Full Text Journal Articles by
Author Duminda N Wijeysundera

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Perioperative risk assessment - focus on functional capacity.

Ciara Hanley, Duminda N Wijeysundera,

<h4>Purpose of review</h4>This review examines how functional capacity informs preoperative risk stratification, as well as strengths and limitations of options for estimating functional capacity.<h4>Recent findings</h4>Functional capacity (or cardiopulmonary fitness) overlaps with other important characteristics, including muscular strength, balance, and frailty. Poor functional capacity is associated with postoperative morbidity, especially noncardiovascular ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):309-316]

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2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

, Steve R Ommen, Seema Mital, Michael A Burke, Sharlene M Day, Anita Deswal, Perry Elliott, Lauren L Evanovich, Judy Hung, José A Joglar, Paul Kantor, Carey Kimmelstiel, Michelle Kittleson, Mark S Link, Martin S Maron, Matthew W Martinez, Christina Y Miyake, Hartzell V Schaff, Christopher Semsarian, Paul Sorajja, , Patrick T O'Gara, Joshua A Beckman, Glenn N Levine, Sana M Al-Khatib, Anastasia Armbruster, Kim K Birtcher, Joaquin Ciggaroa, Dave L Dixon, Lisa de Las Fuentes, Anita Deswal, Lee A Fleisher, Federico Gentile, Zachary D Goldberger, Bulent Gorenek, Norrisa Haynes, Adrian F Hernandez, Mark A Hlatky, José A Joglar, W Schuyler Jones, Joseph E Marine, Daniel Mark, Latha Palaniappan, Mariann R Piano, Jacqueline Tamis-Holland, Duminda N Wijeysundera, Y Joseph Woo,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

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The Association between Recent Cannabis Use and Suicidal Ideation in Adults: A Population-based Analysis of the NHANES from 2005 to 2018: L'association Entre L'utilisation Récente de Cannabis et L'idéation Suicidaire Chez les Adultes: Une Analyse Dans la Population de la NHANES de 2005 à 2018.

Calvin Diep, Venkat Bhat, Duminda N Wijeysundera, Hance A Clarke, Karim S Ladha,

<h4>Objective</h4>With the increasing prevalence of cannabis use, there is a growing concern about its association with depression and suicidality. The aim of this study was to examine the relationship between recent cannabis use and suicidal ideation using a nationally representative data set.<h4>Methods</h4>A cross-sectional analysis of adults was undertaken using National ... Read more >>

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2021, :706743721996112]

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The authors respond to: "Delayed discharge and frailty, delirium and functional decline".

Angela Jerath, Duminda N Wijeysundera,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2021, 193(6):E222]

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A practical overview and decision tool for analyzing recurrent events in mental illness: A review.

Tyler S Kaster, Simone N Vigod, Tara Gomes, Duminda N Wijeysundera, Daniel M Blumberger, Rinku Sutradhar,

Mental illnesses are chronic conditions in which an individual will often experience recurrent outcomes such as hospitalization, symptomatic relapse or self-harm behaviours. Most clinical research in psychiatry considers only the first event, and does not analyze subsequent recurrent events. Methods exist to analyze recurrent events; however, these methods are underused ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2021, 137:7-13]

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Association of six-minute walk test distance with postoperative complications in non-cardiac surgery: a secondary analysis of a multicentre prospective cohort study.

Ryan J Ramos, Karim S Ladha, Brian H Cuthbertson, Mark A Shulman, Paul S Myles, Duminda N Wijeysundera, ,

<h4>Purpose</h4>The six-minute walk test (6MWT) is a simple and valid test for assessing cardiopulmonary fitness. Nevertheless, the relationship between preoperative 6MWT distance and postoperative complications is uncertain. We conducted a secondary analysis of the 6MWT nested cohort substudy of the Measurement of Exercise Tolerance before Surgery study to determine if ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(4):514-529]

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Perioperative troponin screening and detection of myocardial injury.

Duminda N Wijeysundera,

Int Anesthesiol Clin (International anesthesiology clinics)
[2021, 59(1):1-8]

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Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study.

Alberto Hernández, Montserrat Viñals, Asunción Pablos, Francisco Vilás, Peter J Papadakos, Duminda N Wijeysundera, Sergio D Bergese, Marc Vives,

<h4>Background</h4>There is still no specific treatment strategies for COVID-19 other than supportive management.<h4>Design</h4>A prospective case-control study determined by admittance to the hospital based on bed availability.<h4>Participants</h4>Eighteen patients with COVID-19 infection (laboratory confirmed) severe pneumonia admitted to hospital between 20th March and 19th April 2020. Patients admitted to the hospital during ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 90:107261]

Cited: 3 times

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Delayed discharge after major surgical procedures in Ontario, Canada: a population-based cohort study.

Angela Jerath, Jason Sutherland, Peter C Austin, Dennis T Ko, Harindra C Wijeysundera, Stephen Fremes, Paul Karanicolas, Daniel McCormack, Duminda N Wijeysundera,

<h4>Background</h4>Addressing nonmedical reasons for delays in hospital discharge is important for improving the flow of patients through acute care hospital beds. Because this problem is understudied among adult surgical patients, we examined the incidence of and identified factors associated with delayed hospital discharge after major elective and emergency surgical procedures ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(46):E1440-E1452]

Cited: 2 times

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Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes.

W Scott Beattie, Manoj Lalu, Matthew Bocock, Simon Feng, Duminda N Wijeysundera, Peter Nagele, Lee A Fleisher, Andrea Kurz, Bruce Biccard, Kate Leslie, Simon Howell, Giovani Landoni, Hilary Grocott, Andre Lamy, Toby Richards, Paul Myles, ,

<h4>Background</h4>Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of perioperative cardiovascular adverse events are heterogeneous. As part of the international Standardized Endpoints in Perioperative Medicine initiative, this study aimed to find consensus amongst clinical trialists on a set of standardised and valid cardiovascular outcomes ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):56-66]

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New Opioid Use after Invasive Mechanical Ventilation and Hospital Discharge.

Hannah Wunsch, Andrea D Hill, Longdi Fu, Rob A Fowler, Han Ting Wang, Tara Gomes, Eddy Fan, David N Juurlink, Ruxandra Pinto, Duminda N Wijeysundera, Damon C Scales,

<b>Rationale:</b> Patients who receive invasive mechanical ventilation (IMV) are usually exposed to opioids as part of their sedation regimen. The rates of posthospital prescribing of opioids are unknown.<b>Objectives:</b> To determine the frequency of persistent posthospital opioid use among patients who received IMV.<b>Methods:</b> We assessed opioid-naive adults who were admitted to ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(4):568-575]

Cited: 2 times

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MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study.

Shaun M May, Tom E F Abbott, Ana G Del Arroyo, Anna Reyes, Gladys Martir, Robert C M Stephens, David Brealey, Brian H Cuthbertson, Duminda N Wijeysundera, Rupert M Pearse, Gareth L Ackland,

<h4>Background</h4>Elevated plasma or serum troponin, indicating perioperative myocardial injury (PMI), is common after noncardiac surgery. However, underlying mechanisms remain unclear. Acute coronary syndrome (ACS) is associated with the early appearance of circulating microRNAs, which regulate post-translational gene expression. We hypothesised that if PMI and ACS share pathophysiological mechanisms, common microRNA ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(5):661-671]

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A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study.

Bernhard Riedel, Michael H-G Li, C H Angus Lee, Hilmy Ismail, Brian H Cuthbertson, Duminda N Wijeysundera, Kwok M Ho, ,

<h4>Background</h4>Accurate assessment of functional capacity, a predictor of postoperative morbidity and mortality, is essential to improving surgical planning and outcomes. We assessed if all 12 items of the Duke Activity Status Index (DASI) were equally important in reflecting exercise capacity.<h4>Methods</h4>In this secondary cross-sectional analysis of the international, multicentre Measurement of ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):181-190]

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Patient-level Characteristics and Inequitable Access to Inpatient Electroconvulsive Therapy for Depression: A Population-based Cross-sectional Study: Caractéristiques au niveau du patient et accès inéquitable à la thérapie électroconvulsive pour patients hospitalisés.

Tyler S Kaster, Daniel M Blumberger, Tara Gomes, Rinku Sutradhar, Zafiris J Dasklakis, Duminda N Wijeysundera, Simone N Vigod,

<h4>Objective</h4>A variety of patient characteristics drive the use of electroconvulsive therapy (ECT) in depression. However, the extent to which each characteristic influences the receipt of ECT, and whether they are appropriate, is unknown. The aim of this study is to identify patient-level characteristics associated with receiving inpatient ECT for depression.<h4>Method</h4>We ... Read more >>

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2021, 66(2):147-158]

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Association between mothers' postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort study.

Jennifer Bethell, Mark D Neuman, Brian T Bateman, Karim S Ladha, Andrea Hill, Guohua Li, Duminda N Wijeysundera, Hannah Wunsch,

<h4>Background</h4>Postoperative opioid prescriptions may be associated with risks of unintentional poisoning and drug diversion in other household members. The objective of this study was to explore the association between mothers' postoperative opioid prescriptions and incidence of opioid-related events in their children (aged 1 to 24 years).<h4>Data and methods</h4>This retrospective cohort ... Read more >>

Health Rep (Health reports)
[2020, 31(6):12-19]

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Ozone therapy for patients with COVID-19 pneumonia: a Quasi-Randomized Controlled Trial

Alberto Hernández, Montserrat Viñals, Asunción Pablos, Francisco Vilás, Peter Papadakos, Duminda Wijeysundera, Sergio Bergese, Marc Vives,

<h4>Background</h4> There is still no specific treatment strategies for COVID-19 other than supportive management. The potential biological benefits of ozonated autohemotherapy include reduced tissue hypoxia, decreased hypercoagulability, modulated immune function with inhibition of inflammatory mediators, improved phagocytic function, and impaired viral replication. <h4>Objective</h4> To determine the impact of the use ... Read more >>

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Association of preoperative spirometry with cardiopulmonary fitness and postoperative outcomes in surgical patients: A multicentre prospective cohort study.

Ashwin Sankar, Kevin E Thorpe, Andrea S Gershon, John T Granton, Duminda N Wijeysundera,

<h4>Background</h4>Preoperative spirometry and cardiopulmonary exercise testing (CPET) may stratify risk for respiratory complications. This secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study examined whether CPET performance (i.e., cardiopulmonary fitness) confounds associations of spirometry with outcomes.<h4>Methods</h4>The analysis included 1200 participants having major non-cardiac surgery at 25 hospitals ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 23:100396]

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Persistent Postoperative Opioid Use: A Systematic Literature Search of Definitions and Population-based Cohort Study.

Naheed K Jivraj, Faizal Raghavji, Jennifer Bethell, Duminda N Wijeysundera, Karim S Ladha, Brian T Bateman, Mark D Neuman, Hannah Wunsch,

BACKGROUND:While persistent opioid use after surgery has been the subject of a large number of studies, it is unknown how much variability in the definition of persistent use impacts the reported incidence across studies. The objective was to evaluate the incidence of persistent use estimated with different definitions using a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(6):1528-1539]

Cited: 4 times

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The association between patient-reported pain scores and physical activity in the postoperative period: A prospective observational study.

Calvin Diep, Dorothy Wong, Duminda N Wijeysundera, Joel Katz, Hance A Clarke, Karim S Ladha,

J Clin Anesth (Journal of clinical anesthesia)
[2020, 66:109916]

Cited: 0 times

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Recommendations for the Prescription of Opioids at Discharge After Abdominopelvic Surgery: A Systematic Review.

David D Q Zhang, Fahima Dossa, Anuj Arora, Maria C Cusimano, Brittany Speller, Tari Little, Karim Ladha, Savtaj Brar, David R Urbach, Andrea C Tricco, Duminda N Wijeysundera, Hance A Clarke, Nancy N Baxter,

<h4>Importance</h4>The prescription of opioids at discharge after abdominopelvic surgery is variable and often excessive. A lack of guidance for abdominopelvic surgeons may explain the suboptimal nature of current prescribing practices.<h4>Objective</h4>To systematically review existing recommendations on the prescription of opioids at discharge, the appropriate disposal of opioids, and the prevention of ... Read more >>

JAMA Surg (JAMA surgery)
[2020, 155(5):420-429]

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Drug Enforcement Agency 2014 Hydrocodone Rescheduling Rule and Opioid Dispensing after Surgery.

Mark D Neuman, Sean Hennessy, Dylan S Small, Craig Newcomb, Lakisha Gaskins, Colleen M Brensinger, Duminda N Wijeysundera, Brian T Bateman, Hannah Wunsch,

<h4>Background</h4>In 2014, the U.S. Drug Enforcement Agency reclassified hydrocodone from Schedule III to Schedule II of the Controlled Substances Act, resulting in new restrictions on refills. The authors hypothesized that hydrocodone rescheduling led to decreases in total opioid dispensing within 30 days of surgery and reduced new long-term opioid dispensing ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(5):1151-1164]

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Subomohyoid Anterior Suprascapular Block versus Interscalene Block for Arthroscopic Shoulder Surgery: A Multicenter Randomized Trial.

Faraj W Abdallah, Duminda N Wijeysundera, Andreas Laupacis, Richard Brull, Aaron Mocon, Nasir Hussain, Kevin E Thorpe, Vincent W S Chan,

BACKGROUND:Interscalene brachial plexus block, the pain relief standard for shoulder surgery, is an invasive technique associated with important complications. The subomohyoid anterior suprascapular block is a potential alternative, but evidence of its comparative analgesic effect is sparse. The authors tested the hypothesis that anterior suprascapular block is noninferior to interscalene ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):839-853]

Cited: 1 time

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Socioeconomic Status and Days Alive and Out of Hospital after Major Elective Noncardiac Surgery: A Population-based Cohort Study.

Angela Jerath, Peter C Austin, Dennis T Ko, Harindra C Wijeysundera, Stephen Fremes, Daniel McCormack, Duminda N Wijeysundera,

BACKGROUND:Socioeconomic status is an important but understudied determinant of preoperative health status and postoperative outcomes. Previous work has focused on the impact of socioeconomic status on mortality, hospital stay, or complications. However, individuals with low socioeconomic status are also likely to have fewer supports to facilitate them remaining at home ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):713-722]

Cited: 1 time

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Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries: A Retrospective Cohort Analysis.

Akash Goel, Brandon McGuinness, Naheed K Jivraj, Duminda N Wijeysundera, Murray A Mittleman, Brian T Bateman, Hance Clarke, Lakshmi P Kotra, Karim S Ladha,

<h4>Background</h4>Although cannabis is known to have cardiovascular and psychoactive effects, the implications of its use before surgery are currently unknown. The objective of the present study was to determine whether patients with an active cannabis use disorder have an elevated risk of postoperative complications.<h4>Methods</h4>The authors conducted a retrospective population-based cohort ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):625-635]

Cited: 4 times

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Impact of postoperative intensive care unit utilization on postoperative outcomes in adults undergoing major elective noncardiac surgery.

Angela Jerath, Peter C Austin, Daniel McCormack, Duminda N Wijeysundera,

OBJECTIVE:There is a wide variation between hospitals with respect to rates of use of postoperative intensive care unit (ICU) after major noncardiac surgery. Whether ICU care improves patient-centered outcomes remains unknown. Days alive and out of hospital (DAH) is a novel patient-centered outcome that has been validated for surgical patients. ... Read more >>

J Clin Anesth (Journal of clinical anesthesia)
[2020, 62:109707]

Cited: 0 times

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