Full Text Journal Articles by
Author Durdu Altuner

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Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats.

Fevzi Bedir, Hüseyin Kocatürk, Turgut Yapanoğlu, Cebrail Gürsul, Remzi Arslan, Renad Mammadov, Abdülkadir Çoban, Durdu Altuner, Halis Suleyman,

The current study investigates the biochemical and histopathological effects of taxifolin on acrylamide-induced kidney damage. A 50 mg/kg dose of taxifolin was administered via oral gavage to the taxifolin + acrylamide (TACR) group (n-6) consisting of male albino Wistar rats. The same volume of distilled water used as solvent was orally administered to ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 139:111660]

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Protective effect of lutein against acrolein-induced ototoxicity in rats.

Ertugrul Erhan, Ismail Salcan, Rana Bayram, Bahadir Suleyman, Muhammet Dilber, Gulce Naz Yazici, Taha Abdulkadir Coban, Durdu Altuner, Halis Suleyman,

<h4>Background</h4>Acrolein is a reactive aldehyde that forms during burning of wood and other fuels. It is also a product of lipid peroxidation (LPO) reactions and is present in cigarette smoke. Acrolein is known to cause oxidative stress and inflammatory nerve tissue damage. Lutein is a tetraterpenoid molecule with antioxidant and ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 137:111281]

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Effect of taxifolin on methanol-induced oxidative and inflammatory optic nerve damage in rats.

Ibrahim Ahiskali, Can Lokman Pinar, Murat Kiki, Murat Cankaya, Celaleddin Semih Kunak, Durdu Altuner,

<b>Purpose:</b> Oxidative stress and inflammation have been demonstrated in the pathogenesis of methanol toxicity. Taxifolin has antioxidant and anti-inflammatory properties. In this study, we examined the protective effect of taxifolin against methanol-induced optic nerve toxicity. <b>Materials and methods:</b> Animals were divided into four groups (<i>n</i> = 6): healthy control group (HG), methotrexate ... Read more >>

Cutan Ocul Toxicol (Cutaneous and ocular toxicology)
[2019, 38(4):384-389]

Cited: 1 time

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Effect of taxifolin on development of retinopathy in alloxan-induced diabetic rats.

Ibrahim Ahiskali, Can Lokman Pinar, Murat Kiki, Renad Mammadov, Asli Ozbek Bilgin, Ahmet Hacimuftuoglu, Murat Cankaya, Ferda Keskin Cimen, Durdu Altuner,

<b>Purpose:</b> Diabetic retinopathy (DR) is one of the leading causes of blindness. In DR patients, antioxidant defence is disrupted, and production of reactive oxygen species and pro-inflammatory cytokines such as interleukin 1β (IL-1β) and tumour necrosis factor alpha (TNF-α) increases. Taxifolin has been reported to suppress reactive oxygen species, IL-1β ... Read more >>

Cutan Ocul Toxicol (Cutaneous and ocular toxicology)
[2019, 38(3):227-232]

Cited: 2 times

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Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats1.

Renad Mammadov, Bahadir Suleyman, Durdu Altuner, Elif Demirci, Nihal Cetin, Adnan Yilmaz, Huseyin Baykal, Hilal Alpcan, Emine Akyuz Turumtay, Halis Suleyman,

<h4>Purpose</h4>To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).<h4>Methods</h4>The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 ... Read more >>

Acta Cir Bras (Acta cirurgica brasileira)
[2019, 34(3):e201900305]

Cited: 2 times

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The effect of anakinra to nephrotoxicity with cisplatin induced in rats: Biochemical, gene expression and histopathological evaluation.

Adalet Ozcicek, Fatih Ozcicek, Ferda Keskin Cimen, Renad Mammadov, Murat Cankaya, Talat Ezmeci, Durdu Altuner,

<h4>Background</h4>Oxidative stress and interleukin-1 beta (IL-1β) have been reported to play a role in the pathogenesis of nephrotoxicity induced by cisplatin.<h4>Objectives</h4>The objective of this study was to investigate the effect of anakinra, which is an IL-1β receptor antagonist, on cisplatin-induced nephrotoxicity in rats, through biochemical, gene expression and histopathological analyses.<h4>Material ... Read more >>

Adv Clin Exp Med (Advances in clinical and experimental medicine : official organ Wroclaw Medical University)
[2018, 27(12):1643-1650]

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The investigation of the protective effects of nimesulide on experimental testicular ischemia-reperfusion injury in rats.

Eyüp Can Polat, Ali Seydi Bozkurt, Ferda Keskin Cimen, Mine Gulaboglu, Durdu Altuner,

<h4>Introduction and objectives</h4>Testicular ischemia/reperfusion (I/R) injury develops after torsion and following detorsion of the testis. Reactive oxygen species were produced and oxidative damage begins to occur due to I/R process. Nimesulide, which is a specific cyclooxygenase-2 inhibitor drug, have antioxidant, antiinflammatory, analgesics and antipyretic effects. We aimed to investigate biochemically ... Read more >>

Rev Int Androl (Revista internacional de andrologia)
[2020, 18(2):55-62]

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The effect of rutin on cisplatin-induced oxidative cardiac damage in rats.

İsmail Topal, Aslı Özbek Bilgin, Ferda Keskin Çimen, Nezahat Kurt, Zeynep Süleyman, Yasin Bilgin, Adalet Özçiçek, Durdu Altuner,

<h4>Objective</h4>Cisplatin is an anticancer drug used for treating childhood solid tumors. Symptoms related to cisplatin-induced cardiovascular adverse effects may be mild or severe. Rutin (vitamin P1) has many properties, including as antioxidant, anticancer, antidiabetic, antimicrobial, antiulcer, and tissue renewal properties. Therefore, we aimed to biochemically, histopathologically, and immunohistochemically demonstrate the ... Read more >>

Anatol J Cardiol (Anatolian journal of cardiology)
[2018, 20(3):136-142]

Cited: 10 times

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The Protective Effect of Thiamine Pryophosphate Against Sugar-Induced Retinal Neovascularisation in Rats.

Emine Cinici, Renad Mammadov, Huseyin Findik, Bahadir Suleyman, Nihal Cetin, Ilknur Calik, Hilal Balta, Ismail Hakki Tas, Ebru Sener, Durdu Altuner,

The aim of this study was to investigate the effect of thiamine pyrophosphate (TPP), administered via sugar water, on retinal neovascularisation in rats. Animals were assigned to three groups, namely the TPP sugar-water group (TPSWG, <i>n</i> = 12), the control group (CG, <i>n</i> = 12) and the healthy group (HG, ... Read more >>

Int J Vitam Nutr Res (International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition)
[2018, 88(3-4):137-143]

Cited: 0 times

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The effect of thiamine and its metabolites on peripheral neuropathic pain induced by cisplatin in rats.

Didem Onk, Renad Mammadov, Bahadir Suleyman, Ferda Keskin Cimen, Murat Cankaya, Vahdet Gul, Durdu Altuner, Onur Senol, Yucel Kadioglu, Ismail Malkoc, Halis Suleyman,

Thiamine pyrophosphate (TPP) is the active metabolite of thiamine. This study aimed to investigate the effects of thiamine and TPP on cisplatin-induced peripheral neuropathic pain (PNP). Male albino Wistar type Rattus norvegicus were divided into six groups (n=6) that received 2 mg/kg cisplatin (CIS), 25 mg/kg thiamine (TM), 2 mg/kg ... Read more >>

Exp Anim (Experimental animals)
[2018, 67(2):259-269]

Cited: 4 times

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The effect of metyrosine on oxidative gastric damage induced by ischemia/reperfusion in rats. Biochemical and histopathological evaluation.

Orhan Çimen, Ferda Keskin Çimen, Mine Gülaboğlu, Aslı Özbek Bilgin, Arif Burak Çekiç, Hüseyin Eken, Zeynep Süleyman, Yasin Bilgin, Durdu Altuner,

PURPOSE:To investigate the effect of metyrosine against I/R induced gastric damage in rats. METHODS:Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, and distilled water was given to the ... Read more >>

Acta Cir Bras (Acta cirurgica brasileira)
[2018, 33(3):259-267]

Cited: 1 time

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Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion.

Turgut Yapanoglu, Fatih Ozkaya, Ali Haydar Yilmaz, Renad Mammadov, Ferda Keskin Cimen, Erkan Hirik, Durdu Altuner,

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and ... Read more >>

Korean J Physiol Pharmacol (The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology)
[2017, 21(5):457-464]

Cited: 1 time

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Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats.

Emine Cinici, Nihal Cetin, Bahadir Suleyman, Durdu Altuner, Oguzhan Yarali, Hilal Balta, Ilknur Calik, Levent Tumkaya, Halis Suleyman,

<h4>Aim</h4>To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol.<h4>Methods</h4>The animals were divided into four groups: a control group (CG), an ethambutol control (ETC) group, TM plus ethambutol group (TMG), and TPP plus ethambutol group (TPPG). One hour after intraperitoneal ... Read more >>

Int J Ophthalmol (International journal of ophthalmology)
[2016, 9(10):1390-1395]

Cited: 0 times

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The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats.

Elif Oral Ahiskalioglu, Pelin Aydin, Ali Ahiskalioglu, Bahadir Suleyman, Ufuk Kuyrukluyildiz, Nezahat Kurt, Durdu Altuner, Resit Coskun, Halis Suleyman,

Introduction:We compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats. Material and methods:Three groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2018, 14(3):645-654]

Cited: 2 times

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Can thıamıne pyrophosphate prevent desflurane ınduced hepatotoxıcıty ın rats?

Aynur Arslan, Ufuk Kuyrukluyildiz, Orhan Binici, Nihal Cetin, Mecdi Gurhan Balci, Mehmet Kuzucu, Adnan Yilmaz, Durdu Altuner, Taha Abdulkadir Coban,

<h4>Purpose</h4>To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity.<h4>Methods</h4>Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitoneally TDG. After one hour of TPP administration, desflurane was applied for two hours. ... Read more >>

Acta Cir Bras (Acta cirurgica brasileira)
[2016, 31(3):168-175]

Cited: 0 times

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Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation.

Emine Cinici, Ibrahim Ahiskali, Nihal Cetin, Bahadir Suleyman, Osman Kukula, Durdu Altuner, Abdulkadir Coban, Hilal Balta, Mehmet Kuzucu, Halis Suleyman,

<h4>Purpose</h4>Information is lacking on the protective effects of thiamine pyrophosphate (TPP) against hyperglycemia-induced retinopathy in rats. This study investigated the biochemical and histopathological aspects of the effect of TPP on hyperglycemia-induced retinopathy induced by alloxan in rats.<h4>Materials and methods</h4>The rats were separated into a diabetic TPP-administered group (DTPG), a diabetes ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2016, 64(6):434-439]

Cited: 3 times

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Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats.

Aynur Arslan, Adalet Ozcicek, Bahadir Suleyman, Taha Abdulkadir Coban, Ferda Keskin Cimen, Hatice Sevim Nalkiran, Mehmet Kuzucu, Durdu Altuner, Nihal Cetin, Halis Suleyman,

Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide on the small intestine mucositis induced by methotrexate (MTX) in rats. Experimental animals were divided into the control ... Read more >>

Exp Anim (Experimental animals)
[2016, 65(4):329-336]

Cited: 2 times

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The effect of metamizole on ischemia/reperfusion injury in the rat ovary: An analysis of biochemistry, molecular gene expression, and histopathology.

Serkan Kumbasar, Suleyman Salman, Ragip Atakan Al, Cengiz Ozturk, Oguzhan Yarali, Hamit Hakan Alp, Durdu Altuner, Bahadir Suleyman,

<h4>Objectives</h4>In this study, we investigated the effect of metamizole on ischemia/reperfusion (I/R) injury an analysis of biochemistry, molecular gene expression, and histopathology in the rat ovary of female albino Wistar rats.<h4>Materials and methods</h4>Animals were divided into four groups; control group with induced ischemia-reperfusion (IRC), ischemia-reperfusion +100 mg/kg metamizole sodium (MS) ... Read more >>

Indian J Pharmacol (Indian journal of pharmacology)
[2016, 48(1):32-36]

Cited: 1 time

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The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats.

Celalettin Semih Kunak, Osman Kukula, Emre Mutlu, Fatma Genç, Gülçer Güleç Peker, Ufuk Kuyrukluyıldız, Orhan Binici, Durdu Altuner, Hamit Hakan Alp,

<h4>Unlabelled</h4>Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature.<h4>Objective</h4>This study investigates the effect of etoricoxib on oxidative stress induced ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2015, 2015:598162]

Cited: 7 times

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The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels.

Mehmet Aksoy, Ali Ahiskalioglu, Ilker Ince, Mine Celik, Aysenur Dostbil, Ufuk Kuyrukluyildiz, Durdu Altuner, Nezahat Kurt, Halis Suleyman,

Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact ... Read more >>

Exp Anim (Experimental animals)
[2015, 64(4):391-396]

Cited: 2 times

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Protective effect of resveratrol against methotrexate-induced oxidative stress in the small intestinal tissues of rats.

Aynur Arslan, Fatih Ozcicek, Ferda Keskin Cimen, Durdu Altuner, Oguzhan Yarali, Nezahat Kurt, Levent Tumkaya, Cengiz Ozturk, Halis Suleyman,

The effect of resveratrol on the damage induced by methotrexate (MTX) in rat duodenum and jejunum tissue was investigated and evaluated in comparison with famotidine. The rats were divided into four groups as healthy group (HG), resveratrol+MTX (RMTX) group, famotidine+MTX (FMTX) group and the control group which received MTX (MTXC). ... Read more >>

Int J Clin Exp Med (International journal of clinical and experimental medicine)
[2015, 8(7):10491-10500]

Cited: 7 times

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A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats.

Ilker Ince, Mehmet Aksoy, Ali Ahiskalioglu, Mehmet Comez, Aysenur Dostbil, Mine Celik, Ismayil Yilmaz, Renad Mammadov, Hasan Dogan, Basak Boztok Ozgermen, Durdu Altuner,

<h4>Background</h4>This study investigated the effects of metamizole and paracetamol on pain and oxidative stress induced by scalpel incision and carrageenan in rats.<h4>Materials and methods</h4>Total of 144 rats were divided into groups of 12 animals. Six groups each were used for scalpel incision and carrageenan tests. Pain was inflicted by applying ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2015, 28(3):173-180]

Cited: 5 times

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The effect of thiamine pyrophosphate on ethambutol-induced ocular toxicity.

Emine Cinici, Nihal Cetin, Ibrahim Ahiskali, Bahadir Suleyman, Durdu Altuner, Hamit Hakan Alp, Ebru Sener, Ilknur Calik, Halis Suleyman,

<h4>Context</h4>Ethambutol-induced retinal oxidative damage in patients with tuberculosis is still not being adequately treated. The protective effect of thiamine pyrophosphate against oxidative damage in some tissues has been reported, but no information on the protective effects of thiamine pyrophosphate against ethambutol-induced oxidative retinal damage has been found in the medical ... Read more >>

Cutan Ocul Toxicol (Cutaneous and ocular toxicology)
[2016, 35(3):222-227]

Cited: 4 times

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Effect of disulfiram on ketamine-induced cardiotoxicity in rats.

Nihal Cetin, Bahadir Suleyman, Durdu Altuner, Ufuk Kuyrukluyildiz, Fatih Ozcicek, Resit Coskun, Nazahat Kurt, Halis Suleyman,

It is known that ketamine increases the production of catecholamines, causing oxidative damage to the heart. Suppression of the production of catecholamines by disulfiram, a drug with antioxidant properties, indicates that disulfiram may decrease ketamine-induced cardiotoxicity. The objective of the present study was to investigate the effect of disulfiram on ... Read more >>

Int J Clin Exp Med (International journal of clinical and experimental medicine)
[2015, 8(8):13540-13547]

Cited: 2 times

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Effect of infliximab against cisplatin-induced nephrotoxicity.

Erkan Cure, Aynur Kirbas, Levent Tumkaya, Medine C Cure, Osman Z Sahin, Yildiray Kalkan, Suleyman Yuce, Durdu Altuner,

<h4>Objectives</h4>To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-α), prevents cisplatin (Cis)-induced nephrotoxicity.<h4>Methods</h4>The study was performed in the Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey, between November 2012 and May 2013. Thirty male Wistar albino rats were divided into 3 groups, a control ... Read more >>

Saudi Med J (Saudi medical journal)
[2014, 35(9):953-958]

Cited: 6 times

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