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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

Cited: 0 times

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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Association of gastric emptying with postprandial appetite and satiety sensations in obesity.

Daniel Gonzalez-Izundegui, Alejandro Campos, Gerardo Calderon, Maria L Ricardo-Silgado, Lizeth Cifuentes, Paul A Decker, Eric J Vargas, Linh Tran, Duane Burton, Barham Abu Dayyeh, Michael Camilleri, Jeanette E Eckel-Passow, Andres Acosta,

<h4>Objective</h4>Satiety, defined as the duration of the sensation of fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, the association between gastric emptying (GE) and VAS appetite is unknown.<h4>Methods</h4>In this cross-sectional study, 134 participants (mean [SEM] ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(9):1497-1507]

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Randomised study: effects of the 5-HT4 receptor agonist felcisetrag vs placebo on gut transit in patients with gastroparesis.

Victor Chedid, Justin Brandler, Kayla Arndt, Priya Vijayvargiya, Xiao Jing Wang, Duane Burton, W Scott Harmsen, Jenifer Siegelman, Chunlin Chen, Yinzhong Chen, Cristina Almansa, George Dukes, Michael Camilleri,

<h4>Background</h4>Gastroparesis is defined by delayed gastric emptying with associated symptoms in the absence of mechanical obstruction.<h4>Aim</h4>To evaluate pharmacokinetics and pharmacodynamics of felcisetrag, a highly selective 5-HT<sub>4</sub> receptor agonist, on total gut transit in patients with documented delayed gastric emptying of solids.<h4>Methods</h4>Single-centre, placebo-controlled study of 36 participants receiving placebo, 0.1mg, 0.3mg ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(9):1010-1020]

Cited: 2 times

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Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic.

Andres Acosta, Michael Camilleri, Barham Abu Dayyeh, Gerardo Calderon, Daniel Gonzalez, Alison McRae, William Rossini, Sneha Singh, Duane Burton, Matthew M Clark,

<h4>Objective</h4>Little is known about the predictors of response to obesity interventions.<h4>Methods</h4>In 450 participants with obesity, body composition, resting energy expenditure, satiety, satiation, eating behavior, affect, and physical activity were measured by validated studies and questionnaires. These variables were used to classify obesity phenotypes. Subsequently, in a 12-month, pragmatic, real-world trial ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(4):662-671]

Cited: 0 times

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Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers.

Xiao Jing Wang, Duane D Burton, Margaret Breen-Lyles, Michael Camilleri,

Gastric emptying and gastric accommodation play a role in generation of upper gastrointestinal symptoms. Although both functions have been measured simultaneously using MRI or <sup>99m</sup>Tc SPECT methodology, the correlation of these two functions has not been evaluated simultaneously using a solid and liquid meal. To study relationships of whole or ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(5):G759-G767]

Cited: 2 times

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Randomised clinical trial: significant biochemical and colonic transit effects of the farnesoid X receptor agonist tropifexor in patients with primary bile acid diarrhoea.

Michael Camilleri, Sara Linker Nord, Duane Burton, Ibironke Oduyebo, Yiming Zhang, Jin Chen, Koeun Im, Prafulla Bhad, Michael K Badman, David S Sanders, Julian R F Walters,

<h4>Background</h4>In primary bile acid diarrhoea, feedback by farnesoid X receptor (FXR) and fibroblast growth hormone 19 (FGF19) on hepatic bile acid production is impaired.<h4>Aims</h4>To evaluate the safety, mechanisms and efficacy of negative feedback by FXR activation with tropifexor, a non-bile acid FXR agonist, in patients with primary bile acid diarrhoea.<h4>Methods</h4>In ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(5):808-820]

Cited: 2 times

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Associations of gastric volumes, ingestive behavior, calorie and volume intake, and fullness in obesity.

Priya Vijayvargiya, Victor Chedid, Xiao Jing Wang, Jessica Atieh, Daniel Maselli, Duane D Burton, Matthew M Clark, Andres Acosta, Michael Camilleri,

Whereas gastric emptying significantly predicts calorie intake, the association between gastric capacity and satiation and satiety is unclear. To study the associations between gastric volumes and ingestive behaviors with satiation and satiety in obesity, 62 healthy adult obese patients (57 female) with no eating disorders underwent measurements of satiety, as ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2020, 319(2):G238-G244]

Cited: 1 time

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Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes.

Gerardo Calderon, Alison McRae, Juraj Rievaj, Judith Davis, Inuk Zandvakili, Sara Linker-Nord, Duane Burton, Geoffrey Roberts, Frank Reimann, Bronislava Gedulin, Adrian Vella, Nicholas F LaRusso, Michael Camilleri, Fiona M Gribble, Andres Acosta,

<h4>Background</h4>The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to determine whether the BA pathway is altered and correctable in human obesity and diabetes.<h4>Methods</h4>We conducted 3 investigations: 1) BA receptor pathways were studied ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 55:102759]

Cited: 4 times

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GLP-1 Analog Modulates Appetite, Taste Preference, Gut Hormones, and Regional Body Fat Stores in Adults with Obesity.

Hoda Kadouh, Victor Chedid, Houssam Halawi, Duane D Burton, Matthew M Clark, Disha Khemani, Adrian Vella, Andres Acosta, Michael Camilleri,

<h4>Purpose</h4>Obesity is associated with alterations in appetite, gastrointestinal hormone levels and excessive fat mass. We previously published a double-blind, placebo-controlled, randomized, 16-week trial on effects of once-daily glucagon-like peptide-1 (GLP-1) analog, liraglutide on weight, satiation, and gastric functions in obese volunteers. The aim of this substudy is to compare to ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(5):]

Cited: 9 times

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Association between gastrointestinal phenotypes and weight gain in younger adults: a prospective 4-year cohort study.

Gregory Pajot, Michael Camilleri, Gerardo Calderon, Judith Davis, Deborah Eckert, Duane Burton, Andres Acosta,

<h4>Background/objectives</h4>Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain in younger adults.<h4>Subjects/methods</h4>At baseline, 126 adult participants under the ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2020, 44(12):2472-2478]

Cited: 3 times

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Physical activity is associated with accelerated gastric emptying and increased ghrelin in obesity.

Judith Davis, Michael Camilleri, Deborah Eckert, Duane Burton, Michael Joyner, Andres Acosta,

<h4>Background</h4>Rapid gastric emptying, increased food intake, and alterations in gastrointestinal hormones are associated with obesity. The effect of regular physical activity (PA) on food intake, gastric emptying (GE), gastric accommodation, and gastrointestinal (GI) hormones in adults with obesity remains unclear. Our aim was to compare, at time of presentation, weight ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(11):e13879]

Cited: 3 times

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Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients With Bile Acid Diarrhea in a Randomized Trial.

Priya Vijayvargiya, Michael Camilleri, Paula Carlson, Asha Nair, Sara Linker Nord, Michael Ryks, Deborah Rhoten, Duane Burton, Irene Busciglio, Alan Lueke, W Scott Harmsen, Leslie J Donato,

<h4>Background & aims</h4>Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of colesevelam on bowel functions, consistent with luminal BA sequestration by colesevelam. We compared the effects of colesevelam vs placebo on symptoms and gene expression patterns in the ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(13):2962-2970.e6]

Cited: 2 times

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Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial.

Justin Brandler, Laurence J Miller, Xiao Jing Wang, Duane Burton, Irene Busciglio, Kayla Arndt, William S Harmsen, Michael Camilleri,

Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD). Secretin is a key regulator of GA in animal studies. Our aim was to study the effects of secretin on gastric motility, satiation, postprandial symptoms, and key hormones. We performed two double-blind, randomized, saline-controlled crossover trials ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2020, 318(4):G635-G645]

Cited: 2 times

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Utility of the plasma pancreatic polypeptide response to modified sham feeding in diabetic gastroenteropathy and non-ulcer dyspepsia.

Anshuman Desai, Phillip A Low, Michael Camilleri, Wolfgang Singer, Duane Burton, Subhankar Chakraborty, Adil E Bharucha,

<h4>Background</h4>The relationship between cardiovascular and gastrointestinal (ie, plasma pancreatic polypeptide [PP] response to modified sham feeding [MSF]) indices of vagal function is unclear. Hyperglycemia inhibits PP secretion via vagally mediated mechanisms. Our aims were to (a) compare the PP response, (b) its relationship with glycemia, and (c) the relationship between ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(2):e13744]

Cited: 1 time

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Increased fecal primary bile acids in multiple myeloma with engraftment syndrome diarrhea after stem cell transplant.

Priya Vijayvargiya, Wilson Gonsalves, Duane Burton, William J Hogan, Teresa Miceli, William Rossini, Ann Taylor, Alan Lueke, Leslie Donato, Michael Camilleri,

Autologous stem cell transplant (ASCT) for multiple myeloma (MM) is associated with diarrhea during the peri-transplant period. We aimed to appraise mechanisms of peri-ASCT diarrhea in a prospective, longitudinal study of patients with MM. We compared by repeated measures (RM)-ANOVA daily bowel movements (BMs) and consistency [7-point Bristol Stool Form ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2019, 54(11):1898-1907]

Cited: 0 times

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Relationship between symptoms during a gastric emptying study and intestinal chemosensitivity with daily symptoms.

Subhankar Chakraborty, Anshuman Desai, Magnus Halland, Duane Burton, Michael Camilleri, Alan R Zinsmeister, Adil E Bharucha,

<h4>Background</h4>Non-ulcer dyspepsia (NUD) is a heterogeneous disorder, which is characterized by upper gastrointestinal symptoms and sensorimotor disturbances, including abnormal gastric emptying (GE) and increased intestinal chemosensitivity, and associated with greater plasma glucagon-like peptide-1 (GLP-1) levels during duodenal lipid infusion. However, the relationship(s) between these disturbances and daily symptoms in NUD ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2019, 31(10):e13686]

Cited: 3 times

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Correction: Activated T-Follicular Helper 2 Cells Are Associated With Disease Activity in IgG4-Related Sclerosing Cholangitis and Pancreatitis.

Michael Camilleri, Paula Carlson, Victor Chedid, Priya Vijayvargiya, Duane Burton, Irene Busciglio,

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2019, 10(5):1]

Cited: 0 times

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Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea.

Michael Camilleri, Paula Carlson, Victor Chedid, Priya Vijayvargiya, Duane Burton, Irene Busciglio,

<h4>Introduction</h4>Aquaporin (AQP) channels are involved in regulating fluid homeostasis in the colon. Several AQP channels were detected in human colon epithelial cells. In a previous study, rats fed 1% (wt/wt) sodium cholate had increased AQP3, 7, and 8 levels, suggesting AQP involvement in bile acid diarrhea (BAD). Our aim was ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2019, 10(4):e00019]

Cited: 4 times

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GI Dysfunctions in Diabetic Gastroenteropathy, Their Relationships With Symptoms, and Effects of a GLP-1 Antagonist.

Subhankar Chakraborty, Magnus Halland, Duane Burton, Anshuman Desai, Bridget Neja, Phillip Low, Wolfgang Singer, Michael Camilleri, Alan R Zinsmeister, Adil E Bharucha,

<h4>Context</h4>Delayed gastric emptying (GE) is common but often asymptomatic in diabetes. The relationship between symptoms, glycemia, and neurohormonal functions, including glucagonlike peptide 1 (GLP-1), are unclear.<h4>Objectives</h4>To assess whether GE disturbances, symptoms during a GE study, and symptoms during enteral lipid infusion explain daily symptoms and whether GLP-1 mediates symptoms during ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2019, 104(6):1967-1977]

Cited: 5 times

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Gastric accommodation measurements by single photon emission computed tomography and two-dimensional scintigraphy in diabetic patients with upper gastrointestinal symptoms.

Victor Chedid, Houssam Halawi, Justin Brandler, Duane Burton, Michael Camilleri,

<h4>Objective</h4>To compare estimates of gastric accommodation (GA) with single photon emission computed tomography (SPECT) to measurements based on intragastric meal distribution immediately post-meal ingestion (IMD<sup>0</sup> ).<h4>Methods</h4>We evaluated 108 diabetics with upper gastrointestinal (UGI) symptoms who had undergone gastric emptying of solids (GE) by scintigraphy and GA measurements by SPECT. Immediately ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2019, 31(6):e13581]

Cited: 2 times

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Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome.

Priya Vijayvargiya, Michael Camilleri, Duane Burton, Irene Busciglio, Alan Lueke, Leslie J Donato,

BACKGROUND:Biomarkers in irritable bowel syndrome (IBS) may guide targeted therapy in this multifactorial disease. It has been suggested that 75% accuracy and cost <$500 categorise biomarkers as cost-effective. AIM:To identify differences in faecal bile acids, faecal fat and fasting serum C4 (7a-hydroxy-4-cholesten-3-one) and fibroblast growth factor 19 (FGF19) among patients ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 49(6):744-758]

Cited: 7 times

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Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea.

Priya Vijayvargiya, Michael Camilleri, Victor Chedid, Paula Carlson, Irene Busciglio, Duane Burton, Leslie J Donato,

BACKGROUND & AIMS:Patients with bile acid diarrhea (BAD) are identified based on increased levels of BAs in fecal samples collected over a 48-hr period while on a 100-gram fat diet (48-hr BA), retention of 75Se-labeled homocholic acid taurine, or serum levels of C4 or FGF19. BAD increases fecal weight and ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(5):922-929.e2]

Cited: 12 times

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Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial.

Ibironke Oduyebo, Michael Camilleri, Alfred D Nelson, Disha Khemani, Sara Linker Nord, Irene Busciglio, Duane Burton, Deborah Rhoten, Michael Ryks, Paula Carlson, Leslie Donato, Alan Lueke, Kathline Kim, Stephen J Rossi, Alan R Zinsmeister,

OBJECTIVE:NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials in type 2 diabetes and primary biliary cholangitis, NGM282 was associated with dose-related abdominal cramping and diarrhea. We aimed to examine effects of NGM282 ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2018, 113(5):725-734]

Cited: 9 times

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Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial.

Houssam Halawi, Disha Khemani, Deborah Eckert, Jessica O'Neill, Hoda Kadouh, Karen Grothe, Matthew M Clark, Duane D Burton, Adrian Vella, Andres Acosta, Alan R Zinsmeister, Michael Camilleri,

<h4>Background</h4>Liraglutide, a long-acting GLP-1 receptor agonist, is approved for treatment of obesity; however, the mechanisms of action of liraglutide are incompletely understood. We compared effects of liraglutide versus placebo on gastric motor functions, satiation, satiety, and weight in obese individuals over 16 weeks.<h4>Methods</h4>We did a randomised, double-blind, placebo-controlled pilot trial ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2017, 2(12):890-899]

Cited: 44 times

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