Full Text Journal Articles by
Author Douglas W White


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Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases.

Jonathan S Hausmann, Kevin Kennedy, Julia F Simard, Jean W Liew, Jeffrey A Sparks, Tarin T Moni, Carly Harrison, Maggie J Larché, Mitchell Levine, Sebastian E Sattui, Teresa Semalulu, Gary Foster, Salman Surangiwala, Lehana Thabane, Richard P Beesley, Karen L Durrant, Elsa F Mateus, Serena Mingolla, Michal Nudel, Candace A Palmerlee, Dawn P Richards, David F L Liew, Catherine L Hill, Suleman Bhana, Wendy Costello, Rebecca Grainger, Pedro M Machado, Philip C Robinson, Paul Sufka, Zachary S Wallace, Jinoos Yazdany, Emily Sirotich, ,

<h4>Background</h4>The impact and consequences of the COVID-19 pandemic on people with rheumatic disease are unclear. We developed the COVID-19 Global Rheumatology Alliance Patient Experience Survey to assess the effects of the COVID-19 pandemic on people with rheumatic disease worldwide.<h4>Methods</h4>Survey questions were developed by key stakeholder groups and disseminated worldwide through ... Read more >>

Lancet Rheumatol (The Lancet. Rheumatology)
[2021, 3(10):e707-e714]

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Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation.

Shana M Owens, Darby G Oldenburg, Douglas W White, J Craig Forrest,

Gammaherpesviruses (GHVs) are DNA tumor viruses that establish lifelong, chronic infections in lymphocytes of humans and other mammals. GHV infections are associated with numerous cancers, especially in immunocompromised hosts. While it is known that GHVs utilize host germinal center (GC) B cell responses during latency establishment, an understanding of how ... Read more >>

J Virol (Journal of virology)
[2020, 95(1):]

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Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge.

Darby G Oldenburg, Dean A Jobe, Steven D Lovrich, Rhonda L LaFleur, Douglas W White, Jennifer C Dant, Steven M Callister,

We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with <i>Borrelia burgdorferi</i> by <i>Ixodes scapularis</i> ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2020, 32(3):481-485]

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Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Nick D Van Skike, Nana K Minkah, Chad H Hogan, Gary Wu, Peter T Benziger, Darby G Oldenburg, Mehmet Kara, Deborah M Kim-Holzapfel, Douglas W White, Scott A Tibbetts, Jarrod B French, Laurie T Krug,

[This corrects the article DOI: 10.1371/journal.ppat.1006843.]. ...

PLoS Pathog (PLoS pathogens)
[2018, 14(9):e1007319]

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Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.

Brian F Niemeyer, Lauren M Oko, Eva M Medina, Darby G Oldenburg, Douglas W White, Carlyne D Cool, Eric T Clambey, Linda F van Dyk,

Gammaherpesviruses are common viruses associated with lifelong infection and increased disease risk. Reactivation from latency aids the virus in maintaining infection throughout the life of the host and is responsible for a wide array of disease outcomes. Previously, we demonstrated that the virus-encoded cyclin (v-cyclin) of murine gammaherpesvirus 68 (γHV68) ... Read more >>

J Virol (Journal of virology)
[2018, 92(6):]

Cited: 3 times

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The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.

S Louis Bridges, Douglas W White, Angus B Worthing, Ellen M Gravallese, James R O'Dell, Kamala Nola, Jonathan Kay, Stanley B Cohen, ,

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2018, 70(3):334-344]

Cited: 11 times

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Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs.

Arundhati Gupta, Darby G Oldenburg, Eduardo Salinas, Douglas W White, J Craig Forrest,

Latency-associated nuclear antigen (LANA) is a multifunctional protein encoded by members of the <i>Rhadinovirus</i> genus of gammaherpesviruses. Studies using murine gammaherpesvirus 68 (MHV68) demonstrated that LANA is important for acute replication, latency establishment, and reactivation <i>in vivo</i> Despite structural similarities in their DNA-binding domains (DBDs), LANA homologs from Kaposi sarcoma-associated ... Read more >>

J Virol (Journal of virology)
[2017, 91(19):]

Cited: 7 times

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Unsupervised learning techniques reveal heterogeneity in memory CD8+ T cell differentiation following acute, chronic and latent viral infections.

Mingyong Liu, Erik S Barton, Ryan N Jennings, Darby G Oldenburg, Juliann M Whirry, Douglas W White, Jason M Grayson,

CD8<sup>+</sup> T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8<sup>+</sup> T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8<sup>+</sup> T cells into uninfected recipients, and examined surface proteins, cytokines and transcription factors ... Read more >>

Virology (Virology)
[2017, 509:266-279]

Cited: 2 times

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RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency.

Alexis L Santana, Darby G Oldenburg, Varvara Kirillov, Laraib Malik, Qiwen Dong, Roman Sinayev, Kenneth B Marcu, Douglas W White, Laurie T Krug,

RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency. Lipopolysaccharide (LPS)/toll-like receptor (TLR)4 engagement enhances rhadinovirus reactivation. We developed two new systems to examine the interaction of RTA with host NF-kappaB (NF-κB) signaling during murine gammaherpesvirus 68 ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2017, 6(1):]

Cited: 3 times

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A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality.

Pratyusha Mandal, Bridgette E Krueger, Darby Oldenburg, Katherine A Andry, R Suzanne Beard, Douglas W White, Erik S Barton,

The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals. The precise immune mechanisms that prevent gammaherpesvirus reactivation and tumorigenesis are poorly defined. Murine gammaherpesvirus 68 (MHV68) is closely related to EBV and KSHV, and type ... Read more >>

PLoS Pathog (PLoS pathogens)
[2011, 7(11):e1002371]

Cited: 25 times

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Pitfalls in the evaluation of shortness of breath.

Charlotte Page Wills, Megann Young, Douglas W White,

This article illustrates the challenges practitioners face evaluating shortness of breath, a common emergency department complaint. Through a series of patient encounters, pitfalls in the evaluation of shortness of breath are reviewed and discussed. ... Read more >>

Emerg Med Clin North Am (Emergency medicine clinics of North America)
[2010, 28(1):163-81, ix]

Cited: 2 times

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Latent herpesvirus infection arms NK cells.

Douglas W White, Catherine R Keppel, Stephanie E Schneider, Tiffany A Reese, James Coder, Jacqueline E Payton, Timothy J Ley, Herbert W Virgin, Todd A Fehniger,

Natural killer (NK) cells were identified by their ability to kill target cells without previous sensitization. However, without an antecedent "arming" event, NK cells can recognize, but are not equipped to kill, target cells. How NK cells become armed in vivo in healthy hosts is unclear. Because latent herpesviruses are ... Read more >>

Blood (Blood)
[2010, 115(22):4377-4383]

Cited: 46 times

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Herpesvirus latency and symbiotic protection from bacterial infection.

Erik S Barton, Douglas W White, Herbert W Virgin,

Viral Immunol (Viral immunology)
[2009, 22(1):3-4; author reply 5-6]

Cited: 10 times

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CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions.

Kyle J Eash, Jacquelyn M Means, Douglas W White, Daniel C Link,

The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Accumulating evidence suggests that ... Read more >>

Blood (Blood)
[2009, 113(19):4711-4719]

Cited: 143 times

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Videos in clinical medicine. Placement of a femoral venous catheter.

Janet Y Tsui, Adam B Collins, Douglas W White, Jasmine Lai, Jeffrey A Tabas,

N Engl J Med (The New England journal of medicine)
[2008, 358(26):e30]

Cited: 6 times

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(C)Re-combining textbook models of virus spread within the host.

Erik S Barton, Douglas W White,

Classic viral pathogenesis models postulate that tissues supporting efficient virus replication promote virus dissemination, which culminates in clinical illness. In this issue of Cell Host & Microbe, Sacher and colleagues use Cre/loxP recombination to label murine cytomegalovirus during replication in distinct cell types in vivo. Strikingly, they demonstrate that the ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2008, 3(4):201-202]

Cited: 0 times

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Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease.

Vera L Tarakanova, Friederike Kreisel, Douglas W White, Herbert W Virgin,

Gammaherpesvirus infection is associated with an increased incidence of lymphoproliferative disease in immunocompromised hosts. Murine gammaherpesvirus 68 (gammaHV68) infection of BALB beta(2)-microglobulin-deficient (BALB beta(2)m(-/-)) mice provides an animal model for analysis of the mechanisms responsible for the induction of a lymphoproliferative disease, atypical lymphoid hyperplasia (ALH), that is pathologically similar ... Read more >>

J Virol (Journal of virology)
[2008, 82(2):1034-1039]

Cited: 21 times

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Herpesvirus latency confers symbiotic protection from bacterial infection.

Erik S Barton, Douglas W White, Jason S Cathelyn, Kelly A Brett-McClellan, Michael Engle, Michael S Diamond, Virginia L Miller, Herbert W Virgin,

All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known as latency. Latency persists for the life of the host and is presumed to be parasitic, as it leaves the individual at risk for subsequent viral reactivation and disease. Here ... Read more >>

Nature (Nature)
[2007, 447(7142):326-329]

Cited: 382 times

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Extraskeletal mesenchymal chondrosarcoma: case report.

Douglas W White, Justin Q Ly, Douglas P Beall, Mark D McMillan, Joseph H McDermott,

This is a case report of an extraskeletal mesenchymal chondrosarcoma (ESMC) that originally occurred in the retroperitoneum of a 24-year-old female and later metastasized to the left proximal humerus. Mesenchymal chondrosarcomas are very rare in comparison to conventional chondrosarcomas and even more so when arising from an extraskeletal location. In ... Read more >>

Clin Imaging (Clinical imaging)
[2003, 27(3):187-190]

Cited: 4 times

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