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Author E Ann Yeh

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Silent new brain MRI lesions in children with MOG-antibody associated disease.

Giulia Fadda, Brenda Banwell, Patrick Waters, Ruth Ann Marrie, E Ann Yeh, Julia O'Mahony, Douglas A Arnold, Amit Bar-Or, ,

Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are associated clinically with either a monophasic or relapsing disease course. We investigated the frequency and clinical importance of acquired asymptomatic brain MRI lesions in a prospective incident cohort of 74 MOG-IgG positive children with serial MRI scans over a median of 5 years from presentation. ... Read more >>

Ann Neurol (Annals of neurology)
[2020, :]

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Could wider social networks prevent disability in MS and other neurologic disorders?

Dalia L Rotstein, E Ann Yeh,

Neurology (Neurology)
[2020, 95(11):463-464]

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Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis.

Silvia Tenembaum, E Ann Yeh, ,

Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:339]

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Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations.

Mark S Freedman, Virginia Devonshire, Pierre Duquette, Paul S Giacomini, Fabrizio Giuliani, Michael C Levin, Xavier Montalban, Sarah A Morrow, Jiwon Oh, Dalia Rotstein, E Ann Yeh, ,

The Canadian Multiple Sclerosis Working Group has updated its treatment optimization recommendations (TORs) on the optimal use of disease-modifying therapies for patients with all forms of multiple sclerosis (MS). Recommendations provide guidance on initiating effective treatment early in the course of disease, monitoring response to therapy, and modifying or switching ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(4):437-455]

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Increased mental health care use by mothers of children with multiple sclerosis.

Ruth Ann Marrie, Julia O'Mahony, Colleen Maxwell, Vicki Ling, E Ann Yeh, Douglas L Arnold, Amit Bar-Or, Brenda Banwell, ,

OBJECTIVE:We compared the prevalence of physical and mental conditions and rate of health care utilization in mothers of children with multiple sclerosis (MS) (MS-mothers) with that of mothers of children without MS (non-MS-mothers). METHODS:Using population-based administrative data from Ontario, Canada, we identified MS-mothers and non-MS-mothers, matched on maternal age at ... Read more >>

Neurology (Neurology)
[2020, 94(10):e1040-e1050]

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Tracking therapies in MS: More evidence in favor of neurofilament.

E Ann Yeh, Maria Pia Sormani,

Neurology (Neurology)
[2020, 94(11):465-466]

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Serial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes.

Patrick Waters, Giulia Fadda, Mark Woodhall, Julia O'Mahony, Robert A Brown, Denise A Castro, Giulia Longoni, Sarosh R Irani, Bo Sun, E Ann Yeh, Ruth Ann Marrie, Douglas L Arnold, Brenda Banwell, Amit Bar-Or, ,

Importance:Identifying the course of demyelinating disease associated with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is critical to guide appropriate treatment choices. Objective:To characterize serial anti-MOG antibody serologies and clinical and imaging features at presentation and during follow-up in an inception cohort of prospectively monitored children with acquired demyelination. Design, Setting, and ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(1):82-93]

Cited: 3 times

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Deep learning segmentation of orbital fat to calibrate conventional MRI for longitudinal studies.

Robert A Brown, Dumitru Fetco, Robert Fratila, Giulia Fadda, Shangge Jiang, Nuha M Alkhawajah, E Ann Yeh, Brenda Banwell, Amit Bar-Or, Douglas L Arnold, ,

In conventional non-quantitative magnetic resonance imaging, image contrast is consistent within images, but absolute intensity can vary arbitrarily between scans. For quantitative analysis of intensity data, images are typically normalized to a consistent reference. The most convenient reference is a tissue that is always present in the image, and is ... Read more >>

Neuroimage (NeuroImage)
[2020, 208:116442]

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Factors associated with health care utilization in pediatric multiple sclerosis.

Ruth Ann Marrie, Julia O'Mahony, Colleen Maxwell, Vicki Ling, Christine Till, Emily Barlow-Krelina, E Ann Yeh, Douglas L Arnold, Amit Bar-Or, Brenda Banwell, ,

BACKGROUND:We assessed whether clinical characteristics and health-related quality of life (HRQOL) are independently associated with subsequent hospitalizations and physician visits among children with multiple sclerosis (MS); and whether differences in HRQOL account for differences in physician visits between children with MS, monophasic acquired demyelinating syndromes (ADS) and healthy children. METHODS:We ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 38:101511]

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Therapeutic plasma exchange in children with acute demyelination: Kids are not small adults!

E Ann Yeh, Kevin Rostásy,

Neurology (Neurology)
[2019, 93(22):953-954]

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Depressive symptoms, sleep patterns, and physical activity in adolescents with narcolepsy.

Arpita Parmar, E Ann Yeh, Daphne J Korczak, Shelly K Weiss, Zihang Lu, Allison Zweerink, Alene Toulany, Brian J Murray, Indra Narang,

STUDY OBJECTIVES:To evaluate the association between depressive symptoms, sleep patterns (duration and quality), excessive daytime sleepiness (EDS), and physical activity (PA) in adolescents with narcolepsy. METHODS:This cross-sectional study included adolescents (ages 10-18 years) with narcolepsy attending a tertiary care facility (The Hospital for Sick Children, Toronto, Canada). Adolescents with narcolepsy ... Read more >>

Sleep (Sleep)
[2019, 42(8):]

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Early neuroaxonal injury is seen in the acute phase of pediatric optic neuritis.

Colin Wilbur, Y Arun Reginald, Giulia Longoni, Stephanie A Grover, Agnes M Wong, Donald J Mabbott, Douglas L Arnold, Ruth Ann Marrie, Amit Bar-Or, Brenda Banwell, Fiona Costello, E Ann Yeh, ,

BACKGROUND:Thinning of the retinal nerve fiber layer (RNFL) and ganglion cell/inner plexiform layer (GCIPL) occur in the chronic phase after optic neuritis (ON) in children and reflect neuroaxonal injury. The objective of this study was to describe changes in RNFL and GCIPL thickness in the acute phase following pediatric ON. ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2019, 36:101387]

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Rituximab in children with myelin oligodendrocyte glycoprotein antibody and relapsing neuroinflammatory disease.

Fahad Albassam, Giulia Longoni, Carmen Yea, Colin Wilbur, Stephanie A Grover, E Ann Yeh,

The aim of this study was to evaluate tolerability of and response to rituximab in children with myelin oligodendrocyte glycoprotein (MOG) antibody-positive relapsing neuroinflammatory disease. This was an observational study of prospectively collected data on 12 consecutive children (eight females, four males; median age at onset 10y 6mo [interquartile range ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2020, 62(3):390-395]

Cited: 2 times

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Vaccination: Not a trigger for MS.

E Ann Yeh, Jennifer Graves,

Neurology (Neurology)
[2019, 93(9):377-378]

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High rates of health care utilization in pediatric multiple sclerosis: A Canadian population-based study.

Ruth Ann Marrie, Julia O'Mahony, Colleen J Maxwell, Vicki Ling, E Ann Yeh, Douglas L Arnold, Amit Bar-Or, Brenda Banwell, ,

We aimed to compare health care utilization of children with pediatric-onset multiple sclerosis to that of age, sex and geographically-matched children without multiple sclerosis. Using population-based administrative data from Ontario, Canada for the period 2003-2014, we applied a validated case definition to identify persons aged ≤18 years with multiple sclerosis. ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0218215]

Cited: 1 time

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Demyelinating lesions and progressive MS: Location, location, location.

E Ann Yeh, Robert J Fox,

Neurology (Neurology)
[2019, 93(7):283-284]

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Improving Outcomes in Pediatric Multiple Sclerosis: Current and Emerging Treatments.

Colin Wilbur, E Ann Yeh,

Pediatric-onset multiple sclerosis (MS) comprises 2-5% of MS cases, and is known to be associated with high disease activity and the accumulation of disability at an earlier age than their adult-onset counterparts. Appropriate therapy leading to disease control has the potential to alter the known trajectory of adverse long-term physical, ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2019, 21(3):137-152]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 2 times

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An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome.

Colin Wilbur, Carmen Yea, Christoph Licht, Meredith S Irwin, E Ann Yeh,

BACKGROUND:Treatment of opsoclonus-myoclonus syndrome (OMS) has historically involved corticosteroids and intravenous immunoglobulin (IVIG) for a duration of 6-12 months or longer. This study evaluated whether a brief upfront immunomodulatory therapy protocol with rituximab reduces the duration of OMS therapy without adversely affecting OMS outcomes. PROCEDURE:Retrospective chart review was performed for ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(8):e27776]

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A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis.

Giulia Fadda, Robert A Brown, Roberta Magliozzi, Berengere Aubert-Broche, Julia O'Mahony, Russell T Shinohara, Brenda Banwell, Ruth Ann Marrie, E Ann Yeh, D Louis Collins, Douglas L Arnold, Amit Bar-Or, ,

OBJECTIVE:Central nervous system pathology in multiple sclerosis includes both focal inflammatory perivascular injury and injury to superficial structures, including the subpial region of the cortex, which reportedly exhibits a gradient of damage from the surface inward. We assessed how early in the multiple sclerosis course a "surface-in" process of injury ... Read more >>

Ann Neurol (Annals of neurology)
[2019, 85(3):340-351]

Cited: 2 times

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Treatment of rituximab-associated chronic CNS enterovirus using IVIg and fluoxetine.

Lauren Sham, Ari Bitnun, Helen Branson, Lili-Naz Hazrati, Sharon D Dell, Rae S M Yeung, Joley Johnstone, E Ann Yeh,

Neurology (Neurology)
[2019, 92(19):916-918]

Cited: 1 time

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Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis.

Samantha Stephens, Shahriar Shams, Joshua Lee, Stephanie A Grover, Giulia Longoni, Tara Berenbaum, Marcia Finlayson, Robert W Motl, E Ann Yeh,

OBJECTIVES:To examine the longitudinal relationship between physical activity and fatigue and depression among youth with demyelinating conditions. STUDY DESIGN:From September 2013 to March 2017, we performed a longitudinal study of consecutive youth diagnosed at their first visit with pediatric onset multiple sclerosis (POMS) or monophasic acquired demyelinating syndromes (mono-ADS) at ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 209:226-232.e2]

Cited: 1 time

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Evolution of regional brain atrophy in children with multiple sclerosis: Gray matters.

E Ann Yeh, Arman Eshaghi,

Neurology (Neurology)
[2019, 92(15):694-695]

Cited: 0 times

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Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis.

Ina Mexhitaj, Mukanthu H Nyirenda, Rui Li, Julia O'Mahony, Ayman Rezk, Ayal Rozenberg, Craig S Moore, Trina Johnson, Dessa Sadovnick, D Louis Collins, Douglas L Arnold, Bruno Gran, E Ann Yeh, Ruth Ann Marrie, Brenda Banwell, Amit Bar-Or,

Elucidation of distinct T-cell subsets involved in multiple sclerosis immune-pathophysiology continues to be of considerable interest since an ultimate goal is to more selectively target the aberrant immune response operating in individual patients. While abnormalities of both effector (Teff) and regulatory (Treg) T cells have been reported in patients with ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(3):617-632]

Cited: 5 times

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