Full Text Journal Articles by
Author Dylan J Dues

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LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.

Dylan J Dues, Darren J Moore,

Mutations in leucine-rich repeat kinase 2 (LRRK2) instigate an autosomal dominant form of Parkinson's disease (PD). Despite the neuropathological heterogeneity observed in LRRK2-PD, accumulating evidence suggests that alpha-synuclein and tau pathology are observed in a vast majority of cases. Intriguingly, the presence of protein aggregates spans both LRRK2-PD and idiopathic ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:719]

Cited: 0 times

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Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways.

Emily Machiela, Thomas Liontis, Dylan J Dues, Paige D Rudich, Annika Traa, Leslie Wyman, Corah Kaufman, Jason F Cooper, Leira Lew, Saravanapriah Nadarajan, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mitochondria are dynamic organelles that can change shape and size depending on the needs of the cell through the processes of mitochondrial fission and fusion. In this work, we investigated the role of mitochondrial dynamics in organismal stress response. By using C. elegans as a genetic model, we could visualize ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(6):8475-8492]

Cited: 0 times

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Resistance to Stress Can Be Experimentally Dissociated From Longevity.

Dylan J Dues, Emily K Andrews, Megan M Senchuk, Jeremy M Van Raamsdonk,

On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2019, 74(8):1206-1214]

Cited: 4 times

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Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Ziyun Wu, Megan M Senchuk, Dylan J Dues, Benjamin K Johnson, Jason F Cooper, Leira Lew, Emily Machiela, Claire E Schaar, Heather DeJonge, T Keith Blackwell, Jeremy M Van Raamsdonk,

BACKGROUND:The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity. RESULTS:Here, we examined the contribution of the mitoUPR to the survival and ... Read more >>

BMC Biol (BMC biology)
[2018, 16(1):147]

Cited: 6 times

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Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Megan M Senchuk, Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Zachary B Madaj, Megan J Bowman, Mary E Winn, Jeremy M Van Raamsdonk,

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that genes regulated by the FOXO transcription ... Read more >>

PLoS Genet (PLoS genetics)
[2018, 14(3):e1007268]

Cited: 14 times

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Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.

Dylan J Dues, Claire E Schaar, Benjamin K Johnson, Megan J Bowman, Mary E Winn, Megan M Senchuk, Jeremy M Van Raamsdonk,

Mutations affecting components of the mitochondrial electron transport chain have been shown to increase lifespan in multiple species including the worm Caenorhabditis elegans. While it was originally proposed that decreased generation of reactive oxygen species (ROS) resulting from lower rates of electron transport could account for the observed increase in ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2017, 108:362-373]

Cited: 12 times

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Measuring Oxidative Stress in Caenorhabditis elegans: Paraquat and Juglone Sensitivity Assays.

Megan M Senchuk, Dylan J Dues, Jeremy M Van Raamsdonk,

Oxidative stress has been proposed to be one of the main causes of aging and has been implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be measured by quantifying survival following exposure to a reactive oxygen species (ROS)-generating compound such as paraquat or juglone. Sensitivity to ... Read more >>

Bio Protoc (Bio-protocol)
[2017, 7(1):]

Cited: 8 times

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Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes.

Emily Machiela, Dylan J Dues, Megan M Senchuk, Jeremy M Van Raamsdonk,

Huntington's disease (HD) is an adult onset neurodegenerative disorder for which there is currently no cure. While HD patients and animal models of the disease exhibit increased oxidative damage, it is currently uncertain to what extent oxidative stress contributes to disease pathogenesis. In this work, we use a genetic approach ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2016, 96:1-11]

Cited: 17 times

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Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways.

Dylan J Dues, Emily K Andrews, Claire E Schaar, Alexis L Bergsma, Megan M Senchuk, Jeremy M Van Raamsdonk,

In this work, we examine the relationship between stress resistance and aging. We find that resistance to multiple types of stress peaks during early adulthood and then declines with age. To dissect the underlying mechanisms, we use C. elegans transcriptional reporter strains that measure the activation of different stress responses ... Read more >>

Aging (Albany NY) (Aging)
[2016, 8(4):777-795]

Cited: 32 times

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Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.

Jason F Cooper, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Megan M Senchuk, Jeremy M Van Raamsdonk,

Aging is the greatest risk factor for the development of Parkinson's disease (PD). However, the role of aging in the pathogenesis of PD is not known and it is currently uncertain why the symptoms take many decades to develop when inherited mutations that cause the disease can be present from ... Read more >>

(NPJ Parkinson's disease)
[2015, 1:15022]

Cited: 26 times

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Intrastriatal transplantation of adenovirus-generated induced pluripotent stem cells for treating neuropathological and functional deficits in a rodent model of Huntington's disease.

Kyle D Fink, Andrew T Crane, Xavier Lévêque, Dylan J Dues, Lucas D Huffman, Allison C Moore, Darren T Story, Rachel E Dejonge, Aaron Antcliff, Phillip A Starski, Ming Lu, Laurent Lescaudron, Julien Rossignol, Gary L Dunbar,

Induced pluripotent stem cells (iPSCs) show considerable promise for cell replacement therapies for Huntington's disease (HD). Our laboratory has demonstrated that tail-tip fibroblasts, reprogrammed into iPSCs via two adenoviruses, can survive and differentiate into neuronal lineages following transplantation into healthy adult rats. However, the ability of these cells to survive, ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2014, 3(5):620-631]

Cited: 14 times

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Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum.

Kyle D Fink, Julien Rossignol, Ming Lu, Xavier Lévêque, Travis D Hulse, Andrew T Crane, Veronique Nerriere-Daguin, Robert D Wyse, Phillip A Starski, Matthew T Schloop, Dylan J Dues, Steve J Witte, Cheng Song, Ludovic Vallier, Tuan H Nguyen, Philippe Naveilhan, Ignacio Anegon, Laurent Lescaudron, Gary L Dunbar,

Induced pluripotent stem cells (iPSCs) offer certain advantages over embryonic stem cells in cell replacement therapy for a variety of neurological disorders. However, reliable procedures, whereby transplanted iPSCs can survive and differentiate into functional neurons, without forming tumors, have yet to be devised. Currently, retroviral or lentiviral reprogramming methods are ... Read more >>

Cell Transplant (Cell transplantation)
[2014, 23(11):1407-1423]

Cited: 8 times

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