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Author Dudley J. Pennell

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Imaging Findings of COVID-19-Related Cardiovascular Complications

Eleni Nakou, Estefania De Garate, Kate Liang, Matthew Williams, Dudley J. Pennell, Chiara Bucciarelli-Ducci,

Other than respiratory disease, patients with coronavirus disease 2019 (COVID-19) commonly have cardiovascular manifestations, which are recognised as significant risk factors for increased mortality. COVID-19 patients may present with a wide spectrum of clinical presentations ranging from asymptomatic heart disease detected incidentally by cardiac investigations (troponin, BNP, imaging) to cardiogenic ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement.

Vassilios S Vassiliou, Menelaos Pavlou, Tamir Malley, Brian P Halliday, Vasiliki Tsampasian, Claire E Raphael, Gary Tse, Miguel Silva Vieira, Dominique Auger, Russell Everett, Calvin Chin, Francisco Alpendurada, John Pepper, Dudley J Pennell, David E Newby, Andrew Jabbour, Marc R Dweck, Sanjay K Prasad,

The increasing prevalence of patients with aortic stenosis worldwide highlights a clinical need for improved and accurate prediction of clinical outcomes following surgery. We investigated patient demographic and cardiovascular magnetic resonance (CMR) characteristics to formulate a dedicated risk score estimating long-term survival following surgery. We recruited consecutive patients undergoing CMR ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):20183]

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Left ventricular noncompaction in pediatric population: could cardiovascular magnetic resonance derived fractal analysis aid diagnosis?

Sylvia Krupickova, Suzan Hatipoglu, Giovanni DiSalvo, Inga Voges, Daniel Redfearn, Sandrine Foldvari, Christian Eichhorn, Sian Chivers, Filippo Puricelli, Grazia Delle-Donne, Courtney Barth, Dudley J Pennell, Sanjay K Prasad, Piers E F Daubeney,

<h4>Background</h4>Cardiovascular magnetic resonance (CMR) derived fractal analysis of the left ventricle (LV) has been shown in adults to be a useful quantitative measure of trabeculation with high reproducibility and accuracy for the diagnosis of LV non-compaction (LVNC). The aim of this study was to investigate the utility and feasibility of ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):90]

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Heart Rate as a Marker of Relapse During Withdrawal of Therapy in Recovered Dilated Cardiomyopathy.

Brian P Halliday, Ali Vazir, Ruth Owen, John Gregson, Rebecca Wassall, Amrit S Lota, Zohya Khalique, Upasana Tayal, Richard E Jones, Daniel Hammersley, Antonis Pantazis, A John Baksi, Stuart Rosen, Dudley J Pennell, Martin R Cowie, John G F Cleland, Sanjay K Prasad,

<h4>Objectives</h4>The objective of this study was to determine the relationship between heart rate and relapse among patients in the TRED-HF (Therapy withdrawal in REcovered Dilated cardiomyopathy trial).<h4>Background</h4>Understanding markers and mechanisms of relapse among patients with recovered dilated cardiomyopathy (DCM) may enable personalized management.<h4>Methods</h4>The relationship between serial heart rate measurements and ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2021, 9(7):509-517]

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CMR unveiling the cause of post CoVid-19 infection chest pain.

Suzan Hatipoglu, Alexander R Lyon, Dudley J Pennell,

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2021, 37(6):2025-2026]

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Cardiovascular magnetic resonance normal values in children for biventricular wall thickness and mass.

Sylvia Krupickova, Julian Risch, Sabiha Gati, Amke Caliebe, Samir Sarikouch, Philipp Beerbaum, Filippo Puricelli, Piers E F Daubeney, Courtney Barth, Rick Wage, Simona Boroni Grazioli, Anselm Uebing, Dudley J Pennell, Inga Voges,

<h4>Background</h4>Pediatric patients are becoming increasingly referred for cardiovascular magnetic resonance (CMR). Measurement of ventricular wall thickness is typically part of the assessment and can be of diagnostic importance, e.g. in arterial hypertension. However, normal values for left ventricular (LV) and right ventricular (RV) wall thickness in pediatric patients are lacking. ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):1]

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Cardiovascular magnetic resonance predictors of heart failure in hypertrophic cardiomyopathy: the role of myocardial replacement fibrosis and the microcirculation.

Claire E Raphael, Frances Mitchell, Gajen Sunthar Kanaganayagam, Alphonsus C Liew, Elisa Di Pietro, Miguel Silva Vieira, Lina Kanapeckaite, Simon Newsome, John Gregson, Ruth Owen, Li-Yueh Hsu, Vassilis Vassiliou, Robert Cooper, Aamir Ali Mrcp, Tevfik F Ismail, Brandon Wong, Kristi Sun, Peter Gatehouse, David Firmin, Stuart Cook, Michael Frenneaux, Andrew Arai, Rory O'Hanlon, Dudley J Pennell, Sanjay K Prasad,

<h4>Introduction</h4>Heart failure (HF) in hypertrophic cardiomyopathy (HCM) is associated with high morbidity and mortality. Predictors of HF, in particular the role of myocardial fibrosis and microvascular ischemia remain unclear. We assessed the predictive value of cardiovascular magnetic resonance (CMR) for development of HF in HCM in an observational cohort study.<h4>Methods</h4>Serial ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):26]

Cited: 1 time

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Oxidised LDL and Anti-Oxidised LDL Antibodies Are Reduced by Lipoprotein Apheresis in a Randomised Controlled Trial on Patients with Refractory Angina and Elevated Lipoprotein(a).

Tina Z Khan, Adam Hartley, Dorian Haskard, Mikhail Caga-Anan, Dudley J Pennell, Peter Collins, Mahmoud Barbir, Ramzi Khamis,

<b>Aims:</b> An abundance of epidemiological evidence demonstrates that elevated lipoprotein(a) (Lp(a)) represents a significant contributing risk factor towards the development of cardiovascular disease. In particular, raised Lp(a) may play a mechanistic role in patients with refractory angina. Studies have also shown a correlation between oxidised LDL (oxLDL) levels and atherosclerotic ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(1):]

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Late-Gadolinium Enhancement Interface Area and Electrophysiological Simulations Predict Arrhythmic Events in Patients With Nonischemic Dilated Cardiomyopathy.

Gabriel Balaban, Brian P Halliday, Bradley Porter, Wenjia Bai, Ståle Nygåard, Ruth Owen, Suzan Hatipoglu, Nuno Dias Ferreira, Cemil Izgi, Upasana Tayal, Ben Corden, James Ware, Dudley J Pennell, Daniel Rueckert, Gernot Plank, Christopher A Rinaldi, Sanjay K Prasad, Martin J Bishop,

<h4>Objectives</h4>This study sought to investigate whether shape-based late gadolinium enhancement (LGE) metrics and simulations of re-entrant electrical activity are associated with arrhythmic events in patients with nonischemic dilated cardiomyopathy (NIDCM).<h4>Background</h4>The presence of LGE predicts life-threatening ventricular arrhythmias in NIDCM; however, risk stratification remains imprecise. LGE shape and simulations of electrical ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(2):238-249]

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SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.

Tim Leiner, Jan Bogaert, Matthias G Friedrich, Raad Mohiaddin, Vivek Muthurangu, Saul Myerson, Andrew J Powell, Subha V Raman, Dudley J Pennell,

The Society for Cardiovascular Magnetic Resonance (SCMR) last published its comprehensive expert panel report of clinical indications for CMR in 2004. This new Consensus Panel report brings those indications up to date for 2020 and includes the very substantial increase in scanning techniques, clinical applicability and adoption of CMR worldwide. We ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2020, 22(1):76]

Cited: 10 times

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Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update : Society for Cardiovascular Magnetic Resonance (SCMR): Board of Trustees Task Force on Standardized Post-Processing.

Jeanette Schulz-Menger, David A Bluemke, Jens Bremerich, Scott D Flamm, Mark A Fogel, Matthias G Friedrich, Raymond J Kim, Florian von Knobelsdorff-Brenkenhoff, Christopher M Kramer, Dudley J Pennell, Sven Plein, Eike Nagel,

With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters, however, agreement on specific standards for the interpretation and post-processing of CMR studies is required ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2020, 22(1):19]

Cited: 51 times

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Diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy: a comparison of motion-compensated spin echo and stimulated echo techniques.

Zohya Khalique, Andrew D Scott, Pedro F Ferreira, Sonia Nielles-Vallespin, David N Firmin, Dudley J Pennell,

<h4>Objectives</h4>Diffusion tensor cardiovascular magnetic resonance (DT-CMR) interrogates myocardial microstructure. Two frequently used in vivo DT-CMR techniques are motion-compensated spin echo (M2-SE) and stimulated echo acquisition mode (STEAM). Whilst M2-SE is strain-insensitive and signal to noise ratio efficient, STEAM has a longer diffusion time and motion compensation is unnecessary. Here we compare STEAM and ... Read more >>

MAGMA (Magma (New York, N.Y.))
[2020, 33(3):331-342]

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Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators.

Ben Corden, Julian Jarman, Nicola Whiffin, Upasana Tayal, Rachel Buchan, Joban Sehmi, Andrew Harper, William Midwinter, Karen Lascelles, Vias Markides, Mark Mason, John Baksi, Antonis Pantazis, Dudley J Pennell, Paul J Barton, Sanjay K Prasad, Tom Wong, Stuart A Cook, James S Ware,

<h4>Importance</h4>There is a need for better arrhythmic risk stratification in nonischemic dilated cardiomyopathy (DCM). Titin-truncating variants (TTNtvs) in the TTN gene are the most common genetic cause of DCM and may be associated with higher risk of arrhythmias in patients with DCM.<h4>Objective</h4>To determine if TTNtv status is associated with the ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(6):e196520]

Cited: 4 times

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Osteoprotegerin and Myocardial Fibrosis in Patients with Aortic Stenosis.

Brodie L Loudon, Eleana Ntatsaki, Simon Newsome, Brian Halliday, Amrit Lota, Aamir Ali, Tamir Malley, Subothini Selvendran, Nikhil Aggarwal, Willis Lam, Jackie Donovan, Dominque Auger, Claire E Raphael, Paul D Flynn, Dudley J Pennell, Vassilios S Vassiliou, Sanjay K Prasad,

Left ventricular myocardial fibrosis in patients with aortic stenosis (AS) confers worse prognosis. Plasma osteoprotegerin (OPG), a cytokine from the TNF receptor family, correlates with the degree of valve calcification in AS, reflecting the activity of the tissue RANKL/RANK/OPG (receptor activator of nuclear factor κΒ ligand/RANK/osteoprotegerin) axis, and is associated ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):14550]

Cited: 2 times

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Outcome in Dilated Cardiomyopathy Related to the Extent, Location, and Pattern of Late Gadolinium Enhancement.

Brian P Halliday, A John Baksi, Ankur Gulati, Aamir Ali, Simon Newsome, Cemil Izgi, Monika Arzanauskaite, Amrit Lota, Upasana Tayal, Vassilios S Vassiliou, John Gregson, Francisco Alpendurada, Michael P Frenneaux, Stuart A Cook, John G F Cleland, Dudley J Pennell, Sanjay K Prasad,

<h4>Objectives</h4>This study sought to investigate the association between the extent, location, and pattern of late gadolinium enhancement (LGE) and outcome in a large dilated cardiomyopathy (DCM) cohort.<h4>Background</h4>The relationship between LGE and prognosis in DCM is incompletely understood.<h4>Methods</h4>The authors examined the association between LGE and all-cause mortality and a sudden cardiac ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2019, 12(8 Pt 2):1645-1655]

Cited: 38 times

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Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy.

Brian P Halliday, Ankur Gulati, Aamir Ali, Simon Newsome, Amrit Lota, Upasana Tayal, Vassilios S Vassiliou, Monika Arzanauskaite, Cemil Izgi, Kaushiga Krishnathasan, Arvind Singhal, Kayla Chiew, John Gregson, Michael P Frenneaux, Stuart A Cook, Dudley J Pennell, Peter Collins, John G F Cleland, Sanjay K Prasad,

<h4>Aim</h4>To evaluate the relationship between sex, age and outcome in dilated cardiomyopathy (DCM).<h4>Methods and results</h4>We used proportional hazard modelling to examine the association between sex, age and all-cause mortality in consecutive patients with DCM. Overall, 881 patients (290 women, median age 52 years) were followed for a median of 4.9 years. Women ... Read more >>

Eur J Heart Fail (European journal of heart failure)
[2018, 20(10):1392-1400]

Cited: 23 times

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An in-vivo comparison of stimulated-echo and motion compensated spin-echo sequences for 3 T diffusion tensor cardiovascular magnetic resonance at multiple cardiac phases.

Andrew D Scott, Sonia Nielles-Vallespin, Pedro F Ferreira, Zohya Khalique, Peter D Gatehouse, Philip Kilner, Dudley J Pennell, David N Firmin,

BACKGROUND:Stimulated-echo (STEAM) and, more recently, motion-compensated spin-echo (M2-SE) techniques have been used for in-vivo diffusion tensor cardiovascular magnetic resonance (DT-CMR) assessment of cardiac microstructure. The two techniques differ in the length scales of diffusion interrogated, their signal-to-noise ratio efficiency and sensitivity to both motion and strain. Previous comparisons of the ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2018, 20(1):1]

Cited: 15 times

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Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot.

Matthew Cauldwell, Michael A Quail, Gillian S Smith, Ee Ling Heng, Sarah Ghonim, Anselm Uebing, Lorna Swan, Wei Li, Roshni R Patel, Dudley J Pennell, Philip J Steer, Mark R Johnson, Michael A Gatzoulis, Sonya V Babu-Narayan,

<h4>Background</h4>The aim was to assess whether cardiovascular adaptation to pregnancy in women with repaired tetralogy of Fallot (TOF) adversely affects hemodynamic stability, in particular with respect to right ventricular (RV) dilatation, pulmonary regurgitation, or aortic root dilatation.<h4>Methods and results</h4>This was a retrospective cohort study of women with repaired TOF with ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(7):]

Cited: 3 times

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Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study.

Ee Ling Heng, Michael A Gatzoulis, Anselm Uebing, Babulal Sethia, Hideki Uemura, Gillian C Smith, Gerhard-Paul Diller, Karen P McCarthy, Siew Yen Ho, Wei Li, Piers Wright, Veronica Spadotto, Philip J Kilner, Paul Oldershaw, Dudley J Pennell, Darryl F Shore, Sonya V Babu-Narayan,

BACKGROUND:Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm post-PVR changes and predictors of reverse remoeling. METHODS:Fifty-seven patients with ... Read more >>

Circulation (Circulation)
[2017, 136(18):1703-1713]

Cited: 14 times

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Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction.

Brian P Halliday, Ankur Gulati, Aamir Ali, Kaushik Guha, Simon Newsome, Monika Arzanauskaite, Vassilios S Vassiliou, Amrit Lota, Cemil Izgi, Upasana Tayal, Zohya Khalique, Colin Stirrat, Dominique Auger, Nilesh Pareek, Tevfik F Ismail, Stuart D Rosen, Ali Vazir, Francisco Alpendurada, John Gregson, Michael P Frenneaux, Martin R Cowie, John G F Cleland, Stuart A Cook, Dudley J Pennell, Sanjay K Prasad,

<h4>Background</h4>Current guidelines only recommend the use of an implantable cardioverter defibrillator in patients with dilated cardiomyopathy for the primary prevention of sudden cardiac death (SCD) in those with a left ventricular ejection fraction (LVEF) <35%. However, registries of out-of-hospital cardiac arrests demonstrate that 70% to 80% of such patients have ... Read more >>

Circulation (Circulation)
[2017, 135(22):2106-2115]

Cited: 81 times

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Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction.

Vassilios S Vassiliou, Katharina Wassilew, Donnie Cameron, Ee Ling Heng, Evangelia Nyktari, George Asimakopoulos, Anthony de Souza, Shivraman Giri, Iain Pierce, Andrew Jabbour, David Firmin, Michael Frenneaux, Peter Gatehouse, Dudley J Pennell, Sanjay K Prasad,

<h4>Objectives</h4>Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T <sub>1</sub> mapping versus assessment at a single ventricular level.<h4>Materials and methods</h4>For assessment of T <sub>1</sub> mapping precision, a cohort of 15 healthy ... Read more >>

MAGMA (Magma (New York, N.Y.))
[2018, 31(1):101-113]

Cited: 4 times

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Characterization of left and right atrial function in healthy volunteers by cardiovascular magnetic resonance.

Alicia M Maceira, Juan Cosin-Sales, Sanjay K Prasad, Dudley J Pennell,

<h4>Background</h4>Left and right atrial function show a different pattern in advanced age in order to maintain adequate ventricular filling. It has been shown that left atrial (LA) function has a prognostic value in a number of heart conditions. Cardiovascular magnetic resonance (CMR) provides high quality images of the left and ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2016, 18(1):64]

Cited: 21 times

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Magnetic resonance imaging phantoms for quality-control of myocardial T1 and ECV mapping: specific formulation, long-term stability and variation with heart rate and temperature.

Vassilios S Vassiliou, Ee Ling Heng, Peter D Gatehouse, Jacqueline Donovan, Claire E Raphael, Shivraman Giri, Sonya V Babu-Narayan, Michael A Gatzoulis, Dudley J Pennell, Sanjay K Prasad, David N Firmin,

<h4>Background</h4>Magnetic resonance imaging (MRI) phantoms are routinely used for quality assurance in MRI centres; however their long term stability for verification of myocardial T1/ extracellular volume fraction (ECV) mapping has never been investigated.<h4>Methods</h4>Nickel-chloride agarose gel phantoms were formulated in a reproducible laboratory procedure to mimic blood and myocardial T1 and ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2016, 18(1):62]

Cited: 10 times

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Body Surface Area and Baseline Blood Pressure Predict Subclinical Anthracycline Cardiotoxicity in Women Treated for Early Breast Cancer.

Paul Kotwinski, Gillian Smith, Jackie Cooper, Julie Sanders, Louise Ma, Albert Teis, David Kotwinski, Michael Mythen, Dudley J Pennell, Alison Jones, Hugh Montgomery, ,

<h4>Background and aims</h4>Anthracyclines are highly effective chemotherapeutic agents which may cause long-term cardiac damage (chronic anthracycline cardiotoxicity) and heart failure. The pathogenesis of anthracycline cardiotoxicity remains incompletely understood and individual susceptibility difficult to predict. We sought clinical features which might contribute to improved risk assessment.<h4>Methods</h4>Subjects were women with early breast ... Read more >>

PLoS One (PloS one)
[2016, 11(12):e0165262]

Cited: 10 times

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Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis.

Claire E Raphael, Jennifer Keegan, Kim H Parker, Robin Simpson, Julian Collinson, Vass Vassiliou, Ricardo Wage, Peter Drivas, Stephen Strain, Robert Cooper, Ranil de Silva, Rod H Stables, Carlo Di Mario, Michael Frenneaux, Dudley J Pennell, Justin E Davies, Alun D Hughes, David Firmin, Sanjay K Prasad,

<h4>Background</h4>Wave intensity analysis (WIA) of the coronary arteries allows description of the predominant mechanisms influencing coronary flow over the cardiac cycle. The data are traditionally derived from pressure and velocity changes measured invasively in the coronary artery. Cardiovascular magnetic resonance (CMR) allows measurement of coronary velocities using phase velocity mapping ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2016, 18(1):93]

Cited: 4 times

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