]

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Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion.

Maria Gudbrandsen, Anke Bletsch, Caroline Mann, Eileen Daly, Clodagh M Murphy, Vladimira Stoencheva, Charlotte E Blackmore, Maria Rogdaki, Leila Kushan, Carrie E Bearden, Declan G M Murphy, Michael C Craig, Christine Ecker,

<h4>Background</h4>A crucial step to understanding the mechanistic underpinnings of autism spectrum disorder (ASD), is to examine if the biological underpinnings of ASD in genetic high-risk conditions, like 22q11.2 deletion syndrome (22q11.2DS), are similar to those in idiopathic illness. This study aimed to examine if ASD symptomatology in 22q11.2DS is underpinned ... Read more >>

Mol Autism (Molecular autism)
[2020, 11(1):46]

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