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Author Dylan Blacquiere

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Prevalence and the predictive performance of the dynamic CT-angiography spot sign in an observational cohort with intracerebral hemorrhage.

Dar Dowlatshahi, Hee Sahng Chung, Michael Reaume, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Franco Momoli, Richard Aviv, Andrew M Demchuk, Santanu Chakraborty,

The CT-angiography (CTA) spot sign is a predictor of hematoma expansion (HE). We have previously reported on the use of dynamic CTA (dCTA) to detect spot sign, and to study its formation over the acquisition period. In this study, we report the frequency of dCTA spot sign in acute intracerebral ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(47):e23278]

Cited: 1 time

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Distribution and predictive performance of the temporal phase of dynamic spot sign appearance in acute intracerebral hemorrhage.

Hee Sahng Chung, Santanu Chakraborty, Michael Reaume, Vignan Yogendrakumar, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Richard I Aviv, Dar Dowlatshahi,

<h4>Background</h4>Dynamic CT angiography (dCTA) contrast extravasation, known as the "dynamic spot sign", can predict hematoma expansion (HE) in intracerebral hemorrhage (ICH). Recent reports suggest the phase of spot sign appearance is related to the magnitude of HE. We used dCTA to explore the association between the phase of spot sign ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0236196]

Cited: 0 times

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Decreased Stroke Presentation Rates at a Comprehensive Stroke Center during COVID-19.

Dar Dowlatshahi, Grant Stotts, Aline Bourgoin, Sophia Gocan, Laura Dunn, Jodi Powell, Frank L Silver, Greg Walker, Vignan Yogendrakumar, Robert Fahed, Dylan Blacquiere, Michel Shamy,

We reviewed stroke care delivery during the COVID-19 pandemic at our stroke center and provincial telestroke system. We counted referrals to our prevention clinic, code strokes, thrombolysis, endovascular thrombectomies, and activations of a provincial telestroke system from February to April of 2017-2020. In April 2020, there was 28% reduction in ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2021, 48(1):118-121]

Cited: 1 time

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Canadian Stroke Best Practice Guidance During the COVID-19 Pandemic.

Eric E Smith, Anita Mountain, Michael D Hill, Theodore H Wein, Dylan Blacquiere, Leanne K Casaubon, Elizabeth Linkewich, Norine Foley, Gord Gubitz, Anne Simard, M Patrice Lindsay, ,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(4):474-478]

Cited: 3 times

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Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial.

Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, ,

BACKGROUND:S44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitability in a transcranial magnetic stimulation study in healthy volunteers. The Randomized Efficacy and Safety Trial of Oral GABAA α5 antagonist S44819 after Recent ischemic Event ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(3):226-233]

Cited: 2 times

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Clinical Reasoning: Recurrent strokes secondary to unknown vasculopathy.

Ronda Lun, Naomi Niznick, Ruth Padmore, Jonathan Mack, Michel Shamy, Grant Stotts, Dylan Blacquiere,

Neurology (Neurology)
[2020, 94(22):e2396-e2401]

Cited: 0 times

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A Delayed Modified ICH Score Outperforms Baseline Scoring in Acute Intracerebral Hemorrhage.

Ronda Lun, Vignan Yogendrakumar, Dylan Blacquiere, Michel Shamy, Grant Stotts, Dar Dowlatshahi,

The Modified Intracerebral Hemorrhage (MICH) score is a simple tool created to provide prognostication in basal ganglia hemorrhages. Current prognostic scores, including the MICH, are based on the assessment of baseline patient characteristics, failing to account for significant developments, such as intraventricular extension and clinical deterioration, which may occur over ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2020, 10(3):217-220]

Cited: 0 times

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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel Cr Rohr, Daniela Iancu, Demetrios J Sahlas, Amy Y X Yu, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce C V Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, ,

<h4>Background</h4>Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.<h4>Methods</h4>For ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10227):878-887]

Cited: 36 times

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Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

Hans-Christoph Diener, Ralph L Sacco, J Donald Easton, Christopher B Granger, Richard A Bernstein, Shinichiro Uchiyama, Jörg Kreuzer, Lisa Cronin, Daniel Cotton, Claudia Grauer, Martina Brueckmann, Marina Chernyatina, Geoffrey Donnan, José M Ferro, Martin Grond, Bernd Kallmünzer, Jerzy Krupinski, Byung-Chul Lee, Robin Lemmens, Jaime Masjuan, Miroslav Odinak, Jeffrey L Saver, Peter D Schellinger, Danilo Toni, Kazunori Toyoda, ,

<h4>Background</h4>Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most cryptogenic strokes are considered to be embolic and of undetermined source. An earlier randomized trial showed that rivaroxaban is no more effective than aspirin in preventing recurrent stroke after a presumed embolic stroke from an undetermined source. Whether dabigatran ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(20):1906-1917]

Cited: 43 times

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Best practice interprofessional stroke care collaboration and simulation: The student perspective.

Diane MacKenzie, Gail Creaser, Kim Sponagle, Gordon Gubitz, Peter MacDougall, Dylan Blacquiere, Stephen Miller, Gordon Sarty,

Interprofessional practice (IPP) is the accepted standard of care for clients following a stroke. A brief, embedded and evidence-based IPP team simulation was designed to address stroke care knowledge and IPP competencies for students within limited curriculum space. Each team was required to construct a collaborative care plan for their ... Read more >>

J Interprof Care (Journal of interprofessional care)
[2017, 31(6):793-796]

Cited: 0 times

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Canadian Stroke Best Practice Recommendations: Telestroke Best Practice Guidelines Update 2017.

Dylan Blacquiere, M Patrice Lindsay, Norine Foley, Colleen Taralson, Susan Alcock, Catherine Balg, Sanjit Bhogal, Julie Cole, Marsha Eustace, Patricia Gallagher, Antoinette Ghanem, Alexander Hoechsmann, Gary Hunter, Khurshid Khan, Alier Marrero, Brian Moses, Kelley Rayner, Andrew Samis, Elisabeth Smitko, Marilyn Vibe, Gord Gubitz, Dariush Dowlatshahi, Stephen Phillips, Frank L Silver, ,

Every year, approximately 62,000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2016 update of the Canadian Stroke Best Practice Recommendations Telestroke guideline is a comprehensive summary of current evidence-based and consensus-based recommendations appropriate for use by all healthcare providers and system planners who organize ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2017, 12(8):886-895]

Cited: 16 times

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Fast-Track Systems Improve Timely Carotid Endarterectomy in Stroke Prevention Outpatients.

Sophia Gocan, Aline Bourgoin, Dylan Blacquiere, Rany Shamloul, Dar Dowlatshahi, Grant Stotts,

<h4>Background</h4>For optimal stroke prevention, best practices guidelines recommend carotid endarterectomy (CEA) for symptomatic patients within two weeks; however, 2013 Ontario data indicated that only 9% of eligible patients from outpatient Stroke Prevention Clinics (SPCs) achieved this target. The goal of our study was to identify modifiable system factors that could ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2016, 43(5):648-654]

Cited: 2 times

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Canadian Stroke Best Practice Recommendations: Acute Inpatient Stroke Care Guidelines, Update 2015.

Leanne K Casaubon, Jean-Martin Boulanger, Ev Glasser, Dylan Blacquiere, Scott Boucher, Kyla Brown, Tom Goddard, Jacqueline Gordon, Myles Horton, Jeffrey Lalonde, Christian LaRivière, Pascale Lavoie, Paul Leslie, Jeanne McNeill, Bijoy K Menon, Brian Moses, Melanie Penn, Jeff Perry, Elizabeth Snieder, Dawn Tymianski, Norine Foley, Eric E Smith, Gord Gubitz, Michael D Hill, Patrice Lindsay, ,

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2016, 11(2):239-252]

Cited: 24 times

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Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015.

Leanne K Casaubon, Jean-Martin Boulanger, Dylan Blacquiere, Scott Boucher, Kyla Brown, Tom Goddard, Jacqueline Gordon, Myles Horton, Jeffrey Lalonde, Christian LaRivière, Pascale Lavoie, Paul Leslie, Jeanne McNeill, Bijoy K Menon, Brian Moses, Melanie Penn, Jeff Perry, Elizabeth Snieder, Dawn Tymianski, Norine Foley, Eric E Smith, Gord Gubitz, Michael D Hill, Ev Glasser, Patrice Lindsay, ,

The 2015 update of the Canadian Stroke Best Practice Recommendations Hyperacute Stroke Care guideline highlights key elements involved in the initial assessment, stabilization, and treatment of patients with transient ischemic attack (TIA), ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and acute venous sinus thrombosis. The most notable change in this 5th edition is the addition of ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2015, 10(6):924-940]

Cited: 92 times

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Intracerebral Hematoma Morphologic Appearance on Noncontrast Computed Tomography Predicts Significant Hematoma Expansion.

Dylan Blacquiere, Andrew M Demchuk, Mohammed Al-Hazzaa, Anirudda Deshpande, William Petrcich, Richard I Aviv, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva Blas, Imanuel Dzialowski, Anna Czlonkowska, Jean-Martin Boulanger, Cheemun Lum, Gord Gubitz, Vasantha Padma, Jayanta Roy, Carlos S Kase, Rohit Bhatia, Michael D Hill, Dar Dowlatshahi, ,

<h4>Background and purpose</h4>Hematoma expansion in intracerebral hemorrhage is associated with higher morbidity and mortality. The computed tomography (CT) angiographic spot sign is highly predictive of expansion, but other morphological features of intracerebral hemorrhage such as fluid levels, density heterogeneity, and margin irregularity may also predict expansion, particularly in centres where ... Read more >>

Stroke (Stroke)
[2015, 46(11):3111-3116]

Cited: 29 times

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Rapid Assessment and Treatment of Transient Ischemic Attacks and Minor Stroke in Canadian Emergency Departments: Time for a Paradigm Shift.

Noreen Kamal, Michael D Hill, Dylan P V Blacquiere, Jean-Martin Boulanger, Karl Boyle, Brian Buck, Kenneth Butcher, Marie-Christine Camden, Leanne K Casaubon, Robert Côté, Andrew M Demchuk, Dar Dowlatshahi, Veronique Dubuc, Thalia S Field, Esseddeeg Ghrooda, Laura Gioia, David J Gladstone, Mayank Goyal, Gordon J Gubitz, Devin Harris, Robert G Hart, Gary Hunter, Thomas Jeerakathil, Albert Jin, Khurshid Khan, Eddy Lang, Sylvain Lanthier, M Patrice Lindsay, Ariane Mackey, Jennifer Mandzia, Manu Mehdiratta, Jeffrey Minuk, Wieslaw Oczkowski, Céline Odier, Andrew Penn, Jeffery Perry, Jacqueline A Pettersen, Stephen J Phillips, Alexandre Y Poppe, Gustavo Saposnik, Daniel Selchen, Michel Shamy, Mike Sharma, Ashkan Shoamanesh, Ashfaq Shuaib, Frank Silver, Grant Stotts, Rick Swartz, Arturo Tamayo, Jeanne Teitelbaum, Steve Verreault, Theodore Wein, Samuel Yip, Shelagh B Coutts,

Stroke (Stroke)
[2015, 46(10):2987-2990]

Cited: 9 times

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Delays in carotid endarterectomy: the process is the problem.

Dylan Blacquiere, Michael Sharma, Prasad Jetty,

<h4>Background</h4>Current recommendations for carotid endarterectomy (CEA) for symptomatic carotid stenosis state benefit is greatest when performed within two weeks of symptoms. However, only a minority of cases are operated on within this guideline, and no systematic examinations of reasons for these delays exist.<h4>Methods</h4>All CEA cases performed at our institution by ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2013, 40(4):585-589]

Cited: 3 times

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Satisfaction with palliative care after stroke: a prospective cohort study.

Dylan Blacquiere, Khadija Bhimji, Hilary Meggison, John Sinclair, Michael Sharma,

<h4>Background and purpose</h4>The determinants of satisfaction for families of acute stroke patients receiving palliative care have not been extensively studied. We surveyed families to determine how they perceived palliative care after stroke.<h4>Methods</h4>Families of patients palliated after ischemic stroke, intracerebral, or subarachnoid hemorrhage were approached. Four weeks after the patient's death, ... Read more >>

Stroke (Stroke)
[2013, 44(9):2617-2619]

Cited: 4 times

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Thrombolysis despite recent stroke: a case series.

Mohammed Alhazzaa, Mukul Sharma, Dylan Blacquiere, Grant Stotts, Matthew Hogan, Dar Dowlatshahi,

<h4>Background and purpose</h4>Thrombolysis in ischemic stroke is contraindicated in patients who have had a stroke within 3 months. However, it is unclear whether thrombolytic therapy is associated with adverse outcomes in this population. We report the characteristics and outcomes of patients treated with systemic recombinant tissue-type plasminogen activator in the ... Read more >>

Stroke (Stroke)
[2013, 44(6):1736-1738]

Cited: 11 times

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Ongoing bleeding in acute intracerebral haemorrhage.

Dar Dowlatshahi, Matthew J Hogan, Mukul Sharma, Grant Stotts, Dylan Blacquiere, Santanu Chakraborty,

Lancet (Lancet (London, England))
[2013, 381(9861):152]

Cited: 13 times

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CTA source images as a predictor of final infarct volume are time-dependent.

Dylan Blacquiere, Miguel Bussière, Cheemun Lum, Dar Dowlatshahi,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2010, 37(6):866-867]

Cited: 0 times

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Evaluating an organized palliative care approach in patients with severe stroke.

Dylan P V Blacquiere, Gord J Gubitz, David Dupere, Deborah McLeod, Stephen Phillips,

<h4>Background</h4>A recent survey found few guidelines on the provision of palliative care following stroke; none examined the efficacy or results of any such process. The role of the patient's family in decision making and in conflicts with staff has not been evaluated. We sought to formally evaluate the use of ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2009, 36(6):731-734]

Cited: 7 times

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Formation of N-alkylprotoporphyrin IX from metabolism of diallyl sulfone in lung and liver.

Gordon P Black, Kathy S Collins, Dylan P Blacquiere, Poh-Gek Forkert,

Diallyl sulfone (DASO2) is a garlic derivative formed during cooking or after ingestion. Bioactivation of DASO2 in murine lung and liver results in formation of an epoxide that inactivates CYP2E1 and significantly decreases cytochrome P450 and heme levels. In this study, we tested the hypothesis that DASO2 metabolism leads to ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2006, 34(6):895-900]

Cited: 5 times

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